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Cancer Biology & Therapy Volume 16, 2015 - Issue 5
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Clinical Study

Clinico-pathological correlation of serial measurement of circulating tumor cells in 24 metastatic colorectal cancer patients receiving chemotherapy reveals interpatient heterogeneity correlated with CEA levels but independent of KRAS and BRAF mutation

Avisnata DasHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA;Penn State Milton S Hershey Medical Center; Hershey, PA, USA
,
Miriam KunkelHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA;Penn State Milton S Hershey Medical Center; Hershey, PA, USA
,
Jamal JoudehHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA;Penn State Milton S Hershey Medical Center; Hershey, PA, USA
,
David T DickerHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA
,
Angelique ScicchitanoHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA
,
Joshua E AllenHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA
,
Nabeel SarwaniDepartments of Radiology, Hershey, PA, USA
,
Zhaohai YangDepartment of Pathology; Penn State Hershey Cancer Institute; Hershey, PA, USA
,
Jussuf KaifiHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USA
,
Junjia ZhuPublic Health Sciences; Penn State Hershey Medical Center; Hershey, PA, USA
,
Jason LiaoPenn State Milton S Hershey Medical Center; Hershey, PA, USA
&
Wafik S El-DeiryHematology/Oncology Division; Penn State Hershey Cancer Institute; Hershey, PA, USACorrespondence[email protected]
 show all
Pages 709-713 | Received 24 Feb 2015, Accepted 06 Mar 2015, Published online: 21 May 2015

References

  • Cohen SJ, Punt CJA, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al. Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer. J Clin Oncol 2008 July 1, 2008;26(19): 3213-21; http://dx.doi.org/10.1200/JCO.2007.15.8923
  • Alix-Panabieres C, Pantel K. Circulating tumor cells: liquid biopsy of cancer. Clin Chem 2013 January; 59(1): 110-8; http://dx.doi.org/10.1373/clinchem.2012.194258
  • Sastre J, Maestro ML, Puente J, Veganzones S, Alfonso R, Rafael S, Garcia-Saenz JA, Vidauretta M, Martin M, Arroyo M, et al. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. Ann Oncol 2008; 19: 935-938.
  • Iinuma H, Watanabe, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, et al. Clinical Significance of Circulating Tumor Stem Cells, Including Cancer Stem-like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients with Dukes' Stage B and C Colorectal Cancer. J Clin Oncol 2011; 29(12): 1547-1555; http://dx.doi.org/10.1200/JCO.2010.30.5151
  • Faltas B, Zeidan A, Peters K, Das A, Joudeh J, Navaraj A, Dolloff NG, Harvey HA, Jiang Y, Allen JE, et al. Identifying Circulating Tumor Stem Cells That Matter: The Key to Prognostication and Therapeutic Targeting. J Clin Oncol 2011; 29(21): 2946-2947; PMID: 21690466; http://dx.doi.org/10.1200/JCO.2011.36.6179
  • Peters KL, Allen JE, Dicker DT, Das A, Joudeh J, El-Deiry WS. CTC profiling: Integration of biomarker analysis with current VeridexCellSearch technology. Cancer Res 2011; 71 (8 supplement) 5248-5248; http://dx.doi.org/10.1158/1538-7445.AM2011-5248
  • Das A, Allen JE, Dicker DT, Peters KL, Joudeh J, El-Deiry WS. Quantum dot multiplexing of prognostic marker and stem cell marker expression in colorectal cancer circulating tumor cells. Cancer Res 2011; (8 supplement) 3818-3818.
  • Allen JE, Saroya BS, Kunkel M, Dicker DT, Das A, Peters KL, Joudeh J, Zhu J, El-Deiry WS. Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs. Oncotarget 2013( Vol 5 No 7).

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