Combination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment

Reference

• Bapst S, ed. Cancer Stem Cells. New Jersey: A John Wiley & Sons, Inc.; 2009
   Google Scholar
• McCulloch EA, Till JE. Perspectives on the properties of stem cells. Nat Med 2005; 11:1026-8; PMID:16211027; http://dx.doi.org/10.1038/nm1005-1026
   PubMed Web of Science ®Google Scholar
• Bergsagel DE, Valeriote FA. Growth characteristics of a mouse plasma cell tumor. Cancer Res 1968; 28:2187-96; PMID:5723963
   PubMed Web of Science ®Google Scholar
• Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367:645-8; PMID:7509044; http://dx.doi.org/10.1038/367645a0
   PubMed Web of Science ®Google Scholar
• Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100:3983-8; PMID:12629218; http://dx.doi.org/10.1073/pnas.0530291100
   PubMed Web of Science ®Google Scholar
• Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB. Identification of human brain tumour initiating cells. Nature 2004; 432:396-401; PMID:15549107; http://dx.doi.org/10.1038/nature03128
   PubMed Web of Science ®Google Scholar
• Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63:5821-8; PMID:14522905
   PubMed Web of Science ®Google Scholar
• Yu, John S. (Ed.) Cancer Stem Cells, Methods and Protocols, Methods in Molecular Biology .Volume 568 2009. ISBN: 978-1-58829-938-3 (Print) 978-1-59745-280-9 (Online). Humana Press. New York City. www.springer.com/humana
   Google Scholar
• Al-Hajj M, Clarke MF. Self-renewal and solid tumor stem cells. Oncogene 2004; 23:7274-82; PMID:15378087; http://dx.doi.org/10.1038/sj.onc.1207947
   PubMed Web of Science ®Google Scholar
• Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK. A distinct “side population” of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 2004; 101:14228-33; PMID:15381773; http://dx.doi.org/10.1073/pnas.0400067101
   PubMed Web of Science ®Google Scholar
• McDermott SP, Wicha MS. Targeting breast cancer stem cells. Mol Oncol 2010; 4:404-19; PMID:20599450; http://dx.doi.org/10.1016/j.molonc.2010.06.005
   PubMed Web of Science ®Google Scholar
• Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 2009; 106:13820-5; PMID:19666588; http://dx.doi.org/10.1073/pnas.0905718106
   PubMed Web of Science ®Google Scholar
• Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756-60; PMID:17051156; http://dx.doi.org/10.1038/nature05236
   PubMed Web of Science ®Google Scholar
• Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008; 100:672-9; PMID:18445819; http://dx.doi.org/10.1093/jnci/djn123
   PubMed Web of Science ®Google Scholar
• Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131:1109-23; PMID:18083101; http://dx.doi.org/10.1016/j.cell.2007.10.054
   PubMed Web of Science ®Google Scholar
• Bardsley MR, Horvath VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL, Lomberk GA, Urrutia RA, et al. Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010; 139:942-52; PMID:20621681; http://dx.doi.org/10.1053/j.gastro.2010.05.083
   PubMed Web of Science ®Google Scholar
• Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009; 138:645-59; PMID:19682730; http://dx.doi.org/10.1016/j.cell.2009.06.034
   PubMed Web of Science ®Google Scholar
• Naujokat C, Steinhart R. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol 2012; 2012:950658; PMID:23251084; http://dx.doi.org/10.1155/2012/950658
   PubMedGoogle Scholar
• Kopp F, Hermawan A, Oak PS, Herrmann A, Wagner E, Roidl A. Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration. Mol Cancer 2014; 13:16; PMID:24468090; http://dx.doi.org/10.1186/1476-4598-13-16
   PubMed Web of Science ®Google Scholar
• Tang QL, Zhao ZQ, Li JC, Liang Y, Yin JQ, Zou CY, Xie XB, Zeng YX, Shen JN, Kang T, et al. Salinomycin inhibits osteosarcoma by targeting its tumor stem cells. Cancer Lett 2011; 311:113-21; PMID:21835542; http://dx.doi.org/10.1016/j.canlet.2011.07.016
   PubMed Web of Science ®Google Scholar
• Riccioni R, Dupuis ML, Bernabei M, Petrucci E, Pasquini L, Mariani G, Cianfriglia M, Testa U. The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor. Blood Cells Mol Dis 2010; 45:86-92; PMID:20444629; http://dx.doi.org/10.1016/j.bcmd.2010.03.008
   PubMed Web of Science ®Google Scholar
• Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM. Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 2007; 120:468-77; PMID:17227796; http://dx.doi.org/10.1242/jcs.03348
   PubMed Web of Science ®Google Scholar
• Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A 2007; 104:618-23; PMID:17202265; http://dx.doi.org/10.1073/pnas.0606599104
   PubMed Web of Science ®Google Scholar
• Teng Y, Wang X, Wang Y, Ma D. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun 2010; 392:373-9; PMID:20074550; http://dx.doi.org/10.1016/j.bbrc.2010.01.028
   PubMed Web of Science ®Google Scholar
• Mitani M, Yamanishi T, Miyazaki Y, Otake N. Salinomycin effects on mitochondrial ion translocation and respiration. Antimicrob Agents Chemother 1976; 9:655-60; PMID:131509; http://dx.doi.org/10.1128/AAC.9.4.655
   PubMed Web of Science ®Google Scholar
• Patel S, Rameshwar P. Cancer Stem cells. Protocol Exchange; http://dx.doi.org/1038/protex.2013.023
   Google Scholar
• Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003; 17:1253-70; PMID:12756227; http://dx.doi.org/10.1101/gad.1061803
   PubMed Web of Science ®Google Scholar
• Van Pham Phuc, Thanh Vu Binh, Chinh Phan Nhan Lu, et al., eds. Biomedical Tissue Culture,: InTech; 2012; http://dx.doi.org/10.5772/3071
   Google Scholar
• Kondo T. Stem cell-like cancer cells in cancer cell lines. Cancer Biomark 2007; 3:245-50; PMID:17917153
   PubMedGoogle Scholar
• Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ. The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development 2001; 128:3117-31; PMID:11688561
   PubMed Web of Science ®Google Scholar
• Gudjonsson T, Villadsen R, Nielsen HL, Ronnov-Jessen L, Bissell MJ, Petersen OW. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev 2002; 16:693-706; PMID:11914275; http://dx.doi.org/10.1101/gad.952602
   PubMed Web of Science ®Google Scholar
• Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A 1992; 89:9064-8; PMID:1384042; http://dx.doi.org/10.1073/pnas.89.19.9064
   PubMed Web of Science ®Google Scholar
• Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-15; PMID:18485877; http://dx.doi.org/10.1016/j.cell.2008.03.027
   PubMed Web of Science ®Google Scholar
• Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5:744-9; PMID:16148886; http://dx.doi.org/10.1038/nrc1694
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang H, Wang X, Wang J, Zhang X, Zhang Q. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials 2012; 33:679-91; PMID:22019123; http://dx.doi.org/10.1016/j.biomaterials.2011.09.072
   PubMed Web of Science ®Google Scholar
• Kim JH, Chae M, Kim WK, Kim YJ, Kang HS, Kim HS, Yoon S. Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein. Br J Pharmacol 2011; 162:773-84; PMID:20973777; http://dx.doi.org/10.1111/j.1476-5381.2010.01089.x
   PubMed Web of Science ®Google Scholar
• Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J, Wirth T, Schemmer P, Büchler MW, Zöller M, et al. Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Cancer Res 2010; 70:5004-13; PMID:20530687; http://dx.doi.org/10.1158/0008-5472.CAN-10-0066
   PubMed Web of Science ®Google Scholar
• Honeth G, Bendahl PO, Ringner M, Saal LH, Gruvberger-Saal SK, Lövgren K, Grabau D, Fernö M, Borg A, Hegardt C. The CD44+/CD24− phenotype is enriched in basal-like breast tumors. Breast Cancer Res 2008; 10:R53; PMID:18559090; http://dx.doi.org/10.1186/bcr2108
   PubMed Web of Science ®Google Scholar
• Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10:5367-74; PMID:15328174; http://dx.doi.org/10.1158/1078-0432.CCR-04-0220
   PubMed Web of Science ®Google Scholar
• Holliday DL, Speirs V. Choosing the right cell line for breast cancer research. Breast Cancer Res 2011; 13:215; PMID:21884641; http://dx.doi.org/10.1186/bcr2889
   PubMed Web of Science ®Google Scholar
• Ricardo S, Vieira AF, Gerhard R, Leitão D, Pinto R, Cameselle-Teijeiro JF, Milanezi F, Schmitt F, Paredes J. Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. J Clin Pathol 2011; 64:937-46; PMID:21680574; http://dx.doi.org/10.1136/jcp.2011.090456
   PubMed Web of Science ®Google Scholar
• Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 2007; 11:259-73; PMID:17349583; http://dx.doi.org/10.1016/j.ccr.2007.01.013
   PubMed Web of Science ®Google Scholar
• Park SY, Lee HE, Li H, Shipitsin M, Gelman R, Polyak K. Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res 2010; 16:876-87; PMID:20103682; http://dx.doi.org/10.1158/1078-0432.CCR-09-1532
   PubMed Web of Science ®Google Scholar
• Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008; 10:R25; PMID:18366788; http://dx.doi.org/10.1186/bcr1982
   PubMed Web of Science ®Google Scholar
• Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, Goulet R Jr, Badve S, Nakshatri H. CD44+/CD24− breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006; 8:R59; PMID:17062128; http://dx.doi.org/10.1186/bcr1610
   PubMed Web of Science ®Google Scholar