Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model

References

• Amend N, Niessen KV, Seeger T, Wille T, Worek F, Thiermann H. 2020. Diagnostics and treatment of nerve agent poisoning-current status and future developments. Ann N Y Acad Sci. 1479(1):13–28. doi:10.1111/nyas.14336.
   PubMed Web of Science ®Google Scholar
• Aracava Y, Pereira EF, Akkerman M, Adler M, Albuquerque EX. 2009. Effectiveness of donepezil, rivastigmine, and (+/−)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine. J Pharmacol Exp Ther. 331(3):1014–1024. doi:10.1124/jpet.109.160028.
   PubMed Web of Science ®Google Scholar
• Backman SB, Bachoo M, Polosa C. 1993. Mechanism of the bradycardia produced in the cat by the anticholinesterase neostigmine. J Pharmacol Exp Ther. 265(1):194–200. https://www.ncbi.nlm.nih.gov/pubmed/8474006.
   PubMed Web of Science ®Google Scholar
• Beck KD, Zhu G, Beldowicz D, Brennan FX, Ottenweller JE, Moldow RL, Servatius RJ. 2001. Central nervous system effects from a peripherally acting cholinesterase inhibiting agent: interaction with stress or genetics. Ann N Y Acad Sci. 933:310–314. doi:10.1111/j.1749-6632.2001.tb05833.x.
   PubMed Web of Science ®Google Scholar
• Bonhage MR, Chilcoat CD, Li Q, Melendez V, Flournoy WS. 2009. Evaluation of two scopolamine and physostigmine pretreatment regimens against nerve agent poisoning in the dog. J Vet Pharmacol Ther. 32(2):146–153. doi:10.1111/j.1365-2885.2008.01013.x.
   PubMed Web of Science ®Google Scholar
• Carpenter JM, Brown KA, Diaz AN, Dockman RL, Benbow RA, Harn DA, Norberg T, Wagner JJ, Filipov NM. 2021. Delayed treatment with the immunotherapeutic LNFPIII ameliorates multiple neurological deficits in a pesticide-nerve agent prophylactic mouse model of Gulf War Illness. Neurotoxicol Teratol. 87:107012. doi:10.1016/j.ntt.2021.107012.
   PubMed Web of Science ®Google Scholar
• Center for Drug Evaluation and Research. 2003. Clinical pharmacology and biopharmaceutics review(s). Pyridostigmine bromide. Application number: 20–414.
   Google Scholar
• Dyer O. 2004. US and UK scientists disagree about causes of Gulf war syndrome. BMJ. 329(7472):940. doi:10.1136/bmj.329.7472.940-b.
   Google Scholar
• Ehlert FJ. 2003. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci. 74(2-3):355–366. doi:10.1016/j.lfs.2003.09.023.
   PubMed Web of Science ®Google Scholar
• Ekstrom F, Pang YP, Boman M, Artursson E, Akfur C, Borjegren S. 2006. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates. Biochem Pharmacol. 72(5):597–607. doi:10.1016/j.bcp.2006.05.027.
   PubMed Web of Science ®Google Scholar
• Ellman GL, Courtney KD, Andres V, Feather-Stone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 7:88–95. doi:10.1016/0006-2952(61)90145-9.
   PubMed Web of Science ®Google Scholar
• EU. 2010. Directive 2010/63/EU on the protection of animals used for scientific purposes. OJEU. 276/33.
   Google Scholar
• US Food and Drug Administration. 2003. Pyridostigmine Bromide Tablets, USP 30 mg. 1–17.
   Google Scholar
• Haigh JR, Adler M, Apland JP, Deshpande SS, Barham CB, Desmond P, Koplovitz I, Lenz DE, Gordon RK. 2010. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chem Biol Interact. 187(1–3):416–420. doi:10.1016/j.cbi.2010.02.003.
   PubMed Web of Science ®Google Scholar
• Herbert J, Thiermann H, Worek F, Wille T. 2017. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning. Toxicology. 389:94–100. doi:10.1016/j.tox.2017.07.011.
   PubMed Web of Science ®Google Scholar
• Herbert J, Thiermann H, Worek F, Wille T. 2019. COPD and asthma therapeutics for supportive treatment in organophosphate poisoning. Clin Toxicol. 57(7):644–651. doi:10.1080/15563650.2018.1540785.
   PubMed Web of Science ®Google Scholar
• Herkert NM, Thiermann H, Worek F. 2011. In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. Toxicol Lett. 206(1):41–46. doi:10.1016/j.toxlet.2011.03.004.
   PubMed Web of Science ®Google Scholar
• Joyce MR, Holton KF. 2020. Neurotoxicity in Gulf War Illness and the potential role of glutamate. Neurotoxicology. 80:60–70. doi:10.1016/j.neuro.2020.06.008.
   PubMed Web of Science ®Google Scholar
• Keeler JR, Hurst CG, Dunn MA. 1991. Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA. 266(5):693–695. doi:10.1001/jama.1991.03470050093029.
   PubMed Web of Science ®Google Scholar
• Kohler A, Escher B, Job L, Koller M, Thiermann H, Skerra A, Worek F. 2021. Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro. Arch Toxicol. 95(8):2815–2823. doi:10.1007/s00204-021-03094-0.
   PubMed Web of Science ®Google Scholar
• Koplovitz I, Harris LW, Anderson DR, Lennox WJ, Stewart JR. 1992. Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents. Fundam Appl Toxicol. 18(1):102–106. doi:10.1016/0272-0590(92)90201-r.
   PubMedGoogle Scholar
• Koplovitz I, Romano JA, Stewart JR. 1989. Assessment of motor performance decrement following soman poisoning in mice. Drug Chem Toxicol. 12(3–4):221–235. doi:10.3109/01480548908999155.
   PubMed Web of Science ®Google Scholar
• Koplovitz I, Stewart JR. 1994. A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicol Lett. 70(3):269–279. doi:10.1016/0378-4274(94)90121-x.
   PubMed Web of Science ®Google Scholar
• Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, et al. 2018. Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings. Drug Des Devel Ther. 12:505–512. doi:10.2147/DDDT.S133038.
   PubMed Web of Science ®Google Scholar
• Layish I, Krivoy A, Rotman E, Finkelstein A, Tashma Z, Yehezkelli Y. 2005. Pharmacologic prophylaxis against nerve agent poisoning. Isr Med Assoc J. 7(3):182–187. https://www.ncbi.nlm.nih.gov/pubmed/15792266.
   PubMed Web of Science ®Google Scholar
• Lenina OA, Zueva IV, Zobov VV, Semenov VE, Masson P, Petrov KA. 2020. Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning. Sci Rep. 10(1):16611. doi:10.1038/s41598-020-73822-6.
   PubMed Web of Science ®Google Scholar
• Lenz DE, Yeung D, Smith JR, Sweeney RE, Lumley LA, Cerasoli DM. 2007. Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review. Toxicology. 233(1–3):31–39. doi:10.1016/j.tox.2006.11.066.
   PubMed Web of Science ®Google Scholar
• Lorenzoni PJ, Kay CSK, Ducci RD, Fustes OJH, Werneck LC, Scola RH. 2020. Celebrating the 70 years of pyridostigmine on therapy of Myasthenia Gravis: historical aspects of the preliminary trials. Arq Neuropsiquiatr. 78(3):179–181. doi:10.1590/0004-282x20190189.
   PubMed Web of Science ®Google Scholar
• Macht VA, Woodruff JL, Burzynski HE, Grillo CA, Reagan LP, Fadel JR. 2020. Interactions between pyridostigmine bromide and stress on glutamatergic neurochemistry: insights from a rat model of Gulf War Illness. Neurobiol Stress. 12:100210. doi:10.1016/j.ynstr.2019.100210.
   PubMed Web of Science ®Google Scholar
• McGarry KG, Lalisse RF, Moyer RA, Johnson KM, Tallan AM, Winters TP, Taris JE, McElroy CA, Lemmon EE, Shafaat HS, et al. 2020. A Novel, Modified human butyrylcholinesterase catalytically degrades the chemical Warfare nerve agent, Sarin. Toxicol Sci. 174(1):133–146. doi:10.1093/toxsci/kfz251.
   PubMed Web of Science ®Google Scholar
• McIsaac RJ, Albrecht E. 1975. Depression of transmission through the isolated superior cervical ganglion of the rat by physostigmine sulphate. Neuropharmacology. 14(2):439–445. doi:10.1016/0028-3908(75)90036-2.
   PubMed Web of Science ®Google Scholar
• Miller SA, Blick DW, Kerenyi SZ, Murphy MR. 1993. Efficacy of physostigmine as a pretreatment for organophosphate poisoning. Pharmacol Biochem Behav. 44(2):343–347. doi:10.1016/0091-3057(93)90472-6.
   PubMed Web of Science ®Google Scholar
• Myhrer T, Aas P. 2016. Pretreatment and prophylaxis against nerve agent poisoning: are undesirable behavioral side effects unavoidable? Neurosci Biobehav Rev. 71:657–670. doi:10.1016/j.neubiorev.2016.10.017.
   PubMed Web of Science ®Google Scholar
• Myhrer T, Enger S, Aas P. 2013. Determination of anti-convulsant and life-preserving capacities of three types of auto-injector therapies against soman intoxication in rats. Drug Test Anal. 5(8):693–701. doi:10.1002/dta.1414.
   PubMed Web of Science ®Google Scholar
• Park JH, Lee JY, Kim KT, Joe HE, Cho HJ, Shin YK, Kim DD. 2018. Physostigmine-loaded liposomes for extended prophylaxis against nerve agent poisoning. Int J Pharm. 553(1-2):467–473. doi:10.1016/j.ijpharm.2018.10.053.
   PubMed Web of Science ®Google Scholar
• Peng X, Perkins MW, Simons J, Witriol AM, Rodriguez AM, Benjamin BM, Devorak J, Sciuto AM. 2014. Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats. Inhal Toxicol. 26(7):371–379. doi:10.3109/08958378.2014.899410.
   PubMed Web of Science ®Google Scholar
• Schlepütz M, Rieg AD, Seehase S, Spillner J, Perez-Bouza A, Braunschweig T, Schroeder T, Bernau M, Lambermont V, Schlumbohm C, et al. 2012. Neurally mediated airway constriction in human and other species: a comparative study using precision-cut lung slices (PCLS). PLoS One. 7(10):e47344. doi:10.1371/journal.pone.0047344.
   PubMed Web of Science ®Google Scholar
• Schlepütz M, Uhlig S, Martin C. 2011. Electric field stimulation of precision-cut lung slices. J Appl Physiol (1985). 110(2):545–554. doi:10.1152/japplphysiol.00409.2010.
   PubMed Web of Science ®Google Scholar
• Nam JH, Kim MS, Song YJ, Kim CH, Kim WS, Yu CH, Joe HE, Hur GH, Seo MR, Kim Y, et al. 2023. Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and procyclidine: implications of the delivery system for the potential application against VX nerve agent intoxication in humans. Arch Toxicol. 97(3):697–710. doi:10.1007/s00204-022-03438-4.
   PubMed Web of Science ®Google Scholar
• Thiermann H, Worek F. 2022. Pro: oximes should be used routinely in organophosphate poisoning. Br J Clin Pharmacol. 88(12):5064–5069. doi:10.1111/bcp.15215.
   PubMed Web of Science ®Google Scholar
• Wetherell J, Hall T, Passingham S. 2002. Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig. Neurotoxicology. 23(3):341–349. doi:10.1016/s0161-813x(02)00082-7.
   PubMed Web of Science ®Google Scholar
• White RF, Steele L, O’Callaghan JP, Sullivan K, Binns JH, Golomb BA, Bloom FE, Bunker JA, Crawford F, Graves JC, et al. 2016. Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: effects of toxicant exposures during deployment. Cortex. 74:449–475. doi:10.1016/j.cortex.2015.08.022.
   PubMed Web of Science ®Google Scholar
• Wigenstam E, Artursson E, Bucht A, Thors L. 2022. Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction. Chem Biol Interact. 364:110061. doi:10.1016/j.cbi.2022.110061.
   PubMed Web of Science ®Google Scholar
• Wigenstam E, Forsberg E, Bucht A, Thors L. 2021. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicol Appl Pharmacol. 419:115512. doi:10.1016/j.taap.2021.115512.
   PubMed Web of Science ®Google Scholar
• Von Bredow J, Corcoran K, Maitland G, Kaminskis A, Adams N, Wade J. 1991. Efficacy evaluation of physostigmine and anticholinergic adjuncts as a pretreatment for nerve agent intoxication. Toxicol Sci. 17(4):782–789. doi:10.1093/toxsci/17.4.782.
   Google Scholar
• Worek F, Kleine A, Szinicz L. 1995. Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning. Hum Exp Toxicol. 14(8):634–642. doi:10.1177/096032719501400803.
   PubMed Web of Science ®Google Scholar
• Worek F, Szinicz L. 1995. Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment. Arch Toxicol. 69(5):322–329. doi:10.1007/s002040050178.
   PubMed Web of Science ®Google Scholar
• Worek F, Widmann R, Knopff O, Szinicz L. 1998. Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Arch Toxicol. 72(4):237–243. doi:10.1007/s002040050495.
   PubMed Web of Science ®Google Scholar