Nephroprotective effect of cilostazol and verapamil against thioacetamide-induced toxicity in rats may involve Nrf2/HO-1/NQO-1 signaling pathway

References

• Abdelsameea AA, Mohamed AM, Amer MG, Attia SM. 2016. Cilostazol attenuates gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol. 68:247–253.
   PubMed Web of Science ®Google Scholar
• Abuelezz SA, Hendawy N. 2018. Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway. Behav Pharmacol. 29:28–40.
   PubMed Web of Science ®Google Scholar
• Al-Attar AM, Alrobai AA, Almalki DA. 2017. Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice. Saudi J Biol Sci. 24:15–22.
   PubMed Web of Science ®Google Scholar
• Amirtharaj GJ, Natarajan SK, Pulimood A, Balasubramanian K, Venkatraman A, Ramachandran A. 2017. Role of oxygen free radicals, nitric oxide and mitochondria in mediating cardiac alterations during liver cirrhosis induced by thioacetamide. Cardiovasc Toxicol. 17:175–184.
   PubMed Web of Science ®Google Scholar
• Bashandy SA, Alaamer A, Moussa SA, Omara E. 2018. Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats. Canadian J Physiol Pharmacol. 96(4):337–344.
   PubMed Web of Science ®Google Scholar
• Buege J, Aust S. 1978. Microsomal lipid peroxidation. Meth Enzymol. 52:302–310.
   PubMedGoogle Scholar
• Chen Y, Pandiri I, Joe Y, Kim HJ, Kim S-K, Park J, Ryu J, Cho GJ, Park JW, Ryter SW, et al. 2016. Synergistic effects of cilostazol and probucol on ER stress-induced hepatic steatosis via heme oxygenase-1-dependent activation of mitochondrial biogenesis. Oxid Med Cell Longev. 2016:1.
   Google Scholar
• Cote A, da Silva R, Cuello AC. 1993. Current protocols for light microscopy immunocytochemistry. In: Cuello AC, editor. Immunohistochemistry II. Chichester: John Wiley & Sons. p. 147–168
   Google Scholar
• David JA, Rifkin WJ, Rabbani PS, Ceradini DJ. 2017. The Nrf2/Keap1/ARE pathway and oxidative stress as a therapeutic target in type ii diabetes mellitus. J Diabetes Res. 2017:1.
   Google Scholar
• Develi-Is S, Bekpinar S, Kalaz EB, Evran B, Unlucerci Y, Gulluoglu M, Uysal M. 2013. The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine. Cell Biochem Funct. 31:122–128.
   PubMed Web of Science ®Google Scholar
• El Awdan SA, Amin MM, Hassan A. 2018. Cilostazol attenuates indices of liver damage induced by thioacetamide in albino rats through regulating inflammatory cytokines and apoptotic biomarkers. Eur J Pharmacol. 822:168–176.
   PubMed Web of Science ®Google Scholar
• Fawcett J, Scott J. 1960. A rapid and precise method for the determination of urea. J Clin Pathol. 13:156–159.
   PubMed Web of Science ®Google Scholar
• Gang G-T, Hwang JH, Kim Y-H, Noh J-R, Kim K-S, Jeong JY, Choi DE, Lee KW, Jung J-Y, Shong M. 2014. Protection of NAD (P) H: quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice. Free Rad Biol Med. 67:139–149.
   PubMed Web of Science ®Google Scholar
• Ghosh S, Sarkar A, Bhattacharyya S, Sil PC. 2016. Silymarin protects mouse liver and kidney from thioacetamide induced toxicity by scavenging reactive oxygen species and activating PI3K-Akt pathway. Front Pharmacol. 7:481.
   PubMed Web of Science ®Google Scholar
• Houghton D, Plamp C, 3rd, DeFehr J, Bennett W, Porter G, Gilbert D. 1978. Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. Am J pathol. 93:137.
   PubMed Web of Science ®Google Scholar
• Kadir FA, Kassim NM, Abdulla MA, Yehye WA. 2013. Effect of oral administration of ethanolic extract of Vitex negundo on thioacetamide-induced nephrotoxicity in rats. BMC Complement Alter Med. 13:294.
   PubMed Web of Science ®Google Scholar
• Kędziora-Kornatowska K, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kędziora J, Bartosz G. 2002. The effect of verapamil on the antioxidant defence system in diabetic kidney. Clinica Chimica Acta. 322:105–112.
   PubMed Web of Science ®Google Scholar
• Kim J, Seok YM, Jung K-J, Park KM. 2009. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Am J Physiol-Renal Physiol. 297:F461–F470.
   PubMed Web of Science ®Google Scholar
• Koh JS, Yi C-o, Heo RW, Ahn J-W, Park JR, Lee JE, Kim J-H, Hwang J-Y, Roh GS. 2015. Protective effect of cilostazol against doxorubicin-induced cardiomyopathy in mice. Free Radic Biol Med. 89:54–61.
   PubMed Web of Science ®Google Scholar
• Lawal AO, Ellis EM. 2011. Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. Environ Toxicol Pharmacol. 32:54–62.
   PubMed Web of Science ®Google Scholar
• Lee DH, Park JS, Lee YS, Sung SH, Lee Y-h, Bae SH. 2017. The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity. BMB Reports. 50:91–96.
   PubMed Web of Science ®Google Scholar
• Levey AS, Perrone RD, Madias NE. 1988. Serum creatinine and renal function. Annu Rev Med. 39:465–490.
   PubMed Web of Science ®Google Scholar
• Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 47:469–474.
   PubMedGoogle Scholar
• Miguel FM, Schemitt EG, Colares JR, Hartmann RM, Morgan-Martins MI, Marroni NP. 2017. Action of vitamin E on experimental severe acute liver failure. Arq Gastroenterol. 54:123–129.
   PubMedGoogle Scholar
• Moron MS, Depierre JW, Mannervik B. 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta.582:67–78.
   PubMed Web of Science ®Google Scholar
• Nezu M, Suzuki N, Yamamoto M. 2017. Targeting the KEAP1-NRF2 system to prevent kidney disease progression. Am J Nephrol. 45:473–483.
   PubMed Web of Science ®Google Scholar
• Okwa IB, Akindele AJ, Agbaje EO, Oshinuga OT, Anunobi CC, Adeyemi OO. 2013. Effect of subclinical, clinical and supraclinical doses of calcium channel blockers on models of drug-induced hepatotoxicity in rats. EXCLI J. 12:231
   PubMed Web of Science ®Google Scholar
• Ozbek E. 2012. Induction of oxidative stress in kidney. Int J Nephrol. 2012:1.
   Google Scholar
• Ridnour LA, Sim JE, Hayward MA, Wink DA, Martin SM, Buettner GR, Spitz DR. 2000. A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media. Anal Biochem. 281:223–229.
   PubMed Web of Science ®Google Scholar
• Rosei EA, Dal Palù C, Leonetti G, Magnani B, Pessina A, Zanchetti A. Investigators AZobotV. 1997. Clinical results of the verapamil in hypertension and atherosclerosis study. VHAS investigators. J Hypertens. 15:1337–1344.
   PubMed Web of Science ®Google Scholar
• Sarica K, Kafkasli A, Narter F, Ozturk O, Yazici O, Hamarat B, Sahin C, Eryildirim B. 2016. Hyperoxaluria-induced tubular ischemia: the effects of verapamil on the antioxidant capacity of the affected kidneys. Urolithiasis. 44:509–519.
   PubMed Web of Science ®Google Scholar
• Sirag HM. 2007. Biochemical studies on thioacetamide toxicity in male albino rats and the role of tomato juice as an antioxidant. Mansoura J Forensic Med Clin Toxicol. 15:90–114.
   Google Scholar
• Stefanello ST, Hartmann DD, Amaral GP, Courtes AA, Leite MT, da Silva TC, Gonçalves DF, Souza MB, da Rosa PC, Dornelles L. 2017. Antioxidant protection by β‐selenoamines against thioacetamide‐induced oxidative stress and hepatotoxicity in mice. J Biochem Mol toxicol. 31:e21974.
   Google Scholar
• Suzuki T, Yamamoto M. 2015. Molecular basis of the Keap1-Nrf2 system. Free Radic Biol Med. 88:93–100.
   PubMed Web of Science ®Google Scholar
• Wahsh E, Abu-Elsaad N, El-Karef A, Ibrahim T. 2016. The vitamin D receptor agonist, calcipotriol, modulates fibrogenic pathways mitigating liver fibrosis in-vivo: an experimental study. Eur J Pharmacol. 789:362–369.
   PubMed Web of Science ®Google Scholar
• Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, Iguchi M, Tamai H, Ueda K, Ito T, et al. 2014. Nrf2-inducing anti-oxidation stress response in the rat liver-new beneficial effect of lansoprazole. PLoS One. 9:e97419.
   PubMed Web of Science ®Google Scholar
• Zhang H, Xu H, Xie H, Li F, Yu X, Sui D. 2014. Cardiovascular protective effects of IL-1ra-Fc-IL-18BP on experimental myocardial infarction by inhibiting oxidative stress and inflammation in a rat model. Die Pharmazie Int J Pharm Sci. 69:769–774.
   Google Scholar
• Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J. 2018. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 97:481–488.
   PubMed Web of Science ®Google Scholar