Brain Regional Heterogeneity and Toxicological Mechanisms of Organophosphates and Carbamates

REFERENCES

• Acosta, D., Anuforo, D. C., and Smith, R. V. 1980. Cytotoxicity of acetaminophen and papaverine in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol. 53:306–314.
   PubMed Web of Science ®Google Scholar
• Albano, C. B., Muralikrishnan, D., and Ebadi, M. 2002. Distribution of coen-zyme Q homologues in brain. Neurochem. Res. 27:359–368.
   PubMed Web of Science ®Google Scholar
• Aldous, C. N., Farr, C. H., and Sharma, R. P. 1982. Effects of leptophos on rat brain levels and turnover rates of biogenic amines and their metabolites. Ecotoxicol. Environ. Safety. 6:570–576.
   PubMed Web of Science ®Google Scholar
• Anden, N. E. 1974. Effects of oxotremorine and physostigmine on the turnover of dopamine in the corpus striatum and the limbic system. J. Pharmac. Pharmacol. 26:738–740.
   PubMed Web of Science ®Google Scholar
• Anderson, D. E., Yuan, X. J., Tseng, C. M., Rubin, J. L., Rosen, G. M., and Tod, M. L. 1993. Nitrone spin traps block calcium channels and induce pulmonary artery relaxation dependent of free radicals. Biochem. Biophys. Res. Commun. 193:878–885.
   PubMed Web of Science ®Google Scholar
• Andreoli, S. P. 1993. ATP depletion and cell injury: What is the relationship? J. Lab. Clin. Med. 122:232–233.
   PubMed Web of Science ®Google Scholar
• Appleyard, M. E., Tayer, S. C., and Little, H. J. 1990. Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist. Br. J. Pharmacol. 101:599–604.
   PubMed Web of Science ®Google Scholar
• Atack, J. R., Perry, E. K., Bonham, J. R., Candy, J. M., and Perry, R. H. 1986. Molecular forms of acetylcholinesterase and butyrylcholinesterase in the aged human central nervous system. J. Neurochem. 47:263–277.
   PubMed Web of Science ®Google Scholar
• Bagetta, G., Massoud, R., Rodino, P., Federici, G., and Nistico, G. 1993. Systetic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats. Eur. J. Pharmacol. 237:61–64.
   PubMed Web of Science ®Google Scholar
• Balcioglu, A., and Maher, T. J. 1993. Determination of kainic acid-induced release of nitric oxide using a novel hemoglobin trapping technique with microdialysis. J. Neurochem. 61:2311–2313.
   PubMed Web of Science ®Google Scholar
• Barclay, L. R. C., and Vinquist, M. R. 2000. Do spin traps also act as classical chain-breaking antioxidants? A quantitative study of phenyl tert-butylnitrone (PBN) in solution and in liposomes. Free Radic. Biol. Med. 28:1079–1090.
   PubMed Web of Science ®Google Scholar
• Barton, A. J. L., Pearson, R. C. A., Najlerahim, A., and Harrison, P. J. 1993. Pre- and post-mortem influences on brain RNA. J. Neurochem. 61:1—11.
   Google Scholar
• Bast, A., Haenen, G.R.M.M., and Doelman, C.J.A. 1991. Oxidants and antioxidants. Am. J. Med. 31: 2S-13S.
   Google Scholar
• Benishin, C. G., and Carroll, P. T. 1983. Multiple forms of choline-O-acetyltransferase in mouse and rat brain: Solubilization and characterization. J. Neurochem. 41:1030–1039.
   PubMed Web of Science ®Google Scholar
• Bisso, G. M., Meneguz, A., and Michalek, H. 1982. Developmental factors affecting brain acetylcholinesterase inhibition and recovery in DFP-treated rats. Dev. Neurosci. 5:508–519.
   PubMed Web of Science ®Google Scholar
• Bisso, G. M., Briancesco, R., and Michalek, H. 1991. Size and charge isomers of acetylcholinesterase in the cerebral cortex of young and aged rats. Neurochem. Res. 16:517–575.
   Web of Science ®Google Scholar
• Bjorneboe, A., Nenseter, M. S., Hagen, B. F., Bjorneboe, G. E. A., Prydz, K., and Drevon, C. A. 1991. Effect of dietary deficiency and supplement with all-rac-a-tocopherol on hepatic content in rats. J. Nutr. 121:1208–1213.
   PubMed Web of Science ®Google Scholar
• Blusztajn, J. K., and Wurtman, R. J. 1983. Choline and cholinergic neurons. Science 221:614–620.
   PubMed Web of Science ®Google Scholar
• Bolanos, J. P., Heales, S. J. R., Land, J. M., and Clark, J. B. 1995. Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurons and astrocytes in primary culture. J. Neurochem. 64:1965–1972.
   PubMed Web of Science ®Google Scholar
• Bolanos, J. P., Almeida, A., Stewart, V., Peuchen, S., Land, J. M., Clark, J. B., and Heales, S. J. R. 1997. Nitric oxide mediated mitochondrial damage in the brain: Mechanism and implications for neurodegenerative diseases. J. Neurochem. 68:2227–2240.
   PubMed Web of Science ®Google Scholar
• Bonner, T. I. 1989. The molecular basis of muscarinic receptor diversity. Trends Neurol. Sci. 12:148–151.
   PubMed Web of Science ®Google Scholar
• Boyd, R. T. 1997. The molecular biology of neuronal nicotinic acetylcholine receptors. Crit. Rev. Toxicol. 27:299–318.
   PubMed Web of Science ®Google Scholar
• Boyer, P. D. 1998. Energy, life, and ATP. Bioscience Rep. 18:97–117.
   PubMed Web of Science ®Google Scholar
• Brann, M. R., Ellis, J., Jorgensen, H., Hill-Eubanks, D., and Jones, S. V. P. 1993. Muscarinic acetylcholine receptor subtypes: Localization and structure/function. Progr. Brain Res. 98:121–127.
   PubMed Web of Science ®Google Scholar
• Bredt, D. S., and Snyder, S. H. 1992. Nitric oxide, a novel neuronal messenger. Neuron 8:8–11.
   Web of Science ®Google Scholar
• Bredt, D. S., and Synder, S. H. 1994. Nitric oxide: A physiologic messenger molecule. Annu. Rev. Biochem. 63:175–195.
   PubMed Web of Science ®Google Scholar
• Brimijoin, S. 1983. Molecular forms of acetylcholinesterase in brain, nerve, and muscle: Nature, localization, and dynamics. Prog. Neurobiol. 21:291–322.
   PubMed Web of Science ®Google Scholar
• Brookes, P. S., Bolanos, J. B., and Heales, S. J. 1999. The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct. FEBS Lett. 446:261–263.
   PubMed Web of Science ®Google Scholar
• Brooksbank, B. W. L., Martinez, M., Atkinson, D. J., and Balazs, R. 1978. Biochemical development of the human brain. I. Some parameters of the cholinergic system. Dev. Neurosci. 1:267–284.
   Web of Science ®Google Scholar
• Brorson, J. R., Schumacker, P. T., and Zhang, H. 1999. Nitric oxide acutely inhibits neuronal energy production. J. Neurosci. 19:147–158.
   PubMed Web of Science ®Google Scholar
• Brown, G. C. 1999. Nitric oxide and mitochondrial respiration. Biochim. Biophys. Acta. 1411:351–369.
   PubMed Web of Science ®Google Scholar
• Brunori, M., Guiffre, A., Sarti, P., Stubaur, G., and Wilson, M. T. 1999. Nitric oxide and cellular respiration. Cell. Mol. Life Sci. 56:549–557.
   PubMed Web of Science ®Google Scholar
• Burney, S., Tamir, S., and Tannenbaum, S. R. 1997. A mechanistic analysis of nitric oxide-induced cellular toxicity. Nitric oxide 1:130–144.
   PubMed Web of Science ®Google Scholar
• Bus, J. S., and Gibson, J. E. 1974. Bidrin: Perinatal toxicity and effect on the development of brain acetylcholinesterase and choline acetyltransferase in mice. Food Cosmet. Toxicol. 12:313–322.
   PubMedGoogle Scholar
• Butcher, S. H., Butcher, L. L., Harms, M. S., and Jenden, D. J. 1976. Fast fixation of brain in situ by high intensity microwave irradiation: Application to neurochemical studies. J. Microwave Power. 11:61–65.
   PubMedGoogle Scholar
• Butcher, L. L., and Woolf, N. J. 1986. Cholinergic systems in the brain and spinal cord: Anatomic organization and overview of functions. In Alzheimer’s and Parkinson Disease: Advances in behavioral biology, eds. A. Fisher, I. Hanin, and C. Lachman, 5-16. Plenum Press: New York.
   Google Scholar
• Campbell, C. G., Seidler, F. J., and Slotkin, T. A. 1997. Chlorpyrifos interferes with cell development in rat brain regions. Brain Res. Bull. 43:179–189.
   PubMed Web of Science ®Google Scholar
• Cairns, N. J., and Wonnacott, S. 1988. [3H](-)nicotine binding sites in fetal human brain. Brain Res. 475:1–7.
   PubMed Web of Science ®Google Scholar
• Candy, J. M., Perry, E. K., Perry, R. H., Bloxham, C. A., Thompson, J., Johnson, M., Oakley, A. E., and Edwardson, J. A. 1985. Evidence for early prenatal development of cortical cholinergic afferents from the nucleus of Meynert in the human fetus. Neurosci. Lett. 61:91–95.
   PubMed Web of Science ®Google Scholar
• Carney, J. M., and Floyd, R. A. 1991. Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agent: A novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3:47–57.
   PubMed Web of Science ®Google Scholar
• Castano, A., and Tarazona, J. V. 1994. ATP assay on cell monolayers as an index of cytotoxicity. Bull. Environ. Contam. Toxicol. 53:309–316.
   PubMed Web of Science ®Google Scholar
• Castoldi, A. F., Manzo, L., and Costa, L. G. 1993. Cyclic GMPformation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures. Brain Res. 610:57–61.
   PubMed Web of Science ®Google Scholar
• Cevohic, G., Dettbarn, W-D., and Welsch, F. 1972. Effects of an organic phosphate cholinesterase inhibitor on growth hormone and prolactin of pituitary and ChE of brain. Science 175:1256–1258.
   PubMedGoogle Scholar
• Chambers, J. E. 1992. The role of target-site activation of phosphorothionates in acute toxicity. In Organophosphates, chemistry, fate and effects, eds. J. E. Chambers and P. E. Levi, 229-239. Academic Press: San Diego, CA.
   Google Scholar
• Chambers, J. E., and Chambers, H. W. 1990. Time course of inhibition of acetylcholinesterase and aliesterase following parathion and paraoxon exposure in rats. Toxicol. Appl. Pharmacol. 103:420–429.
   PubMed Web of Science ®Google Scholar
• Chapman, J. F., Woodard, L. L., and Silverman, L. M. 1987. Creatine kinase isoenzymes. In Methods in Clinical Chemistry, eds. A. J. Pesce and L. A. Kaplan, 891-896. The C. V. Mosby Co., St. Louis.
   Google Scholar
• Chaudhury, J., Chakraborti, T. K., Chanda, S., and Pope, C. N. 1993. Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos. J. Biochem. Toxicol. 8:207–216.
   PubMedGoogle Scholar
• Choi, D. W. 1990. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc. Brain Metab. Rev. 2:105–147.
   PubMedGoogle Scholar
• Chow, C. K., Ibrahim, W., Wei, Z., and Chan, A. C. 1999. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic. Biol. Med. 27:580–587.
   PubMed Web of Science ®Google Scholar
• Cimino, M., Marini, P., Fornasari, D., Cattabeni, F., and Clementi, F. 1992. Distribution of nicotinic receptors cynomolgus monkey brain and ganglia: Localization of a3 subunitmRNA, a-bungarotoxin and nicotine binding sites. Neuroscience 51:77–86.
   PubMed Web of Science ®Google Scholar
• Clarke, P. B. S., Reuben, M., and El-Bizri, H. 1994. Blockade of nicotinic responses by physostigmine, tacrine, and other cholinesterase inhibitors in rat striatum. Br. J. Pharmacol. 111:695.
   PubMed Web of Science ®Google Scholar
• Clement, J. E. 1989. Role of aliesterases in organophosphatepoisoning. Fundam. Appl. Toxicol. 4:S94–S105.
   Google Scholar
• Clos, J., Ghandour, S., Eberhart, R., Vincendon, G., and Gombos, G. 1989. The cholinergic system in developing cerebellum: Comparative study of normal, hypothyroid, and underfed rats. Dev. Neurosci. 11:188–204.
   PubMed Web of Science ®Google Scholar
• Clouet, D. H., and Waelsch, H. 1963. Amino acid and protein metabolism of the brain. IX. The effect of an organophosphorus inhibitor on the incorporation of [14C] lysine into the proteins of rat brain. J. Neurochem. 10:51–63.
   PubMed Web of Science ®Google Scholar
• Corbett, J. R., Wright, K., and Baillie, A. C. 1984. The biochemical mode of action of pesticides. pp. 99-140, 2nd ed., Academic Press, London.
   Google Scholar
• Costa, L. G., and Murphy, S. D. 1983. [3H]-nicotine binding in rat brain: Alteration after chronic acetylcholinesterase inhibition. J. Pharmacol. Exp. Ther. 226:392–397.
   PubMed Web of Science ®Google Scholar
• Costa, L. G., Schwab, B. W., Hand, H., and Murphy, S. D. 1981. Reduced [3H]quinuclidinyl benzylate binding to muscarinic receptors in disulfoton-tolerant mice. Toxicol. Appl. Pharmacol. 60:441–550.
   PubMed Web of Science ®Google Scholar
• Costa, L. G., Schwab, B. W., and Murphy, S. D. 1982a. Tolerance to anticholinesterase compounds in mammals. Toxicology 25:79–97.
   PubMed Web of Science ®Google Scholar
• Costa, L. G., Schwab, B. W., and Murphy, S. D. 1982b. Differential alterations of cholinergic muscarinic receptors in acute and chronic tolerance to organophosphorus insecticides. Biochem. Pharmacol. 31:3407–3413.
   PubMed Web of Science ®Google Scholar
• Coudray-Lucas, C., Prioux-Guyonneau, M., Sentenac, H., Cohen, Y., and Wepierre, J. 1983. Brain catecholamine metabolism changes and hypothermia in intoxication by anticholinesterase agents. Acta Pharmacol. Et. Toxicol. 52:224–229.
   PubMedGoogle Scholar
• Coudray-Lucas, C., Prioux-Guyonneau, M., Sentenac, H., Cohen, Y., and Wepierre, J. 1987. Changes in brain monoamine content and metabolism induced by paraoxon and soman intoxication. Effect of atropine.Xenobiotica 17:1131–1138.
   PubMed Web of Science ®Google Scholar
• Court, J., and Clementi, F. 1995. Distribution of nicotinic subtypes in human brain. Alzheimer’s Disease Assoc. Disorders 9: 6-14,Suppl. 2.
   Google Scholar
• Court, J. A., Perry, E. K., Johnson, M., Piggott, M. A., Kerwin, J. A., Perry, R. H., and Ince, P. G. 1993. Regional patterns of cholinergic and glutamate activity in the developing and aging human brain. Dev. Brain Res. 74:73–82.
   PubMedGoogle Scholar
• Court, J. A., Perry, E. K., Spurden, D., Griffiths, M., et. al. 1995. The role of the cholinergic system in the development of the human cerebellum. Dev. Brain Res. 90:159–167.
   PubMedGoogle Scholar
• Coyle, J. T., and Yamamura, H. I. 1976. Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. Brain Res. 118:429–440.
   PubMed Web of Science ®Google Scholar
• Dam, K., Seidler, F. J., and Sloktin, T. A. 1998. Developmental neurotoxicity of chlorpyrifos: Delayed targeting of DNA synthesis after repeated administration. Dev. Brain Res. 108:39–45.
   PubMedGoogle Scholar
• Dam, K., Garcia, S. J., Seidler, F. J., and Slotkin, T. A. 1999. Neonatal chlorpyrifos exposure alters synaptic development and neoronal activity in cholinergic and catecholaminergic pathways. Dev. Brain Res. 116:9–20.
   PubMedGoogle Scholar
• Dam, K., Seidler, F. J., and Slotkin, T. A. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotive activity. Dev. BrainRes. 121:179–187.
   PubMed Web of Science ®Google Scholar
• Dawson, V. 1995. Nitric oxide: Role in neurotoxicity. Clin. Exp. Pharmacol. Physiol. 22:305–308.
   PubMed Web of Science ®Google Scholar
• Dawson, V. L., and Dawson, T. M. 1996. Nitric oxide actions in neurochemistry. Neurochem. Intl. 29:97–110.
   PubMed Web of Science ®Google Scholar
• Dawson, V. L., Dawson, T. M., Bartley, D. A., Uhl, G. R., and Snyder, S. H. 1993. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13:2651–2661.
   PubMed Web of Science ®Google Scholar
• DeSarno, P., and Giacobini, E. 1989. Modulation of acetylcholine release by nicotinic receptors in the rat brain. J. Neurosci. Res. 22:194–200.
   PubMed Web of Science ®Google Scholar
• Desole, M. S., Esposito, G., Migheli, R., et al. 1997. Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells. Pharmacol. Res. 36:285–292.
   PubMed Web of Science ®Google Scholar
• Domschke, W., Domagk, G. F., Domschke, S., and Erdmann, W. D. 1970. Uber die Wirkung von Soman und Diisopropylfluorophosphat auf die Enzymbiosynthese in der Rottenleber. Arch. Toxicol. 26:76–83.
   Google Scholar
• Dunlop, D. S., vanElden, W., and Lajtha, A. 1975. A method for measuring brain protein synthesis rates in young and adult rats. J. Neurochem. 24:337344.
   Google Scholar
• Ebadi, M., Marwah, J., and Chopra, R. 2001. Mitochondrial ubiquinone (Coenzyme Q10): Biochemical, functional, medical and therapeutic aspects in human health and disease. Vol. 1 and 2, Prominent Press, Scottsdale, AZ.
   Google Scholar
• Edwards, J. A., and Brimijoin, S. 1982. Divergent regulation of acetyl-cholinesterase and butyrylcholinesterase in tissue of the rat. J. Neurochem. 38:1393–1403.
   PubMed Web of Science ®Google Scholar
• Ehlert, F. J., Kokka, N., and Fairhurst, A. S. 1980. Altered [3H]-quinuclidinyl benzylate binding in the striatum of rats followin chronic cholinesterase inhibition with diisopropylfluorophosphate. Mol. Pharmacol. 17:24–30.
   PubMed Web of Science ®Google Scholar
• El-Etri, M. M., Nickell, W. T., Ennis, M., Saku, K. A., and Shipley, M. T. 1992. Brain norepinephrine reductions in soman-intoxicated rats: Association with convulsions and AChE inhibition, time course, and relation to other monoamines. Exp. Neurol. 118:153–163.
   PubMed Web of Science ®Google Scholar
• Elliott, K. J., Ellis, S. B., Berkhan, K. J., Urrutia, A., Chavez-Noriega, L. E., Johnson, E. C., Velicelebi, G., and Harpold, M. M. 1996. Comparative structure of human neuronal a2-a7 and fS2-fi4 nicotinic acetylcholine receptor subunits and fractional expression of the a2, a3, a4, a7, fS2, and fS4 subunits. J. Mol. Neurosci. 7:217–228.
   PubMed Web of Science ®Google Scholar
• Ellman, G. L., Courtney, K. O., Andres, V., and Featherstone, R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88–95.
   PubMed Web of Science ®Google Scholar
• Eriksson, P., Falkeborn, Y., Nordberg, A., and Slanina, P. 1984. Effects of DDT on muscarine- and nicotine-like binding sites in CNS of immature and adult mice. Toxicol. Lett. 22:329–334.
   PubMed Web of Science ®Google Scholar
• Falbergrova, J., Zhao, Q., Katsura, K. I., and Siesjo, B. K. 1995. N-tert-butyl-a-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc. Natl. Acad. Sci. USA. 92:5057–5061.
   PubMed Web of Science ®Google Scholar
• Farber, E. 1973. ATP and cell integrity. Fed. Proc. 32:1534–1539.
   PubMedGoogle Scholar
• Fariello, R. G., Ghilardi, O., Peschechera, A., Ramacci, M. T., and Angelucci, L. 1988. Regional distribution of ubiquinones and tocopherols in the mouse brain: Lowest content of ubiquinols in the substantia nigra. Neuropharmacology. 10:1077–1080.
   Google Scholar
• Fernando, J. C. R., Hoskins, B., and Ho, I. K. 1984a. Effect of striatal dopamine metabolism and differential motor behavioral tolerance following chronic cholinesterase inhibition with diisopropylfluorophosphate. Pharmacol. Biochem. Behav. 20:951–957.
   PubMed Web of Science ®Google Scholar
• Fernando, J. C. R., Hoskins, B., and Ho, I. K. 1984b. A striatal sertonergic involvement in the behavioral effects of anticholinesterase organophosphates. Eur. J. Pharmacol. 98:129–132.
   PubMed Web of Science ®Google Scholar
• Fielder, E. P., Marks, M. J., and Collins, A. C. 1990. Postnatal development of two nicotinic cholinergic receptors in seven mouse brain regions. Int. J. Dev. Neurosci. 5:533–540.
   Google Scholar
• Firestein, B. L., and Bredt, D. S. 1999. Interaction of neuronal nitric-oxide synthase and phosphofructokinase-m. J. Biol. Chem. 274:10545–10550.
   PubMed Web of Science ®Google Scholar
• Fiscus, R. R., and Van Meter, W. G. 1977. Effects of parathion on turnover and endogenous levels of norepinephrine (NE) and dopamine (DA) in rat brain. Fed. Proc. 36:951.
   Google Scholar
• Fitzgerald, B. B., and Costa, L. G. 1993. Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphate exposure in rats. Fundam. Appl. Toxicol. 20:210216.
   Google Scholar
• Fornai, F., Piaggi, S., Gesi, M., Saviozzi, M., Lenzi, P., Paparelli, A., and Casini, A. F. 2001. Subcellular localization of glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Neuroscience 104:15–31.
   PubMed Web of Science ®Google Scholar
• Fujita, K., Kobayashi, A., Suzuki, S., and Nakazawa, K. 1991. Changes of serotonin and catecholamines are related to pharmacokinetic alterations of chlomipramine in rat brain. Eur. J. Pharmacol. 204:227–233.
   PubMed Web of Science ®Google Scholar
• Garthwaite, J. 1991. Glutamate, nitric oxide, and cell-cell signaling in the nervous system. Trends Neurosci. 14:60–67.
   PubMed Web of Science ®Google Scholar
• Garthwaite, J., and Boulton, C. L. 1995. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57:683–706.
   PubMed Web of Science ®Google Scholar
• Geneser, F. A. 1987. Distribution of acetylcholinesterase in the hippocampal region of the rabbit: II Subiculum and hippocampus. J. Comp. Neurol. 262:90104.
   Web of Science ®Google Scholar
• Glisson, S. N., Karczmar, A. G., and Barnes, L. 1974. Effects of diisopropyl phosphororfluoridate on acetylcholine, cholinesterase, and catecholiamines of several parts of rabbit brain. Neuropharmacology 13:623–631.
   PubMed Web of Science ®Google Scholar
• Gorenstein, C., Gallardo, K. A., and Robertson, R. T. 1991. Molecular forms of acetylcholinesterase in cerebral cortex and dorsal thalamus of developing rats. Dev. BrainRes. 61:271–276.
   PubMed Web of Science ®Google Scholar
• Gotti, C., Fornasari, D., and Clementi, F. 1997. Human neuronal nicotinic receptors. Progr. Neurobiol. 53:199–237.
   PubMed Web of Science ®Google Scholar
• Gross, W. L., Bak, M. I., Ingwall, J. S., Arstall, M. A., Smith, T. W., Balligand, J.-L., and Kelly, R. A. 1966. Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc. Natl. Acad. Sci. USA. 93:5604–5609.
   Google Scholar
• Gulati, A., Hussain, G., and Srimal, R. C. 1991. Effect of repeated administration of clonidine on adrenergic, cholinergic (muscarinic), Dopaminergic, and serotonergic receptors in brain regions of rats. Drug Dev. Res. 22:141152.
   Web of Science ®Google Scholar
• Gunasekar, P. G., Kanthasamy, A. G., Borowitz, J. L., and Isom, G. E. 1995. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: Implication for cell death. J. Neurochem. 65:20162021.
   Web of Science ®Google Scholar
• Gupta, R. C., Welsch, F., Thornburg, J. E., and Paul, B. S. 1983. Effect of chloramphenicol pretreatment on malathion-induced acute toxicity in the rat. J. Toxicol. Environ. Health 11:897–905.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C. 1994a. Mechanistic and clinical approaches in antidotal treatment with memantine and atropine against oxamyl and methomyl acute toxicity. Indian J. Toxicol. 1:1–10.
   Google Scholar
• Gupta, R. C. 1994b. Carbofuran toxicity. J. Toxicol. Environ. Health. 43:383418.
   Google Scholar
• Gupta, R. C. 1999. Carboxylesterases. In Encyclopedia of Toxicology. Vol I. ed. P. Wexler, 229-232. Academic Press: New York.
   Google Scholar
• Gupta, R. C., and Dettbarn, W.-D. 1986. Role of uptake of [14C] valine into protein in the development of tolerance to diisopropylphosphorofluoridate (DFP) toxicity. Toxicol. Appl. Pharmacol. 84:551–560.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Dettbarn, W.-D. 1987a. Iso-OMPA-induced potentiation of soman toxicity in rat. Arch. Toxicol. 61:58–62.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Dettbarn, W.-D. 1987b. Interaction of cycloheximide and diisopropyphosphorolfluoridate (DFP) during subchronic administration in rat. Toxicol. Appl. Pharmacol. 90:52–59.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Dettbarn, W.-D. 1993. Role of carboxylesterases intheprevention and potentiation of N-methylcarbamate toxicity. Chemico-Biol. Interact. 87:295–303.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Dettbarn, W.-D. 2003. Protection by 7-nitroindazole of kainic acid-induced seizures, NO and energy metabolites in rat brain regions. Brain Res. Submitted.
   Google Scholar
• Gupta, R. C., and Goad, J. T. 2000. Role of high-energy phosphates and their metabolites in protection of carbofuran-induced biochemical changes in diaphragm muscle by memantine. Arch. Toxicol. 74:13–20.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Kadel, W. L. 1989a. Concentrated role of carboxylesterases in the potentiation of carbofuran toxicity by iso-OMPA pretreatment. J. Toxicol. Environ. Health 26:447–457.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Kadel, W. L. 1989b. Prevention and antagonism of acute carbofuran intoxication by memantine and atropine. J. Toxicol. Environ. Health 28:111–122.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Kadel, W. L. 1990a. Toxic interaction of tetraisopropylpyrophosphoramide and propoxur: Some insights into the mechanisms. Arch. Environ. Contam. Toxicol. 19:917–920.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., and Kadel, W. L. 1990b. Methyl parathion acute toxicity: Prophylaxis and therapy with memantine and atropine. Arch. Intl. De Pharmacod. EtdeTher 305:208–221.
   PubMedGoogle Scholar
• Gupta, R. C., and Kadel, W. L. 1991. Novel effects of memantine in antagonizing acute aldicarb toxicity: Mechanistic and applied considerations. Drug Dev. Res. 24:329–341.
   Web of Science ®Google Scholar
• Gupta, R. C., Thornberg, J. E., Stedman, D. B., and Welsch, F. 1984. Effect of subchronic administration of methyl parathion on in vivo protein synthesis in pregnant rats and their conceptuses. Toxicol. Appl. Pharmacol. 72:457468.
   Web of Science ®Google Scholar
• Gupta, R. C., Rech, R. H., Lovell, K. L., Welsch, F., and Thornberg, J. E. 1985a. Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methyl parathion. Toxicol. Appl. Pharmacol. 77:405–413.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., Patterson, G. T., and Dettbarn, W.-D. 1985b. Mechanisms involved in the development of tolerance to DFP toxicity. Fundam. Appl. Toxicol. 5:S17:S28.
   Google Scholar
• Gupta, R. C., Patterson, G. T., and Dettbarn, W.-D. 1986. Mechanism of toxicity and tolerance to diisopropylphosphorofluoridate at the neuromuscular junction of the rat. Toxicol. Appl. Pharmacol. 84:S41–S50.
   Web of Science ®Google Scholar
• Gupta, R. C., Patterson, G. T., and Dettbarn, W.-D. 1987a. Biochemical and histochemical alterations following acute soman intoxication in the rat. Toxicol. Appl. Pharmacol. 87:393–402.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., Patterson, G. T., and Dettbarn, W.-D. 1987b. Acute tabun toxicity; Biochemical and histochemical consequences in brain and skeletal muscles of rat. Toxicology 46:329–341.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., Patterson, G. T., and Dettbarn, W.-D. 1991. Comparison of cholinergic and neuromuscular toxicity following acute exposure to sarin and VX in rat. Fundam. Appl. Toxicol. 16:449–458.
   PubMedGoogle Scholar
• Gupta, R. C., Sanecki, R. K., and Goad, J. T. 1998. Biochemical and microscopic changes in brain by acute carbofuran toxicity (Abstract). Toxicol. Sci. 42:156.
   Google Scholar
• Gupta, R. C., Goad, J. T., Milatovic, D., and Dettbarn, W.-D. 2000a. Cholinergic and noncholinergic brain biomarkers of insecticide exposure and effects. Hum. Exper. Toxicol. 19:297–308.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., Milatovic, D., Zivin, M., and Dettbarn, W.-D. 2000b. Seizure-induced changes in energy metabolites and effects of N-tert butyl-a-phenylnitrone (PBN) and vitamin E in the rats. Pflg. Arch. Eur. J. Physiol. 440(Suppl.): R160-162.
   Google Scholar
• Gupta, R. C., Milatovic, D., and Dettbarn, W.-D. 2001a. Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: Protection by antioxidants. Neurotoxicology. 22:271–282.
   PubMed Web of Science ®Google Scholar
• Gupta, R. C., Milatovic, D., and Dettbarn, W.-D. 2001b. Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with di-isopropylphosphorofluoridate or carbofuran: Prevention by N-tert-butyl-a- phenylnitrone or vitamin E. Arch. Toxicol. 75:346–356.
   PubMed Web of Science ®Google Scholar
• Hallak, M., and Giacobini, E. 1986. Relation of brain regional physostigmine concentration to cholinesterase activity and acetylcholine and choline levels in rat. Neurochem. Res. 11:1037–1048.
   PubMed Web of Science ®Google Scholar
• Hallak, M., and Giacobini, E. 1989. Physostigmine, tacrine, and metrifonate: The effect of multiple doses on acetylcholine metabolism in rat brain. Neuropharmacology. 25:199–206.
   Google Scholar
• Hartvig, P., Torstenson, R., Bjurling, P., Fasth, K. J., Langstrom, B., and Nordberg, A. 1997. Regional brain distribution and binding of the muscarinic receptor agonist CI-979 studied by Prositron emission tomography in the monkey. Dem. Geriatr. Cogn. Disord. 8:259–266.
   PubMed Web of Science ®Google Scholar
• Hellstrom-Lindahl, E., Gorbounova, O., Seiger, A., Mousari, M., and Nordberg, A. 1998. Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord. Develop. Brain Res. 108:147–160.
   PubMedGoogle Scholar
• Hu, J., and El-Fakahany, E. E. 1993. Role of intercellular and intracellular communication by nitric oxide in coupling of muscarinic receptors to activation of guanylate cyclase in neuronal cells. J. Neurochem. 61:578–585.
   PubMed Web of Science ®Google Scholar
• Huff, R. A., and Abou-Donia, M. B. 1994. Cis-methyldioxolane specifically recognizes the M2 muscarinic receptor. J. Neurochem. 62:388–391.
   PubMed Web of Science ®Google Scholar
• Huff, R. A., Abu-Quare, A. W., and Abou-Donia, M. B. 2001. Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum. Arch. Toxicol. 75:480–486.
   PubMed Web of Science ®Google Scholar
• Hughes, P., Youg, D., and Dragunow, M. 1993. MK-801 sensitizes rats to pilocarpine induced seizures and status epilepticus. NeuroReport 4:314–316.
   PubMed Web of Science ®Google Scholar
• Jacobsson, S. O. P., Cassel, G. E., and Persson, S. A. 1999. Increased levels of nitrogen oxides and lipid peroxidation in the brain after induced seizures. Arch. Toxicol. 73:269–273.
   PubMed Web of Science ®Google Scholar
• Joli, M., LeNovere, N., Hill, J. A. Jr., and Changeux, J.-P. 1995. Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J. Neurosci. 15:1912–1939.
   PubMed Web of Science ®Google Scholar
• Jope, R. S. 1979. High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis. Brain Res. Rev. 1:313–344.
   Google Scholar
• Jope, R. S., Morreset, R. A., and Sneed, O. C. 1986. Characterization of lithium potentiation of pilocarpine induced status epilepticus in rats. Exp. Neurol. 91:471–480.
   PubMed Web of Science ®Google Scholar
• Jope, R. S., Simonato, M., and Lally, K. 1987. Acetylcholine content in the brain is elevated by status epilepticus induced by lithium and pilocarpine. J. Neurochem. 49:944–951.
   PubMed Web of Science ®Google Scholar
• Kaasik, A., Minajeva, A., DeSousa, E., Ventura-Clapier, R., and Veksler, V. 1999. Nitric oxide inhibits cardiac energy production via inhibition of mitochondrial creatine kinase. FEBS Lett. 444:75–77.
   PubMed Web of Science ®Google Scholar
• Kalin, A., Norling, B., Appelkvist, E. L., and Dallner, G. 1987. Ubiquinone biosynthesis by the microsomal from rat liver. Biochim. Biophys. Acta. 926:70–78.
   PubMed Web of Science ®Google Scholar
• Karczmar, A. G., Srinivasan, R., and Bernsohn, J. 1973. Cholinergic function in the developing fetus. In Fetal Pharmacology, ed. L. Boreus, 127-177. Raven Press: New York.
   Google Scholar
• Kasa, P., Bansaghy, K., Rakonczay, Z., and Gulya, K. 1982. Postnatal development of the acetylcholine system in different parts of the rat cerebellum. J. Neurochem. 39:1726–1732.
   PubMed Web of Science ®Google Scholar
• Kemp, R. B., Cross, D. M., and Meredith, R. W. J. 1986. Adenosine triphosphate as an indicator of cellular toxicity in vitro. Fd. Chem. Toxicol. 24:465466.
   Web of Science ®Google Scholar
• Kewitz, H., Pleul, O., and Mann, E. 1977. Pre- and postnatal development and drug induced alterations of free and bound acetylcholine in rat brain. Naunyh-Schmiedberg's Arch. Pharmacol. 298:149–155.
   Web of Science ®Google Scholar
• Khan, W. A., Dechkovskaia, A. M., Herrick, E. A., Jones, K. H., and Abou-Donia, M. B. 2000. Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. Toxicol. Sci. 57:112120.
   Web of Science ®Google Scholar
• Khandelwal, J. K., Szilagyi, P., Barker, L. A., and Green, J. P. 1981. Simultaneous measurement of acetylcholine and choline in brain by pyrolysis-gas chromatography-mass-spectrometry. Eur. J. Pharmacol. 76:145–156.
   PubMed Web of Science ®Google Scholar
• Kim, Y. B., Hur, G. H., Shin, S. H., Sok, D. E., Kang, J. K., and Lee, Y. S. 1999. Organophosphate-induced brain-injuries: Delayed apoptosis mediated by nitric oxide. Environ. Toxicol. Pharmacol. 17:147–152.
   Google Scholar
• Kobayashi, H., Yuyama, A., Kajita, T., Shimura, K., Ohkawa, T., and Satoh, K. 1985. Effects of insecticidal carbamates on brain acetylcholine content, acetylcholinesterase activity and behavior in mice. Toxicol. Lett. 29:153159.
   Web of Science ®Google Scholar
• Kobayashi, H., Yayama, A., and Chiba, K. 1986. Cholinergic system of brain tissue in rats poisoned with the organophosphate, O,O-dimethyl O-(2,2-dichlorovinyl) phosphate. Toxicol. Appl. Pharmacol. 82:32–39.
   PubMed Web of Science ®Google Scholar
• Kobayashi, H., Yuyama, A., Ohkawa, T., and Kajita, T. 1988. Effect of single or chronic injection with a carbamate, propoxur, on the brain cholinergic system and behavior of mice. Jpn. J. Pharmacol. 47:21–27.
   PubMedGoogle Scholar
• Kobayashi, H., Yuyama, A., Shioya, K., and Sato, K. 1989. Effects of a carbamate, BPMC, on the central cholinergic functions and behavior of mice. Jpn. J. Vet. Sci. 51:789–795.
   PubMedGoogle Scholar
• Koelle, W. A., Smyrl, E.,Ruch, G., Siddons, V., and Koelle, G. B. 1977a. Effects of protection of butyrylcholinesterase on regeneration of ganglionic acetyl-cholinesterase. J. Neurochem. 28:307–311.
   PubMed Web of Science ®Google Scholar
• Koelle, G. B., Koelle, W. A., and Smyrl, E. 1977b. Effects of inactivation of butyrylcholinesterase on steady state and regenerating levels of ganglionic acetylcholinesterase. J. Neurochem. 28:313–319.
   PubMed Web of Science ®Google Scholar
• Kopperschlager, G., and Kirchberger, J. 1996. Methods for the separation of lactate dehydrogenase and clinical significance of the enzyme. J. Chromatogr. 684:25–49.
   Web of Science ®Google Scholar
• Kotegawa, M., Sugiyama, M., Shoji, T., Haramaki, N., and Agura, R. 1993. Effect of a-tocopherol on high-energy phosphate metabolite levels in rat heart by 31P-NMR using a Langendorff perfusion technique. J. Mol. Cell. Cardiol. 25:1067–1074.
   PubMed Web of Science ®Google Scholar
• Kozar, M. D., Overstreet, D. H., Chippendale, T. C., and Russell, R. W. 1976. Changes of acetylcholinesterase activity in three major brain areas and related changes in behavior following acute treatment with diisopropylfluorophosphate. Neuropharmacology 15:291–298.
   PubMed Web of Science ®Google Scholar
• Kuhar, M. J., and Murrin 1979. Sodium-dependent high affinity choline uptake. J. Neurochem. 30:15–21.
   Web of Science ®Google Scholar
• Kuhar, M. J., Sethy, V. H., Roth, R. H., and Aghjanian, G. K. 1973. Choline: Selective accumulation of central cholinergic neurons. J. Neurochem. 20:581593.
   Web of Science ®Google Scholar
• Kuhr, R. J., and Dorough, H. W. 1976. Carbamate insecticides: Chemistry, biochemistry and toxicology, 133-134. Cleveland, OH: CRC Press.
   Google Scholar
• Kumar, A., and Schliebs, R. 1992. Postnatal laminate development of cholinergic receptors, protein kinase c and dihydropyridine-sensitive calcium antagonist binding in rat visual cortex. Effect of visual deprivation. Intl. J. Dev. Neurosci. 10:491–504.
   PubMed Web of Science ®Google Scholar
• Lai, J. C. K., Leung, T. K. C., and Lim, L. 1982. The ontogeny of acetyl-cholinesterase activities in rat brain regions and the effect of chronic treatment with manganese chloride. J. Neurochem. 39:1767–1769.
   PubMed Web of Science ®Google Scholar
• Lajtha, A., and Dunlop, D. 1981. Turnover of protein in the nervous system. Life Sci. 29:755–767.
   PubMed Web of Science ®Google Scholar
• Lassiter, T. L., Barone, Jr, S., and Padilla, S. 1998. Ontogenic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain. Dev. Brain Res. 105:109–123.
   Google Scholar
• Lassiter, T. L., Padilla, S., Mortensen, S. R., Chanda, S. M., Moser, V. C., and Barone, S. Jr. 1998. Gestational exposure to chlorpyrifos: Apparent protection of the fetus. Toxicol. Appl. Pharmacol. 152:56–65.
   PubMed Web of Science ®Google Scholar
• Lander, J. M., and Schambra, U. B. 1999. Morphogenetic roles of acetylcholine. Environ. Health Perspect. 107:65–69.
   PubMed Web of Science ®Google Scholar
• Layer, P. G. 1983. Comparative localization of acetylcholinesterase and pseudocholinesterase during morphogenesis of the chick brain. Proc. Natl. Acad. Sci. U.S.A. 80:6413–6417.
   PubMed Web of Science ®Google Scholar
• Lee, N. H., and El-Fakahany, E. E. 1991. Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem. Pharmacol. 42:199–205.
   PubMed Web of Science ®Google Scholar
• Legrand, C., Bour, J. M., Jacob, C., Capiaumont, J. et al. 1992. Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cell as marker. J. Biotechnol. 25:231–243.
   PubMed Web of Science ®Google Scholar
• Lenox, R. H., Kant, G. J., and Meyerhoff, J. L. 1980. Regional sensitivity of cyclic AMP and cyclic GMP in rat brain to central cholinergic stimulation. Life Sci. 26:2201–2209.
   PubMed Web of Science ®Google Scholar
• Levey, A. I., Kitt, C. A., Simonds, W. F., Price, D. L., and Brann, M. R. 1991. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J. Neurosci. 11:3218–3226.
   PubMed Web of Science ®Google Scholar
• Levy, A., Brandies, R., Treves, T. A., et al. 1994. Transdermal physostigmine in the treatment of Alzheimer's disease. Alzheimer’s Dis. Assoc. Disord. 8:1521.
   Web of Science ®Google Scholar
• Lim, D. K., Hoskins, B., and Ho, I. K. 1986. Correlation of muscarinic receptor density and acetylcholinesterase activity in repeated DFP-treated rats after the termination of DFP administration. Eur. J. Pharmacol. 123:223–228.
   PubMed Web of Science ®Google Scholar
• Lim, D. K., Hoskins, B., and Ho, I. K. 1987a. Evidence for the involvement of presynaptic functions in tolerance to diisopropylfluorophosphate. Toxicol. Appl. Pharmacol. 90:465–476.
   PubMed Web of Science ®Google Scholar
• Lim, D. K., Porter, A. B., Hoskins, B., and Ho, I. K. 1987b. Changes in ACh levels in the rat brain during subacute administration of diisopropylfluorophosphate. Toxicol. Appl. Pharmacol. 90:477–489.
   PubMed Web of Science ®Google Scholar
• Liu, P.-S., Kao, L.-S., and Lin, M. K. 1994. Organophosphates inhibit cate-cholamine secretion and calcium influx in bovine adrenal chromaffin cells. Toxicology 90:81.
   PubMed Web of Science ®Google Scholar
• Liu, J., and Pope, C. N. 1996. Effects of chlorpyrifos on high-affinity choline uptake and [3 H] Hemicholinium-3 binding in rat brain. Fundam.Appl. Toxicol. 34:84–90.
   PubMedGoogle Scholar
• Liu, J., Oliver, K., and Pope, C. N. 1999. Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposure in neonatal and adult rats. Toxicol. Appl. Pharmacol. 158:186–196.
   PubMed Web of Science ®Google Scholar
• Lynch, G. S., Lucas, P. A., and Deadwyler, S. A. 1972. The demonstration of acetylcholinesterase containing neurons within the caudate nucleus of the rat. BrainRes. 45:617–621.
   PubMed Web of Science ®Google Scholar
• Ma, T., Cai, Z., Wellman, S. E., and Ho, I. K. 2001. A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometry. Anal. Biochem. 296:18–28.
   PubMed Web of Science ®Google Scholar
• Mailman, R. B., Krigman, M. R., Frye, G. D., et al. 1983. Effects of postnatal trimethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat. J. Neurochem. 40:1423–1429.
   PubMed Web of Science ®Google Scholar
• Marchand, A., Chapoutier, G., and Massoulie, J. 1977. Developmental aspects of acetylcholinesterase activity in chick brain. FEBS Lett. 78:233–236.
   PubMed Web of Science ®Google Scholar
• Marks, M. J., and Collins, A. C. 1982. Characterization of nicotine binding in mouse brain and comparison with the binding of a-bungarotoxin and quinuclidinyl benzilate. Mol. Pharmacol. 22:554–564.
   PubMed Web of Science ®Google Scholar
• Marquis, J. K. 1985. Non-cholinergic mechanisms of insecticide toxicity. Trends in Pharmacol. Sci. 6:59–60.
   Web of Science ®Google Scholar
• Massoulie, J., Pezzementi, L., Bon, S., Krejci, E., and Vallette, F.-M. 1993. Molecular and cellular biology of cholinesterase. Progr. Neurobiol. 41:3191.
   Web of Science ®Google Scholar
• McBride, J. K., Rodgerson, D. O., and Helborne, L. H. 1990. Human, rabbit, bovine, and porcine creatine kinase isoenzymes are glycoproteins. J. Clin. Lab. Anal. 4:196–198.
   PubMed Web of Science ®Google Scholar
• McDonough, J. H., and Shih, T.-M. 1997. Neuropharmacological mechanisms of nerve agent induced seizure and neuropathology. Neurosci. Behav. Rev. 21:559–579.
   PubMed Web of Science ®Google Scholar
• McLennan, H. R., and Esposti, M. D. 2000. The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. J. Bioenerg. Biomembr. 32:153–162.
   PubMed Web of Science ®Google Scholar
• Meneguz, A., Bisso, G. M., and Michalek, H. 1989. Alterations in the distribution of cholinesterase molecular forms in maternal and fetal brain following diisopropylfluorophosphate treatment of pregnant rats. Neurochem. Res. 14:285–291.
   PubMed Web of Science ®Google Scholar
• Meneguz, A., Bisso, G. M., and Michalek, H. 1992. Age-related changes in acetylcholinesterase and its molecular forms in various brain areas of rats. Neurochem. Res. 17:785–790.
   PubMed Web of Science ®Google Scholar
• Michalek, H., Pintor, A., Fortuna, S., and Bisso, G. M. 1985. Effects of diisopropylfluorophosphate on brain cholinergic systems of rats at early developmental stages. Fundam. Appl. Toxicol. 5:S204–S212.
   Google Scholar
• Miner, L. L., Marks, M. J., and Collins, A. C. 1985. Relationship between nicotine-induced seizures and hippocampal nicotinic receptors. Life Sci. 37:75–83.
   PubMed Web of Science ®Google Scholar
• Milatovic, D., Radic, Z., Zivin, M., and Dettbarn, W.-D. 2000a. Atypical effect of some spin trapping agents: Reversible inhibition of acetylcholinesterase. Free Radic. Biol. Med. 28:597–603.
   PubMed Web of Science ®Google Scholar
• Milatovic, D., Zivin, M., and Dettbarn, W.-D. 2000b. The spin trapping agent phenyl-N-tert-butyl-nitrone (PBN) prevents excitotoxicity in skeletal muscle. Neurosci. Lett. 278:25–28.
   PubMed Web of Science ®Google Scholar
• Milatovic, D., Zivin, M., Gupta, R. C., and Dettbarn, W.-D. 2001. Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus. Brain Res. 912:67–78.
   PubMed Web of Science ®Google Scholar
• Milatovic, D., Gupta, R. C., and Dettbarn, W.-D. 2002. Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. Brain Res. 957:330337.
   Web of Science ®Google Scholar
• Mitchelson, F. 1988. Muscarinic receptor differentiation. Pharmacol. Ther. 37:357–423.
   PubMed Web of Science ®Google Scholar
• Miyajima, T., and Kotake, Y. 1995. Spin trap phenyl N-tert-butylnitrone (PBN) inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem. Biophys. Res. Commun. 215:114—121.
   Web of Science ®Google Scholar
• Miyajima, T., and Kotake, Y. 1997. Optimal time and dosage of phenyl N-tert-butylnitrone (PBN) for the inhibition of nitric oxide synthase induction in mice. Free Radic. Biol. Med. 22:463–470.
   PubMed Web of Science ®Google Scholar
• Modak, A. T., Stavinoha, W. B., and Weintraub, S. T. 1975. Dichlorvos and the cholinergic system: Effect on cholinesterase and acetylcholine and choline contents of rat tissues. Arch. Int. de Pharmacodyn. Et de Ther. 217:293301.
   Google Scholar
• Molinengo, L., and Orsetti, M. 1998. Actions of diisopropylfluorophosphate and of diacetylmonoxime on acetylcholine levels and on cholinesterase activity in the central nervous system. Arch. Int. de Pharmacodyn. Etde Ther. 295:17–27.
   Google Scholar
• Monks, T. J., Ghersi-Egea, J.-F., Philbert, M., Cooper, A. J. L, and Lock, E. A. 1999. Symposium overview: The role of glutathione in neuroprotection and neurotoxicity. Toxicol. Sci. 51:161–177.
   Google Scholar
• Moro, V., Badaut, J., Springhetti, V., Edvinsson, L., Seylaz, J., and Lasbennes, F. 1995. Regional Study of the co-localization of neuronal nitric oxide synthase with muscarinic receptors in the rat cerebral cortex. Neuroscience. 69:797805.
   Web of Science ®Google Scholar
• Morris, B. J., Hicks, A. A., Wisden, W., Darlison, M. G., Hunt, S. P., and Barnard, E. A. 1990. Distinct regional expression of nicotinic acetylcholine genes in chick brain. Mol. Brain Res. 7:305–315.
   PubMedGoogle Scholar
• Morrisett,R. A., Jope, R. S., Snead, O. C. III. 1987. Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: Comparison with kainic acid. Exp. Neurol. 98:594–604.
   PubMed Web of Science ®Google Scholar
• Muller, F., Dumez, Y., and Massoulie, J. 1985. Molecular forms and solubility of acetylcholinesterase during the embryonic development of rats and human brain. Brain Res. 331:295–302.
   PubMed Web of Science ®Google Scholar
• Naeff, B., Schlumpf, M., Lichtensteiger, W. 1992. Pre- and postnatal development of high-affinity [3H]nicotine binding sites rat brain regions: An autora-diographic study. Dev. Brain Res. 68:163–174.
   PubMedGoogle Scholar
• Necchi, D., Virgili, M., Monti, B., Contestabile, A., and Scherini, E. 2002. Regional alterations of the NO/NOS system in the aging brain: A biochemical, histochemical, and immunochemical study in the rat. Brain Res. 933:31–41.
   PubMed Web of Science ®Google Scholar
• Nohl, H., Kozlov, A. V., Staniek, K., and Gille, L. 2001. The multiple functions of coenzyme Q. Bioorg. Chem. 29:1–13.
   PubMed Web of Science ®Google Scholar
• Nordberg, A., and Wahlstrom, G. 1988. Long-term effects on biotransformation of labeled choline in different parts of the rat brain induced by single choline injections. Pharmacol. Toxicol. 62:69–73.
   PubMedGoogle Scholar
• Norris, P. J., Faull, R. L., and Emson, P. C. 1996. Neuronal nitric oxide synthase (NOS) mRNA expression and NADPH-diphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains. Mol. Brain Res. 41:36–49.
   PubMedGoogle Scholar
• Nowicki, J. P., Duval, D., Poignet, H., and Scatton, B. 1991. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 204:339–340.
   PubMed Web of Science ®Google Scholar
• Olney, J., Labruyere, J., and Price, M. 1989. Pathological changes induced cerebrocortical neurons by phencyclidine and related drugs. Science. 244:13601362.
   Web of Science ®Google Scholar
• Payne, L. K., Stansbury, H. A., and Weiden, M. H. J. 1966. The synthesis and insecticidal properties of some cholinergic trisubstituted acetaldehyde O-(methyl-carbamoyl) oximes. J. Agri. Food Chem. 14:356–365.
   Web of Science ®Google Scholar
• Pazdernik, T. L., Cross, R., Nelson, S., Samson, F., and McDonough, Jr. J. 1983. Soman-induced depression of brain activity in TAB-pretreated rats: 2-deoxyglucose study. Neurotoxicology 4:27–34.
   PubMed Web of Science ®Google Scholar
• Pazdernik, T. L., Cross, R., Giesler, M., Nelson, S., Samson, F., and McDonough, Jr. J. 1985. Delayed effects of soman: Brain glucose use and pathology. Neurotoxicology. 6:61–70.
   PubMed Web of Science ®Google Scholar
• Pazdernik, T. L., Nelson, S. R., Cross, R., and Samson, F. E. 1996. Chemical-induced seizures: Free radicals as a final common pathway. Proc. Med. Def. Biosci. Rev. 1:413–422.
   Google Scholar
• Pazdernik, T. L., Emerson, M. R., Cross, R., Nelson, S. R., and Samson, F. E. 2001. Soman-induced seizures: Limbic activity, oxidative stress and neuro-protective proteins. J. Appl. Toxicol. 21:S87–S94.
   Web of Science ®Google Scholar
• Pedersen, P. L. 1999. Mithchondrial events in the life and death of animal cells: A brief review. J. Bioenerg. Biomembr. 31:291–304.
   PubMedGoogle Scholar
• Perry, E. K., Smith, C. J., Atack, J. R., Candy, J. M., Johnson, M., and Perry, R. H. 1986. Neocortical cholinergic enzyme and receptor activities in the human fetal brain. J. Neurochem. 47:1262–1269.
   PubMed Web of Science ®Google Scholar
• Planas, A. M., Soriano, M. A., Ferrer, I., and Rodriguez, F. E. 1995. Kainic acid-induced heat shock protein-70, mRNA and protein expression is inhibited by MK-801 in certain rat brain regions. Eur. J. Neurosci. 7:293–304.
   PubMed Web of Science ®Google Scholar
• Pogun, S., Demirgoren, S., Taskiran, D., Kanit, L., Yilmaz, O., Koylu, E. O., Balkan, B., and London, E. D. 2000. Nicotine modulates nitric oxide in rat brain. Eur. J. Neuropsychopharmacol. 10:463–472.
   PubMed Web of Science ®Google Scholar
• Pope, C. N. 1999. Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health PartB. 2:161–181.
   PubMed Web of Science ®Google Scholar
• Priox-Guyonneau, M., Coudray-Lucas, C., Coq, H. M., Cohen, Y., and Wepierre, J. 1982. Modification of rat brain 5-hydroxytryptamine metabolism by sub-lethal doses of organophosphate agents. Acta Pharmacol. et Toxicol. 51:278284.
   Google Scholar
• Rakonczay, Z., Vincedon, G., and Zanetta, J. P. 1981. Heterogeneity of rat brain acetylcholinesterase: A study by gel filtration and gradient contrifugation. J. Neurochem. 37:662–669.
   PubMed Web of Science ®Google Scholar
• Ravikumar, B. V., and Sastry, P. S. 1985. Cholinergic muscarinic receptors in human fetal brain: Ontogeny of [3H]quinuclidinyl benzilate binding sites in corpus striatum, brainstem, and cerebellum. J. Neurochem. 45:1948–1950.
   PubMed Web of Science ®Google Scholar
• Reinis, S., and Goldman, J. M. 1980. The development of the brain: Biological and functional perspectives. Springfield, IL., Charles C. Thomas.
   Google Scholar
• Rice, M. E., and Russo-Menna, I. 1998. Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience. 82:1213–1223.
   PubMed Web of Science ®Google Scholar
• Romero-Vecchione, E., Fatranska, M., and Kvetnansky, R. 1987. Acetyl-cholinesterase activity in several hypothalamic and brain stem nuclei after acute and chronic immobilization stress in rats. Endocrinol. Experint. 21:159165.
   Google Scholar
• Rosenberg, P. A. 1988. Catecholamine toxicity in cerebral cortex in dissociated cell culture. J. Neurosci. 8:2887–2894.
   PubMed Web of Science ®Google Scholar
• Rotter, A., Field, P. M., and Raisman, G. 1979. Muscarinic receptors in the central nervous system of the rat. III. Postnatal development of binding of [3H]propylbenzylcholine mustard. Brain Res. Rev. 1:185–205.
   Google Scholar
• Rubboli, F., Court, J. A., Sala, C., Morris, B., Chini, B., Perry, E., and Clementi, F. 1994. Distribution of nicotinic receptors in the human hippocampus and thalamus. Eur. J. Neurosci. 6:1596–1604.
   PubMed Web of Science ®Google Scholar
• Russel, R. W., Overstreet, D. H., Cotman, C. W., Carson, V. G., Churchill, L., Dalglish, F. W., and Vasquez, B. J. 1975. Experimental tests of hypotheses about neurochemical mechanisms underlying behavior tolerance to the anticholinesterase diisopropylfluorophosphate. J. Pharmacol. Exp. Ther. 192:7385.
   Web of Science ®Google Scholar
• Russo-Neustadt, A., Rotter, A., and Frostholm, A. 1991. Distribution of muscarinic receptors in the developing rodent cerebellum. Brain Res. 548:179186.
   Web of Science ®Google Scholar
• Saelens, J. K., Simke, J. P., Schuman, J., and Allens, M. P. 1974. Agents which influence acetylcholine metabolism in mouse brain. Arch. Int. de Pharmacodyn. Et de Ther. 209:250.
   PubMedGoogle Scholar
• Salvaterra, P. M., Mahler, H. R., and Moore, W. J. 1975. Subcellular and regional distribution of 125I-labeled a-Bungarotoxin binding in rat brain and its relationship to acetylcholinesterase and choline acetyltransferase. J. Biol. Chem. 250:6469–6475.
   PubMed Web of Science ®Google Scholar
• Salvaterra, P. M., and Foders, R. M. 1979. [125I]2a-Bungarotoxin and [3H]quinuclidinyl benzilate binding in central nervous system of different species. J. Neurochem. 32:1509–1517.
   PubMed Web of Science ®Google Scholar
• Santhoshkumar, P., Karanth, S., and Shivanandappa, T. 1996. Neurotoxicity and pattern of acetylcholinesterase inhibition in the brain regions of rat by bromophos and ethylbromophos. Fundam. Appl. Toxicol. 32:23–30.
   PubMedGoogle Scholar
• Saraste, M. 1999. Oxidative phosphorylation at the fin de siecle. Science. 2831488–1493.
   Google Scholar
• Sargent, P. B. 1993. The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16:403–443.
   PubMed Web of Science ®Google Scholar
• Sarti, P., Lendaro, E., Eppoliti, R., Bellilli, A., Benedetfi, P. A., and Brunori, M. 1999. Modulation of mitochondrial nitric oxide: Investigation by single-cell fluorescence microscopy. FASEB J. 13:191–197.
   PubMed Web of Science ®Google Scholar
• Savolainen, K. M., Nelson, S. R., Samson, F. E., and Pazdernik, T. L. 1988. Soman-induced convulsions affect the inositol lipid signaling system: Potentiation by lithium; attenuation by atropine and diazepam. Toxicol. Appl. Pharmacol. 96:305–314.
   PubMed Web of Science ®Google Scholar
• Savolainen, K. M., Muona, O., Nelson, S. R., Samson, F. E., and Pazdernik, T. L. 1991. Lithium modifies convulsions and brain phosphoinositide turnover induced by organophosphates. Pharmacol. Toxicol. 68:346–354.
   PubMedGoogle Scholar
• Sawamura, A., Hashizume, K., and Tanaka, T. 2002. Electrophysiological, behavioral and metabolic features of globus pallidus seizures induced by a microinjection of kainic acid in rats. BrainRes. 935:1–8.
   PubMed Web of Science ®Google Scholar
• Schambra, U. B., Sulik, K. K, Petrusz, P., and Lauder, J. M. 1989. Ontogeny of cholinergic neurons in the mouse brain. J. Comp. Neurol. 288:101–122.
   PubMed Web of Science ®Google Scholar
• Schiller, G. D. (1979) Reduced binding of [3H]quinuclidinyl benzilate associated with chronically low acetylcholinesterase activity. Life Sci. 24:11591164.
   Web of Science ®Google Scholar
• Schliebs, R., Zivin, M., Steinbach, J., and Rothe, T. 1989. Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid. J. Neurochem. 53:212–218.
   PubMed Web of Science ®Google Scholar
• Schwab, B. W., Hand, H., Costa, L. G., and Murphy, S. D. 1981. Reduced muscarinic receptor binding in tissues of rats tolerant to the insecticide disulfoton. Neurotoxicology. 2:635–648.
   PubMed Web of Science ®Google Scholar
• Schwartz, R. D., and Keller, K. J. 1983. Nicotinic cholinergic receptor binding sites in the brain: Regulation in vivo. Science. 220:214–216.
   PubMed Web of Science ®Google Scholar
• Schwartz, R. D., and Keller, K. J. 1985. In vivo regulation of 3H-acetylcholine recognition sites in brain by nicotinic cholinergic drug. J. Neurochem. 45:427433.
   Web of Science ®Google Scholar
• Schwartz, R. D., McGee, R. Jr., and Keller, K. J. 1982. Nicotinic cholinergic receptors labeled by [3H]-acetylcholine in rat brain. Mol. Pharmacol. 22:5662.
   Google Scholar
• Seguela, P., Wadiche, J., Dineley-Miller, K., Dani, J. A., and Patrick, J. W. 1993. Molecular cloning, functional properties, and distribution of rat brain a7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:596604.
   Web of Science ®Google Scholar
• Shafik, E. N., Aiken, S. P., and McArdle, J. J. 1991. Regional catecholamine levels in brains of normal and ethanol-tolerant long-sleep and short-sleep mice. Brain Res. 563:44–48.
   PubMed Web of Science ®Google Scholar
• Shahed, A. R., Werchan, P. M., and Stavinoha, W. B. 1996. Differences in actylcholine but not choline in brain tissue fixed by freeze fixation or microwave heating. Meth. Find. Exp. Clin. Pharmacol. 18:349–351.
   PubMedGoogle Scholar
• Shih, T.-M. 1982. Time course effects of soman on acetylcholine and choline levels in six discrete areas of the rat brain. Psychopharmacology. 78:170–175.
   PubMed Web of Science ®Google Scholar
• Simonian, N. A., and Coyle, J. T. 1996. Oxidative stress in neurodegenerative diseases. Ann. Rev. Pharmacol. Toxicol. 36:83–106.
   PubMed Web of Science ®Google Scholar
• Singh, V. K., and McGeer, E. G. 1977. Choline acetyltransferase in developing rat brain and spinal cord. Brain Res. 127:159–163.
   PubMed Web of Science ®Google Scholar
• Singh, H. C., Singh, R. H., and Udapa, K. N. 1979. Electric footshock induced changes in free, bound and total acetylcholine and acetylcholinesterase in different brain regions of rats. Indian J. Exp. Biol. 17:304–306.
   PubMed Web of Science ®Google Scholar
• Sivam, S. P., Norris, J. C., Lim, D. K., Hoskins, B., and Ho, I. K. 1983. Effect of acute and chronic cholinesterae inhibition with diisopropylfluorophosphate on muscarinic, dopamine and GABA receptors of the rat striatum. J. Neurochem. 40:1414–1422.
   PubMed Web of Science ®Google Scholar
• Slotkin, T. A., and Bartolome, J. 1986. Role of ornithine decarboxylase and the polyamines in nervous system development. A review. Brain Res. Bull. 17:307–320.
   PubMed Web of Science ®Google Scholar
• Slotkin, T. A., Cousins, M. M., Tate, C. A., and Seidler, F. J. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 902:229–243.
   PubMed Web of Science ®Google Scholar
• Somani, S. M., and Dube, S. N. 1989. Physostigmine-An overview as pretreatment drug for organophosphate intoxication. Int. J. Clin, Pharmacol. Ther. Toxicol. 27:367–387.
   PubMed Web of Science ®Google Scholar
• Sorimachi, M., and Kataoka, K. 1974. Choline uptake by nerve terminals: A sensitive and a specific marker of cholinergic innervation. Brain Res. 72:350353.
   Web of Science ®Google Scholar
• Sorimachi, M., and Kataoka, K. 1975. High affinity choline uptake: An early index of cholinergic innervation in rat brain. Brain Res. 94:325–336.
   PubMed Web of Science ®Google Scholar
• Srinivas, V. K., Habibullah, C. M., Ayesha, O., Hassan, S. I., et. al. 1993. Lactate dehydrogenase: A marker of cellular integrity. Meth. Find. Exp. Clin. Pharmacol. 15:709–713.
   Google Scholar
• Staniek, K., and Nohl, H. 2000. Are mitochondria a permanent source of reactive oxygen species? Biochim. Biophys. Acta. 1460:268–275.
   PubMed Web of Science ®Google Scholar
• Stanton, H. C., Albert, J. R., and Mersmann, H. J. 1979. Studies on the pharmacology and safety of dichlorvos in pigs and pregnant sows. Am. J. Vet. Res. 40:315–320.
   PubMed Web of Science ®Google Scholar
• Stavinoha, W. B., Ryan, L. C., and Smith, P. W. 1969. Biochemical effects of an organophosphorus cholinesterase inhibitor on the rat brain. Ann. N. Y. Acad. Sci. 160:378–382.
   PubMedGoogle Scholar
• Stavinoha, W. B., Weintraub, S. T., and Modak, A. T. 1973. The use of microwave heating to inactivate cholinesterase in the rat brain prior to analysis for acetylcholine. J. Neurochem. 20:361–371.
   PubMed Web of Science ®Google Scholar
• Stavinoha, W. B., Weintraub, S. T., and Modak, A. T. 1974. Regional concentration of choline and acetylcholine in the rat brain. J. Neurochem. 23:885–886.
   PubMed Web of Science ®Google Scholar
• Stavinoha, W. B., Modak, A. T., and Weintraub, S. T. 1976. Rate of accumulation of acetylcholine in discrete regions of the rat brain after dichlorvos treatment. J. Neurochem. 27:1375–1378.
   PubMed Web of Science ®Google Scholar
• Stavinoha, W. B. 1993. Use of microwave for rapid fixation of tissues in vivo. Scanning. 15:115–117.
   PubMed Web of Science ®Google Scholar
• Stavinoha, W. B., Sawa, A., Frazer, J., and Weintraub, S. T. 1997. Acetylcholine: Oscillation of levels in mouse brain following electroshock. Brain Res. Bull. 43:47–52.
   PubMed Web of Science ®Google Scholar
• Sultatos, L. G., Costa, L. G., and Murphy, S. D. 1982. Factors involved in differential toxicity of the insecticides chlorpyrifos and methyl chlorpyrifos in mice. Toxicol. Appl. Pharmacol. 65:144—152.
   Web of Science ®Google Scholar
• Sung, S. C., and Ruff, B. A. 1983. Molecular forms of sucrose extractable and particulate acetylcholinesterase in the developing and adult rat brain. Neurochem. Res. 8:303–311.
   PubMed Web of Science ®Google Scholar
• Szabo, C. 1996. Physiological and pathological roles of nitric oxide in the central nervous system. BrainRes. Bull. 41:131–141.
   PubMed Web of Science ®Google Scholar
• Tang, J. T., Carr, R. L., and Chambers, J. E. 1999. Changes in brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development. Toxicol. Sci. 51:265–272.
   PubMed Web of Science ®Google Scholar
• Tayebati, S. K., Vitali, D., Scordella, S., and Amenta, F. 2001. Muscarinic cholinergic receptors subtypes in rat cerebellar cortex: Light microscope autoradiography of age-related changes. Brain Res. 889:256–259.
   PubMed Web of Science ®Google Scholar
• Tayyaba, K., and Hasan, M. 1985. Vitamin E protects against metasystox-induced adverse effect on lipid metabolism in the rat brain and spinal cord. Acta Pharmacol. Toxicol. 57:190–196.
   PubMedGoogle Scholar
• Trimarchi, G. R., and Buccafusco, J. J. 1987. Changes in regional brain synaptosomal high affinity choline uptake during the development of hypertention in spontaneously hypertensive rats. Neurochem. Res. 12:247–254.
   PubMed Web of Science ®Google Scholar
• Trommer, B. A., Schmidt, D. E., and Wecker, L. 1982. Exogenous choline enhances the synthesis of acetylcholine only under conditions of increased cholinergic neuronal activity. J. Neurochem. 39:1704–1709.
   PubMed Web of Science ®Google Scholar
• Turrens, J. F. 1997. Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 17:3–8.
   PubMed Web of Science ®Google Scholar
• Turunen, M., Swiezewska, E., Chojnacki, T., Sindelar, P., and Dallner, G. 2002. Regulatory aspects of coenzyme Q metabolism. Free Rad. Res. 36:437–443.
   PubMed Web of Science ®Google Scholar
• Van Acker, S. A. B. E., Koymans, L. M. N., Bast, A. 1993. Molecular pharmacology of vitamin E: Structural aspects of antioxidant activity. Free Radic. Biol. Med. 15:311–328.
   PubMed Web of Science ®Google Scholar
• Van De Kamp, J. L., and Collins, A. C. 1992. Species differences in diisopropylfluorophosphate-induced decreases in the number of nicotinic receptors. Pharmacol. Biochem. Behav. 42:131–141.
   PubMed Web of Science ®Google Scholar
• Van Den Beukel, I., Dijcks, F. A., Vanderheyden, P., Vauquelin, G., and Oortgiesen, M. 1997. Differential muscarinic receptor binding of acetyl-cholinesterase inhibitors in rat brain, human brain, and Chinese hamster ovary cells expressing human receptors. J. Pharmacol. Exp. Ther. 281:11131119.
   Web of Science ®Google Scholar
• Vatassery, G. T., Angerhoffer, C. K., Knox, C. A., and Deshmukh, D. S. 1984. Concentrations of vitamin E in various neuroanatomical regions and subcellular fractions, and the uptake of vitamin E by specific areas, of rat brain. Biochim. Biophys. Acta. 792:118–122.
   PubMed Web of Science ®Google Scholar
• Vernetti, L. A., McDonald, J. R., Wolfgang, G. H. I., Dominick, M. A., et. al. 1993. ATP depletion is associated with cytotoxicity of a novel lipid regulator in guinea pig adrenocortical cells. Toxicol. Appl. Pharmacol. 118:30–38.
   PubMed Web of Science ®Google Scholar
• Virgili, M., Poli, A., Beraudi, A., Giuliani, A., and Villani, L. 2001. Regional distribution of nitric oxide synthase and NADPH-diaphorase activities in the central nervous system of teleosts. Brain Res. 901:202–207.
   PubMed Web of Science ®Google Scholar
• Wada, E., Wada, K., Baulter, J., Deneris, E., Heinemann, S., Patrick, J., and Swanson, L. W. 1989. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNA in the central nervous system: A hybridization histochemical study in the rat. J. Comp. Neurol. 284:314335.
   Web of Science ®Google Scholar
• Wade, P. D., and Timiras, P. S. 1980. A regional study of the molecular acetyl-cholinesterase in the brain of developing and adults rats. Dev. Neurosci. 3:101108.
   Web of Science ®Google Scholar
• Wasterlain, C. G., and Shirasaka, Y. 1994. Seizures, brain damage, and brain development. Brain Dev. 16:279–295.
   PubMed Web of Science ®Google Scholar
• Wecker, L., and Dettbarn, W.-D. 1979. Relationship between choline availability and acetylchoine synthesis in discrete regions of rat brain. J. Neurochem. 32:961–967.
   PubMed Web of Science ®Google Scholar
• Wecker, L., Mobley, P. L., and Dettbarn, W.-D. 1977. Central cholinergic mechanisms underlying adaptation to reduced cholinesterase activity. Biochem.Pharmacol. 26:633–637.
   PubMed Web of Science ®Google Scholar
• Wecker, L., and Schmidt, D. E. 1979. Neuropharmacological consequences of choline administration. BrainRes. 184:234–238.
   Web of Science ®Google Scholar
• Wecker, L., Flynn, C. J., Stouse, M. R., and Trommer, B. A. 1982. Choline availability: Effects of the toxicity of centrally active drugs. Drug Nutrient Interactions. 1:125–130.
   PubMedGoogle Scholar
• Welsch, F., and Dettbarn, W.-D. 1971. Protein synthesis in lobster walking leg nerves. Comp. Biochem. Physiol. B. 38:393–403.
   Google Scholar
• Whalley, C. E., and Shih, T.-M. 1989. Effects of soman and sarin on high affinity choline uptake by rat brain synaptosomes. Brain Res. Bull. 22:853–858.
   PubMed Web of Science ®Google Scholar
• Whitehouse, P. J. 1993. Cholinergic therapy in dementia. Acta Neurol. Scand. Suppl. 149:42–45.
   PubMedGoogle Scholar
• Whiting, P. J., Schopfer, R., Conroy, W. G., Gore, M. J., Keyser, K. T., Shimasaki, S., Esch, F., and Lindstrom, J. M. 1991. Expression of nicotinic acetylcholine receptor subtypes in brain and retina. Mol. Brain Res. 10:61–70.
   PubMedGoogle Scholar
• Whitney, K. D., Seidler, F. J., and Slotkin, T. A. 1995. Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms. Toxicol. Appl. Pharmacol. 134:53–62.
   PubMed Web of Science ®Google Scholar
• Woolf, N. J. 1991. Cholinergic systems in mammalian brain and spinal cord. Progr. Neurobiol. 37:475–524.
   PubMed Web of Science ®Google Scholar
• Wotta, D. R., and El-Fakahany, E. E. 1997. Muscarinic receptor-mediated activation of nitric oxide synthase. Drug Develop. Res. 40:205–214.
   Web of Science ®Google Scholar
• Wu, A. H. B. 1998. Creatine kinase, isoenzymes, and variants. In Cardiac Markers, ed. A. H. B. Wu, 113-125. Humana Press: Totowa, N.J.
   Google Scholar
• Yamada, S. M., Isogai, M., Okadaira, H., and Hayashi, E. 1983a. Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration antagonism by physostigmine and atropine. J. Pharmacol. Exp. Ther. 226:519–525.
   PubMed Web of Science ®Google Scholar
• Yamada, S. M., Isogai, M., Okadaira, H., and Hayashi, E. 1983b. Regional adaptation of muscarinic receptors and choline uptake in brain following administration of diisopropylfluorophosphate and atropinate. Brain Res. 268:315–320.
   PubMed Web of Science ®Google Scholar
• Yamada, S., Yushiyuka, K., Mitsutaka, I., Takayanagi, N., and Hayashi, E. 1986. Ontogenesis of nicotinic acetylcholine receptors and presynaptic cholinergic neurons in mammalian brain. Life Sci. 38:637–644.
   PubMed Web of Science ®Google Scholar
• Yamanura, H. I., and Snyder, S. H. 1973. High affinity transport of choline into synaptosomes of rat brain. J. Neurochem. 21:1355–1374.
   PubMed Web of Science ®Google Scholar
• Yamamura, H. I., and Snyder, S. H. 1974. Muscarinic cholinergic binding in rat brain. Proc. Natl. Acad. Sci. USA. 71:1725–1729.
   PubMed Web of Science ®Google Scholar
• Yavin, E., and Harel, S. 1979. Muscarinic binding sites in the developing rabbit brain, regional distribution and ontogenesis in the prenatal and early neonatal cerebellum. FEBS Lett. 97:151–154.
   PubMed Web of Science ®Google Scholar
• Zhang, X. A., Wahlstrom, G., and Nordberg, A. 1990. Influence of development and aging on nicotinic receptor subtypes in rodent brain. Int. J. Dev. Neurosci. 8:715–721.
   PubMed Web of Science ®Google Scholar
• Zhang, J., Dawson, V. L., Dawson, T. M., and Snyder, S. H. 1994. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science. 263:687689.
   Web of Science ®Google Scholar
• Zivin, M., Milatovic, D., and Dettbarn, W.-D. 1999a. Nitron spin trapping compound N-tert-butyl-a-phenylnitrone (PBN) prevents seizures induced by anticholinesterases. Brain Res. 850:63–72.
   PubMed Web of Science ®Google Scholar
• Zivin, M., Milatovic, D., and Dettbarn, W.-D. 1999b. The effect of status epilepticus on cytochrome c oxidase activity in the rat brain (Abstract). FASEB J. 13:A1102.
   Web of Science ®Google Scholar