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Research Article

Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250

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Pages 12-22 | Received 29 Apr 2017, Accepted 03 Jul 2017, Published online: 25 Jul 2017

References

  • Abbas MT. 2014. The protective effect of quercetin on diazinon-induced oxidative stress in rats. Iraqi Nation J Chem. 53:96–122.
  • Abdel-Daim MM, Abuzead SMM, Halawa SM. 2013. Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. PLoS One. 8:1–7.
  • Aebi H. 1984. Catalase in vitro. Meth Enzymol. 105:121–126.
  • Ahmed HO, Said SE, Afaf SO, Ayman KA. 2011. Toxicological and pathological evaluation of pro-longed bromuconazole fungicide exposure in male rats. Med J Cairo Univ. 79:555–564.
  • Anjaneyulu M, Chopra K. 2003. Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a Mouse model of diabetic neuropathic pain. Prog Neuropsychopharmacol Biol Psychiatr. 27:1001–1005.
  • Beauchamp C, Fridovich I. 1971. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 44:276–287.
  • Ben Amara I, Ben Saad H, Hamdaoui L, Karray A, Boudawara T, Ben Ali Y, Zeghal N. 2015. Maneb disturbs expression of superoxide dismutase and glutathione peroxidase, increases reactive oxygen species production, and induces genotoxicity in liver of adult mice. Environ Sci Pollut Res. 22:12309.
  • Buchenauer H. 1995. DMI-fungicides – side effects on the plant and problems of resistance. In: Lyr H, editor. Modern selective fungicides. New York: Gustav Fischer Verlag; p. 259–290.
  • Cao G, Sofic E, Prior RL. 1997. Antioxidant and prooxidant behavior of flavonoids: structure–activity relationships. Free Radic Biol Med. 22:749–760.
  • Chakroun S, Ezzi L, Grissa I, Kerkeni E, Neffati F, Bhouri R, Sallem A, Najjar MF, Hassine M, Mehdi M, et al. 2016. Hematological, biochemical, and toxicopathic effects of subchronic acetamiprid toxicity in Wistar rats. Environ Sci Pollut Res Int. 23:25191–25199.
  • Chander V, Singh D, Chopra K. 2003. Catechin, a natural antioxidant protects against rhabdomyolysis-induced myoglobinuric acute renal failure. Pharmacol Res. 48:503–509.
  • Che Othman SF, Idid SZ, Koya MS, Rehan AM, Kamarudin KR. 2011. Antioxidant study of garlic and red onion: a comparative study. Pertanika J Trop Agric Sci. 34:253–261.
  • Chomczynski P, Sacchi N. 2006. The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on. Nat Protoc. 1:581–585.
  • Danuta P, Jan KL, Grazyna K, Joanna K, Bozena W, Krystyna L. 2001. Studies of early hepatocellular proliferation and peroxisomal proliferation in Wistar rats treated with herbicide diclofop. Toxicology. 158:119–126.
  • Di Carlo G, Mascolo N, Izzo AA, Capasso F. 1999. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 65:337–353.
  • Djeffal A, Messarah M, Boumendjel A, Kadeche L, El Feki A. 2015. Protective effects of vitamin C and selenium supplementation on methomyl-induced tissue oxidative stress in adult rats. Toxicol Ind Health. 31:31–43.
  • Draper HH, Hadley M. 1990. Malondialdehyde determination as index of lipid peroxidation. Meth Enzymol. 186:421–431.
  • Durak D, Kalender S, Uzun FG, Demir F, Kalender Y. 2010. Mercury chloride induced oxidative stress and the protective effect of vitamins C and E in human erythrocytes in vitro. Afr J Biotechnol. 9:488–495.
  • Favier A. 2003. Intérêt conceptionnel et experimental dans la compr ehension des mecanismes des maladies et potentiel therapeutique. L’actual Chim. 11:108–115.
  • Flohe L, Gunzler WA. 1984. Assays of glutathione peroxidase. Methods Enzymol. 105:114–121.
  • Formica JF, Regelson W. 1995. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol. 33:1061–1080.
  • Ghannoum MA, Rice LB. 1999. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 12:501–517.
  • Gueraud F, Atalay M, Bresgen N, Cipak A, Eckl PM, Huc L, Jouanin I, Siems W, Uchida K. 2010. Chemistry and biochemistry of lipid peroxidation products. Free Radic Res. 44:1098–1124.
  • Halliwell B. 1996. Vitamin C antioxidant or pro-oxidant in vivo. Free Radic Res. 25:439–454.
  • Hamada MS, Yin Y, Ma Z. 2011. Sensitivity to iprodione, difenoconazole and fludioxonil of Rhizoctonia cerealis isolates collected from wheat in China. Crop Prot. 30:1028–1033.
  • Harborne JB, Williams ChA. 2000. Advances in flavonoid research since 1992. Phytochemistry. 55:481–504.
  • Horsfield A, Wicks T, Davies K, Wilson D, Paton S. 2010. Effect of fungicide use strategies on the control of early blight (Alternaria solani) and potato yield. Aust Plant Pathol. 39:368–375.
  • Jaballi I, Ben Saad H, Bkhairia I, Kammoun I, Droguet M, Magné C, Boudawara T, Kallel C, Nasri M, Hakim A, et al. 2017. Increasing maneb doses induces reactive oxygen species overproduction and nephrotoxicity in adult mice. Toxicol Mech Methods. 5:382–393.
  • Jacques-Silva MC, Nogueira CW, Broc LC. 2001. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacol Toxicol. 88:119–144.
  • James EL. 2006. Agricultural medicine—a practical guide. New York, NY: Springer.
  • Jeon SE, Choi-Kwon S, Park KA, Lee HJ, Park MS, Lee JH, Kwon SB, Park KC. 2003. Dietary supplementation of (+)-catechin protects against UVB induced skin damage by modulating antioxidant enzyme activities. Photoderm Photoimm Photomed. 19:235–241.
  • Kadeche L, Bourogaa E, Saoudi M, Boumendjel A, Djeffal A, El Feki A, Messarah M. 2016. Quercetin attenuates metribuzin-induced biochemical and hematological toxicity in adult rats. Int J Pharm Sci Rev Res. 40:38–46.
  • Kalender S, Kalender Y, Durak D, Ogutcu A, Uzunhisarcikli M, Cevrimli BS, Yildirim M. 2007. Methyl parathion induced nephrotoxicity in male rats and protective role of vitamins C and E. Pestic Biochem Phys. 88:213–218.
  • Kalender S, Ogutcu A, Uzunhisarcikli M, Acikgoz F, Durak D, Ulusoy Y, Kalender Y. 2005. Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes. Toxicology. 211:197–206.
  • Kanno S, Shouji A, Hirata R, Asou K, Ishikawa M. 2004. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in p388 cells. Life Sci. 75:353–365.
  • Karaoz E, Gultekin F, Akdogan M, Oncu M, Gokcimen A. 2002. Protective role of melatonin and a combination of vitamin C and vitamin E on lung toxicity induced by chlorpyrifos-ethyl in rats. Exp Toxicol Pathol. 54:97–108.
  • Kayali R, Cakatay U, Akcay T, Altug T. 2006. Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat. Cell Biochem Funct. 24:79–85.
  • Limón-Pacheco J, Gonsebatt ME. 2009. The role of antioxidants and antioxidant related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res. 674:137–147.
  • Liu PK, Arora T. 2002. Transcripts of damaged genes in the brain during cerebral oxidative stress. J Neurosci Res. 70:713–720.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–340.
  • Mehta A, Verma RS, Srivastava N. 2009. Chlorpyrifos-induced alterations in the levels of hydrogen peroxide nitrate and nitrite in rat brain and liver. Pest Biochem Phys. 94:55–59.
  • Morales AI, Vicente-Sánchez C, Sandoval JM, Egido J, Mayoral P, Arévalo MA, Fernández-Tagarro M, López-Novoa JM, Pérez-Barriocanal F. 2006. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol. 44:2092–2100.
  • Moridani MY, Pourahmad J, Bui H, Siraki A, O’Brien PJ. 2003. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic Biol Med. 34:245–253.
  • Ogutcu A, Suludere Z. Kalender 2008. Dichlorvos-induced hepatotoxicity in rats and the protective effects of vitamins C and E. Environ Toxicol Pharmacol. 26:355–361.
  • Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, et al. 2003. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 22:18–35.
  • Padma VV, Baskaran R, Roopesh RS, Poornima P. 2012. Quercetin attenuates lindane induced oxidative stress in Wistar rats. Mol Biol Rep. 39:6895–6905.
  • Ragsdale NN. 1977. Inhibition of fungal ergosterol synthesis. In: Siegel MR, Sisler HD, editors. Antifungal compounds: interactions in biological and ecological systems. New York: Marcel Dekker Inc.; p. 333–363.
  • Saoudi M, Messarah M, Boumendjel A, Jamoussi K, Abdelfattah F. 2011. Protective effects of vitamin C against haematological and biochemical toxicity induced by deltamethrin in male Wistar rats. Ecotoxicol Environ Saf. 74:1765–1769.
  • Scott RB, Reddy KS, Husain K, Schlorff EC, Rybak LP, Somani SM. 2000. Dose response of ethanol on antioxidant defense system of liver, lung, and kidney in rat. Pathophysiology. 7:25–32.
  • Sellins KS, Cohen JJ. 1995. Nuclear changes in the cytotoxic T lymphocyte-induced model of apoptosis. Immunol Rev. 146:241–266.
  • Shchepetkin IA, Cherdyntseva NV, Kagiia VT. 2003. Effect of sanazole and metrinidazole on production of reactive oxygen species by macrophages. Antibiot Khimioter. 48:7–10.
  • Sheehan DJ, Hitchcock CA, Sibley CM. 1999. Current and emerging azole antifungal agents. Clin Microbiol Rev. 12:40–79.
  • Sultatos LG, Minor LD, Murphy SD. 1985. Metabolic activation of phosphorothioate pesticides: role of the liver. J Pharmacol Exp Ther. 232:624–628.
  • Sultatos LG. 1987. The role of the liver in mediating the acute toxicity of the pesticide methyl parathion in the mouse. Drug Metab Dispos. 15:613–617.
  • Tennant BC. 1997. Hepatic function. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical biochemistry of domestic animals. San Diego (CA): Academic Press; p. 327–352.
  • Uzun FG, Kalender Y. 2013. Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin. Food Chem Toxicol. 55:549–556.
  • Uzunhisarcikli M, Kalender Y, Dirican K, Kalender S, Ogutcu A, Buyukkomurcu F. 2007. Acute, subacute and subchronic administration of methyl parathion induced testicular damage in male rats and protective role of vitamins C and E. Pestic Biochem Phys. 87:115–122.
  • Valenzuela A. 1991. The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress. Life Sci. 48:301–309.
  • Vanden Bossche H, Marichal P, Gorrens J, Coene M-C. 1990. Biochemical basis for the activity and selectivity of oral antifungal drugs. Br J Clin Pract Suppl. 71:41–46.
  • Vawdrey LL, Grice KRE, Westerhuis D. 2008. Field and laboratory evaluations of fungicides for the control of brown spot (Corynespora cassiicola) and black spot (Asperisporium caricae) of papaya in far. Australas Plant Path. 37:552–558.
  • Zal F, Mostafavi-Pour Z, Vessal M. 2007. Comparison of the effects of vitamin E and/or quercetin in attenuating chronic cyclosporine A-induced nephrotoxicity in male rats. Clin Exp Pharmacol Physiol. 34:720–724.
  • Zarn JA, Bruschweiler BJ, Schlatter JR. 2003. Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase. Environ Health Perspect. 111:255–261.

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