Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells

References

• Kaelin WG, Jr., Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30:393–402. doi:10.1016/j.molcel.2008.04.009. PMID:18498744
   PubMed Web of Science ®Google Scholar
• Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92:5510–4. doi:10.1073/pnas.92.12.5510. PMID:7539918
   PubMed Web of Science ®Google Scholar
• Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43–54. doi:10.1016/S0092-8674(01)00507-4. PMID:11595184
   PubMed Web of Science ®Google Scholar
• Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337–40. doi:10.1126/science.1066373. PMID:11598268
   PubMed Web of Science ®Google Scholar
• Huang J, Zhao Q, Mooney SM, Lee FS. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem. 2002;277:39792–800. doi:10.1074/jbc.M206955200. PMID:12181324
   PubMed Web of Science ®Google Scholar
• Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271–5. doi:10.1038/20459. PMID:10353251
   PubMed Web of Science ®Google Scholar
• Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH, et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2000;275:25733–41. doi:10.1074/jbc.M002740200. PMID:10823831
   PubMed Web of Science ®Google Scholar
• Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 2000;19:4298–309. doi:10.1093/emboj/19.16.4298. PMID:10944113
   PubMed Web of Science ®Google Scholar
• Sadlecki P, Bodnar M, Grabiec M, Marszalek A, Walentowicz P, Sokup A, Zegarska J, Walentowicz-Sadlecka M. The role of Hypoxia-inducible factor-1 alpha , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients. Biomed Res Int. 2014;2014:616850. doi:10.1155/2014/616850. PMID:24745019
   PubMedGoogle Scholar
• McDonald PC, Dedhar S. Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. Subcell Biochem. 2014;75:255–69. doi:10.1007/978-94-007-7359-2_13. PMID:24146383
   PubMedGoogle Scholar
• Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 2009;107:1053–62. doi:10.1002/jcb.22214. PMID:19479945
   PubMed Web of Science ®Google Scholar
• Melillo G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 2007;26:341–52. doi:10.1007/s10555-007-9059-x. PMID:17415529
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. doi:10.3322/caac.21332. PMID:26742998
   PubMed Web of Science ®Google Scholar
• Attard G, Parker C, Eeles RA, Schroder F, Tomlins SA, Tannock I, et al. Prostate cancer. Lancet. 2016;387:70–82. doi:10.1016/S0140-6736(14)61947-4. PMID:26074382
   PubMed Web of Science ®Google Scholar
• Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830–5. PMID:10582706
   PubMed Web of Science ®Google Scholar
• Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000;157:411–21. doi:10.1016/S0002-9440(10)64554-3. PMID:10934146
   PubMed Web of Science ®Google Scholar
• Zhong H, Hanrahan C, van der Poel H, Simons JW. Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells. Biochem Biophys Res Commun. 2001;284:352–6. doi:10.1006/bbrc.2001.4981. PMID:11394885
   PubMed Web of Science ®Google Scholar
• Miranda E, Nordgren IK, Male AL, Lawrence CE, Hoakwie F, Cuda F, Court W, Fox KR, Townsend PA, Packham GK, et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013;135:10418–25. doi:10.1021/ja402993u. PMID:23796364
   PubMed Web of Science ®Google Scholar
• Sato M, Hirose K, Kashiwakura I, Aoki M, Kawaguchi H, Hatayama Y, Akimoto H, Narita Y, Takai Y. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015;12:3462–8. doi:10.3892/mmr.2015.3862. PMID:26017562
   PubMed Web of Science ®Google Scholar
• Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Rao SV, Joshi KS. Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1alpha and induces G2/M arrest under hypoxia in prostate cancer cells. Prostate Cancer Prostatic Dis. 2012;15:15–27. doi:10.1038/pcan.2011.51. PMID:22083267
   PubMed Web of Science ®Google Scholar
• Mun J, Jabbar AA, Devi NS, Liu Y, Van Meir EG, Goodman MM. Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide , a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent. Bioorg Med Chem. 2012;20:4590–7. doi:10.1016/j.bmc.2012.04.064. PMID:22682301
   PubMedGoogle Scholar
• Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem. 1996;271:32529–37. doi:10.1074/jbc.271.51.32529. PMID:8955077
   PubMed Web of Science ®Google Scholar
• Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell. 2007;25:207–17. doi:10.1016/j.molcel.2007.01.001. PMID:17244529
   PubMed Web of Science ®Google Scholar
• Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, et al. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature. 2012;487:380–4. doi:10.1038/nature11207. PMID:22801492
   PubMed Web of Science ®Google Scholar
• Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007;131:584–95. doi:10.1016/j.cell.2007.08.045. PMID:17981124
   PubMed Web of Science ®Google Scholar
• Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1alpha (HIF-1alpha) for lysosomal degradation. J Biol Chem. 2013;288:10703–14. doi:10.1074/jbc.M112.414771. PMID:23457305
   PubMed Web of Science ®Google Scholar
• Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I. The Role of the PERK/eIF2alpha/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress. Curr Mol Med. 2016;16:533–44. doi:10.2174/1566524016666160523143937. PMID:27211800
   PubMed Web of Science ®Google Scholar
• Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009;136:731–45. doi:10.1016/j.cell.2009.01.042. PMID:19239892
   PubMed Web of Science ®Google Scholar
• Li J, Shi M, Cao Y, Yuan W, Pang T, Li B, Sun Z, Chen L, Zhao RC. Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun. 2006;342:1341–51. doi:10.1016/j.bbrc.2006.02.094. PMID:16516853
   PubMed Web of Science ®Google Scholar
• Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, et al. Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell. 2014;25:118–31. doi:10.1016/j.ccr.2013.12.008. PMID:24434214
   PubMed Web of Science ®Google Scholar
• Stewart AK. Medicine. How thalidomide works against cancer. Science. 2014;343:256–7. doi:10.1126/science.1249543. PMID:24436409
   PubMed Web of Science ®Google Scholar
• Kumar S, Meuter A, Thapa P, Langstraat C, Giri S, Chien J, Rattan R, Cliby W, Shridhar V. Metformin intake is associated with better survival in ovarian cancer: A case-control study. Cancer. 2013;119:555–62. doi:10.1002/cncr.27706. PMID:23208739
   PubMed Web of Science ®Google Scholar
• Matsuyama M, Hayama T, Funao K, Kawahito Y, Sano H, Takemoto Y, Nakatani T, Yoshimura R. Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis. Oncol Rep. 2007;18:99–104. PMID:17549353
   PubMed Web of Science ®Google Scholar
• Savari S, Liu M, Zhang Y, Sime W, Sjolander A. CysLT(1)R antagonists inhibit tumor growth in a xenograft model of colon cancer. PLoS One. 2013;8:e73466. doi:10.1371/journal.pone.0073466. PMID:24039952
   PubMed Web of Science ®Google Scholar
• Park JY, Jung HJ, Seo I, Jha BK, Suh SI, Suh MH, Baek WK. Translational suppression of HIF-1alpha by miconazole through the mTOR signaling pathway. Cell Oncol (Dordr). 2014;37:269–79. doi:10.1007/s13402-014-0182-8. PMID:25070654
   PubMed Web of Science ®Google Scholar
• Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol. 2001;21:3995–4004. doi:10.1128/MCB.21.12.3995-4004.2001. PMID:11359907
   PubMed Web of Science ®Google Scholar
• Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999;13:1422–37. doi:10.1101/gad.13.11.1422. PMID:10364159
   PubMed Web of Science ®Google Scholar
• Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006;34:7–11. doi:10.1042/BST0340007. PMID:16246168
   PubMed Web of Science ®Google Scholar
• Molle G, Dugast JY, Duclohier H, Daumas P, Heitz F, Spach G. Ionophore properties of a synthetic alpha-helical transmembrane fragment of the mitochondrial H+ ATP synthetase of Saccharomyces cerevisiae. Comparison with alamethicin. Biophys J. 1988;53:193–203.
   Google Scholar
• Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J Cell Biol. 2006;172:201–9. doi:10.1083/jcb.200508099. PMID:16418533
   PubMed Web of Science ®Google Scholar