References
- Api AM. (2001). Lack of effect of coumarin on the formation of micronuclei in an in vivo mouse micronucleus assay. Food Chem Toxicol 39:837–41.
- Benigni R, Bossa C, Tcheremenskaia O. (2013). Nongenotoxic carcinogenicity of chemicals: mechanisms of action and early recognition through a set of structural alerts. Chem Rev 113:2940–57.
- Creton S, Aardema MJ, Carmichael PL, et al. (2012). Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs. Mutagenesis 27:93–101.
- Dertinger SD, Torous DK, Tometsko AM. (1993). In vitro system for detecting nongenotoxic carcinogens. Environ Mol Mutagen 21:332–8.
- Ellinger-Ziegelbauer H, Gmuender H, Bandenburg A, Juergen Ahr H. (2008). Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies. Mutat Res 637:23–39.
- Garcia-Canton C, Anadon A, Meredith C. (2012). γH2AX as a novel endpoint to detect DNA damage: applications for the assessment of the in vitro genotoxicity of cigarette smoke. Toxicol In Vitro 26:1075–86.
- Gomes-Carneiro MR, Viana ME, Felzenszwalb I, Paumgartten FJ. (2005). Evaluation of beta-myrcene, alpha-terpinene and (+)- and (−)- alpha-pinene in the Salmonella/microsome assay. Food Chem Toxicol 43:247–52.
- Gorelick NJ. (1995). Genotoxicity of trans-anethole in vitro. Mutat Res 326:199–209.
- Gunz D, Shepherd SE, Lutz WK. (1993). Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay? Environ Mol Mutagen 21:209–11.
- Herceg Z, Lambert M-P, Veldhoven K, et al. (2013). Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis 34:1955–67.
- Kinoshita A, Wanibuchi H, Wei M, Fukushima S. (2006). Hormesis in carcinogenicity of non-genotoxic carcinogens. J Toxicol Pathol 19:111–22.
- Kirby PE, Pizzarello RF, Lawlor TE, et al. (1983). Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay. Environ Mutagen 5:657–63.
- Klaunig JE, Kamendulis LM, Hocevar BA. (2010). Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 38:96–109.
- Lee SJ, Yum YN, Kim SC, et al. (2013). Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis. Nat Sci Rep 3:2783.
- Lake BG. (1999). Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol 37:423–53.
- Lyko F, Beisel C, Marhold J, Paro R. (2006). Epigenetic regulation in Drosophila. Curr Top Microbiol Immunol 310:23–44.
- Maron DM, Ames BN. (1983). Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173–215.
- Melnick RL, Kohn MC, Portier C. (1996). Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis. Environ Health Perspect 104:123–34.
- Mortelmans K, Zeiger E. (2000). The Ames Salmonella/microsome mutagenicity assay. Mutat Res 455:29–60.
- NTP. (1993). National Toxicology Program, Toxicology and carcinogenic studies of coumarin (CAS No. 94-64-5) in F344/N rats and B6C3F1 mice (Gavage studies). Technical report series No. 422. NIH Publication No. 92-31153, US Department of Health and Humans Services, Bethesda, MD.
- OECD. (1997). Organization for Economic Co-operation and Development guideline for the testing of chemicals, No. 471, Bacterial Reverse Mutation Test.
- OECD. (2014a). Organization for Economic Co-operation and Development (OECD) guideline for testing of chemicals, No. 473, In vitro mammalian chromosomal aberration test.
- OECD. (2014b). Organization for Economic Co-operation and Development (OECD) guideline for the testing of chemicals, No. 474, Mammalian erythrocyte micronucleus test.
- Omura S, Uehara T, Morikawa Y, et al. (2014). Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats. J Toxicol Sci 39:785–94.
- Rao T, Young J, Weeks C, et al. (1979). Effects of the co-carcinogen benzo(e)pyrene on microsome-mediated chemical mutagenesis in Salmonella typhymurium. Environ Mutagen 1:5–112.
- Schulte-Hermann R. (1985). Tumor promotion in the liver. Arch Toxicol 57:147–58.
- Siegel RL, Miller KD, Jemal A. (2015). Cancer statistics, 2015. Cancer J Clin 55:5–29.
- Vinesis P, Schatzkin A, Potter JD. (2010). Models of carcinogenesis: an overview. Carcinogenesis 31:1703–9.
- WHO. (1991). Food additives series 28; http://www.inchem.org/
- Waters MD, Stack HF, Jackson MA, Bridges BA. (1993). Hazard identification: efficiency of short-term tests in identifying germ cell mutagens and putative nongenotoxic carcinogens. Environ Health Perspect 101:61–72.
- Yamasaki H. (1995). Non-genotoxic mechanisms of carcinogenesis: studies of cell transformation and gap junctional intercellular communication. Toxicol Lett 77:55–61.