The Role of Mitochondria in Epilepsy: Implications for Neurodegenerative Diseases

References

• Bengzon, J., Kokaia, Z., Elmer, E., Nanobashvili, A., Kokaia, M., and Lindvall, O. 1997. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc. Natl. Acad. Sci. USA 94:10432–10437.
   PubMed Web of Science ®Google Scholar
• Blümcke, I., Zuschratter, W., Schewe, J. C., Suter, B., Lie, A. A., Riederer, B. M., Meier, B., Schramm, J., Elger, C. E., and Wiestler, O. D. 1999. Cellular pathology of hilar neurons in Ammon’s horn sclerosis. J. Comp. Neurol. 414:437–453.
   PubMedGoogle Scholar
• Brini, M., Pinton, P., King, M. P., Davidson, M., Schon, E. A., and Rizutto, R. 1999. A calcium signalling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency. Nat. Med. 5:951–954.
   PubMedGoogle Scholar
• Brown, M. D., Zhadanov, S., Allen, J. C., Hosseini, S., Newman, N. J., Atamonov, V. V., Mikhailovskaya, I. E., Sukernik, R. I., and Wallace, D. C. 2001. Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families. Hum. Genet. 109:33–39.
   PubMed Web of Science ®Google Scholar
• Canfoglia, L., Franceschetti, S., Antozzi, C., Carrara, C., Farina, L., Granata, T., Lamantea, E., Savoiardo, M., Uziel, G., Villani, F., Zeviani, M., and Avanzini, G. 2001. Epileptic phenotypes associated with mitochondrial disorders. Neurology 56:1340–1346.
   PubMedGoogle Scholar
• deVries, D. D., van Engelen, B. G., Gabreels, F. J., Ruitenbeek, W., and van Oost, B. A. 1993. A second missense mutation in the mitochondrial ATPase 6 gene in Leigh’s syndrome. Ann. Neurol. 34:410–412.
   PubMedGoogle Scholar
• Jaksch, M., Klopstock, T., Kurlemann, G., Dorner, M., Hofmann, S., Kleinle, S., Hegemann, S., Weissert, M., Muller-Hocker, J., Pongratz, D., and Gerbitz, K. D. 1998. Progressive myoclonus epilepsy associated with mutations in the tRNA (Ser(UCN)) gene. Ann. Neurol 44:635–640.
   PubMed Web of Science ®Google Scholar
• Kovacs, R., Schuchmann, S., Gabriel, S., Kardos, J., and Heinemann, U. 2001. Ca2+ signalling and changes of mitochondrial function during low-Mg++–induced epileptoform activity in organotypic hippocampal slice cultures. Eur. J. Neurosci. 13:1311–1319.
   PubMedGoogle Scholar
• Kubova, H., Druga, R., Lukasiuk, K., Suchomelova, L., Haugvicova, R., Jirmanova, I., and Pitkanen, A. 2001. Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats. J. Neurosci. 21:3593–3599.
   PubMedGoogle Scholar
• Kudin, A. P., Kudina, T. A., Seyfried, J., Vielhaber, S., Beck, H., Elger, C. E., and Kunz, W. S. 2002. Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Eur. J. Neurosci. 15:1105–1114.
   PubMed Web of Science ®Google Scholar
• Kunz, W. S., Goussakov, I. V., Beck, H., and Elger, C. E. 1999. Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res. 826:236–242.
   PubMedGoogle Scholar
• Kunz, W. S., Kudin, A. P., Vielhaber, S., Blümcke, I., Zuschratter, W., Schramm, J., Beck, H., and Elger, C. E. 2000. Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Ann. Neurol. 48:766–773.
   PubMed Web of Science ®Google Scholar
• Liang, L. P., Ho, Y. S., and Patel, M. 2000. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 101:563–570.
   PubMed Web of Science ®Google Scholar
• Manfredi, G., Schon, E. A., Bonilla, E., Moraes, C. T., Shauske, S., and DiMauro, S. 1996. Identification of a mutation in the mitochondrial tRNACys gene associated with mitochondrial encephalopathy. Hum. Mutat. 7:158–163.
   PubMedGoogle Scholar
• Manfredi, G., Schon, E. A., Moreas, C. T., Bonilla, E., Berry, G. T., Sladky, J. T., and DiMauro, S. 1995. A new mutation associated with MELAS is located in a mitochondrial polypeptide-coding gene. Neuromuscul. Disord. 5:391–398.
   PubMed Web of Science ®Google Scholar
• Meldrum, B. S. 1993. Excitotoxicity and selective neuronal loss in epilepsy. Brain Pathol. 3:405–412.
   PubMed Web of Science ®Google Scholar
• Nakamura, M., Nakano, S., Goto, Y., Ozawa, M., Nagahama, Y., Fukuyama, H., Akiguchi, I., Kaji, R., Kimura, J. 1995. A novel point mutation in the mitochondrial tRNASer(UCN) gene detected in a family with MERRF/MELAS overlap syndrome. Biochem. Biophys. Res. Commun. 214:86–93.
   PubMed Web of Science ®Google Scholar
• Santorelli, F. M., Vazques-Acevedo, M., Gonzalez-Astiarazan, A., Ridaura-Sauz, C., Gonzalez-Halphen, D., and DiMauro, S. 1995. A novel mitochondrial DNA point mutation associated with mitochondrial encephalocardiomyopathy. Biochem. Biophys. Res. Commun. 216:835–840.
   PubMedGoogle Scholar
• Schuchmann, S., Buchheim, K., Meierkord, H., and Heinemann, U. 1999.Arelative energy failure is associated with low Mg++ but not with 4-aminopyridine-induced seizure-like events in entorhinal cortex. J. Neurophysiol. 81:399–403.
   PubMedGoogle Scholar
• Schuelke, M., Bakker, M., Stoltenburg, G., Sperner, J., and von Moers, A. 1998. Epilepsia partialis continua associated with a homoplasmic mitochondrial tRNA (Ser(UCN)) mutation. Ann. Neurol. 44:700–704.
   PubMedGoogle Scholar
• Silvestri, G., Moreas, C. T., Shanske, S., Oh, S. J., and DiMauro, S. 1992. A new mtDNA mutation in the tRNALys gene associated with myoclonic epilepsy and ragged red fibers (MERRF). Am. J. Hum. Genet. 51:1213–1217.
   PubMedGoogle Scholar
• Taniike, M., Kukushima, H., Yanagihara, I., Tsukamoto, H., Tanaka, J., Fujimura, H., Nagai, T., Sano, T., Yamaoka, K., and Inui, K. 1992. Mitochondrial tRNAIle mutation in fatal cardiomyopathy. Biochem. Biophys. Res. Commun. 186:47–53.
   PubMedGoogle Scholar
• Varlamov, D. A., Kudin, A. P., Vielhaber, S., Schröder, R., Sassen, R., Becker, A., Kunz, D., Haug, K., Rebstock, J., Heils, A., Elger, C. E., and Kunz, W. S. 2002. Metabolic consequences of a novel missense mutation of the mtDNA COI gene. Hum. Mol. Genet. 11:1797–1805.
   PubMedGoogle Scholar
• Zeviani, M., Muntoni, F., Savarese, N., Serra, G., Tiranti, V., Carrara, F., Mariotti, C., and DiDonato, S. 1993. A MERRF/MELAS overlap syndrome with anew point mutation in the mitochondrial DNA tRNALys gene. Eur. J. Hum. Genet. 1:80–87.
   PubMedGoogle Scholar