Upregulation of microRNA-129-5p inhibits cell invasion, migration and tumor angiogenesis by inhibiting ZIC2 via downregulation of the Hedgehog signaling pathway in cervical cancer

References

• Banno K, Iida M, Yanokura M, Kisu I, Iwata T, Tominaga E, Tanaka K, Aoki D. MicroRNA in cervical cancer: oncomiRs and tumor suppressor miRs in diagnosis and treatment. Sci World J. 2014;2014:.1–8. doi:10.1155/2014/178075.
   Google Scholar
• Zhang W, Ou J, Lei F, Hou T, Wu S, Niu C, Xu L, Zhang Y. C14ORF166 overexpression is associated with pelvic lymph node metastasis and poor prognosis in uterine cervical cancer. Tumour Biol. 2016;37(1):369–379. doi:10.1007/s13277-015-3806-3.
   PubMedGoogle Scholar
• Parkhurst JO, Vulimiri M. Cervical cancer and the global health agenda: insights from multiple policy-analysis frameworks. Glob Public Health. 2013;8(10):1093–1108. doi:10.1080/17441692.2013.850524.
   PubMed Web of Science ®Google Scholar
• Di J, Rutherford S, Chu C. Review of the Cervical Cancer Burden and Population-Based Cervical Cancer Screening in China. Asian Pac J Cancer Prev. 2015;16(17):7401–7407.
   PubMedGoogle Scholar
• Fan Z, Cui H, Xu X, Lin Z, Zhang X, Kang L, Han B, Meng J, Yan Z, Yan X, et al. MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3. Oncotarget. 2015; 6(28): 25266–25280. doi:10.18632/oncotarget.4457.
   PubMedGoogle Scholar
• Liu P, Xin F, Ma CF. Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer. Genet Mol Res. 2015;14(4):17995–18002. doi:10.4238/2015.December.22.25.
   PubMed Web of Science ®Google Scholar
• Li M, Tian L, Wang L, Yao H, Zhang J, Lu J, Sun Y, Gao X, Xiao H, Liu M. Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC. PLoS One. 2013;8(10):e77829. doi:10.1371/journal.pone.0077829.
   PubMed Web of Science ®Google Scholar
• Chan DW, Liu VW, Leung LY, Yao KM, Chan KK, Cheung AN, Ngan HY. Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells. J Pathol. 2011;225(4):525–534. doi:10.1002/path.2901.
   PubMed Web of Science ®Google Scholar
• Karaayvaz M, Zhai H, Ju J. miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. Cell Death Dis. 2013;4:.e659–e659. doi:10.1038/cddis.2013.193.
   PubMed Web of Science ®Google Scholar
• Yu Y, Zhao Y, Sun XH, Ge J, Zhang B, Wang X, Cao XC. Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer. Oncotarget. 2015;6(33):34423–34436. doi:10.18632/oncotarget.5406.
   PubMedGoogle Scholar
• Tan G, Cao X, Dai Q, Zhang B, Huang J, Xiong S, Zhang Y, Chen W, Yang J, Li H. A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. Oncotarget. 2015;6(11):8676–8686. doi:10.18632/oncotarget.3254.
   PubMedGoogle Scholar
• Inaguma S, Ito H, Riku M, Ikeda H, Kasai K. Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget. 2015;6(29):28257–28268. doi:10.18632/oncotarget.4960.
   PubMedGoogle Scholar
• Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D’Incalci M, Erba E, et al. The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer. Clin Cancer Res. 2012; 18(16): 4313–4324. doi:10.1158/1078-0432.CCR-12-0037.
   PubMed Web of Science ®Google Scholar
• Tewari KS, Sill MW, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, et al. Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240). Lancet. 2017; doi:10.1016/S0140-6736(17)31607-0.
   Google Scholar
• Ciavattini A, Sopracordevole F, Di Giuseppe J, Moriconi L, Lucarini G, Mancioli F, Zizzi A, Goteri G. Cervical intraepithelial neoplasia in pregnancy: interference of pregnancy status with p16 and Ki-67 protein expression. Oncol Lett. 2017;13(1):301–306. doi:10.3892/ol.2016.5441.
   PubMed Web of Science ®Google Scholar
• Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis–correlation in invasive breast carcinoma. N Engl J Med. 1991;324(1):1–8. doi:10.1056/NEJM199101033240101.
   PubMed Web of Science ®Google Scholar
• Du PL, Wu KS, Fang JY, Zeng Y, Xu ZX, Tang WR, Xu XL, Lin K. Cervical Cancer Mortality Trends in China, 1991-2013, and Predictions for the Future. Asian Pac J Cancer Prev. 2015;16(15):6391–6396.
   PubMedGoogle Scholar
• Chandra V, Das T, Gulati P, Biswas NK, Rote S, Chatterjee U, Ghosh SN, Deb S, Saha SK, Chowdhury AK, et al. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters. PLoS One. 2015; 10(3): e0116390. doi:10.1371/journal.pone.0116390.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li S, Yan Q, Chen X, Yang Y, Liu X, Wan X. Interferon-beta induced microRNA-129-5p down-regulates HPV-18 E6 and E7 viral gene expression by targeting SP1 in cervical cancer cells. PLoS One. 2013;8(12):e81366. doi:10.1371/journal.pone.0081366.
   PubMed Web of Science ®Google Scholar
• Xue J, Niu J, Wu J, Wu ZH. MicroRNAs in cancer therapeutic response: friend and foe. World J Clin Oncol. 2014;5(4):730–743. doi:10.5306/wjco.v5.i4.730.
   PubMedGoogle Scholar
• Qi L, Xing LN, Wei X, Song SG. Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer. Genet Mol Res. 2014;13(3):5094,5106. doi:10.4238/2014.July.7.2.
   Web of Science ®Google Scholar
• Guo W, Yi X, Ren F, Liu L, Wu S, Yang J. Activation of SHH signaling pathway promotes vasculogenesis in post-myocardial ischemic-reperfusion injury. Int J Clin Exp Pathol. 2015;8(10):12464–12472.
   PubMed Web of Science ®Google Scholar
• Lee JS, Park YS, Kwon JT, Nam TK, Lee TJ, Kim JK. Radiological apoplexy and its correlation with acute clinical presentation, angiogenesis and tumor microvascular density in pituitary adenomas. J Korean Neurosurg Soc. 2011;50(4):281–287. doi:10.3340/jkns.2011.50.4.281.
   PubMed Web of Science ®Google Scholar
• Liu Y, Hei Y, Shu Q, Dong J, Gao Y, Fu H, Zheng X, Yang G. VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma. PLoS One. 2012;7(4):e35800. doi:10.1371/journal.pone.0035800.
   PubMed Web of Science ®Google Scholar
• Chen H, Wang J, Yang H, Chen D, Li P. Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis. Oncol Lett. 2016;12(4):2664–2673. doi:10.3892/ol.2016.4932.
   PubMed Web of Science ®Google Scholar
• Marechal R, Bachet JB, Calomme A, Demetter P, Delpero JR, Svrcek M, Cros J, Bardier-Dupas A, Puleo F, Monges G, et al. Sonic hedgehog and Gli1 expression predict outcome in resected pancreatic adenocarcinoma. Clin Cancer Res. 2015; 21(5): 1215–1224. doi:10.1158/1078-0432.CCR-14-0667.
   PubMed Web of Science ®Google Scholar
• Shen ZH, Zhao KM, Du T. HOXA10 promotes nasopharyngeal carcinoma cell proliferation and invasion via inducing the expression of ZIC2. Eur Rev Med Pharmacol Sci. 2017;21(5):945–952.
   PubMed Web of Science ®Google Scholar