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Research Paper

Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia

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Pages 290-303 | Received 10 Aug 2016, Accepted 04 Sep 2016, Published online: 16 May 2017

References

  • Zhang D, Loughran TP, Jr. Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment. Hematology Am Soc Hematol Educ Program 2012; 2012:652-9; PMID:23233648; https://doi.org/10.1182/asheducation-2012.1.652
  • Lamy T, Loughran TP, Jr. How I treat LGL leukemia. Blood 2011; 117:2764-74; PMID:21190991; https://doi.org/10.1182/blood-2010-07-296962
  • Steinway SN, LeBlanc F, Loughran TP, Jr. The pathogenesis and treatment of large granular lymphocyte leukemia. Blood Rev 2014; 28:87-94; PMID:24679833; https://doi.org/10.1016/j.blre.2014.02.001
  • Abroun S, Saki N, Ahmadvand M, Asghari F, Salari F, Rahim F. STATs: An Old Story, Yet Mesmerizing. Cell J 2015; 17:395-411; PMID:26464811
  • Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107:351-62; PMID:11160159; https://doi.org/10.1172/JCI9940
  • Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmaki H, Andersson EI, Lagstrom S, Clemente MJ, Olson T, Jalkanen SE, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366:1905-13; PMID:22591296; https://doi.org/10.1056/NEJMoa1114885
  • Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 2012; 120:3048-57; PMID:22859607; https://doi.org/10.1182/blood-2012-06-435297
  • Rajala HL, Porkka K, Maciejewski JP, Loughran TP, Jr., Mustjoki S. Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. Ann Med 2014; 46:114-22; PMID:24512550; https://doi.org/10.3109/07853890.2014.882105
  • Yang CY, Leung PS, Adamopoulos IE, Gershwin ME. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol 2013; 45:217-26; PMID:23359064; https://doi.org/10.1007/s12016-013-8361-3
  • Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 2008; 4:80-90; PMID:18212810; https://doi.org/10.1038/ncpendmet0716
  • Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. One,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 1983; 221:1181-3; PMID:6310748; https://doi.org/10.1126/science.6310748
  • Manolagas SC, Werntz DA, Tsoukas CD, Provvedini DM, Vaughan JH. One,25-Dihydroxyvitamin D3 receptors in lymphocytes from patients with rheumatoid arthritis. J Lab Clin Med 1986; 108:596-600; PMID:3023512
  • Rigby WF, Stacy T, Fanger MW. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest 1984; 74:1451-5; PMID:6332829; https://doi.org/10.1172/JCI111557
  • Cantorna MT, Waddell A. The vitamin D receptor turns off chronically activated T cells. Ann N Y Acad Sci 2014; 1317:70-5; PMID:24673331; https://doi.org/10.1111/nyas.12408
  • Chen PT, Hsieh CC, Wu CT, Yen TC, Lin PY, Chen WC, Chen MF. 1alpha,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling. Mol Cancer Ther 2015; 14:1365-75; PMID:25824337; https://doi.org/10.1158/1535-7163.MCT-14-0952
  • Muthian G, Raikwar HP, Rajasingh J, Bright JJ. One,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. J Neurosci Res 2006; 83:1299-309; PMID:16547967; https://doi.org/10.1002/jnr.20826
  • Wang Q, Li H, Xie H, Fu M, Guo B, Ding Y, Li W, Yu H. Twenty-five-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol 2013; 135:43-50; PMID:23333931; https://doi.org/10.1016/j.jsbmb.2013.01.008
  • Teleni L, Baker J, Koczwara B, Kimlin MG, Walpole E, Tsai K, Isenring EA. Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutr Rev 2013; 71:611-21; PMID:24032365; https://doi.org/10.1111/nure.12047
  • Gocek E, Studzinski GP. The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy. J Clin Med 2015; 4:504-34; PMID:26239344; https://doi.org/10.3390/jcm4040504
  • Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev 2016; 96:365-408; PMID:26681795; https://doi.org/10.1152/physrev.00014.2015
  • Vidal M, Ramana CV, Dusso AS. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol Cell Biol 2002; 22:2777-87; PMID:11909970; https://doi.org/10.1128/MCB.22.8.2777-2787.2002
  • Lange CM, Gouttenoire J, Duong FH, Morikawa K, Heim MH, Moradpour D. Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α. J Immunol 2014; 192:6037-44; PMID:24821973; https://doi.org/10.4049/jimmunol.1302296
  • Loughran TP, Jr., Zickl L, Olson TL, Wang V, Zhang D, Rajala HL, Hasanali Z, Bennett JM, Lazarus HM, Litzow MR, et al. Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998). Leukemia 2015; 29:886-94; PMID:25306898; https://doi.org/10.1038/leu.2014.298
  • Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000; 374:334-8; PMID:10666315; https://doi.org/10.1006/abbi.1999.1605
  • Weeres MA, Robien K, Ahn YO, Neulen ML, Bergerson R, Miller JS, Verneris MR. The effects of 1,25-dihydroxyvitamin D3 on in vitro human NK cell development from hematopoietic stem cells. J Immunol 2014; 193:3456-62; PMID:25149465; https://doi.org/10.4049/jimmunol.1400698
  • Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta 2012; 1821:21-56; PMID:22020178; https://doi.org/10.1016/j.bbalip.2011.09.014
  • Larsen L, Ropke C. Suppressors of cytokine signalling: SOCS. APMIS 2002; 110:833-44; PMID:12645661; https://doi.org/10.1034/j.1600-0463.2002.1101201.x
  • Bohmer FD, Friedrich K. Protein tyrosine phosphatases as wardens of STAT signaling. JAKSTAT 2014; 3:e28087; PMID:24778927
  • Sunn KL, Cock TA, Crofts LA, Eisman JA, Gardiner EM. Novel N-terminal variant of human VDR. Mol Endocrinol 2001; 15:1599-609; PMID:11518809; https://doi.org/10.1210/mend.15.9.0693
  • Gardiner EM, Esteban LM, Fong C, Allison SJ, Flanagan JL, Kouzmenko AP, Eisman JA. Vitamin D receptor B1 and exon 1d: functional and evolutionary analysis. J Steroid Biochem Mol Biol 2004; 89-90:233-8; PMID:15225777; https://doi.org/10.1016/j.jsbmb.2004.03.078
  • Ishaq M, Fan M, Wigmore K, Gaddam A, Natarajan V. Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC α in mediating calcineurin-induced transactivation. J Immunol 2002; 169:732-8; PMID:12097375; https://doi.org/10.4049/jimmunol.169.2.732
  • Szabova L, Macejova D, Dvorcakova M, Mostbock S, Blazickova S, Zorad S, Walrand S, Cardinault N, Vasson MP, Rock E, et al. Expression of nuclear retinoic acid receptor in peripheral blood mononuclear cells (PBMC) of healthy subjects. Life Sci 2003; 72:831-6; PMID:12479981; https://doi.org/10.1016/S0024-3205(02)02307-X
  • Young HA, Hardy KJ. Interferon-gamma: producer cells, activation stimuli, and molecular genetic regulation. Pharmacol Ther 1990; 45:137-51; PMID:2105509; https://doi.org/10.1016/0163-7258(90)90012-Q
  • Rigby WF, Denome S, Fanger MW. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest 1987; 79:1659-64; PMID:2884234; https://doi.org/10.1172/JCI113004
  • Boissier MC, Assier E, Falgarone G, Bessis N. Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine 2008; 75:373-5; PMID:18571969; https://doi.org/10.1016/j.jbspin.2008.04.005
  • Alroy I, Towers TL, Freedman LP. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol 1995; 15:5789-99; PMID:7565732; https://doi.org/10.1128/MCB.15.10.5789
  • Cippitelli M, Santoni A. Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur J Immunol 1998; 28:3017-30; PMID:9808170; https://doi.org/10.1002/(SICI)1521-4141(199810)28:10%3c3017::AID-IMMU3017%3e3.0.CO;2-6
  • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140:883-99; PMID:20303878; https://doi.org/10.1016/j.cell.2010.01.025
  • Stio M, Treves C, Celli A, Tarantino O, d'Albasio G, Bonanomi AG. Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis. Am J Gastroenterol 2002; 97:679-89; PMID:11922564; https://doi.org/10.1111/j.1572-0241.2002.05549.x
  • Gepner P, Amor B, Fournier C. One,25-dihydroxyvitamin D3 potentiates the in vitro inhibitory effects of cyclosporin A on T cells from rheumatoid arthritis patients. Arthritis Rheum 1989; 32:31-6; PMID:2521453; https://doi.org/10.1002/anr.1780320106
  • Lamy T, Liu JH, Landowski TH, Dalton WS, Loughran TP, Jr. Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia. Blood 1998; 92:4771-7; PMID:9845544
  • Doi K, Liu Q, Gowda K, Barth BM, Claxton D, Amin S, Loughran TP, Jr., Wang HG. Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression. Cancer Biol Ther 2014; 15:1077-86; PMID:24842334; https://doi.org/10.4161/cbt.29186
  • McGrath T, Latoud C, Arnold ST, Safa AR, Felsted RL, Center MS. Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression. Biochem Pharmacol 1989; 38:3611-9; PMID:2573357; https://doi.org/10.1016/0006-2952(89)90134-2

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