Down-regulation of KLF5 in cancer-associated fibroblasts inhibit gastric cancer cells progression by CCL5/CCR5 axis

References

• Siegel RL, Miller KD, Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7-30. doi:10.3322/caac.21332
   PubMed Web of Science ®Google Scholar
• Tamura G: Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol. 2006;12:192-8. doi:10.3748/wjg.v12.i2.192
   PubMed Web of Science ®Google Scholar
• Quail DF, Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423-37. doi:10.1038/nm.3394
   PubMed Web of Science ®Google Scholar
• Luo H, Tu G, Liu Z, Liu M. Cancer-associated fibroblasts: a multifaceted driver of breast cancer progression. Cancer Lett. 2015;361:155-63. doi:10.1016/j.canlet.2015.02.018
   PubMed Web of Science ®Google Scholar
• Cirri P, Chiarugi P: Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res. 2011;1:482-97.
   PubMed Web of Science ®Google Scholar
• Pietras K, Ostman A: Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res. 2010;316:1324-31. doi:10.1016/j.yexcr.2010.02.045
   PubMed Web of Science ®Google Scholar
• Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, et al. Helicobacter pylori promotes the expression of Kruppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One. 2013;8:e54344. doi:10.1371/journal.pone.0054344
   PubMed Web of Science ®Google Scholar
• Bieker JJ: Kruppel-like factors: three fingers in many pies. J Biol Chem. 2001;276:34355-8. doi:10.1074/jbc.R100043200
   PubMed Web of Science ®Google Scholar
• McConnell BB, Kim SS, Yu K, Ghaleb AM, Takeda N, Manabe I, Nusrat A, Nagai R, Yang VW. Kruppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology. 2011;141:1302-13, 1313.e1-6. doi:10.1053/j.gastro.2011.06.086
   PubMed Web of Science ®Google Scholar
• Wan H, Luo F, Wert SE, Zhang L, Xu Y, Ikegami M, Maeda Y, Bell SM, Whitsett JA. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development. 2008;135:2563-72. doi:10.1242/dev.021964
   PubMed Web of Science ®Google Scholar
• Tong D, Czerwenka K, Heinze G, Ryffel M, Schuster E, Witt A, Leodolter S, Zeillinger R. Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Clin Cancer Res. 2006;12:2442-8. doi:10.1158/1078-0432.CCR-05-0964
   PubMed Web of Science ®Google Scholar
• Chen C, Bhalala HV, Vessella RL, Dong JT. KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate. 2003;55:81-8. doi:10.1002/pros.10205
   PubMed Web of Science ®Google Scholar
• Dong JT, Chen C: Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci. 2009;66:2691-706. doi:10.1007/s00018-009-0045-z
   PubMed Web of Science ®Google Scholar
• Yang TS, Yang XH, Chen X, Wang XD, Hua J, Zhou DL, Zhou B, Song ZS. MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN. FEBS Lett. 2014;588:2162-9. doi:10.1016/j.febslet.2014.04.050
   PubMed Web of Science ®Google Scholar
• Herrera M, Islam AB, Herrera A, Martín P, García V, Silva J, Garcia JM, Salas C, Casal I, de Herreros AG, et al: Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res. 2013;19:5914-26. doi:10.1158/1078-0432.CCR-13-0694
   PubMed Web of Science ®Google Scholar
• Li H, Fan X, Houghton J: Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem. 2007;101:805-15. doi:10.1002/jcb.21159
   PubMed Web of Science ®Google Scholar
• Bhowmick NA, Neilson EG, Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature. 2004;432:332-7. doi:10.1038/nature03096
   PubMed Web of Science ®Google Scholar
• Orimo A, Weinberg RA: Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle. 2006;5:1597-601. doi:10.4161/cc.5.15.3112
   PubMed Web of Science ®Google Scholar
• Shen XJ, Zhang H, Tang GS, Wang XD, Zheng R, Wang Y, Zhu Y, Xue XC, Bi JW. Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer. Int J Biol Sci. 2015;11:370-9. doi:10.7150/ijbs.10666
   PubMed Web of Science ®Google Scholar
• Zhao X, He Y, Gao J, Fan L, Li Z, Yang G, Chen H. Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One. 2013;8:e59102. doi:10.1371/journal.pone.0059102
   PubMed Web of Science ®Google Scholar
• Sung CO, Lee KW, Han S, Kim SH. Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes. Am J Pathol. 2011;179:1827-38.. doi:10.1016/j.ajpath.2011.06.032
   PubMed Web of Science ®Google Scholar
• Tang D, Gao J, Wang S, Ye N, Chong Y, Huang Y, Wang J, Li B, Yin W, Wang D. Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression. Tumour Biol. 2016;37:1889-99. doi:10.1007/s13277-015-3942-9
   PubMedGoogle Scholar
• He XJ, Tao HQ, Hu ZM, et al: Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin beta1. Cancer Sci. 2014;105:1402-10. doi:10.1111/cas.12539
   PubMed Web of Science ®Google Scholar
• Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W. et al. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer. Cancer Med. 2015;4:1667-78. doi:10.1002/cam4.515
   PubMed Web of Science ®Google Scholar
• Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C. Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013;288:26731-40. doi:10.1074/jbc.M113.483958
   PubMed Web of Science ®Google Scholar
• He M, Han M, Zheng B, Shu YN, Wen JK. Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells. J Biochem. 2009;146:683-91. doi:10.1093/jb/mvp115
   PubMed Web of Science ®Google Scholar
• Zhu N, Gu L, Findley HW, Chen C, Dong JT, Yang L, Zhou M. KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. J Biol Chem. 2006;281:14711-8. doi:10.1074/jbc.M513810200
   PubMed Web of Science ®Google Scholar
• Gao Y, Wu K, Chen Y, Zhou J, Du C, Shi Q, Xu S, Jia J, Tang X, Li F, et al: Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription. Oncotarget. 2015;6:43791-805. doi:10.18632/oncotarget.6101
   PubMed Web of Science ®Google Scholar
• Jia L, Zhou Z, Liang H, Wu J, Shi P, Li F, Wang Z, Wang C, Chen W, Zhang H, et al. KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2. Oncogene 2016;35:2040-51. doi:10.1038/onc.2015.263
   PubMed Web of Science ®Google Scholar
• Zhang B, Zhang Z, Xia S, Xing C, Ci X, Li X, Zhao R, Tian S, Ma G, Zhu Z, et al. KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells. Mol Cell Biol. 2013;33:4919-35. doi:10.1128/MCB.00787-13
   PubMed Web of Science ®Google Scholar
• Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, et al: Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010;120:254-65. doi:10.1172/JCI40295
   PubMed Web of Science ®Google Scholar
• Sun R, Chen X, Yang VW: Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. J Biol Chem. 2001;276:6897-900. doi:10.1074/jbc.C000870200
   PubMed Web of Science ®Google Scholar
• Abe K, Sugiura H, Hashimoto Y, Ichikawa T, Koarai A, Yamada M, Numakura T, Onodera K, Tanaka R, Sato K, et al. Possible role of Kruppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease. Respir Res. 2016;17:7. doi:10.1186/s12931-016-0322-y
   PubMed Web of Science ®Google Scholar
• Liu J, Chen S, Wang W, et al: Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-beta pathways. Cancer Lett. 2016;379:49-59. doi:10.1016/j.canlet.2016.05.022
   PubMed Web of Science ®Google Scholar
• Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, Chang KJ, Lee EY, Lee WH. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One. 2011;6:e15313.. doi:10.1371/journal.pone.0015313
   PubMed Web of Science ®Google Scholar
• Rizvi S, Mertens JC, Bronk SF, Hirsova P, Dai H, Roberts LR, Kaufmann SH, Gores GJ. Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis. J Biol Chem. 2014;289:22835-49. doi:10.1074/jbc.M114.563064
   PubMed Web of Science ®Google Scholar
• Bai YP, Shang K, Chen H, Ding F, Wang Z, Liang C, Xu Y, Sun MH, Li YY. FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7. Cancer Sci. 2015;106:1278-87. doi:10.1111/cas.12745
   PubMed Web of Science ®Google Scholar
• David L, Dulong V, Coquerel B, Le Cerf D, Cazin L, Lamacz M, Vannier JP. Collagens, stromal cell-derived factor-1alpha and basic fibroblast growth factor increase cancer cell invasiveness in a hyaluronan hydrogel. Cell Prolif. 2008;41:348-64. doi:10.1111/j.1365-2184.2008.00515.x
   PubMed Web of Science ®Google Scholar
• Soria G, Ben-Baruch A: The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett. 2008;267:271-85. doi:10.1016/j.canlet.2008.03.018
   PubMed Web of Science ®Google Scholar
• Mrowietz U, Schwenk U, Maune S, Bartels J, Küpper M, Fichtner I, Schröder JM, Schadendorf D. The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br J Cancer. 1999;79:1025-31. doi:10.1038/sj.bjc.6690164
   PubMed Web of Science ®Google Scholar
• Cambien B, Richard-Fiardo P, Karimdjee BF, et al: CCL5 neutralization restricts cancer growth and potentiates the targeting of PDGFRbeta in colorectal carcinoma. PLoS One. 2011;6:e28842. doi:10.1371/journal.pone.0028842
   PubMed Web of Science ®Google Scholar
• Vaday GG, Peehl DM, Kadam PA, Lawrence DM. Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate. 2006;66:124-34. doi:10.1002/pros.20306
   PubMed Web of Science ®Google Scholar
• Fukui R, Nishimori H, Hata F, Yasoshima T, Ohno K, Nomura H, Yanai Y, Tanaka H, Kamiguchi K, Denno R, et al. Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer. J Surg Res. 2005;129:94-100. doi:10.1016/j.jss.2005.04.030
   PubMed Web of Science ®Google Scholar
• Wang T, Wei Y, Tian L, Song H, Ma Y, Yao Q, Feng M, Wang Y, Gao M, Xue Y. C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis. Int J Sur. 2016;32:136-42.. doi:10.1016/j.ijsu.2016.07.008
   PubMed Web of Science ®Google Scholar
• Sugasawa H, Ichikura T, Tsujimoto H, Kinoshita M, Morita D, Ono S, Chochi K, Tsuda H, Seki S, Mochizuki H. Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. J Surg Oncol. 2008;97:445-50. doi:10.1002/jso.20984
   PubMed Web of Science ®Google Scholar
• Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, Lengyel E. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012;2:1100-8. doi:10.1158/2159-8290.CD-12-0206
   PubMed Web of Science ®Google Scholar