Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice

References

• Danese S, Fiorino G, Peyrin-Biroulet L. Early intervention in Crohn's disease: towards disease modification trials. Gut. 2017;66(12):2179–87. doi:10.1136/gutjnl-2017-314519. PMID:28874419.
   PubMed Web of Science ®Google Scholar
• Vancamelbeke M, Vanuytsel T, Farré R, Verstockt S, Ferrante M, Van Assche G, Rutgeerts P, Schuit F, Vermeire S, Arijs I, et al. Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(10):1718–29. doi:10.1097/MIB.0000000000001246. PMID:28885228.
   PubMed Web of Science ®Google Scholar
• Biancone L, Armuzzi A, Scribano ML, D'Inca R, Castiglione F, Papi C, Angelucci E, Daperno M, Mocciaro F, Riegler G, et al. Inflammatory bowel disease phenotype as risk factor for cancer in a prospective multicentre nested case-control IG-IBD study. J Crohns Colitis. 2016;10(8):913–24. doi:10.1093/ecco-jcc/jjw048. PMID:26933032.
   PubMed Web of Science ®Google Scholar
• Burisch J, Munkholm P. The epidemiology of inflammatory bowel disease. Scand J Gastroenterol. 2015;50(8):942–51. doi:10.3109/00365521.2015.1014407. PMID:25687629.
   PubMed Web of Science ®Google Scholar
• Satia JA, Tseng M, Galanko JA, Martin C, Sandler RS. Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer Study. Nutr Cancer. 2009;61(2):179–93 doi:10.1080/01635580802419806. PMID:19235034.
   PubMed Web of Science ®Google Scholar
• Leal MC, Däbritz J. Immunoregulatory role of myeloid-derived cells in inflammatory bowel disease. Inflamm Bowel Dis. 2015;21(12):2936–47. doi:10.1097/MIB.0000000000000511. PMID:26244650.
   PubMed Web of Science ®Google Scholar
• Colangelo T, Polcaro G, Muccillo L, D'Agostino G, Rosato V, Ziccardi P, Lupo A, Mazzoccoli G, Sabatino L, Colantuoni V. The tumour microenvironment dilemma in colorectal cancer. Biochimica et Biophysica Acta. 2017;1867(1):1–18. PMID:27864070.
   PubMed Web of Science ®Google Scholar
• Kraus S, Sion D, Arber N. Can we select patients for colorectal cancer prevention with aspirin? Curr Pharm Des. 2015;21(35):5127–34. doi:10.2174/1381612821666150915111000. PMID:26369678.
   PubMed Web of Science ®Google Scholar
• Dubinsky MC. Reviewing treatments and outcomes in the evolving landscape of ulcerative colitis. Postgrad Med. 2017;129(5):538–53. doi:10.1080/00325481.2017.1319730. PMID:28425825.
   PubMed Web of Science ®Google Scholar
• Bharti S, Rani N, Krishnamurthy B, Arya DS. Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med. 2014;80(6):437–51. doi:10.1055/s-0034-1368351. PMID:24710903.
   PubMed Web of Science ®Google Scholar
• Alam MA, Subhan N, Rahman MM, Uddin SJ, Reza HM, Sarker SD. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr. 2014;5(4):404–17. doi:10.3945/an.113.005603. PMID:25022990.
   PubMed Web of Science ®Google Scholar
• Kulasekaran G, Ganapasam S. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015;409(1-2):199–211. doi:10.1007/s11010-015-2525-9. PMID:26280522.
   PubMed Web of Science ®Google Scholar
• Raha S, Yumnam S, Hong GE, Lee HJ, Saralamma VV, Park HS, Heo JD, Lee SJ, Kim EH, Kim JA, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015;47(3):1061–9. doi:10.3892/ijo.2015.3095. PMID:26201693.
   PubMed Web of Science ®Google Scholar
• Chtourou Y, Aouey B, Kebieche M, Fetoui H. Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways. Chem Biol Interact. 2015;239:76–86. doi:10.1016/j.cbi.2015.06.036. PMID:26120027.
   PubMed Web of Science ®Google Scholar
• Banjerdpongchai R, Wudtiwai B, Khaw-On P, Rachakhom W, Duangnil N, Kongtawelert P. Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways. Tumour Biol. 2015;37(1):227–37. doi:10.1007/s13277-015-3774-7. PMID:26194866.
   PubMedGoogle Scholar
• Lewinska A, Siwak J, Rzeszutek I, Wnuk M. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Toxicol In Vitro. 2015;29(3):417–25. doi:10.1016/j.tiv.2014.12.005. PMID:25499067.
   PubMed Web of Science ®Google Scholar
• Zhang YS, Li Y, Wang Y, Sun SY, Jiang T, Li C, Cui SX, Qu XJ. Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc (Min/+) mouse model. J Cancer Res Clin Oncol. 2016;142(5):913–25. doi:10.1007/s00432-015-2097-9. PMID:26702935.
   PubMed Web of Science ®Google Scholar
• Katoh H, Wang D, Daikoku T, Sun H, Dey SK, Dubois RN. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell. 2013;24(5):631–44. doi:10.1016/j.ccr.2013.10.009. PMID:24229710.
   PubMed Web of Science ®Google Scholar
• Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9(3):162–74. doi:10.1038/nri2506. PMID:19197294.
   PubMed Web of Science ®Google Scholar
• Cubillos-Ruiz JR, Bettigole SE, Glimcher LH. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell 2017;168(4):692–706. doi:10.1016/j.cell.2016.12.004. PMID:28187289.
   PubMed Web of Science ®Google Scholar
• Hoefkens E, Nys K, John JM, Van Steen K, Arijs I, Van der Goten J, Van Assche G, Agostinis P, Rutgeerts P, Vermeire S, et al. Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress. Autophagy. 2013;9(12):2046–55. doi:10.4161/auto.26337. PMID:24247223.
   PubMed Web of Science ®Google Scholar
• Wang L, Chen M, Yang J, Zhang Z. LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells. Autophagy 2013;9(5):756–69. doi:10.4161/auto.23814. PMID:23482084.
   PubMed Web of Science ®Google Scholar
• Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, et al. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res. 2007;67(3):881–9. doi:10.1158/0008-5472.CAN-05-3767. PMID:17283118.
   PubMed Web of Science ®Google Scholar
• Smith T, Hutchison P, Schrör K, Clària J, Lanas A, Patrignani P, Chan AT, Din F, Langley R, Elwood P, et al. Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK. Ecancermedicalscience. 2015;9:581. PMID:26557879.
   PubMedGoogle Scholar
• Thiagarajan P, Jankowski JA. Aspirin and NSAIDs; benefits and harms for the gut. Best Pract Res Clin Gastroenterol. 2012;26(2):197–206. doi:10.1016/j.bpg.2012.01.007. PMID:22542157.
   PubMed Web of Science ®Google Scholar
• Singh Ranger G. The role of aspirin in colorectal cancer chemoprevention. Crit Rev Oncol Hematol. 2016;104:87–90. doi:10.1016/j.critrevonc.2016.05.011. PMID:27289249.
   PubMed Web of Science ®Google Scholar
• Li P, Wang S, Guan X, Liu B, Wang Y, Xu K, Peng W, Su W, Zhang K. Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats. Food Chem Toxicol 2013;60:1–9. doi:10.1016/j.fct.2013.07.019. PMID:23871784.
   PubMed Web of Science ®Google Scholar
• Jang Y, Kim TK, Shim WS. Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats. Pharmacology. 2013;92(3-4):191–7. doi:10.1159/000354579. PMID:24080610.
   PubMed Web of Science ®Google Scholar
• Kontaki E, Boumpas DT, Tzardi M, Mouzas IA, Papadakis KA, Verginis P. Aberrant function of myeloid-derived suppressor cells (MDSCs) in experimental colitis and in inflammatory bowel disease (IBD) immune responses. Autoimmunity. 2017;50(3):170–81. doi:10.1080/08916934.2017.1283405. PMID:28276713.
   PubMed Web of Science ®Google Scholar
• Ma N, Liu Q, Hou L, Wang Y, Liu Z. MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer. Int J Immunopathol Pharmacol. 2017;30(2):152–62. doi:10.1177/0394632017711055. PMID:28534709.
   PubMed Web of Science ®Google Scholar
• Sharifi MN, Mowers EE, Drake LE, Macleod KF. Measuring autophagy in stressed cells. Methods Mol Biol. 2015;1292:129–50. doi:10.1007/978-1-4939-2522-3_10. PMID:25804753.
   PubMedGoogle Scholar
• Han F, Zhang H, Xia X, Xiong H, Song D, Zong X, Wang Y. Porcine β-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol. 2015;194(4):1882–93. doi:10.4049/jimmunol.1402300. PMID:25601921.
   PubMed Web of Science ®Google Scholar
• Volmer R, van der Ploeg K, Ron D. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci USA. 2013;110(12):4628–33. doi:10.1073/pnas.1217611110. PMID:23487760
   PubMed Web of Science ®Google Scholar
• George Z, Omosun Y, Azenabor AA, Partin J, Joseph K, Ellerson D, He Q, Eko F, Bandea C, Svoboda P, et al. The roles of unfolded protein response pathways in chlamydia pathogenesis. J Infect Dis. 2017;215(3):456–65. PMID:27932618.
   PubMed Web of Science ®Google Scholar
• Meidenbauer JJ, Ta N, Seyfried TN. Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice. Nutr Metab (Lond). 2014;11:23. doi:10.1186/1743-7075-11-23. PMID:24910707.
   PubMed Web of Science ®Google Scholar
• Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69(2):238–49. PMID:8350599.
   PubMed Web of Science ®Google Scholar