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Research Paper

CRMP4a suppresses cell motility by sequestering RhoA activity in prostate cancer cells

, , , , , , , , , & ORCID Icon show all
Pages 1193-1203 | Received 23 Apr 2018, Accepted 17 Jun 2018, Published online: 06 Aug 2018

References

  • Steeg PS. 2016. Targeting metastasis. Nat Rev Cancer. 16:201–218. doi:10.1038/nrc.2016.25.
  • Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17:302–317. doi:10.1038/nrc.2017.6.
  • Jansen S, Gosens R, Wieland T, Schmidt M. 2018. Paving the Rho in cancer metastasis: rho GTPases and beyond. Pharmacol Ther. 183:1–21. doi:10.1016/j.pharmthera.2017.09.002.
  • Nagai J, Baba R, Ohshima T. 2017. CRMPs Function in Neurons and Glial Cells: potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury. Mol Neurobiol. 54:4243–4256. doi:10.1007/s12035-016-0005-1.
  • Rosslenbroich V, Dai L, Baader SL, Noegel AA, Gieselmann V, Kappler J. 2005. Collapsin response mediator protein-4 regulates F-actin bundling. Exp Cell Res. 310:434–444. doi:10.1016/j.yexcr.2005.08.005.
  • Alabed YZ, Pool M, Ong Tone S, Fournier AE. 2007. Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition. J Neurosci. 27:1702–1711. doi:10.1523/JNEUROSCI.5055-06.2007.
  • Tan F, Thiele CJ, Li Z. 2014. Collapsin response mediator proteins: potential diagnostic and prognostic biomarkers in cancers (Review). Oncol Lett. 7:1333–1340. doi:10.3892/ol.2014.1909.
  • Gao X, Pang J, Li LY, Liu WP, Di JM, Sun QP, Fang YQ, Liu XP, Pu XY, He D, et al. Expression profiling identifies new function of collapsin response mediator protein 4 as a metastasis-suppressor in prostate cancer. Oncogene. 2010;29:4555–4566. doi:10.1038/onc.2010.213.
  • Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, et al. Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Oncotarget. 2016;7:22893–22910. doi:10.18632/oncotarget.8290.
  • Li K, Pang J, Cheng H, Liu WP, Di JM, Xiao HJ, Luo Y, Zhang H, Huang WT, Chen MK, et al. Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase. Oncotarget. 2015;6:10030–10044. doi:10.18632/oncotarget.3192.
  • Zhou W, Xie P, Pang M, Yang B, Fang Y, Shu T, Liu C, Wang X, Zhang L, et al. Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model. Int J Oncol. 2015;46:290–298. doi:10.3892/ijo.2014.2705.
  • Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, et al. Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. J Biol Chem. 2014;289:30133–30143. doi:10.1074/jbc.M114.570440.
  • Havel LS, Kline ER, Salgueiro AM, Marcus AI. 2015. Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity. Oncogene. 34:1979–1990. doi:10.1038/onc.2014.123.
  • Liao X, Thrasher JB, Holzbeierlein J, Stanley S, Li B. 2004. Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer. Endocrinology. 145:2941–2949. doi:10.1210/en.2003-1519.
  • Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M, Madsen CD, Caley MP, et al. miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res. 2013;41:5400–5412. doi:10.1093/nar/gkt245.
  • Steffen A, Stradal TE, Rottner K. 2017. Signalling Pathways Controlling Cellular Actin Organization. Handb Exp Pharmacol. 235:153–178. doi:10.1007/164_2016_35.
  • Rottner K, Faix J, Bogdan S, Linder S, Kerkhoff E. 2017. Actin assembly mechanisms at a glance. J Cell Sci. 130:3427–3435. doi:10.1242/jcs.206433.
  • Narumiya S, Tanji M, Ishizaki T. 2009. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev. 28:65–76. doi:10.1007/s10555-008-9170-7.
  • Haga RB, Ridley AJ. 2016. Rho GTPases: regulation and roles in cancer cell biology. Small GTPases. 7:207–221. doi:10.1080/21541248.2016.1232583.
  • Ridley AJ. 2015. Rho GTPase signalling in cell migration. Curr Opin Cell Biol. 36:103–112. doi:10.1016/j.ceb.2015.08.005.
  • Cuvelier D, Thery M, Chu YS, Dufour S, Thiery JP, Bornens M, Nassoy P, Mahadevan L. The universal dynamics of cell spreading. Curr Biol. 2007;17:694–699. doi:10.1016/j.cub.2007.02.058.
  • Gao X, Li LY, Rassler J, Pang J, Chen MK, Liu WP, Chen Z, Ren SC, Zhou FJ, Xie KJ, et al. Prospective Study of CRMP4 Promoter Methylation in Prostate Biopsies as a Predictor For Lymph Node Metastases. J Natl Cancer Inst. 2017;109(6):djw282.
  • Huang QX, Xiao CT, Chen Z, Lu MH, Pang J, Di JM, Luo ZH, Gao X. Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients. Asian J Androl. 2018;20:56–61. doi:10.4103/aja.aja_3_17.
  • Gao X, Mao YH, Xiao C, Li K, Liu W, Li LY, Pang J. Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-kappaB/DNMT1 signaling pathway. Prostate. 2018. doi:10.1002/pros.23512.
  • Yoneda A, Morgan-Fisher M, Wait R, Couchman JR, Wewer UM. 2012. A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol. 32:1788–1804. doi:10.1128/MCB.06235-11.
  • Leung T, Ng Y, Cheong A, Ng CH, Tan I, Hall C, Lim L. p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. FEBS Lett. 2002;532:445–449.
  • Morgan-Fisher M, Couchman JR, Yoneda A. 2013. Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. J Biol Chem. 288:31229–31240. doi:10.1074/jbc.M113.505602.
  • Arimura N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y, Kaibuchi K. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for Two Separate Signaling Pathways for Growth Cone Collapse. J Biol Chem. 2000;275:23973–23980.
  • Arimura N, Menager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, et al. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol. 2005;25:9973–9984. doi:10.1128/MCB.25.22.9973-9984.2005.

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