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Journal Club

PD-L1 blockade with avelumab: A new paradigm for treating Merkel cell carcinoma

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Pages 937-939 | Received 17 Aug 2017, Accepted 15 Oct 2017, Published online: 27 Nov 2017

References

  • Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbe C, Linette GP, Milella M et al. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol. 2016;17:1374–85. doi:10.1016/S1470-2045(16)30364-3.
  • Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP et al. PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. N Engl J Med. 2016;374:2542–2552. doi:10.1056/NEJMoa1603702.
  • Bhatia S, Afanasiev O, Nghiem P. Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer. Curr Oncol Rep. 2011;13:488–497. doi:10.1007/s11912-011-0197-5.
  • Goh G, Walradt T, Markarov V, Blom A, Riaz N, Doumani R, Stafstrom K, Moshiri A, Yelistratova L, Levinsohn J et al. Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy. Oncotarget. 2016;7:3403–15. doi:10.18632/oncotarget.6494.
  • Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR et al. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol. 2011;29:1539–46. doi:10.1200/JCO.2010.30.6308.
  • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 2002;99:12293–297. doi:10.1073/pnas.192461099.
  • Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005;65:1089–96.
  • Lipson EJ, Vincent JG, Loyo M, Kagohara LT, Luber BS, Wang H, Xu H, Nayar SK, Wang TS, Sidransky D et al. PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus and overall survival. Cancer Immunol Res. 2013;1:54–63. doi:10.1158/2326-6066.CIR-13-0034.
  • Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson K, Iyer JG, Ibrani D, Koelle DM, Nghiem P. Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers. Clin Cancer Res. 2013;19:5351–5360. doi:10.1158/1078-0432.CCR-13-0035.
  • BAVENCIO – avelumab injection, solution, concentrate. EMD Serono, Inc.: Rockland, MD, 2017.
  • Boyerinas B, Jochems C, Fantini M, Heery CR, Gulley JL, Tsang KY, Schlom J. Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015;3:1148–1157. doi:10.1158/2326-6066.CIR-15-0059.
  • Suzanne L., Topalian SB, Antoine H, Ahmad A, Jan Paul De B, Ragini R. K, Anthony G, Jean-Pierre D, Uwe M. M, Jose Maria Lopez P, Ana O, et al. Non-comparative, open-label, multiple cohort, phase 1/2 study to evaluate nivolumab (NIVO) in patients with virus-associated tumors (CheckMate 358): Efficacy and safety in Merkel cell carcinoma (MCC). Abstract CT074 presented at: AACR Annual Meeting; 2017 Apr 3; Washington, DC.
  • Sandra P. D'Angelo JR, Jessica Cecile H, Celeste L, Bartosz C., Guilherme R, Patrick T, Isaac B, Isabella Z, Marcis B, Meliessa H, et al. First-line (1L) avelumab treatment in patients (pts) with metastatic Merkel cell carcinoma (mMCC): Preliminary data from an ongoing study. Abstract 9530 presented at: ASCO Annual Meeting; 2017 Jun 3; Chicago, Illinois.
  • Howard L Kaufman JSR, Omid H, Shailender B., Patrick T, Sandra P. D'Angelo, Kent C. S, Celeste L., Michele M, Isaac B, Karl D, et al. Durable responses to avelumab (anti-PD-L1) in patients with Merkel cell carcinoma progressed after chemotherapy: 1 year efficacy update. Abstract CT079 presented at: AACR Annual Meeting; 2017 Apr 3; Washington, DC, 2017.

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