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Cancer Biology & Therapy Volume 19, 2018 - Issue 2
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Research Papers

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

Laurence BoothDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA
,
Jane L. RobertsDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA
,
Andrew PoklepovicDepartment of Medicine, Virginia Commonwealth University, Richmond, VA, USA
,
John KirkwoodUniversity of Pittsburgh Cancer Institute, Melanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory L1.32c, Pittsburgh, PA, USA
,
Cindy SanderUniversity of Pittsburgh Cancer Institute, Melanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory L1.32c, Pittsburgh, PA, USAORCID Iconhttp://orcid.org/0000-0002-4136-1342
ORCID Icon,
Francesca Avogadri-ConnorsPuma Biotechnology Inc. 1880 Wilshire Blvd, Los Angeles, CA, USA
,
Richard E. Cutler JrPuma Biotechnology Inc. 1880 Wilshire Blvd, Los Angeles, CA, USA
,
Alshad S. LalaniPuma Biotechnology Inc. 1880 Wilshire Blvd, Los Angeles, CA, USA
&
Paul DentDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USACorrespondence[email protected]
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Pages 132-137 | Received 08 Oct 2017, Accepted 09 Oct 2017, Published online: 08 Dec 2017

References

  • Booth L, Roberts JL, Tavallai M, Webb T, Leon D, Chen J, McGuire WP, Poklepovic A, Dent P. The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling. Oncotarget. 2016;7:19620–30.
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  • Booth L, Roberts JL, Poklepovic A, Avogadri-Connors F, Cutler RE, Lalani AS, Dent P. HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo. Oncotarget. 2017; 8:90262-90277.
  • Zhang Y, Zhang J, Liu C, Du S, Feng L, Luan X, Zhang Y, Shi Y, Wang T, Wu Y, et al. Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells. Cancer Lett. 2016;382:176–85.
  • Zhang X, Song Y, Feng M, Zhou X, Lu Y, Gao L, Yu C, Jiang X, Zhao J. Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activatedprotein kinase in the liver. J Lipid Res. 2015;56:963–71.
  • Soto-Acosta R, Bautista-Carbajal P, Cervantes-Salazar M, Angel-Ambrocio AH, Del Angel RM. DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. PLoS Pathog. 2017;13:e1006257. doi:10.1371/journal.ppat.1006257. eCollection 2017 Apr.
  • McCormick, F. KRAS as a Therapeutic Target. Clin Cancer Res. 2015;21:1797–801.
  • Hamed H, Mitchell C, Park MA, Hanna D, Martin AP, Harrison B, Hawkins W, Curiel DA, Fisher PB, Grant S, et al. Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo. Cancer Biol Ther. 2008;7:587–93.

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