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Research Papers

Estrogen and insulin synergistically promote type 1 endometrial cancer progression

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Pages 1000-1010 | Received 24 Jul 2017, Accepted 15 Oct 2017, Published online: 27 Nov 2017

Reference

  • Allen NE, Key TJ, Dossus L, Rinaldi S, Cust A, Lukanova A, Peeters PH, Onland-Moret NC, Lahmann PH, Berrino F, Panico S, Larranaga N, Pera G, Tormo MJ, Sanchez MJ, Ramon Quiros J, Ardanaz E, Tjonneland A, Olsen A, Chang-Claude J, Linseisen J, Schulz M, Boeing H, Lundin E, Palli D, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Bingham S, Khaw KT, Bueno-de-Mesquita HB, Trichopoulou A, Trichopoulos D, Naska A, Tumino R, Riboli E, Kaaks R. ‘Endogenous sex hormones and endometrial cancer risk in women in the european prospective investigation into cancer and nutrition (Epic)’. Endocr Relat Cancer. 2008;15:485–97. doi:10.1677/ERC-07-0064.
  • Bokhman JV. ‘Two pathogenetic types of endometrial Carcinoma’. Gynecol Oncol. 1983;15:10–7. doi:10.1016/0090-8258(83)90111-7.
  • Bradley LM, Gierthy JF, Pentecost BT. ‘Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the Mcf-7 human breast cancer cell line’. J Steroid Biochem Mol Biol. 2008;109:185–96. doi:10.1016/j.jsbmb.2007.10.006.
  • Brown SB, Hankinson SE. ‘Endogenous estrogens and the risk of Breast, Endometrial, and Ovarian Cancers’. Steroids. 2015;99:8–10. doi:10.1016/j.steroids.2014.12.013.
  • Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J, ‘Cancer Statistics in China, 2015’. CA Cancer J Clin. 2016;66:115–32. doi:10.3322/caac.21338.
  • Diamanti-Kandarakis E, Papailiou J, Palimeri S, ‘Hyperandrogenemia: Pathophysiology and its role in ovulatory dysfunction in Pcos’. Pediatr Endocrinol Rev. 2006;3 Suppl 1:198–204.
  • Hapangama DK, Kamal AM, Bulmer JN. ‘Estrogen receptor beta: The guardian of the Endometrium’. Hum Reprod Update. 2015;21:174–93. doi:10.1093/humupd/dmu053.
  • Joung KH, Jeong JW, Ku BJ. ‘The association between Type 2 diabetes mellitus and Women Cancer: The epidemiological evidences and putative mechanisms’. Biomed Res Int. 2015;2015:920618.
  • Kamal A, Tempest N, Parkes C, Alnafakh R, Makrydima S, Adishesh M, Hapangama DK. ‘Hormones and endometrial Carcinogenesis’. Horm Mol Biol Clin Investig. 2016;25:129–48.
  • Kurita T, Wang YZ, Donjacour AA, Zhao C, Lydon JP, O'Malley BW, Isaacs JT, Dahiya R, Cunha GR. ‘Paracrine regulation of apoptosis by steroid hormones in the Male and Female reproductive system’. Cell Death Differ. 2001;8:192–200. doi:10.1038/sj.cdd.4400797.
  • Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. ‘The Antiproliferative action of progesterone in uterine epithelium is mediated by Hand2’. Science. 2011;331:912–6. doi:10.1126/science.1197454.
  • Mathew D, Drury JA, Valentijn AJ, Vasieva O, Hapangama DK. ‘In Silico, in Vitro and in Vivo analysis identifies a potential role for Steroid hormone regulation of Foxd3 in Endometriosis-Associated genes’. Hum Reprod. 2016;31:345–54.
  • Meng YG, Han WD, Zhao YL, Huang K, Si YL, Wu ZQ, Mu YM, ‘Induction of the Lrp16 Gene by estrogen promotes the invasive growth of Ishikawa human endometrial Cancer cells through the downregulation of E-Cadherin’. Cell Res. 2007;17:869–80. doi:10.1038/cr.2007.79.
  • Mu N, Zhu Y, Wang Y, Zhang H, Xue F. ‘Insulin resistance: A significant risk factor of Endometrial Cancer’. Gynecol Oncol. 2012;125:751–7. doi:10.1016/j.ygyno.2012.03.032.
  • Plymate SR, Matej LA, Jones RE, Friedl KE. ‘Inhibition of Sex hormone-binding globulin production in the Human Hepatoma (Hep G2) Cell line by Insulin and Prolactin’. J Clin Endocrinol Metab. 1988;67:460–4. doi:10.1210/jcem-67-3-460.
  • Schindler AE. ‘Progestogen deficiency and endometrial Cancer Risk’. Maturitas. 2009;62:334–7. doi:10.1016/j.maturitas.2008.12.018.
  • Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Group Australian National Endometrial Cancer Study, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV, Jr., Kolonel LN, Henderson BE, Hankinson SE, Hakansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL. ‘Type I and Ii Endometrial Cancers: Have they different risk factors?’. J Clin Oncol. 2013;31:2607–18. doi:10.1200/JCO.2012.48.2596.
  • Shao R, Li X, Feng Y, Lin JF, Billig H. ‘Direct effects of Metformin in the Endometrium: A hypothetical mechanism for the treatment of Women with Pcos and Endometrial Carcinoma’. J Exp Clin Cancer Res. 2014;33:41. doi:10.1186/1756-9966-33-41.
  • Siegel RL, Miller KD, Jemal A. ‘Cancer Statistics, 2016’. CA Cancer J Clin. 2016;66:7–30. doi:10.3322/caac.21332.
  • Suba Z. ‘Interplay between insulin resistance and Estrogen deficiency as Co- Activators in Carcinogenesis’. Pathology & Oncology Research. 2012;18:123–33. doi:10.1007/s12253-011-9466-8.
  • Tian W, Zhu Y, Wang Y, Teng F, Zhang H, Liu G, Ma X, Sun D, Rohan T, Xue F. ‘Visfatin, A potential biomarker and prognostic factor for endometrial Cancer’. Gynecol Oncol. 2013;129:505–12. doi:10.1016/j.ygyno.2013.02.022.
  • Vermeulen A, Verdonck L. ‘Sex Hormone concentrations in post-menopausal women’. Clin Endocrinol (Oxf). 1978;9:59–66.
  • Wang Y, Hua S, Tian W, Zhang L, Zhao J, Zhang H, Zhang W, Xue F. ‘Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are Phosphatidylinositol 3-Kinase/Akt Dependent’. Gynecol Oncol. 2012;125:734–41. doi:10.1016/j.ygyno.2012.03.012.
  • Wang Y, Zhu Y, Zhang L, Tian W, Hua S, Zhao J, Zhang H, Xue F. ‘Insulin promotes proliferation, Survival, and Invasion in Endometrial Carcinoma by Activating the Mek/Erk Pathway’. Cancer Lett. 2012;322:223–31. doi:10.1016/j.canlet.2012.03.026.
  • Wu MH, Chou YC, Chou WY, Hsu GC, Chu CH, Yu CP, Yu JC, Sun CA. ‘Relationships between critical period of Estrogen exposure and circulating levels of Insulin-Like Growth Factor-I (Igf-I) in Breast Cancer: Evidence from a case-control study’. Int J Cancer. 2010;126:508–14. doi:10.1002/ijc.24722.

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