Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis

References

• Abdel-Rahman EM, Alhamad T, Reeves WB, Awad AS. 2012. Management of diabetic nephropathy in the elderly: special considerations. J Nephrol Ther. 2:124.
   PubMedGoogle Scholar
• Alam U, Asghar O, Azmi S, Malik RA. 2014. General aspects of diabetes mellitus. Handb Clin Neurol. 126:211–222.
   PubMedGoogle Scholar
• Beutler E, Duron O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J Lab Clin Med. 61:882–888.
   PubMed Web of Science ®Google Scholar
• Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–72254.
   PubMed Web of Science ®Google Scholar
• Chen G, Yang X, Yang X, Li L, Luo J, Dong H, Xu L, Yi P, Wang K, Zou X, et al. 2017. Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving β cell function and reducing insulin resistance in diabetic rats. BMC Complement Altern Med. 17:507.
   PubMed Web of Science ®Google Scholar
• Chen X, Wu R, Kong Y, Yang Y, Gao Y, Sun D, Liu Q, Dai D, Lu Z, Wang N, et al. 2017. Tanshinone IIA attenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation. Oncotarget. 8:31915–31922.
   PubMedGoogle Scholar
• Chung SS, Vadgama JV. 2015. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 35:39–46.
   PubMed Web of Science ®Google Scholar
• Duan W, Yang Y, Yi W, Yan J, Liang Z, Wang N, Li Y, Chen W, Yu S, Jin Z, et al. 2013. New role of JAK2/STAT3 signaling in endothelial cell oxidative stress injury and protective effect of melatonin. PLoS One. 8:e57941.
   PubMed Web of Science ®Google Scholar
• Elmarakby AA, Sullivan JC. 2012. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovasc Ther. 30:49–59.
   PubMed Web of Science ®Google Scholar
• Elsherbiny NM, El-Sherbiny M, Said E. 2015. Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib. J Physiol Biochem. 71:635–648.
   PubMed Web of Science ®Google Scholar
• Gao Q, Liang X, Shaikh AS, Zang J, Xu W, Zhang Y. 2018. JAK/STAT signal transduction: promising attractive targets for immune, inflammatory and hematopoietic diseases. Curr Drug Targets. 19:487–500.
   PubMed Web of Science ®Google Scholar
• He G, Karin M. 2011. NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 21:159–168.
   PubMed Web of Science ®Google Scholar
• Hsu JD, Wu CC, Hung CN, Wang CJ, Huang HP. 2016. Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice. J Food Drug Anal. 24:730–737.
   PubMed Web of Science ®Google Scholar
• Jia H, Cui J, Jia X, Zhao J, Feng Y, Zhao P, Zang D, Yu J, Zhao T, Wang H, et al. 2017. Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft- vs. host disease: old drug, new use. Mol Med Rep. 16:9480–9486.
   PubMed Web of Science ®Google Scholar
• Kuhad A, Chopra K. 2009. Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway. Life Sci. 84:296–301.
   PubMed Web of Science ®Google Scholar
• Li L, Yin Q, Tang X, Bai L, Zhang J, Gou S, Zhu H, Cheng J, Fu P, Liu F. 2014. C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway. PLoS One. 9:e113639.
   PubMed Web of Science ®Google Scholar
• Ma Z, Zhu L, Liu Y, Wang Z, Yang Y, Chen L, Lu Q. 2017. Lovastatin alleviates endothelial-to-mesenchymal transition in glomeruli via suppression of oxidative stress and TGF-β1 signaling. Front Pharmacol. 8:473.
   PubMed Web of Science ®Google Scholar
• Montgomery HAC, Dymock J. 1961. The determination of nitrite in water. Analyst. 86:414–416.
   Web of Science ®Google Scholar
• Narres M, Claessen H, Droste S, Kvitkina T, Koch M, Kuss O, Icks A. 2016. The incidence of end-stage renal disease in the diabetic (compared to the non-diabetic) population: a systematic review. PLoS One. 11:e0147329.
   PubMed Web of Science ®Google Scholar
• Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H, Chauhan D, Anderson KC, Frank DA. 2008. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood. 112:5095–5102.
   PubMed Web of Science ®Google Scholar
• Nishikimi M, Appaji N, Yagi K. 1972. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 46:849–854.
   PubMed Web of Science ®Google Scholar
• Omodanisi EI, Aboua YG, Oguntibeju OO. 2017. Assessment of the anti-hyperglycaemic, anti-inflammatory and antioxidant activities of the methanol extract of Moringaoleifera in diabetes-induced nephrotoxic male Wistar rats. Molecules. 22:439.
   PubMed Web of Science ®Google Scholar
• Potočnjak I, Broznić D, Kindl M, Kropek M, Vladimir-Knežević S, Domitrović R. 2017. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STA 3, and NF-κB activation. Food Chem Toxicol. 107:215–225.
   PubMed Web of Science ®Google Scholar
• Said E, Zaitone SA, Eldosoky M, Elsherbiny NM. 2018. Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats. Chem Biol Interact. 281:111–120.
   PubMed Web of Science ®Google Scholar
• Sanchez-Niño MD, Sanz AB, Lorz C, Gnirke A, Rastaldi MP, Nair V, Egido J, Ruiz-Ortega M, Kretzler M, Ortiz A. 2010. BASP1 promotes apoptosis in diabetic nephropathy. J Am Soc Nephrol. 21:610–621.
   PubMed Web of Science ®Google Scholar
• Satoh K. 1978. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 90:37–43.
   PubMed Web of Science ®Google Scholar
• Sha J, Sui B, Su X, Meng Q, Zhang C. 2017. Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy. Mol Med Rep. 16:7715–7723.
   PubMed Web of Science ®Google Scholar
• Sheikh BA, Pari L, Rathinam A, Chandramohan R. 2015. Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Biochimie.112:57–65.
   PubMed Web of Science ®Google Scholar
• Tang J, Liu CY, Lu MM, Zhang J, Mei WJ, Yang WJ, Xie YY, Huang L, Peng ZZ, Yuan QJ, et al. 2015. Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation. Mol Cell Biochem. 407:77–87.
   PubMed Web of Science ®Google Scholar
• Wang X, Shaw S, Amiri F, Eaton DC, Marrero MB. 2002. Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells. Diabetes. 51:3505–3509.
   PubMed Web of Science ®Google Scholar
• Verzola D, Gandolfo MT, Ferrario F, Rastaldi MP, Villaggio B, Gianiorio F, Giannoni M, Rimoldi L, Lauria F, Miji M, et al. 2007. Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int. 72:1262–1272.
   PubMed Web of Science ®Google Scholar
• Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA. 2018. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis. 9:119.
   PubMed Web of Science ®Google Scholar
• Xu Y, Bai L, Chen X, Li Y, Qin Y, Meng X, Zhang Q. 2018. 6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice. Biomed Pharmacother. 97:633–641.
   PubMed Web of Science ®Google Scholar
• Yang F, Hu M, Lei Q, Xia Y, Zhu Y, Song X, Li Y, Jie H, Liu C, Xiong Y, et al. 2015. Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model. Cell Death Dis. 6:e1701.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Ye T, Yu X, Lei Q, Yang F, Xia Y, Song X, Liu L, Deng H, Gao T, et al. 2016. Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma. Sci Rep. 6:20253.
   PubMed Web of Science ®Google Scholar