TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway

References

• Le Cornet C, Lortet-Tieulent J, Forman D, Beranger R, Flechon A, Fervers B, Schüz J, Bray F. Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data. Eur J Cancer 2014; 50:831-9; PMID:24369860; http://dx.doi.org/10.1016/j.ejca.2013.11.035
   PubMed Web of Science ®Google Scholar
• Giannatempo P, Greco T, Mariani L, Nicolai N, Tana S, Fare E, Raggi D, Piva L, Catanzaro M, Biasoni D, et al. Radiotherapy or chemotherapy for clinical stage IIA and IIB seminoma: a systematic review and meta-analysis of patient outcomes. Ann Oncol 2015; 26:657-68; PMID:25214543; http://dx.doi.org/10.1093/annonc/mdu447
   PubMed Web of Science ®Google Scholar
• Horwich A, Shipley J, Huddart R. Testicular germ-cell cancer. Lancet 2006; 367:754-65; PMID:16517276; http://dx.doi.org/10.1016/S0140-6736(06)68305-0
   PubMed Web of Science ®Google Scholar
• Hanna NH, Einhorn LH. Testicular cancer–discoveries and updates. N Eng J Med 2014; 371:2005-16; PMID:25409373; http://dx.doi.org/10.1056/NEJMra1407550
   PubMed Web of Science ®Google Scholar
• Horwich A, Nicol D, Huddart R. Testicular germ cell tumours. Bmj 2013; 347:f5526; PMID:24065428; http://dx.doi.org/10.1136/bmj.f5526
   PubMedGoogle Scholar
• Juliachs M, Munoz C, Moutinho CA, Vidal A, Condom E, Esteller M, Graupera M, Casanovas O, Germà JR, Villanueva A, et al. The PDGFRbeta-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors. Clin Cancer Res 2014; 20:658-67; PMID:24277456; http://dx.doi.org/10.1158/1078-0432.CCR-13-1131
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Fujii T, Jo Y, Kinugawa K, Fujisawa M. Possible mechanism responsible for the acquisition of resistance to cis-diamminedichloroplatinum (II) by cultured human testicular seminoma cells. J Urol 2004; 171:1929-33; PMID:15076314; http://dx.doi.org/10.1097/01.ju.0000122901.70300.20
   PubMed Web of Science ®Google Scholar
• Squillante CM, Vaughn DJ. Targeted therapies in germ cell tumors. Urol Oncol 2015; 33:363-9; PMID:25544153; http://dx.doi.org/10.1016/j.urolonc.2014.09.008
   PubMed Web of Science ®Google Scholar
• Fung C, Vaughn DJ. Complications associated with chemotherapy in testicular cancer management. Nat Rev Urol 2011; 8:213-22; PMID:21403662; http://dx.doi.org/10.1038/nrurol.2011.26
   PubMed Web of Science ®Google Scholar
• Jiang X, Li D, Yang J, Wen J, Chen H, Xiao X, et al. Characterization of a novel human testis-specific gene: testis developmental related gene 1 (TDRG1). Tohoku J Exp Med 2011; 225:311-8; PMID:22123530; http://dx.doi.org/10.1620/tjem.225.311
   PubMed Web of Science ®Google Scholar
• Chen H, Sun J, He Y, Zou Q, Wu Q, Tang Y. Expression and localization of testis developmental related gene 1 (TDRG1) in human spermatozoa. Tohoku J Exp Med 2015; 235:103-9; PMID:25749352; http://dx.doi.org/10.1620/tjem.235.103
   PubMed Web of Science ®Google Scholar
• Wang Y, Gan Y, Tan Z, Zhou J, Kitazawa R, Jiang X, et al. TDRG1 functions in testicular seminoma are dependent on the PI3K/Akt/mTOR signaling pathway. Onco Targets Ther 2016; 9:409-20; PMID:26855590; http://dx.doi.org/10.2147/OTT.S97294
   PubMed Web of Science ®Google Scholar
• Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-7; PMID:12040186; http://dx.doi.org/10.1126/science.296.5573.1655
   PubMed Web of Science ®Google Scholar
• Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995; 376:599-602; PMID:7637810; http://dx.doi.org/10.1038/376599a0
   PubMed Web of Science ®Google Scholar
• Nakai Y, Nonomura N, Oka D, Shiba M, Arai Y, Nakayama M, Inoue H, Nishimura K, Aozasa K, Mizutani Y, et al. KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. Biochem Biophys Res Commun 2005; 337:289-96; PMID:16188233; http://dx.doi.org/10.1016/j.bbrc.2005.09.042
   PubMed Web of Science ®Google Scholar
• Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005; 24:7455-64; PMID:16288292; http://dx.doi.org/10.1038/sj.onc.1209085
   PubMed Web of Science ®Google Scholar
• West KA, Castillo SS, Dennis PA. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug resist Updat 2002; 5:234-48; PMID:12531180; http://dx.doi.org/10.1016/S1368-7646(02)00120-6
   PubMed Web of Science ®Google Scholar
• Russell SM, Lechner MG, Mokashi A, Megiel C, Jang JK, Taylor CR, Looijenga LH, French CA, Epstein AL. Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology 2013; 81:464 e1-9; PMID:23374840; http://dx.doi.org/10.1016/j.urology.2012.09.029
   PubMed Web of Science ®Google Scholar
• Mizuno Y, Gotoh A, Kamidono S, Kitazawa S. [Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2)]. Nihon Hinyokika Gakkai zasshi The japanese journal of urology 1993; 84:1211-8; PMID:8394948; http://dx.doi.org/10.5980/jpnjurol1989.84.1211
   PubMedGoogle Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method 2001; 25:402-8; PMID:11846609; http://dx.doi.org/10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Gan Y, Yang J, Wang Y, Tan Z, Jiang X, Tang Y. study on shRNA-mediated reduction of testis developmental related gene 1 expression and its effects on the proliferation, invasion and apoptosis of NTERA-2 cells. Oncol Lett 2015; 10:61-6; PMID:26170977; http://dx.doi.org/10.3892/ol.2015.3219
   PubMed Web of Science ®Google Scholar
• Wermann H, Stoop H, Gillis AJ, Honecker F, van Gurp RJ, Ammerpohl O, Richter J, Oosterhuis JW, Bokemeyer C, Looijenga LH. Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J Pathol 2010; 221:433-42; PMID:20593487; http://dx.doi.org/10.1002/path.2725
   PubMed Web of Science ®Google Scholar
• Zhang HY, Zhang PN, Sun H. Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur J Obstet Gynecol Reprod Biol 2009; 146:81-6; PMID:19540648; http://dx.doi.org/10.1016/j.ejogrb.2009.04.035
   PubMed Web of Science ®Google Scholar
• Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003; 17:590-603; PMID:12646949; http://dx.doi.org/10.1038/sj.leu.2402824
   PubMed Web of Science ®Google Scholar
• Sun D, Sawada A, Nakashima M, Kobayashi T, Ogawa O, Matsui Y. MK2206 potentiates cisplatin-induced cytotoxicity and apoptosis through an interaction of inactivated Akt signaling pathway. Urol Oncol 2015; 33:111 e17-26; PMID:25499922; http://dx.doi.org/10.1016/j.urolonc.2014.10.018
   PubMed Web of Science ®Google Scholar
• Neri LM, Borgatti P, Capitani S, Martelli AM. The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta 2002; 1584:73-80; PMID:12385889; http://dx.doi.org/10.1016/S1388-1981(02)00300-1
   PubMed Web of Science ®Google Scholar
• Yang L, Shi T, Liu F, Ren C, Wang Z, Li Y, Tu X, Yang G, Cheng X. REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells. PloS One 2015; 10:e0120334; PMID:25781640; http://dx.doi.org/10.1371/journal.pone.0120334
   PubMed Web of Science ®Google Scholar
• Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science 2003; 299:214-5; PMID:12522239; http://dx.doi.org/10.1126/science.1081274
   PubMed Web of Science ®Google Scholar
• Ciaputa R, Nowak M, Madej JA, Poradowski D, Janus I, Dziegiel P, Gorzynska E, Kandefer-Gola M. Inhibin-alpha, E-cadherin, calretinin and Ki-67 antigen in the immunohistochemical evaluation of canine and human testicular neoplasms. Folia Histochem Cytobiol 2014; 52:326-34; PMID:25511291; http://dx.doi.org/10.5603/FHC.a2014.0036
   PubMed Web of Science ®Google Scholar
• Chieffi P, Chieffi S, Franco R, Sinisi AA. Recent advances in the biology of germ cell tumors: implications for the diagnosis and treatment. J Endocrinol Invest 2012; 35:1015-20; PMID:23143673; http://dx.doi.org/10.3275/8716
   PubMed Web of Science ®Google Scholar
• Cost NG. Testicular germ cell tumors. Current concepts and management strategies. Minerva Urol Nefrol = The Italian journal of urology and nephrology 2013; 65:133-55; PMID:23703101
   PubMed Web of Science ®Google Scholar
• Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 2014; 740:364-78; PMID:25058905; http://dx.doi.org/10.1016/j.ejphar.2014.07.025
   PubMed Web of Science ®Google Scholar
• Voutsadakis IA. The chemosensitivity of testicular germ cell tumors. Cell Oncol 2014; 37:79-94; PMID:24692098; http://dx.doi.org/10.1007/s13402-014-0168-6
   PubMed Web of Science ®Google Scholar
• Nordentoft I, Dyrskjot L, Bodker JS, Wild PJ, Hartmann A, Bertz S, Lehmann J, Orntoft TF, Birkenkamp-Demtroder K. Increased expression of transcription factor TFAP2alpha correlates with chemosensitivity in advanced bladder cancer. BMC Cancer 2011; 11:135; PMID:21489314; http://dx.doi.org/10.1186/1471-2407-11-135
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen L, Huang G, He D, He J, Xu W, Zou C, Zong F, Li Y, Chen B, et al. Klotho sensitizes human lung cancer cell line to cisplatin via PI3k/Akt pathway. PloS One 2013; 8:e57391; PMID:23437382; http://dx.doi.org/10.1371/journal.pone.0057391
   PubMedGoogle Scholar
• Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997; 387:673-6; PMID:9192891; http://dx.doi.org/10.1038/42648
   PubMed Web of Science ®Google Scholar
• Ye ZW, Ghalali A, Hogberg J, Stenius U. Silencing p110beta prevents rapid depletion of nuclear pAkt. Biochem Biophys Res Commun 2011; 415:613-8; PMID:22074824; http://dx.doi.org/10.1016/j.bbrc.2011.10.120
   PubMed Web of Science ®Google Scholar
• Van de Sande T, Roskams T, Lerut E, Joniau S, Van Poppel H, Verhoeven G, Swinnen JV. High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol 2005; 206:214-9; PMID:15880754; http://dx.doi.org/10.1002/path.1760
   PubMed Web of Science ®Google Scholar
• Zhang X, Tang N, Hadden TJ, Rishi AK. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 2011; 1813:1978-86; PMID:21440011; http://dx.doi.org/10.1016/j.bbamcr.2011.03.010
   PubMed Web of Science ®Google Scholar
• Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol 2011; 31:2787-801; PMID:21576368; http://dx.doi.org/10.1128/MCB.05437-11
   PubMed Web of Science ®Google Scholar
• Estaquier J, Vallette F, Vayssiere JL, Mignotte B. The mitochondrial pathways of apoptosis. Adv Exp Med Biol 2012; 942:157-83; PMID:22399422; http://dx.doi.org/10.1007/978-94-007-2869-1_7
   PubMed Web of Science ®Google Scholar
• Zeng KW, Wang XM, Ko H, Kwon HC, Cha JW, Yang HO. Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway. Eur J Pharmacol 2011; 672:45-55; PMID:21978835; http://dx.doi.org/10.1016/j.ejphar.2011.09.177
   PubMed Web of Science ®Google Scholar
• Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003; 39:615-47; PMID:12493639; http://dx.doi.org/10.1016/S0161-5890(02)00252-3
   PubMed Web of Science ®Google Scholar