47
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Subjective biosafety assessment of bisdemethoxycurcumin from the rhizomes of Curcuma longa

, , , &
Pages 676-693 | Received 20 Jan 2024, Accepted 27 Feb 2024, Published online: 13 Mar 2024

References

  • Ahmed T, Gilani AH. 2009. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease. Pharmacol Biochem Behav. 91(4):554–559. doi: 10.1016/j.pbb.2008.09.010.
  • Chunekar KC. 2015. Bhavaprakasha Nighantu, Hindi commentary. Bhavamishra (edited from Bhavaprakasha Nighantu), editor. Varanasi: Chaukhambha Bharati Academy.
  • Creager ANH. 2014. CHAPTER 2: the political life of mutagens: a history of the Ames test. In: Soraya B, Nathalie J, editors. Powerless science?: science and politics in a toxic world. New York (NY): Berghahn Books; p. 46–64. doi: 10.1515/9781782382379-005.
  • Edwards RL, Luis PB, Nakashima F, Kunihiro AG, Presley S-H, Funk JL, Schneider C. 2020. Mechanistic differences in the inhibition of NF-κB by turmeric and its curcuminoid constituents. J Agric Food Chem. 68(22):6154–6160. doi: 10.1021/acs.jafc.0c02607.
  • He D, Chen S, Xiao Z, Wu H, Zhou G, Xu C, Chang Y, Li Y, Wang G, Xie M. 2020. Bisdemethoxycurcumin exerts a cell-protective effect via JAK2/STAT3 signaling in a rotenone-induced Parkinson’s disease model in vitro. Folia Histochem Cytobiol. 58(2):127–134. doi: 10.5603/FHC.a2020.0011.
  • Hua Y, Dolence J, Ramanan S, Ren J, Nair S. 2013. Bisdemethoxycurcumin inhibits PDGF‐induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 57(9):1611–1618. doi: 10.1002/mnfr.201200852.
  • Jain R. 2020. Biological activities of bisdesmethoxycurcumin. J Nat Sci Med. 0(0):0. doi: 10.4103/JNSM.JNSM_65_19.
  • Jin F, Chen X, Yan H, Xu Z, Yang B, Luo P, He Q. 2020. Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory. Eur J Pharmacol. 874:173026. doi: 10.1016/j.ejphar.2020.173026.
  • Jin F, Jin Y, Du J, Jiang L, Zhang Y, Zhao Z, Yang B, Luo P, He Q. 2019. Bisdemethoxycurcumin protects against renal fibrosis via activation of fibroblast apoptosis. Eur J Pharmacol. 847:26–31. doi: 10.1016/j.ejphar.2019.01.012.
  • Kulyal P, Kuchibhatla LN, Maheshwari KU, Babu KN, Tetali SD, Raghavendra AS. 2016. Highly sensitive HPLC method for estimation of total or individual curcuminoids in Curcuma cultivars and commercial turmeric powders. Curr Sci. 111(11):1816–1824. doi: 10.18520/cs/v111/i11/1816-1824.
  • Kunnumakkara AB, Hegde M, Parama D, Girisa S, Kumar A, Daimary UD, Garodia P, Yenisetti SC, Oommen OV, Aggarwal BB. 2023. Role of turmeric and curcumin in prevention and treatment of chronic diseases: lessons learned from clinical trials. ACS Pharmacol Transl Sci. 6(4):447–518. doi: 10.1021/acsptsci.2c00012.
  • Liu J, Wang Q, Omari-Siaw E, Adu-Frimpong M, Liu J, Xu X, Yu J. 2020. Enhanced oral bioavailability of Bisdemethoxycurcumin-loaded self-microemulsifying drug delivery system: formulation design, in vitro and in vivo evaluation. Int J Pharm. 590:119887. doi: 10.1016/j.ijpharm.2020.119887.
  • Liu YL, Yang HP, Zhou XD, Gong L, Tang CL, Wang HJ. 2011. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 11(9):1098–1110. doi: 10.2174/156800911798073041.
  • Mahattanadul S, Nakamura T, Panichayupakaranant P, Phdoongsombut N, Tungsinmunkong K, Bouking P. 2009. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. Phytomedicine. 16(4):342–351. doi: 10.1016/j.phymed.2008.12.005.
  • Majeed M, Nagabhushanam K, Narayanan NK, Choudhury AK, Mundkur L, Nayak M, Thazhathidath S. 2019. Reductive metabolites of curcuminoids. Majeed M, Nagabhushanam K, editors. Piscataway (NJ): NutriScience Publishers, LLC.
  • Matsunaga T, Endo S, Soda M, Zhao HT, El-Kabbani O, Tajima K, Hara A. 2009. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site directed mutagenesis. Biochem Biophys Res Commun. 389(1):128–132. doi: 10.1016/j.bbrc.2009.08.107.
  • [OECD] Organization for Economic Cooperation and Development. 2002. Test no. 423: acute oral toxicity – acute toxic class method, OECD guidelines for the testing of chemicals, section 4. Paris: OECD Publishing. doi: 10.1787/9789264071001-en.
  • [OECD] Organization for Economic Cooperation and Development. 2008. Test no. 407: repeated dose 28-day oral toxicity study in rodents, OECD guidelines for the testing of chemicals, section 4. Paris: OECD Publishing. doi: 10.1787/9789264070684-en.
  • [OECD] Organization for Economic Cooperation and Development. 2014. Test no. 474: mammalian erythrocyte micronucleus test. Paris: OECD Publishing. doi: 10.1787/9789264224292-en.
  • [OECD] Organization for Economic Cooperation and Development. 2016. Test no. 421: reproduction/developmental toxicity screening test, OECD guidelines for the testing of chemicals, section 4. Paris: OECD Publishing. doi: 10.1787/9789264264380-en.
  • [OECD] Organization for Economic Cooperation and Development. 2018. Test no. 408: repeated dose 90-day oral toxicity study in rodents, OECD guidelines for the testing of chemicals, section 4. Paris: OECD Publishing. doi: 10.1787/9789264070707-en.
  • OECD. 2020. Test no. 471: bacterial reverse mutation test, OECD guidelines for the testing of chemicals, section 4. Paris: OECD Publishing. doi: 10.1787/9789264071247-en.
  • Ponnusamy S, Zinjarde S, Bhargava S, Rajamohanan P, RaviKumar A. 2012. Discovering bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 135(4):2638–2642. doi: 10.1016/j.foodchem.2012.06.110.
  • Ramezani M, Hatamipour M, Sahebkar A. 2018. Promising anti-tumor properties of bisdemethoxycurcumin: a naturally occurring curcumin analogue. J Cell Physiol. 233(2):880–887. doi: 10.1002/jcp.25795.
  • Ramírez-Muñoz MP, Zúñiga G, Torres-Bugarín O, Portilla E, García-Martínez D, Ramos A, Cantú JM, Sánchez-Corona J. 1999. Evaluation of the micronucleus test in peripheral blood erythrocytes by use of the splenectomized model. Lab Anim Sci. 49(4):418–420.
  • Revathy S, Elumalai S, Benny M, Antony B. 2011. Evaluation of curcuminoids in turmeric rhizome (Curcuma longa L.) collected from different places in India. Biosci Biotechnol Res Asia. 8(1):259–264. doi: 10.13005/bbra/853.
  • Schlegel R, MacGregor JT. 1984. The persistence of micronucleated erythrocytes in the peripheral circulation of normal and splenectomized Fischer 344 rats: implications for cytogenetic screening. Mutat Res. 127(2):169–174. doi: 10.1016/0027-5107(84)90018-6.
  • Sivabalan S, Anuradha C. 2010. A comparative study on the antioxidant and glucose-lowering effects of curcumin and bisdemethoxycurcumin analog through in vitro assays. Int J Pharmacol. 6(5):664–669. doi: 10.3923/ijp.2010.664.669.
  • Sudeep VH, Gouthamchandra K, Chandrappa S, Naveen P, Reethi B, Venkatakrishna K, Shyamprasad K. 2021. In vitro gastrointestinal digestion of a bisdemethoxycurcumin-rich Curcuma longa extract and its oral bioavailability in rats. Bull Natl Res Cent. 45(1):84. doi: 10.1186/s42269-021-00544-8.
  • Wang HJ, Yang ZX, Dai XT, Chen YF, Yang HP, Zhou XD. 2017. Bisdemethoxycurcumin sensitizes cisplatin-resistant lung cancer cells to chemotherapy by inhibition of CA916798 and PI3K/AKT signaling. Apoptosis. 22(9):1157–1168. doi: 10.1007/s10495-017-1395-x.
  • Wei JX, Luo Y, Xu Y, Xiao JH. 2022. Osteoinductive activity of bisdemethoxycurcumin and its synergistic protective effect with human amniotic mesenchymal stem cells against ovariectomy-induced osteoporosis mouse model. Biomed Pharmacother. 146:112605. doi: 10.1016/j.biopha.2021.112605.
  • Widowati W, Wargasetia TL, Afifah E, Mozef T, Kusuma HSW, Nufus H, Arumwardana S, Amalia A, Rizal R. 2018. Antioxidant and antidiabetic potential of Curcuma longa and its compounds. Asian J Agric Biol. 6(2):149–161.
  • Yang ST, Huang AC, Tang NY, Liu HC, Liao CL, Ji BC, Chou YC, Yang MD, Lu HF, Chung JG. 2016. Bisdemethoxycurcumin induced S phase arrest through the inhibition of cyclin A and E and induction of apoptosis via endoplasmic reticulum stress and mitochondria‐dependent pathways in human lung cancer NCI H 460 cells. Environ Toxicol. 31(12):1899–1908. doi: 10.1002/tox.22191.
  • Yodkeeree S, Chaiwangyen W, Garbisa S, Limtrakul P. 2009. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down – regulation of MMPs and uPA. J Nutr Biochem. 20(2):87–95. doi: 10.1016/j.jnutbio.2007.12.003.
  • Yuan L, Lorenz H. 2018. Solvate formation of bis(imethoxy)curcumin: screening and characterization. Crystals. 8(11):407. doi: 10.3390/cryst8110407.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.