Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression

References

• Abd-Allah SH, Shalaby SM, Abd-Elbary E, Saleh AA, El-Magd MA. 2015. Human peripheral blood CD34+ cells attenuate oleic acid-induced acute lung injury in rats. Cytotherapy. 17:443–453.
   PubMed Web of Science ®Google Scholar
• Abd-Alrahman SH, Elhalwagy MEA, Kotb GA, Farid H, Farag AAG, Draz HM, Isa AM, Sabico S. 2014. Exposure to difenoconazole, diclofop-methyl alone and combination alters oxidative stress and biochemical parameters in albino rats. Int J Clin Exp Med. 7:3637–3646.
   PubMed Web of Science ®Google Scholar
• Abdel-Daim M, El-Bialy BE, Rahman HG, Radi AM, Hefny HA, Hassan AM. 2016. Antagonistic effects of Spirulina platensis against sub-acute deltamethrin toxicity in mice: biochemical and histopathological studies. Biomed Pharmacother. 77:79–85.
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Gamble M. 2008. Theory and practice of histological techniques. 6th ed. New York/London: Churchill Livingstone; p. 165e75.
   Google Scholar
• Bruno M, Moore T, Nesnow S, Ge Y. 2009. Protein carbonyl formation in response to propiconazole-induced oxidative stress. J Proteome Res. 8:2070–2078.
   PubMed Web of Science ®Google Scholar
• Edwards SG, Godley NP. 2010. Reduction of Fusarium head blight and deoxynivalenol in wheat with early fungicide applications of prothioconazole. Food Addit Contam. 27:629–635.
   Web of Science ®Google Scholar
• EFSA. 2010. Conclusion on the peer review of the pesticide risk assessment of the active substance bromuconazole. EFSA J. 8:1–84.
   Google Scholar
• El-Magd MA, Kahilo KA, Nasr NE, Kamal T, Shukry M, Saleh AA. 2016. A potential mechanism associated with lead-induced testicular toxicity in rats. Andrologia. [Epub ahead of print]. doi: 10.1111/and.12750.
   PubMedGoogle Scholar
• Gao Q, Wang JJ, Han FM, Chen Y. 2011. Effect of strychnine hydrochloride on liver cytochrome P450 mRNA expression and monooxygenase activities in rat. Acta Pharm Sin B. 1:121–128.
   Google Scholar
• Goetz, A.K., Bao W, Ren H, Schmid JE, Tully DB, Wood C, Rockett JC, Narotsky MG, Sun G, Lambert GR, et al. 2006. Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Toxicol Appl Pharmacol. 215:274–284.
   PubMed Web of Science ®Google Scholar
• Goetz AK, Dix DJ. 2009a. Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. Toxicol Sci. 110:449–462.
   PubMed Web of Science ®Google Scholar
• Goetz AK, Dix DJ. 2009b. Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol. 238:80–89.
   PubMed Web of Science ®Google Scholar
• Heise T, Schmidt F, Knebel C, Rieke S, Haider W, Pfeil R, Kneuer C, Niemann L, Marx-Stoelting P. 2015. Hepatotoxic effects of (tri)azole fungicides in a broad dose range. Arch Toxicol. 89:2105–2117.
   PubMed Web of Science ®Google Scholar
• Hester S, Moore T, Padgett WT, Murphy L, Wood CE, Nesnow S. 2012. The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses. Toxicol Sci. 127:54–65.
   PubMed Web of Science ®Google Scholar
• Juberg DR, Mudra DR, Hazelton GA, Parkinson A. 2006. The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice. Toxicol Appl Pharmacol. 214:178–187.
   PubMed Web of Science ®Google Scholar
• Lim YP, Cheng CH, Chen WC, Chang SY, Hung DZ, Chen JJ, Wan L, Ma WC, Lin YH, et al. 2015. Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Arch Toxicol. 89:57–72.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, CA). 25:402–408.
   PubMed Web of Science ®Google Scholar
• Mazur CS, Kenneke JF, Tebes-Stevens C, Okino MS, Lipscomb JC. 2007. In vitro metabolism of the fungicide and environmental contaminant trans-bromuconazole and implications for risk assessment. J Toxicol Environ Health. 70:1241–1250.
   PubMed Web of Science ®Google Scholar
• Menegola E, Broccia ML, Di Renzo F, Giavini E. 2006. Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects. Reprod Toxicol. 22:186–195.
   PubMed Web of Science ®Google Scholar
• Nesnow S, Ward W, Moore T, Ren H, Hester SD. 2009. Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. Toxicol Sci. 110:68–83.
   PubMed Web of Science ®Google Scholar
• Osman AH, El-Shama SS, Osman AS, Abd El-Hameed AK. 2011. Toxicological and pathological evaluation of prolonged bromuconazole fungicide exposure in male rats. Med J Cairo Univ. 79:555–564.
   Google Scholar
• Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I. 2007. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 99:315–325.
   PubMed Web of Science ®Google Scholar
• Selmanoglu G, Barlas N, Songür S, Koçkaya EA. 2001. Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats. Hum Exp Toxicol. 20:625–630.
   PubMed Web of Science ®Google Scholar
• Shchepetkin IA, Cherdyntseva NV, Kagiia VT. 2003. Effect of sanazole and metrinidazole on production of reactive oxygen species by macrophages. Antibiot Khimioter. 48:7–10.
   PubMedGoogle Scholar
• Sun G, Thai SF, Lambert GR, Wolf DC, Tully DB, Goetz AK, George MH, Grindstaff RD, Dix DJ, Nesnow S, 2006. Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Toxicol Lett. 164:44–53.
   PubMed Web of Science ®Google Scholar
• Sun G, Thai SF, Tully DB, Lambert GR, Goetz AK, Wolf DC, Dix DJ, Nesnow S. 2005. Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver. Toxicol Lett. 155:277–287.
   PubMed Web of Science ®Google Scholar
• Trosken ER, Scholz K, Lutz RW, Völkel W, Zarn JA, Lutz WK. 2004. Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocrine Res. 30:387–394.
   PubMed Web of Science ®Google Scholar
• Tully DB, Bao W, Goetz AK, Blystone CR, Ren H, Schmid JE, Strader LF, Wood CR, Best DS, Narotsky MG, et al. 2006. Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Toxicol Appl Pharmacol. 215:260–273.
   PubMed Web of Science ®Google Scholar
• Vanier KL, Mattiussi AJ, Johnston DL. 2003. Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia. J Pediatr Hematol Oncol. 25:403–404.
   PubMed Web of Science ®Google Scholar
• Yoshinari K, Sueyoshi T, Moore R, Negishi M. 2001. Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers. Mol Pharmacol. 59:278–284.
   PubMed Web of Science ®Google Scholar
• Zhang J, Huang W, Chua SS, Wei P, Moore DD. 2002. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science. 298:422–424.
   PubMed Web of Science ®Google Scholar