965
Views
1
CrossRef citations to date
0
Altmetric
Research Paper

UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system

, , , , , & show all
Pages 598-608 | Received 07 Dec 2017, Accepted 03 Mar 2018, Published online: 13 Apr 2018

References

  • Hilvo M, Salzano AM, Innocenti A, Kulomaa MS, Scozzafava A, Scaloni A, Parkkila S, Supuran CT. Cloning, Expression, Post-Translational Modifications and Inhibition Studies on the Latest Mammalian Carbonic Anhydrase Isoform, CA XV. J Med Chem. 2009;52:646–54. doi:10.1021/jm801267c. PMID:19193158.
  • Opavsky R, Pastorekova S, Zeln¡k V, Gibadulinov A, Stanbridge EJ, Z vada J, Kettmann R, Pastorek J. Human MN/CA9 Gene, A Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain Relationships. Genomics. 1996;33:480–7. doi:10.1006/geno.1996.0223. PMID:8661007.
  • Li Y, Wang H, Tu C, Shiverick KT, Silverman DN, Frost SC. Role of Hypoxia and EGF on Expression, Activity, Localization, and Phosphorylation of Carbonic Anhydrase IX in MDA-MB-231 Breast Cancer Cells. Biochim Biophy Acta. 2011;1813:159–67. doi:10.1016/j.bbamcr.2010.09.018. PMID:20920536.
  • Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, et al. Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes. J Biol Chem. 2008;283:27799–809. doi:10.1074/jbc.M800938200. PMID:18703501.
  • Saarnio J, Parkkila S, Parkkila AK, Waheed A, Casey MC, Zhou XY, Pastorekova S, Pastorek J, Karttunen T, Haukipuro K, et al. Immunohistochemistry of Carbonic Anhydrase Isozyme IX (MN/CA IX) in Human Gut Reveals Polarized Expression in Epithelial Cells with the Highest Proliferative Capacity. J Histochem Cytochem. 1998;46:497–504. doi:10.1177/002215549804600409. PMID:9524195.
  • Wykoff CC, Beasley NJP, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, et al. Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrase. Cancer Res. 2000;60:7075–83. PMID:11156414.
  • Tafreshi NK, Lloyd MC, Proemsey JB, Bui MM, Kim J, Gillies RJ, Morse DL. Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia. Mol Imaging Biol. 2016;18(2):219–31. doi:10.1007/s11307-015-0885-x. PMID:26276155.
  • Span PM, Bussink J, Manders P, Beex LVAM, Sweep CGJ. Carbonic Anhydrase-9 Expression Levels and Prognosis in Human Breast Cancer: Association with Treatment Outcome. Br J Cancer. 2003;89:271–6. doi:10.1038/sj.bjc.6601122. PMID:12865916.
  • Generali D, Fox SB, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield SM, Bruzzi P, Bersiga A, Allevi G, et al. Role of Carbonic Anhydrase IX Expression in Prediction of the Efficacy and Outcome of Primary Epirubicin/Tamoxifen Therapy for Breast Cancer. Endocrine-Related Cancer. 2006;13:921–30. doi:10.1677/erc.1.01216. PMID:16954440.
  • Chia SK, Wykoff CC, Watson PH, Han C, Leek RD, Pastorek J, Gatter KC, Ratcliffe P, Harris AL. Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Cancer. J Clin Oncol. 2001;19:3660–8. doi:10.1200/JCO.2001.19.16.3660.
  • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. Acid Production in Glycolysis-impaired Tumors Provides New Insights into Tumor Metabolism. Clin Cancer Res. 2002;8:1284–91.
  • Swietach P, Vaughan-Jones RD, Harris AL. Regulation of Tumor pH and the Role of Carbonic Anhydrase 9. Cancer Metastasis Rev. 2007;26:299–310. doi:10.1007/s10555-007-9064-0. PMID:17415526.
  • Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD. Tumor-Associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-Dimensional Multicellular Growths. J Biol Chem. 2008;283:20473–83. doi:10.1074/jbc.M801330200. PMID:18482982.
  • Gottlieb RA, Giesing HA, Zhu JY, Engler RL, Babior BM. Cell Acidification in Apoptosis: Granulocyte Cology-stimulating Factor Delays Programed Cell Death in Neutrophils by Up-regulating the Vaculolar H + -ATPase. Proc Natl Acad Sci USA. 1995;92:5965–8. doi:10.1073/pnas.92.13.5965..
  • Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ. Acid-mediated Tumor Invasion: A Multidisplinary Study. Cancer Res. 2006;66:5216–23. doi:10.1158/0008-5472.CAN-05-4193. PMID:16707446.
  • Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol. 2011;39(2):453–63. PMID:21617859.
  • Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, et al. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013;73(5):1524–35. doi:10.1158/0008-5472.CAN-12-2796. PMID:23288510.
  • Bertucci F, Finetti P, Cervera N, Esterni B, Hermitte F, Viens P, Birnbaum D. How basal are triple-negative breast cancers? Int J Cancer. 2008;123(1):236–40. doi:10.1002/ijc.23518. PMID:18398844.
  • Rakha EA, Elsheikh SE, Aleskandarany MA, Habashi HO, Green AR, Powe DG, El-Sayed ME, Benhasouna A, Brunet J, Akslen LA, et al. Triple-Negative Breast Cancer: Distinguishing between Basal and Nonbasal Subtypes. Clin Cancer Res. 2009;15:2302–10.
  • Peddi PF, Ellis MJ, Ma C. Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy. Internat J Breast Cancer. 2012; 2012, Article ID 217185, 7 pages. doi:10.1155/2012/217185:1-7.
  • Dent R, Hanna WM, Trudeau M, Rawlinson E, Sun P, Narod SA. Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res Treat. 2009;115(2):423–8. doi:10.1007/s10549-008-0086-2. PMID:18543098.
  • Sorlie T, Perou CM, Tibshirani R, Aas R, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. Gene Expression Patterns of Breast Carcinomas Distinguish Tumor Subclasses with Clinical Implications. Proc Natl Acad Sci USA. 2001;98:10869–74. doi:10.1073/pnas.191367098.
  • Eiermann W, Vallis KA. Locoregional treatments for triple-negative breast cancer. Ann Oncol. 2012;23 Suppl 6:vi30−34. doi:10.1093/annonc/mds192. PMID:23012299.
  • Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, et al. Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28(7):1145–53. doi:10.1200/JCO.2009.22.4725. PMID:20100965.
  • Wahba HA, El-Hadaad HA. Current approaches in treatment of triple-negative breast cancer. Cancer Biol Med. 2015;12(2):106–16. PMID:26175926.
  • Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, Candiloro I, Pezzella F, Gatter KC, Millar EKA, et al. The Key Hypoxia Regulated Gene CAIX is Upregulated in Basal-like Breast Tumours and is Associated with Resistance to Chemotherapy. British Journal of Cancer. 2009;100:405–11. doi:10.1038/sj.bjc.6604844. PMID:19165203.
  • Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J, Berra E. HIF-1 alpha and CA IX Staining in Invasive Breast Carcinomas: Prognosis and Treatment Outcome. Int J Cancer. 2007;120:1451–8.
  • Hughes P, Marshall D, Reid Y, Parkes H, Gelber C. The costs of using unauthenticated, over-passaged cell lines: how much more data do we need? Biotechniques. 2007;43(5):575, 577−578, 581-572 passim. doi:10.2144/000112598.
  • Li Y, Wang H, Oosterwijk E, Tu C, Shiverick KT, Silverman DN, Frost SC. Expression and Activity of Carbonic Anhydrase IX Is Associated with Metabolic Dysfunction in MDA-MB-231 Breast Cancer Cells. Cancer Investigation. 2009;27:613–23. doi:10.1080/07357900802653464. PMID:19367501.
  • Pastorek J, Pastorekova S, Callebaut I, Mornon JP, Zeln¡k V, Opavsky R, Zat'ovicov M, Liao S, Portetelle D, Stanbridge EJ, et al. Cloning and Characterization of MN, a Human Tumor-associated Protein with a Domain Homologous to Carbonic Anhydrase and a Putative Helix-Loop-Helix DNA Binding Segment. Oncogene. 1994;9:2877–88. PMID:8084592.
  • Zavada J, Zavadova Z, Pastorekova S, Ciampor F, Pastorek J, Zelnik V. Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int J Cancer. 1993;54(2):268–74. doi:10.1002/ijc.2910540218. PMID:8486430.
  • Robertson N, Potter C, Harris AL. Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion. Cancer Res. 2004;64:6160–5. doi:10.1158/0008-5472.CAN-03-2224. PMID:15342400.
  • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe J, Tong F, et al. A Collection of Breast Cancer Cell Lines for the Study of Functionally Distinct Cancer Subtypes. Cancer Cell. 2006;10:515–27. doi:10.1016/j.ccr.2006.10.008. PMID:17157791.
  • Elsheikh SE, Green AR, Rakha EA, Samaka RM, Ammar AA, Powe D, Reis-Filho JS, Ellis IO. Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype. Br J Cancer. 2008;99(2):327–34. doi:10.1038/sj.bjc.6604463. PMID:18612310.
  • Nakagawa M, Bando Y, Nagao T, Morimoto M, Takai C, Ohnishi T, Honda J, Moriya T, Izumi K, Takahashi M, et al. Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer. Anticancer research. 2011;31(6):2389–93. PMID:21737670.
  • Changavi AA, Shashikala A, Ramji AS. Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas. J Lab Physicians. 2015;7(2):79–83. doi:10.4103/0974-2727.163129. PMID:26417156.
  • Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MD. MDA-MB-435 Cells Are Derived from M14 Melanoma Cells – a Loss for Breast Cancer, but a Boon for Melanoma Reseach. Breast Cancer Research and Treatment. 2007;104:13–19. doi:10.1007/s10549-006-9392-8. PMID:17004106.
  • Imbalzano KM, Tatarkova I, Imbalzano AN, Nickerson JA. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int. 2009;9:7. doi:10.1186/1475-2867-9-7. PMID:19291318.
  • Zandberga E, Zayakin P, Abols A, Pupola D, Trapencieris P, Line A. Depletion of carbonic anhydrase IX abrogates hypoxia-induced overexpression of stanniocalcin-1 in triple negative breast cancer cells. Cancer Biol Ther. 2017:1–10.
  • Jeon M, Han J, Nam SJ, Lee JE, Kim S. STC-1 expression is upregulated through an Akt/NF-kappaB-dependent pathway in triple-negative breast cancer cells. Oncol Rep. 2016;36(3):1717–22. doi:10.3892/or.2016.4972. PMID:27461417.
  • Chang AC, Doherty J, Huschtscha LI, Redvers R, Restall C, Reddel RR, Anderson RL. STC1 expression is associated with tumor growth and metastasis in breast cancer. Clin Exp Metastasis. 2015;32(1):15–27. doi:10.1007/s10585-014-9687-9. PMID:25391215.
  • Qu Y, Han B, Yu Y, Yao W, Bose S, Karlan BY, Giuliano AE, Cui X. Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells. PLoS One. 2015;10(7):e0131285. doi:10.1371/journal.pone.0131285. PMID:26147507.
  • Chen A, Beetham H, Black MA, Priya R, Telford BJ, Guest J, Wiggins GA, Godwin TD, Yap AS, Guilford PJ. E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer. 2014;14:552. doi:10.1186/1471-2407-14-552. PMID:25079037.
  • Saha B, Chaiwun B, Imam SS, Tsao-Wei DD, Groshen S, Naritoku WY, Imam SA. Overexpression of E-cadherin protein in metastatic breast cancer cells in bone. Anticancer Res. 2007;27(6B):3903–8. PMID:18225549.
  • Chaffer CL, Thompson EW, Williams ED. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs. 2007;185(1-3):7–19. doi:10.1159/000101298. PMID:17587803.
  • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9(4):265–73. doi:10.1038/nrc2620. PMID:19262571.
  • Schneider BP, Winer EP, Foulkes WD, Garber J, Perou jM, Richardson A, Sledge GW, Carey LA. Triple-Negative Breast Cancer: Risk Factors to Potential Targets. Clin Cancer Res. 2008;14:8010–8.
  • Silverman DN, Lindskog S. The Catalytic Mechanism of Carbonic Anhydrase – Implication of a Rate Limiting Protolysis of Water. Acc Chem Res. 1988;21:30–36. doi:10.1021/ar00145a005.
  • Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT. Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem. 2011;54(6):1896–902. doi:10.1021/jm101541x. PMID:21361354.
  • Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, auf dem Keller U, Leung S, Huntsman D, et al. Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors. Cancer Res. 2011;71:3364–76. doi:10.1158/0008-5472.CAN-10-4261. PMID:21415165.
  • Pastorekova S, Zavadova Z, Kostal M, Babusikova O, Zavada J. A Novel Quasi-viral Agent, MaTu, is a Two-Component System. Virology. 1992;187:620–6. doi:10.1016/0042-6822(92)90464-Z. PMID:1312272.
  • Markwell MAK, Haas SM, Lieber LL, Tolbert NE. A Modification of the Lowry Procedure to Simplify Protein Determination in Membrane and Lipoprotein Samples. Anal Biochem. 1978;87:206–10. doi:10.1016/0003-2697(78)90586-9. PMID:98070.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.