Knockdown of FOXP1 promotes the development of lung adenocarcinoma

References

• Siegel R, Ma J, Zou Z, Jemal A Cancer statistics. CA Cancer J Clin 2014; 64(1):9–29. doi:10.3322/caac.21208
   PubMed Web of Science ®Google Scholar
• Read WL, Page NC, Tierney RM, Piccirillo JF, Govindan R The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database. Lung Cancer 2004; 45(2):137–142. doi:10.1016/j.lungcan.2004.01.019
   PubMed Web of Science ®Google Scholar
• Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 2001; 15(24):3243–3248. doi:10.1101/gad.943001
   PubMed Web of Science ®Google Scholar
• Liu J, Cho SN, Akkanti B, Jin N, Mao J, Long W, Chen T, Zhang Y, Tang X, Wistub II, et al. ErbB2 Pathway activation upon Smad4 loss promotes lung tumor growth and metastasis. Cell Rep 2015; 10(9):1599–1613. doi:10.1016/j.celrep.2015.02.014
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014; 511(7511):543–550. doi:10.1038/nature13385
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research N. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012; 489(7417):519–525. doi:10.1038/nature11404
   PubMed Web of Science ®Google Scholar
• Liu J, Cho SN, Wu SP, Jin N, Moghaddam SJ, Gilbert JL, Wistuba I, DeMayo FJ Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis. Lung Cancer 2017; 112:47–56. doi:10.1016/j.lungcan.2017.08.001
   PubMed Web of Science ®Google Scholar
• Lam EW, Brosens JJ, Gomes AR, Koo CY Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer 2013; 13(7):482–495. doi:10.1038/nrc3539
   PubMed Web of Science ®Google Scholar
• Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A T(3;4)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia 2005; 19(4):652–658. doi:10.1038/sj.leu.2403644
   PubMed Web of Science ®Google Scholar
• Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G, Farinha P, Horsman DE, Gascoyne RD Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res 2005; 11(3):1065–1072.
   PubMed Web of Science ®Google Scholar
• Qiu DP, Han F, Zhuang H, Li QJ, Zhang XZ Overexpression of FoxP1 is a novel biomarker of malignant human pancreatic cancer. Int J Clin Exp Med 2016; 9(6):9054–9063.
   Web of Science ®Google Scholar
• Flori M, Schmid CA, Sumrall ET, Tzankov A, Law CW, Robinson MD, Muller A The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood 2016; 127(11):1438–1448. doi:10.1182/blood-2015-08662635
   PubMed Web of Science ®Google Scholar
• Feng J, Zhang XS, Zhu HJ, Wang XD, Ni SS, Huang JF High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer. Am J Clin Pathol 2012; 138(2):230–235. doi:10.1309/Ajcpdhqfnyjz01yg
   PubMed Web of Science ®Google Scholar
• Choi EJ, Seo EJ, Kim DK, Lee SI, Kwon YW, Jang IH, Kim KH, Suh DS, Kim JH FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells. Oncotarget 2016; 7(3):3496–3509. doi:10.18632/oncotarget.6510
   Google Scholar
• Shu WG, Lu MM, Zhang YZ, Tucker PW, Zhou DY, Morrisey EE Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development 2007; 134(10):1991–2000. doi:10.1242/dev.02846
   PubMed Web of Science ®Google Scholar
• Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A 2001; 98(24):13784–13789. doi:10.1073/pnas.241500798
   PubMed Web of Science ®Google Scholar
• Hou J, Aerts J, Den Hamer B, van Ijcken W, Den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al. Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One 2010; 5(4):e10312. doi:10.1371/journal.pone.0010312
   PubMed Web of Science ®Google Scholar
• Wei TYW, Juan CC, Hisa JY, Su LJ, Lee YCG, Chou HY, Chen JMM, Wu YC, Chiu SC, Hsu CP, et al. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci 2012; 103(9):1640–1650. doi:10.1111/j.1349-7006.2012.02367.x
   PubMed Web of Science ®Google Scholar
• Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008; 455(7216):1069–1075. doi:10.1038/nature07423
   PubMed Web of Science ®Google Scholar
• Rivas-Fuentes S, Salgado-Aguayo A, Pertuz Belloso S, Gorocica Rosete P, Alvarado-Vasquez N, Aquino-Jarquin G Role of chemokines in non-small cell lung cancer: angiogenesis and inflammation. J Cancer 2015; 6(10):938–952. doi:10.7150/jca.12286
   PubMed Web of Science ®Google Scholar
• Arenberg D Chemokines in the biology of lung cancer. J Thorac Oncol 2006; 1(4):287–288. doi:10.1016/S1556-0864(15)31582-3
   PubMed Web of Science ®Google Scholar
• Wang CL, Sun BS, Tang Y, Zhuang HQ, Cao WZ CCR1 knockdown suppresses human non-small cell lung cancer cell invasion. J Cancer Res Clin Oncol 2009; 135(5):695–701. doi:10.1007/s00432-008-0505-0
   PubMed Web of Science ®Google Scholar
• De Smedt L, Palmans S, Govaere O, Moisse M, Boeckx B, De Hertogh G, Prenen H, Van Cutsem E, Tejpar S, Tousseyn T, et al. Expression of FOXP1 and Colorectal Cancer Prognosis. Lab Med 2015; 46(4):299–311. doi:10.1309/LM7IHV2NJI1PHMXC
   PubMed Web of Science ®Google Scholar
• Carlsson P, Mahlapuu M Forkhead transcription factors: key players in development and metabolism. Dev Biol 2002; 250(1):1–23. doi:10.1006/dbio.2002.0780
   PubMed Web of Science ®Google Scholar
• Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, Butcher EC Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol 2006; 34(8):1021–10321. doi:10.1016/j.exphem.2006.05.003
   PubMed Web of Science ®Google Scholar
• Hembruff SL, Cheng N Chemokine signaling in cancer: implications on the tumor microenvironment and therapeutic targeting. Cancer Therapy 2009; 7:254–267.
   PubMedGoogle Scholar
• Sarvaiya PJ, Guo D, Ulasov I, Gabikian P, Lesniak MS Chemokines in tumor progression and metastasis. Oncotarget 2013; 4(12):2171–2185. doi:10.18632/oncotarget.1426
   PubMed Web of Science ®Google Scholar
• Gajewski TF, Schreiber H, Fu YX Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013; 14(10):1014–1022. doi:10.1038/ni.2703
   PubMed Web of Science ®Google Scholar
• Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A 2010; 107(29):13063–13068. doi:10.1073/pnas.1002372107
   PubMed Web of Science ®Google Scholar
• Rodero MP, Auvynet C, Poupel L, Combadiere B, Combadiere C Control of both myeloid cell infiltration and angiogenesis by CCR1 promotes liver cancer metastasis development in mice. Neoplasia 2013; 15(6):641–648. doi:10.1593/neo.121866
   PubMed Web of Science ®Google Scholar
• Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. Br J Cancer 2008; 98(2):410–417. doi:10.1038/sj.bjc.6604124
   PubMed Web of Science ®Google Scholar
• Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. Biochem Biophys Res Commun 1998; 246(1):205–209. doi:10.1006/bbrc.1998.8581
   PubMed Web of Science ®Google Scholar
• Movilla N, Bustelo XR Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol 1999; 19(11):7870–7885. doi:10.1128/MCB.19.11.7870
   PubMed Web of Science ®Google Scholar
• Citterio C, Menacho-Marquez M, Garcia-Escudero R, Larive RM, Barreiro O, Sanchez-Madrid F, Paramio JM, Bustelo XR The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal 2012; 5(244):ra71. doi:10.1126/scisignal.2002962
   PubMed Web of Science ®Google Scholar
• Menacho-Marquez M, Garcia-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcon B, Paramio JM, Bustelo XR The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol 2013; 11(7):e1001615. doi:10.1371/journal.pbio.1001615
   PubMed Web of Science ®Google Scholar
• Marques RB, Dits NF, Erkens-Schulze S, van Weerden WM, Jenster G Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models. PLoS One 2010; 5(10):e13500. doi:10.1371/journal.pone.0013500
   PubMed Web of Science ®Google Scholar
• Liu KC, Huang AC, Wu PP, Lin HY, Chueh FS, Yang JS, Lu CC, Chiang JH, Meng M, Chung JG Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and −9 signaling pathways. Oncol Rep 2011; 26(1):177–184. doi:10.3892/or.2011.1264
   PubMed Web of Science ®Google Scholar
• Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ, Pachter L Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010; 28(5):511–515. doi:10.1038/nbt.1621
   PubMed Web of Science ®Google Scholar
• Tavazoie S, Hughes JD, Campbell MJ, Cho RJ, Church GM Systematic determination of genetic network architecture. Nat Genet 1999; 22(3):281–285. doi:10.1038/10343
   PubMed Web of Science ®Google Scholar
• Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, et al. REGgamma modulates p53 activity by regulating its cellular localization. J Cell Sci 2010; 123(Pt 23):4076–4084. doi:10.1242/jcs.067405
   PubMed Web of Science ®Google Scholar