Naringenin palliates cisplatin and doxorubicin gonadal toxicity in male rats

References

• Adana MY, Akang EN, Peter AI, Jegede AI, Naidu ECS, Tiloke C, Chuturgoon AA, Azu OO. 2018. Naringenin attenuates highly active antiretroviral therapy-induced sperm DNA fragmentations and testicular toxicity in Sprague-Dawley rats. Andrology. 6:166–175.
   PubMed Web of Science ®Google Scholar
• Akolkar G, Bagchi AK, Ayyappan P, Jassal DS, Singal PK. 2017. Doxorubicin-induced nitrosative stress is mitigated by vitamin C via the modulation of nitric oxide synthases. Am J Physiol Cell Physiol. 312:C418–C427.
   PubMed Web of Science ®Google Scholar
• Alhalabi M. 2016. Predictive value of serum Inhibin-B levels as an indicator of the presence of testicular spermatozoa in non-obstructive azoospermia. Middle East Fertil Soc J. 21:246–252.
   Web of Science ®Google Scholar
• Alyoussef A, Al-Gayyar M. 2016. Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite. Andrologia. 48:501–508.
   PubMed Web of Science ®Google Scholar
• Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A, Laganà G, Daglia M, Meneghini S, Nabavi SM, et al. 2017. Flavanones: citrus phytochemical with health-promoting properties. Biofactors. 43:495–506.
   PubMed Web of Science ®Google Scholar
• Bloise E, Ortiga-Carvalho TM, Reis FM, Lye SJ, Gibb W, Matthews SG. 2016. ATP-binding cassette transporters in reproduction: a new frontier. Hum Reprod Update. 22:164–181.
   PubMed Web of Science ®Google Scholar
• Cabral REL, Mendes TB, Vendramini V, Miraglia SM. 2018. Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin-treated rats. Andrology. 6:236–246.
   PubMed Web of Science ®Google Scholar
• Eid AH, Abdelkader NF, Abd El-Raouf OM, Fawzy HM, El-Denshary E-E-DS. 2016. Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation. Arch Pharm Res. 39:1693–1702.
   PubMed Web of Science ®Google Scholar
• Erpek S, Bilgin MD, Dikicioglu E, et al. 2007. The effects of low frequency electric field in rat testis. Rev Med Vet (Toulouse). 158:206–211.
   Web of Science ®Google Scholar
• Fallahzadeh AR, Rezaei Z, Rahimi HR, Barmak MJ, Sadeghi H, Mehrabi S, Rabani SM, Kashani IR, Barati V, Mahmoudi R, et al. 2017. Evaluation of the effect of pentoxifylline on cisplatin-induced testicular toxicity in rats. Toxicol Res. 33:255–263.
   PubMed Web of Science ®Google Scholar
• Fouad AA, Albuali WH, Jresat I. 2016. Protective effect of naringenin against lipopolysaccharide-induced acute lung injury in rats. Pharmacology. 97:224–232.
   PubMed Web of Science ®Google Scholar
• Fouad AA, Qutub HO, Fouad AEA, Audeh AM, Al-Melhim WN. 2017. Epigallocatechin-3-gallate counters cisplatin toxicity of rat testes. Pharm Biol. 55:1710–1714.
   PubMed Web of Science ®Google Scholar
• Ganaie MA. 2015. The protective effects of naringenin on testes gonadotoxicity induced by cisplatin in rats. Bull Env Pharmacol Life Sci. 5:15–21.
   Google Scholar
• Gu Y-P, Yang X-M, Duan Z-H, Luo P, Shang J-H, Xiao W, Tao Y-X, Zhang D-Y, Zhang Y-B, Liu H-Z, et al. 2017. Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide. Exp Ther Med. 14:5889–5895.
   PubMed Web of Science ®Google Scholar
• Guo Y, Sun J, Li T, Zhang Q, Bu S, Wang Q, Lai D. 2017. Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway. Sci Rep. 7:9599
   PubMed Web of Science ®Google Scholar
• Hamza AA, Elwy HM, Badawi AM. 2016. Fenugreek seed extract attenuates cisplatin-induced testicular damage in Wistar rats. Andrologia. 48:211–221.
   PubMed Web of Science ®Google Scholar
• Helmy MM, Hashim AA, Mouneir SM. 2018. Zileuton alleviates acute cisplatin nephrotoxicity: inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis. Prostaglandins Other Lipid Mediat. 135:1–10.
   PubMed Web of Science ®Google Scholar
• Johnsen SG. 1970. Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Horm Res Paediatr. 1:2–25.
   Google Scholar
• Kabel AM. 2018. Zinc/alogliptin combination attenuates testicular toxicity induced by doxorubicin in rats: Role of oxidative stress, apoptosis and TGF-β1/NF-κB signaling. Biomed Pharmacother. 97:439–449.
   PubMed Web of Science ®Google Scholar
• Mostafa HE-S, Abd El-Baset SA, Kattaia AAA, Zidan RA, Al Sadek MMA. 2016. Efficacy of naringenin against permethrin-induced testicular toxicity in rats. Int J Exp Pathol. 97:37–49.
   PubMed Web of Science ®Google Scholar
• Olusoji MJ, Oyeyemi OM, Asenuga ER, et al. 2017. Protective effect of gallic acid on doxorubicin-induced testicular and epididymal toxicity. Andrologia. 49:e12635.
   Web of Science ®Google Scholar
• Park H-s, Oh J-H, Lee J. h, Lee Y-J. 2011. Minor effects of the citrus flavonoids naringin, naringenin and quercetin, on the pharmacokinetics of doxorubicin in rats. Pharmazie. 66:424–429.
   PubMed Web of Science ®Google Scholar
• Rauf A, Uddin G, Raza M, Ahmad B, Jehan N, Siddiqui BS, Molnar J, Csonka A, Szabo D. 2016. Reversal of multidrug resistance in mouse lymphoma cells by extracts and flavonoids from Pistacia integerrima. Asian Pac J Cancer Prev. 17:51–55.
   PubMedGoogle Scholar
• Rizk SM, Zaki HF, Mina MA. 2014. Propolis attenuates doxorubicin-induced testicular toxicity in rats. Food Chem Toxicol. 67:176–186.
   PubMed Web of Science ®Google Scholar
• Sahin Z, Ozkaya A, Cuce G, et al. 2017. Investigation of the effect of naringenin on oxidative stress-related alterations in testis of hydrogen peroxide-administered rats. J Biochem Mol Toxicol. 31:e21928.
   Web of Science ®Google Scholar
• Singh I, Goyal Y, Ranawat P. 2017. Potential chemoprotective role of resveratrol against cisplatin induced testicular damage in mice. Chem Biol Interact. 273:200–211.
   PubMed Web of Science ®Google Scholar
• Vassilakopoulou M, Boostandoost E, Papaxoinis G, de La Motte Rouge T, Khayat D, Psyrri A. 2016. Anticancer treatment and fertility: effect of therapeutic modalities on reproductive system and functions. Crit Rev Oncol Hematol. 97:328–334.
   PubMed Web of Science ®Google Scholar
• Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W. 2017. Naringenin prevents ischaemic stroke damage via anti-apoptotic and anti-oxidant effects. Clin Exp Pharmacol Physiol. 44:862–871.
   PubMed Web of Science ®Google Scholar
• Wesołowska O, Wiśniewski J, Środa-Pomianek K, Bielawska-Pohl A, Paprocka M, Duś D, Duarte N, Ferreira M-JU, Michalak K. 2012. Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants. J Nat Prod. 75:1896–1902.
   PubMed Web of Science ®Google Scholar
• Yaman O, Topcu-Tarladacalisir Y. 2018. L-carnitine counteracts prepubertal exposure to cisplatin induced impaired sperm in adult rats by preventing germ cell apoptosis. Biotech Histochem. 93:157–167.
   PubMed Web of Science ®Google Scholar
• Yang C-C, Chen Y-T, Chen C-H, Chiang JY, Zhen Y-Y, Yip H-K. 2017. Assessment of doxorubicin-induced mouse testicular damage by the novel second-harmonic generation microscopy. Am J Transl Res. 9:5275–5288.
   PubMed Web of Science ®Google Scholar
• Zavras N, Siristatidis C, Siatelis A, Koumarianou A. 2016. Fertility risk assessment and preservation in male and female prepubertal and adolescent cancer patients. Clin Med Insights Oncol. 10:49–57.
   PubMed Web of Science ®Google Scholar