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Research Articles

Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats

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Pages 437-451 | Received 16 Oct 2022, Accepted 08 Jan 2023, Published online: 30 Jan 2023

References

  • Abascal K, Yarnell E. 1929. The many faces of silybum marianum (Milk Thistle): Part 2- Clinical uses, safety, and types of preparations. Phytother Res. 9(5):170–175.
  • Akram M, Kim KA, Kim ES, Syed AS, Kim CY, Lee JS, Bae ON. 2016. Potent anti-inflammatory and analgesic actions of the chloroform extract of Dendropanax morbifera mediated by the Nrf2/HO-1 pathway. Biol Pharm Bull. 39(5):728–736.
  • Almeer RS, Alarifi S, Alkahtani S, Ibrahim SR, Ali D, Moneim A. 2018. The potential hepatoprotective effect of royal jelly against cadmium chloride-induced hepatotoxicity in mice is mediated by suppression of oxidative stress and upregulation of Nrf2 expression. Biomed Pharmacother. 106(May):1490–1498.
  • Alshehri AS, El-Kott AF, El-Gerbed MSA, El-Kenawy AE, Albadrani GM, Khalifa HS. 2022. Kaempferol prevents cadmium chloride-induced liver damage by upregulating Nrf2 and suppressing NF-κB and keap1. Environ Sci Pollut Res. 29(10):13917–13929.
  • Alshehri AS, El-Kott AF, El-Kenawy AE, Khalifa HS, AlRamlawy AM. 2021. Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis. Sci Total Environ. 784:147182.
  • Arab-Nozari M, Mohammadi E, Shokrzadeh M, Ahangar N, Amiri FT, Shaki F. 2020. Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways. Environ Sci Pollut Res Int. 27(19):24048–24058.
  • Bae D, Kim J, Lee SY, Choi EJ, Jung MA, Jeong CS, Na JR, Kim JJ, Kim S. 2015. Hepatoprotective effects of aqueous extracts from leaves of Dendropanax morbifera leveille against alcohol-induced hepatotoxicity in rats and in vitro anti-oxidant effects. Food Sci Biotechnol. 24(4):1495–1503.
  • Bagchi D, Vuchetich PJ, Bagchi M, Hassoun EA, Tran MX, Tang L, Stohs SJ. 1997. Induction of oxidative stress by chronic administration of sodium dichromate [chromium VI. and cadmium chloride [cadmium II. to rats]]. Free Radic Biol Med. 22(3):471–478.
  • Baş H, Apaydın FG, Kalender S, Kalender Y. 2021. Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: protective effects of sesamol on biochemical indices and pathological changes. J Food Biochem. April:1–13.
  • Bashir N, Manoharan V, Miltonprabu S. 2016. Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling. J Nutr Biochem. 32:128–141.
  • Basiglio CL, Sánchez Pozzi EJ, Mottino AD, Roma MG. 2009. Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chem Biol Interact. 179(2-3):297–303.
  • Begic A, Djuric A, Ninkovic M, Stevanovic I, Djurdjevic D, Pavlovic M, Jelic K, Pantelic A, Zebic G, Dejanovic B, et al. 2017. Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. J Enzyme Inhib Med Chem. 32(1):478–489.
  • Bhattacharjee B, Pal PK, Chattopadhyay A, Bandyopadhyay D. 2020. Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: a mechanistic study. Life Sci. 244(October 2019):117324.
  • Cain K, Bratton SB, Cohen GM. 2002. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie. 84(2-3):203–214.
  • Campos R, Garrido A, Guerra R, Valenzuela A. 1989. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 55(5):417–419.
  • Chapatwala KD, Boykin M, Butts A, Rajanna B. 1982. Effect of intraperitoneally injected cadmium on renal and hepatic gluconeogenic enzymes in rats. Drug Chem Toxicol. 5(3):305–317.
  • Choi HJ, Park DH, Song SH, Yoon IS, Cho SS. 2018. Development and validation of a HPLC-UV Method for extraction optimization and biological evaluation of hot-water and ethanolic extracts of Dendropanax morbifera leaves. Molecules. 23(3):650.
  • Choi JH, Kim DW, Park SE, Lee HJ, Kim KM, Kim KJ, Kim MK, Kim SJ, Kim S. 2015. Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille. J Biosci Bioeng. 120(2):181–186.
  • Dawood SM, Mumtaz F, Padiya R. 2022. Zingerone alleviates cadmium-induced nephrotoxicity in rats via its antioxidant and anti-apoptotic properties. Revista de Ciencias Farmaceuticas Basica e Aplicada. 43:1–10.
  • Djukić-Ćosić D, Ćurčić Jovanović M, Plamenac Bulat Z, Ninković M, Maličević Ž, Matović V. 2008. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication. J Trace Elem Med Biol. 22(1):66–72.
  • Đukić-Ćosić D, Baralić K, Javorac D, Djordjevic AB, Bulat Z. 2020. An overview of molecular mechanisms in cadmium toxicity. Curr Opin Toxicol. 19:56–62.
  • El-Refaiy AI, Eissa FI. 2013. Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents. Saudi J Biol Sci. 20(3):265–280.
  • Elkhadragy MF, Abdel Moneim AE. 2017. Protective effect of Fragaria ananassa methanolic extract on cadmium chloride (CdCl2)-induced hepatotoxicity in rats. Toxicol Mech Methods. 27(5):335–345.
  • Eom T, Kim KC, Kim JS. 2020. Dendropanax morbifera leaf polyphenolic compounds: optimal extraction using the response surface method and their protective effects against alcohol-induced liver damage. Antioxidants. 9(2):120.
  • Fouad AA, Al-Mulhim AS, Gomaa W. 2013. Protective effect of cannabidiol against cadmium hepatotoxicity in rats. J Trace Elem Med Biol. 27(4):355–363.
  • Fowler BA. 2009. Monitoring of human populations for early markers of cadmium toxicity: a review. Toxicol Appl Pharmacol. 238(3):294–300.
  • Frenzel A, Grespi F, Chmelewskij W, Villunger A. 2012. Europe PMC funders group Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis. 14(4):584–596.
  • Gillessen A, Schmidt HHJ. 2020. Silymarin as supportive treatment in liver diseases: a narrative review. Adv Ther. 37(4):1279–1301.
  • Go YM, Sutliff RL, Chandler JD, Khalidur R, Kang BY, Anania FA, Orr M, Hao L, Fowler BA, Jones DP. 2015. Low-dose cadmium causes metabolic and genetic dysregulation associated with fatty liver disease in mice. Toxicol Sci. 147(2):524–534.
  • Haddow A, Roe FJ, Dukes CE, Mitchley AC. 1964. Cadmium neoplasia: sarcomata at the site of injection of cadmium sulphate in rats and mice. Br J Cancer. 18(4):667–673.
  • Halliwell B. 1996. Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic Res. 25(1):57–74.
  • Hamza RZ, Al-Eisa RA, El-Shenawy NS. 2022. Possible ameliorative effects of the royal jelly on hepatotoxicity and oxidative stress induced by molybdenum nanoparticles and/or cadmium chloride in male rats. Biology. 11(3):450.
  • Han Y, Lee D-E, Choi C-H, Lee H-J. 2021. Hepatoprotective potential of Dendropanax morbifera leaf extracts on ethanol-induced liver toxicity in Sprague-Dawley rats. J Prev Vet Med. 45(3):115–120.
  • Haouem S, El Hani A. 2013. Effect of cadmium on lipid peroxidation and on some antioxidants in the liver, kidneys and testes of rats given diet containing cadmium-polluted radish bulbs. J Toxicol Pathol. 26(4):359–364.
  • He Q, Kim J, Sharma RP. 2004. Silymarin protects against liver damage in BALB/c mice exposed to Fumonisin B1 despite increasing accumulation of free sphingoid bases. Toxicol Sci. 80(2):335–342.
  • Hu J, Zhang B, Du L, Chen J, Lu Q. 2017. Resveratrol ameliorates cadmium induced renal oxidative damage and inflammation. Int J Clin Exp Med. 10(5):7563–7572.
  • Hyun TK, Kim MO, Lee H, Kim Y, Kim E, Kim JS. 2013. Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Léveille. Food Chem. 141(3):1947–1955.
  • IARC. 1993. International agency for research on cancer evaluation of carcinogenic. Glass. 58:119–130.
  • Ighodaro OM, Akinloye OA. 2018. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med. 54(4):287–293.
  • Ismail TF, Aziz FM. 2017. The protective effect of omega-3 oil against the hepatotoxicity of cadmium chloride in adult and weanling rats. AIP Conf Proc. 1888:020027.
  • Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. 2014. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol. 7(2):60–72.
  • Järup L, Åkesson A. 2009. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol. 238(3):201–208.
  • Kheradmand A, Alirezaei M, Birjandi M. 2010. Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary. Regul Pept. 162(1-3):84–89.
  • Kim ES, Lee JS, Akram M, Kim KA, Shin YJ, Yu JH, Bae ON. 2015. Protective activity of Dendropanax morbifera against cisplatin-induced acute kidney injury. Kidney Blood Press Res. 40(1):1–12.
  • Kim NY, Hwang J, Ryu D, Kyung H. 2014. Anti-diabetic effects of aqueous and ethanol extract of Dendropanax morbifera leveille in streptozotocin-induced diabetes model. J Nutr Health. 47(6):394–402.
  • Klaassen CD, Liu J, Choudhuri S. 1999. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol. 39:267–294.
  • Kumar A, Siddiqi NJ, Alrashood ST, Khan HA, Dubey A, Sharma B. 2021. Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats. Biomed Pharmacother. 139(April):111588.
  • Lasfer M, Vadrot N, Aoudjehane L, Conti F, Bringuier AF, Feldmann G, Reyl-Desmars F. 2008. Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell Biol Toxicol. 24(1):55–62.
  • Lee JW, Kim KS, An HK, Kim CH, Moon HI, Lee YC. 2013. Dendropanoxide induces autophagy through ERK1/2 activation in MG-63 human osteosarcoma cells and autophagy inhibition enhances dendropanoxide-induced apoptosis. PLoS One. 8(12):e83611–8.
  • Liu JR, Yu CW, Hung PY, Hsin LW, Chern JW. 2019. High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma. Biochem Pharmacol. 163(33):458–471.
  • Luo JF, Shen XY, Lio CK, Dai Y, Cheng CS, Liu JX, Yao YD, Yu Y, Xie Y, Luo P, et al. 2018. Activation of Nrf2/HO-1 pathway by Nardochinoid C inhibits inflammation and oxidative stress in lipopolysaccharide-stimulated macrophages. Front Pharmacol. 9(SEP):911–919.
  • Machicao F, Sonnenbichler J. 1977. Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin. Hoppe Seylers Z Physiol Chem. 358(2):141–147.
  • Matović V, Buha A, Bulat Z, Dukić-ĆOsić D. 2011. Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arh Hig Rada Toksikol. 62(1):65–76.
  • Merali Z, Singhal RL. 1975. Effect of selenium on cadmium induced toxicity in rats. Toxicol Appl Pharmacol. 33(1):1193–1205.
  • Mezynska M, Brzóska MM. 2018. Mezynska-BrzÃ3ska2018_Article_EnvironmentalExposureToCadmium.pdf. 3211–3232.
  • Moon HI. 2011. Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats. Hum Exp Toxicol. 30(8):870–875.
  • Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, Sloan DD, Graf TN, Oberlies NH, Lee DYW, et al. 2010. Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection. Gastroenterology. 138(2):671–681.e2.
  • Nomiyama K, Nomiyama H, Kameda N. 1998. Plasma cadmium-metallothionein, a biological exposure index for cadmium-induced renal dysfunction, based on the mechanism of its action. Toxicology. 129(2-3):157–168.
  • Noor KK, Ijaz MU, Ehsan N, Tahir A, Yeni DK, Neamul Kabir Zihad SM, Uddin SJ, Ashraf A, Simal-Gandara J. 2022. Hepatoprotective role of vitexin against cadmium-induced liver damage in male rats: a biochemical, inflammatory, apoptotic and histopathological investigation. Biomed Pharmacother. 150:112934.
  • Nordberg M, Nordberg GF. 1987. On the role of metallothionein in cadmium induced renal toxicity. Experientia Suppl. 52:669–675.
  • Omidifar N, Nili-Ahmadabadi A, Gholami A, Dastan D, Ahmadimoghaddam D, Nili-Ahmadabadi H. 2020. 2020. Biochemical and histological evidence on the protective effects of allium hirtifolium Boiss (Persian Shallot) as an herbal supplement in cadmium-induced hepatotoxicity. Evid Based Complem Alternati Med. 2020:1–8.
  • OMS. 2010. Exposure to cadmium: a major public health concern. Preventing Disease through Healthy Environments. http://www.who.int/ipcs/features/cadmium.pdf
  • Park JH, Lee BM, Kim HS. 2021. Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress. J Toxicol Environ Health B Crit Rev. 24(3):95–118.
  • Park SE, Sapkota K, Choi JH, Kim MK, Kim YH, Kim KM, Kim KJ, Oh HN, Kim SJ, Kim S. 2014. Rutin from Dendropanax morbifera leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling. Neurochem Res. 39(4):707–718.
  • Park YJ, Kim DM, Choi HB, Jeong MH, Kwon SH, Kim HR, Kwak JH, Chung KH. 2022. Dendropanoxide, a triterpenoid from Dendropanax morbifera, ameliorates hepatic fibrosis by inhibiting activation of hepatic stellate cells through autophagy inhibition. Nutrients. 14(1):98.
  • Park Y, Jung Kim KS, Park JH, Lee SH, Kim HR, Lee SH, Choi HB, Cao S, Kumar V, Kwak JH, et al. 2020. Protective effects of dendropanoxide isolated from Dendropanax morbifera against cisplatin-induced acute kidney injury via the AMPK/mTOR signaling pathway. Food Chem Toxicol. 145(August):111605.
  • Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DYW. 2007. Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin. Gastroenterology. 132(5):1925–1936.
  • Rahimzadeh MR, Rahimzadeh MR, Kazemi S, Moghadamnia AA. 2017. Cadmium toxicity and treatment: An update. Caspian J Intern Med. 8(3):135–145.
  • Rizwan S, Naqshbandi A, Farooqui Z, Khan AA, Khan F. 2014. Protective effect of dietary flaxseed oil on arsenic-induced nephrotoxicity and oxidative damage in rat kidney. Food Chem Toxicol. 68:99–107.
  • Sachan R, Kundu A, Dey P, Son JY, Kim KS, Lee DE, Kim HR, Park JH, Lee SH, Kim JH, et al. 2020. Dendropanax morbifera protects against renal fibrosis in streptozotocin-induced diabetic rats. Antioxidants. 9(1):84.
  • Satarug S, Vesey DA, Gobe GC. 2017. Current health risk assessment practice for dietary cadmium: data from different countries. Food Chem Toxicol. 106(Pt A):430–445.
  • Shaker E, Mahmoud H, Mnaa S. 2010. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol. 48(3):803–806.
  • Tandon SK, Singh S, Prasad S, Mathur N. 2001. Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice. Food Chem Toxicol. 39(6):571–577.
  • Teksoy O, Sahinturk V, Cengiz M, İnal B, Ayhancı A. 2020. The protective effects of silymarin on thioacetamide-induced liver damage: measurement of miR-122, miR-192, and miR-194 Levels. Appl Biochem Biotechnol. 191(2):528–539.
  • Thévenod F, Friedmann JM. 1999. Cadmium‐mediated oxidative stress in kidney proximal tubule cells induces degradation of Na +/K + ‐ATPase through proteasomal and endo‐/lysosomal proteolytic pathways. Faseb J. 13(13):1751–1761.
  • Thévenod F, Lee WK. 2013. Cadmium and cellular signaling cascades: interactions between cell death and survival pathways. In. Arch Toxicol. 87(10):1743–1786.
  • Ullah H, Khan MF, Jan SU, Hashmat F. 2015. Cadmium-glutathione complex formation in human t-cell and b-cell lymphocytes after their incubation with organo-cadmium diacetate. Pak J Pharm Sci. 28(6):2075–2081.
  • Uzunhisarcikli M, Aslanturk A, Kalender S, Apaydin FG, Bas H. 2016. Mercuric chloride induced hepatotoxic and hematologic changes in rats. Toxicol Ind Health. 32(9):1651–1662.
  • Vargas-Mendoza N, Madrigal-Santillán E, Morales-González Á, Esquivel-Soto J, Esquivel-Chirino C, García-Luna y González-Rubio MG, Gayosso-de-Lucio JA, Morales-González JA. 2014. Hepatoprotective effect of silymarin. World J Hepatol. 6(3):144–149.
  • Végran F, Boidot R, Solary E, Lizard-Nacol S. 2011. A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly. PLoS One. 6(12):e29058.
  • Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z. 2022. Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells. Front Pharmacol. 13(August):969892–969812.
  • Wang J, Zhang H, Zhang T, Zhang R, Liu R, Chen Y. 2015. Molecular mechanism on cadmium-induced activity changes of catalase and superoxide dismutase. Int J Biol Macromol. 77:59–67.
  • Wang X, Wang T, Pan T, Huang M, Ren W, Xu G, Amin HK, Kassab RB, Abdel Moneim AE. 2020. Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats. Environ Sci Pollut Res Int. 27(6):5981–5992.
  • Yang HY, Kim KS, Lee YH, Park JH, Kim JH, Lee SY, Kim YM, Kim IS, Kacew S, Lee BM, et al. 2019. Dendropanax morbifera ameliorates thioacetamide-induced hepatic fibrosis via TGF-β1/smads pathways. Int J Biol Sci. 15(4):800–811.
  • Zhang C, Lin J, Ge J, Wang LL, Li N, Sun XT, Cao HB, Li JL. 2017. Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis. Toxicol in Vitro. 44(December 2016):349–356.
  • Zhang L, Chen CL, Kang PT, Jin Z, Chen YR. 2017. Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart. Free Radic Biol Med. 108:595–609.

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