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Review Articles

Significant shifts in preclinical and clinical neurotoxicology: a review and commentary

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Pages 173-182 | Received 11 May 2022, Accepted 30 Jul 2022, Published online: 09 Aug 2022

References

  • Anderl JL, Redpath S, Ball AJ. 2009. A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp. 27:1173.
  • Appaiah P, Vasu P. 2020. Neutral amino acids in Pichia pastoris for possible application in phenylketonuria. J Food Biochem. 44(3):e13151.
  • Aroniadou-Anderjaska V, Fritsch B, Qashu F, Braga MFM. 2008. Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3):102–116. https://doi.org/10.1016/j.eplepsyres.2007.11.011.
  • Authier S, Arezzo J, Delatte MS, Kallman M-J, Markgraf C, Paquette D, Pugsley MK, Ratcliffe S, Redfern WS, Stevens J, et al. 2016. Safety pharmacology investigations on the nervous system: an industry survey. J Pharmacol Toxicol Methods. 81:37–46.
  • Banerjee P, Siramshetty VB, Drwal MN, Preissner R. 2016. Computational methods for prediction of in vitro effects of new chemical structures. J Cheminform. 8:51. http://doi.org/10.1186/s13321-016-0162-2.
  • Barh D, Chaitankar V, Yiannakopoulou EC, Salawu EO, Chowbina S, Ghosh P, Azevedo V. 2014. In silico models: from simple networks to complex diseases. Verma AS, Singh A, editors. Animal biotechnology. London: Academic Press; 2014. p. 385–404, Chapter 21.
  • Bencsik A, Lestaevel P. 2021. The challenges of 21st century neurotoxicology: the case of neurotoxicology applied to nanomaterials. Front Toxicol. 3:629256.
  • Bencsik A, Lestaevel P, Guseva Canu I. 2018. Nano- and neurotoxicology: an emerging discipline. Prog Neurobiol. 160:45–63.
  • Birnie MT, Baram TZ. 2022. Principles of emotional brain circuit maturation. Science. 376(6597):1055–1056.
  • Brodin P. 2022. Immune-microbe interactions early in life: a determinant of health and disease long term. Science. 376(6596):945–950.
  • Correia C, Ferreira A, Santos J, Lapa R, Yliperttula M, Urtti A, Vale N. 2021. New in vitro-in silico approach for the prediction of in vivo performance of drug combinations. Molecules (Basel, Switzerland). 26(14):4257.
  • Cory-Slechta DA, Weiss B. 2014. Assessment of behavioral toxicology. In Wallace Hayes A, Claire L. Kruger, editors. Hayes’ principles and methods of toxicology. New York, NY: CRC Press, Taylor and Francis Group.
  • Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AEM, Knaut H, Buzanska L, Goldberg A. 2011. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. ALTEX – Alternat Anim Exp. 28(1):9–15.
  • Crofton KM, Mundy WR, Shafer TJ. 2012. Developmental neurotoxicity testing: a path forward. Congenit Anom (Kyoto). 52(3):140–146.
  • Federal Register. 2015. Annual Update of the HHS Poverty Guidelines 80 FR 3236–3237.
  • Furtado D, Björnmalm M, Ayton S, Bush AI, Kempe K, Caruso F. 2018. Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases. Adv Mater. 30(46):1801362.
  • Gad SC, Gad SE. 2003. A functional observational battery for use in canine toxicity studies: development and validation. Int J Toxicol. 22(6):415–422.
  • Gauvin DV, Baird TJ. 2008. A functional observational battery in non-human primates for regulatory-required neurobehavioral assessments. J Pharmacol Toxicol Methods. 58(2):88–93.
  • Goyer RA. 1995. Nutrition and metal toxicity. Am J Clin Nutr. 61(3 Suppl):646S–650S.
  • Guignet M, Lein PJ. 2019. Neuroinflammation in organophosphate-induced neurotoxicity. In: Aschner M, Costa LG, editors. Role of inflammation in environmental neurotoxicity. London: Academic Press. p. 35–79, Chapter 3.
  • Guo GW, Liang YX. 2001. Aluminum-induced apoptosis in cultured astrocytes and its effect on calcium homeostasis. Brain Res. 888(2):221–226.
  • Hair NL, Hanson JL, Wolfe BL, Pollak SD. 2015. Association of child poverty, brain development, and academic achievement. JAMA Pediatr. 169(9):822–829.
  • Hanson JL, Chandra A, Wolfe BL, Pollak SD. 2011. Association between income and the hippocampus. PLoS One. 6(5):e18712.
  • Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP. 2019. Cannabidiol adverse effects and toxicity. Curr Neuropharmacol. 17(10):974–989.
  • Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. 2019. Vascular cognitive impairment and dementia: JACC Scientific Expert Panel. J Am Coll Cardiol. 73(25):3326–3344.
  • Insell T. 2022. Mental Health Care 2.0. Science. 376:6596, 899.
  • Irwin S. 1968. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia. 13(3):222–257.
  • Jackson SJ, Authier S, Brohmann H, Goody SMG, Jones D, Prior H, Rosch A, Traebert M, Tse K, Valentin JP, et al. 2019. Neurofunctional test batteries in safety pharmacology – current and emerging considerations for the drug development process. J Pharmacol Toxicol Methods. 100:106602.
  • Kadry H, Noorani B, Cucullo L. 2020. A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS. 17(1):69. https://doi.org/10.1186/s12987-020-00230-3.
  • Katsnelson A. 2015. The neuroscience of poverty. Proc Natl Acad Sci U S A. 112(51):15530–15532.
  • Kena G, Musu-Gillette L, Robinson J, Wang X, Rathbun A, Zhang J, Wilkinson-Flicker S, Barmer A. 2015. The condition of education 2015 (NCES 2015-144). Washington (DC): US Department of Education, National Center for Education Statistics. nces.ed.gov/pubsearch. https://nces.ed.gov/programs/coe/pdf/coe_cce.pdf
  • Klinkenberg I, Blokland A. 2010. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev. 34(8):1307–1350.
  • Kroes R, Renwick AG, Cheeseman M, Kleiner J, Mangelsdorf I, Piersma A, Schilter B, Schlatter J, van Schothorst F, Vos JG, European branch of the International Life Sciences Institute, et al. 2004. Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem Toxicol. 42(1):65–83.
  • Lotti M, Moretto A. 2005. Organophosphate-induced delayed polyneuropathy. Toxicol Rev. 24(1):37–49.
  • Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. 2013. Integrative chemical-biological read-across approach for chemical Hazard classification. Chem Res Toxicol. :26:1199–1208.
  • Luby J, Belden A, Botteron K, Marrus N, Harms MP, Babb C, Nishino T, Barch D. 2013. The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events. JAMA Pediatr. 167(12):1135–1142.
  • Lynch WJ, Nicholson KL, Dance ME, Morgan RW, Foley PL. 2010. Animal models of substance abuse and addiction: implications for science, animal welfare, and society. Comp Med. 60(3):177–188.
  • Mackey AP, Finn AS, Leonard JA, Jacoby-Senghor DS, West MR, Gabrieli CFO, Gabrieli JDE. 2015. Neuroanatomical correlates of the income-achievement gap. Psychol Sci. 26(6):925–933.
  • McEwen CA, McEwen BS. 2017. Social structure, adversity, toxic stress, and intergenerational poverty: an early childhood model. Annu Rev Sociol. 43(1):445–472.
  • Monnet-Tschudi F, Zurich M-G, Honegger P. 2007. Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures. Hum Exp Toxicol. 26(4):339–346.
  • Moser VC. 1989. Screening approaches to neurotoxicity: a functional observational battery. J Am Coll Toxicol. 8(1):85–93.
  • Moser VC. 2000. The functional observational battery in adult and developing rats. Neurotoxicology. 21(6):989–996.
  • Moser VC. 2016. Developmental Neurotoxicity Study (DNT) Guidance Document. NAFTA Technical Working Group on Pesticides. https://www.epa.gov/sites/default/files/2017-02/documents/developmental_neurotoxicity_study_internal_guidance_document_final
  • Muller PY, Dambach D, Gemzik B, Hartmann A, Ratcliffe S, Trendelenburg C, Urban L. 2015. Integrated risk assessment of suicidal ideation and behavior in drug development. Drug Disc Today. 20(9):1135–1142.
  • National Research Council. 1992. Environmental neurotoxicology. Washington (DC): The National Academies Press.
  • Naughton SX, Terry AV Jr. 2018. Neurotoxicity in acute and repeated organophosphate exposure. Toxicology. 408:101–112. Evidence Report: Risk of Acute and Late Central Nervous System Effects from Radiation Exposure – NASA Technical Reports Server (NTRS).
  • Nelson GA, Simonsen L, Huff LF. 2016. Evidence Report: Risk of Acute and Late Central Nervous System Effects from Radiation Exposure, NASA Technical Reports Server (NTRS). https://ntrs.nasa.gov/citations/20160004368.
  • Noble KG, Houston SM, Brito NH, Bartsch H, Kan E, Kuperman JM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, et al. 2015. Family income, parental education and brain structure in children and adolescents. Nat Neurosci. 18(5):773–778.
  • Pamies D. 2022. Novel in vitro and in silico approaches to study developmental neurotoxicity. Intl J Molec Sci (publication in progress).
  • Pamies D, Barreras P, Block K, Makri G, Kumar A, Wiersma D, Smirnova L, Zang C, Bressler J, Christian KM, et al. 2017. A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity. ALTEX. 34(3):362–376.
  • Patlewicz G, Simon TW, Rowlands JC, Budinsky RA, Becker RA. 2015. Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes. Regul Toxicol Pharmacol. 71(3):463–477.
  • Pressman P, Clemens R, Blackburn T, Hayes AW. 2021. A commentary on drug safety and genomics: promising new agents may require expansion of guidelines for subject screening in clinical trials. Toxicol Res Appl. 5:1–4.
  • Pressman P, Hayes AW, Clemens R. 2018. Expediting toxicity testing with increased precision, predictive power, and clinical utility. Toxicol Res Appl. 2:1–6.
  • Raizada RD, Richards TL, Meltzoff A, Kuhl PK. 2008. Socioeconomic status predicts hemispheric specialisation of the left inferior frontal gyrus in young children. Neuroimage. 40(3):1392–1401.
  • Raub JA, Mathieu-Nolf M, Hampson NB, Thom SR. 2000. Carbon monoxide poisoning—a public health perspective. Toxicology. 145(1):1–14.
  • Reardon SF. 2011. The widening academic achievement gap between the rich and the poor: new evidence and possible explanations. In: Murnane R, Duncan G, editors. Whither opportunity? Rising inequality and the uncertain life chances of ow-income children. New York (NY): Russell Sage Foundation Press. https://cepa.stanford.edu/content/widening-academic-achievement-gap-between-rich-and-poor-new-evidence-and-possible
  • Ross JF. 2000. ECOs, FOBs, and UFOs: making sense of observational data. Toxicol Pathol. 28(1):132–136.
  • Russo M, Sobh A, Zhang P, Loguinov A, Tagmount A, Vulpe CD, Liu B. 2020. Functional pathway identification with CRISPR/Cas9 genome-wide gene disruption in human dopaminergic neuronal cells following chronic treatment with dieldrin. Toxicol Sci. 176(2):366–381.
  • Sachana M, Bal-Price A, Crofton KM, Bennekou SH, Shafer TJ, Behl M, Terron A. 2019. International regulatory and scientific effort for improved developmental neurotoxicity testing. Toxicol Sci. 167(1):45–57.
  • Salleh MR. 2008. Life event, stress and illness. Malays J Med Sci. 15(4):9–18.
  • Silbereis JC, Pochareddy S, Zhu Y, Li M, Sestan N. 2016. The cellular and molecular landscapes of the developing human central nervous system. Neuron. 89(2):248–268.
  • Stevens C, Lauinger B, Neville H. 2009. Differences in the neural mechanisms of selective attention in children from different socioeconomic backgrounds: an event-related brain potential study. Dev Sci. 12(4):634–646.
  • Sun MK, Alkon DL. 2004. Induced Depressive Behavior Impairs Learning and Memory in Rats Neurosci. 129(1):129–139.
  • Toft M. 2014. Advances in genetic diagnosis of neurological disorders. Acta Neurol Scand. 129(Suppl 198):20–25.
  • Tox 21. 2021. [accessed June 2022]. https://tox21.gov/overview/about-tox21/
  • Tsai Y-H, Lein PJ. 2021. Mechanisms of organophosphate neurotoxicity. Curr Opin Toxicol. 26:49–60.
  • Viviani B, Boraso M, Marchetti N, Marinovich M. 2014. Perspectives on neuroinflammation and excitotoxicity: a neurotoxic conspiracy? Neurotoxicology. 7(43):10–20.
  • Wessel MD, Jurs PC, Tolan JW, Muskal SM. 1998. Prediction of human intestinal absorption of drug compounds from molecular structure. J Chem Inf Comput Sci. 38(4):726–735.
  • Wilson MS, Graham JR, Ball AJ. 2014. Multiparametric high content analysis for assessment of neurotoxicity in differentiated neuronal cell lines and human embryonic stem. Neurotoxicology. 42:33–48.
  • Zhang H, Haghani A, Mousavi AH, Cacciottolo M, D'Agostino C, Safi N, Sowlat MH, Sioutas C, Morgan TE, Finch CE, et al. 2019. Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter. Free Radic Biol Med. 145:33–41.
  • Zhong M, Shoemake C, Fuller A, White D, Hanks C, Brocksmith D, Liu J, Gad S, Bouchard G, Stricker-Krongrad A, et al. 2017. Development of a functional observational battery in the minipig for regulatory neurotoxicity assessments. Int J Toxicol. 36(2):113–123.

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