1,765
Views
21
CrossRef citations to date
0
Altmetric
Research Paper

Effects of high fat diet-induced obesity on mammary tumorigenesis in the PyMT/MMTV murine model

, , , , , , , , & show all
Pages 487-496 | Received 26 Jan 2018, Accepted 15 Oct 2018, Published online: 02 Nov 2018

References

  • Berstad P, Coates RJ, Bernstein L, Folger SG, Malone KE, Marchbanks PA, Weiss LK, Liff JM, McDonald JA, Strom BL, et al. A case-control study of body mass index and breast cancer risk in white and African-American women. Cancer Epidemiol Biomarkers Prev. 2010;19:1532–1544. doi:10.1158/1055-9965.EPI-10-0025.
  • Cheraghi Z, Poorolajal J, Hashem T, Esmailnasab N, Doosti Irani A. Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis. PLoS One. 2012;7:e51446. doi:10.1371/journal.pone.0051446.
  • Anderson GL, Neuhouser ML. Obesity and the risk for premenopausal and postmenopausal breast cancer. Cancer Prev Res (Phila). 2012;5:515–521. doi:10.1158/1940-6207.CAPR-12-0091.
  • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569–578. doi:10.1016/S0140-6736(08)60269-X.
  • Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010;15:556–565. doi:10.1634/theoncologist.2009-0285.
  • Nagrani R, Mhatre S, Rajaraman P, Soerjomataram I, Boffetta P, Gupta S, Parmar V, Badwe R, Dikshit R. Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of South Asian Ethnicity. Eur J Cancer. 2016;66:153–161. doi:10.1016/j.ejca.2016.07.022.
  • Schapira DV, Kumar NB, Lyman GH, Cox CE. Obesity and body fat distribution and breast cancer prognosis. Cancer. 1991;67:523–528.
  • Schapira DV, Kumar NB, Lyman GH. Obesity, body fat distribution, and sex hormones in breast cancer patients. Cancer. 1991;67:2215–2218.
  • Chang S, Buzdar AU, Hursting SD. Inflammatory breast cancer and body mass index. J Clin Oncol. 1998;16:3731–3735. doi:10.1200/JCO.1998.16.12.3731.
  • Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1686–1691. doi:10.1158/1055-9965.EPI-05-0042.
  • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579–591. doi:10.1038/nrc1408.
  • Patterson RE, Cadmus LA, Emond JA, Pierce JP. Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. Maturitas. 2010;66:5–15. doi:10.1016/j.maturitas.2010.01.004.
  • Brown KA, Simpson ER. Obesity and breast cancer: progress to understanding the relationship. Cancer Res. 2010;70:4–7. doi:10.1158/0008-5472.CAN-09-2257.
  • Cleary MP, Grossmann ME, Ray A. Effect of obesity on breast cancer development. Vet Pathol. 2010;47:202–213. doi:10.1177/0300985809357753.
  • Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat. 2010;123:627–635.
  • Hellmann SS, Thygesen LC, Tolstrup JS, Gronbaek M. Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Eur J Cancer Prev. 2010;19:366–373. doi:10.1097/CEJ.0b013e32833b4828.
  • Stark A, Stahl MS, Kirchner HL, Krum S, Prichard J, Evans J. Body mass index at the time of diagnosis and the risk of advanced stages and poorly differentiated cancers of the breast: findings from a case-series study. Int J Obes (Lond). 2010;34:1381–1386.
  • Simpson ER, Brown KA. Minireview: obesity and breast cancer: a tale of inflammation and dysregulated metabolism. Mol Endocrinol. 2013;27:715–725. doi:10.1210/me.2013-1011.
  • Nunez NP, Perkins SN, Smith NC, Berrigan D, Berendes DM, Varticovski L, Barrett JC, Hursting SD. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer. 2008;60:534–541. doi:10.1080/01635580801966195.
  • Nkhata KJ, Ray A, Dogan S, Grande JP, Cleary MP. Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements. Breast Cancer Res Treat. 2009;114:71–83. doi:10.1007/s10549-008-9991-7.
  • Ray A, Nkhata KJ, Grande JP, Cleary MP. Diet-induced obesity and mammary tumor development in relation to estrogen receptor status. Cancer Lett. 2007;253:291–300. doi:10.1016/j.canlet.2007.02.005.
  • Cleary MP, Hu X, Grossmann ME, Juneja SC, Dogan S, Grande JP, Maihle NJ. Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Exp Biol Med (Maywood). 2007;232:70–80.
  • Krishnan K, Bassett JK, Macinnis RJ, English DR, Hopper JL, McLean C, Giles GG, Baglietto L. Associations between weight in early adulthood, change in weight and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2013;22:1409–1416.
  • Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011;4:329–346. doi:10.1158/1940-6207.CAPR-10-0381.
  • Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, et al. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila). 2011;4:1021–1029. doi:10.1158/1940-6207.CAPR-11-0110.
  • Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012;2:356–365. doi:10.1158/2159-8290.CD-11-0241.
  • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, Pollard JW. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol. 2003;163:2113–2126. doi:10.1016/S0002-9440(10)63568-7.
  • Amaral P, Miguel R, Mehdad A, Cruz C, Monteiro Grillo I, Camilo M, Ravasco P. Body fat and poor diet in breast cancer women. Nutr Hosp. 2010;25:456–461.
  • Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010;15:556–565. doi:10.1634/theoncologist.2009-0285.
  • Dirat B, Bochet L, Escourrou G, Valet P, Muller C. Unraveling the obesity and breast cancer links: a role for cancer-associated adipocytes? Endocr Dev. 2010;19:45–52.
  • Nagaiah G, Hazard HW, Abraham J. Role of obesity and exercise in breast cancer survivors. Oncology (Williston Park). 2010;24:342–346.
  • Baer HJ, Tworoger SS, Hankinson SE, Willett WC. Body fatness at young ages and risk of breast cancer throughout life. Am J Epidemiol. 2010;171:1183–1194. doi:10.1093/aje/kwq045.
  • Maccio A, Madeddu C, Gramignano G, Mulas C, Floris C, MassaD, Astara G, Chessa P, Mantovani G. Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications. J Mol Med. 2010;88:677–686. doi:10.1007/s00109-010-0611-8.
  • Chen X, Lu W, Zheng W, Gu K, Chen Z, Zheng Y, Shu XO. Obesity and weight change in relation to breast cancer survival. Breast Cancer Res Treat. 2010;122:823–833. doi:10.1007/s10549-009-0708-3.
  • Malin A, Matthews CE, Shu XO, Cai H, Dai Q, Jin F, Gao YT, Zheng W. Energy balance and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:1496–1501. doi:10.1158/1055-9965.EPI-04-0880.
  • Thomson CA, Thompson PA. Dietary patterns, risk and prognosis of breast cancer. Future Oncol. 2009;5:1257–1269. doi:10.2217/fon.09.86.
  • Brown KA, Simpson ER. Obesity and breast cancer: mechanisms and therapeutic implications. Front Biosci (Elite Ed). 2012;4:2515–2524.
  • Gross A, Newschaffer CJ, Hoffman Bolton JA, Rifai N, Visvanathan K. Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: A prospective study. Cancer Epidemiol Biomarkers Prev. 2013;22:1319–1324.
  • Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C, Jones M. Aromatase–a brief overview. Annu Rev Physiol. 2002;64:93–127. doi:10.1146/annurev.physiol.64.081601.142703.
  • Simpson ER, Brown KA. Obesity and breast cancer: role of inflammation and aromatase. J Mol Endocrinol. 2013;51:T51–9. doi:10.1530/JME-13-0217.
  • Bowers LW, Brenner AJ, Hursting SD, Tekmal RR, deGraffenried LA. Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production. Breast Cancer Res Treat. 2015;149:49–57. doi:10.1007/s10549-014-3223-0.
  • McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar-Rahmani Y, Modugno F, Perri MG, Stanczyk FZ, Van Horn L, Wang CY. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity (Silver Spring). 2006;14:1662–1677. doi:10.1038/oby.2006.191.
  • Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A. History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev. 2009;30:343–375. doi:10.1210/er.2008-0016.
  • Bocchinfuso WP, Korach KS. Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia. 1997;2:323–334.
  • Grotto D, Zied E. The Standard American Diet and its relationship to the health status of Americans. Nutr Clin Pract. 2010;25:603–612. doi:10.1177/0884533610386234.
  • Enos RT, Davis JM, Velazquez KT, McClellan JL, Day SD, Carnevale KA, Murphy EA. Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters. J Lipid Res. 2013;54:152–163. doi:10.1194/jlr.M030700.
  • Warden CH, Fisler JS. Comparisons of diets used in animal models of high-fat feeding. Cell Metab. 2008;7:277. doi:10.1016/j.cmet.2008.03.014.
  • Steiner J, Davis J, McClellan J, Enos R, Carson J, Fayad R, Nagarkatti M, Nagarkatti P, Altomare D, Creek K, et al. Dose-dependent benefits of quercetin on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer. Cancer Biol Ther. 2014;15:1456–1467. doi:10.4161/15384047.2014.955444.
  • EZNA Total RNA Kit II Manual. 2015. Accessed 2016 Oct 27 http://omegabiotek.com/store/wp-content/uploads/2013/09/R6934-Total-RNA-Kit-II-Combo-Online1.pdf
  • Enos RT, Velazquez KT, McClellan JL, Cranford TL, Walla MD, Murphy EA. Lowering the dietary omega-6: omega-3 does not hinder nonalcoholic fatty-liver disease development in a murine model. Nutr Res. 2015;35:449–459. doi:10.1016/j.nutres.2015.04.003.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.