M2-like tumor-associated macrophages-secreted EGF promotes epithelial ovarian cancer metastasis via activating EGFR-ERK signaling and suppressing lncRNA LIMT expression

References

• Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer Biol Med. 2017;14:9–32. doi:10.20892/j.issn.2095-3941.2016.0084.
   PubMed Web of Science ®Google Scholar
• Goff BA. Advanced ovarian cancer: what should be the standard of care? J Gynecol Oncol. 2013;24:83–91. doi:10.3802/jgo.2013.24.1.83.
   PubMed Web of Science ®Google Scholar
• Testa U, Petrucci E, Pasquini L, Castelli G, Pelosi E. Ovarian cancers: genetic abnormalities, tumor heterogeneity and progression, clonal evolution and cancer stem cells. Medicines (Basel). 2018;5:16. doi: 10.3390/medicines5010016.
   PubMedGoogle Scholar
• Sadikovic B, Al-Romaih K, Squire JA, Zielenska M. Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics. 2008;9:394–408. doi:10.2174/138920208785699580.
   PubMed Web of Science ®Google Scholar
• Ghoneum A, Afify H, Salih Z, Kelly M, Said N. Role of tumor microenvironment in ovarian cancer pathobiology. Oncotarget. 2018;9:22832–22849. doi:10.18632/oncotarget.25126.
   PubMedGoogle Scholar
• Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423–1437. doi:10.1038/nm.3394.
   PubMed Web of Science ®Google Scholar
• Fujimura T, Kambayashi Y, Fujisawa Y, Hidaka T, Aiba S. Tumor-associated macrophages: therapeutic targets for skin cancer. Front Oncol. 2018;8:3. doi:10.3389/fonc.2018.00003.
   PubMed Web of Science ®Google Scholar
• Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 2014;6:13. doi:10.12703/P.
   PubMedGoogle Scholar
• Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, et al. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Invest. 2016;126:4157–4173. doi:10.1172/JCI87252.
   PubMed Web of Science ®Google Scholar
• Ke X, Zhang S, Wu M, Lou J, Zhang J, Xu T, Huang L, Huang P, Wang F, Pan S. Tumor-associated macrophages promote invasion via Toll-like receptors signaling in patients with ovarian cancer. Int Immunopharmacol. 2016;40:184–195. doi:10.1016/j.intimp.2016.08.029.
   PubMed Web of Science ®Google Scholar
• Kung JT, Colognori D, Lee JT. Long noncoding RNAs: past, present, and future. Genetics. 2013;193:651–669. doi:10.1534/genetics.112.146704.
   PubMed Web of Science ®Google Scholar
• Li Y, Li W, Liang B, Li L, Wang L, Huang H, Guo S, Wang Y, He Y, Chen L, et al. Identification of cancer risk lncRNAs and cancer risk pathways regulated by cancer risk lncRNAs based on genome sequencing data in human cancers. Sci Rep. 2016;6:39294. doi:10.1038/srep39294.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yu X, Xu Y, Shen H. Identification of dysregulated lncRNAs profiling and metastasis-associated lncRNAs in colorectal cancer by genome-wide analysis. Cancer Med. 2017;6:2321–2330. doi:10.1002/cam4.1168.
   PubMed Web of Science ®Google Scholar
• Gao Y, Meng H, Liu S, Hu J, Zhang Y, Jiao T, Liu Y, Ou J, Wang D, Yao L, et al. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. Hum Mol Genet. 2015;24:841–852. doi:10.1093/hmg/ddu502.
   PubMed Web of Science ®Google Scholar
• Qiu JJ, Wang Y, Ding JX, Jin HY, Yang G, Hua KQ. The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis. Exp Cell Res. 2015;333:238–248. doi:10.1016/j.yexcr.2015.03.005.
   PubMed Web of Science ®Google Scholar
• Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Körner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, et al. LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Mol Med. 2016;8:1052–1064. doi:10.15252/emmm.201606198.
   PubMed Web of Science ®Google Scholar
• Chanput W, Mes JJ, Wichers HJ. THP-1 cell line: an in vitro cell model for immune modulation approach. Int Immunopharmacol. 2014;23:37–45. doi:10.1016/j.intimp.2014.08.002.
   PubMed Web of Science ®Google Scholar
• Colvin EK. Tumor-associated macrophages contribute to tumor progression in ovarian cancer. Front Oncol. 2014;4:137. doi:10.3389/fonc.2014.00137.
   PubMedGoogle Scholar
• Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M. Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors. Pathol Int. 2009;59:300–305. doi:10.1111/j.1440-1827.2009.02369.x.
   PubMed Web of Science ®Google Scholar
• Barros MH, Hauck F, Dreyer JH, Kempkes B, Niedobitek G. Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages. PLoS One. 2013;8:e80908. doi:10.1371/journal.pone.0080908.
   PubMed Web of Science ®Google Scholar
• Zhang M, He Y, Sun X, Li Q, Wang W, Zhao A, Di W. A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients. J Ovarian Res. 2014;7:19. doi:10.1186/1757-2215-7-19.
   PubMed Web of Science ®Google Scholar
• Pogge von Strandmann E, Reinartz S, Wager U, Muller R. Tumor-host cell interactions in ovarian cancer: pathways to therapy failure. Trends Cancer. 2017;3:137–148. doi:10.1016/j.trecan.2016.12.005.
   PubMed Web of Science ®Google Scholar
• Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, Klemm F, Pukrop T, Binder C, Balkwill FR. Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol. 2005;175:1197–1205.
   PubMed Web of Science ®Google Scholar
• Neyen C, Pluddemann A, Mukhopadhyay S, Maniati E, Bossard M, Gordon S, Hagemann T. Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. J Immunol. 2013;190:3798–3805. doi:10.4049/jimmunol.1203194.
   PubMed Web of Science ®Google Scholar
• Roche J. The epithelial-to-mesenchymal transition in cancer. Cancers (Basel). 2018;10. doi:10.3390/cancers10110400.
   Web of Science ®Google Scholar
• Kim DH, Xing T, Yang Z, Dudek R, Lu Q, Chen YH. Epithelial mesenchymal transition in embryonic development, tissue repair and cancer: A comprehensive overview. J Clin Med. 2017;7. doi:10.3390/jcm7010001.
   PubMed Web of Science ®Google Scholar
• van Zijl F, Krupitza G, Mikulits W. Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res. 2011;728:23–34. doi:10.1016/j.mrrev.2011.05.002.
   PubMed Web of Science ®Google Scholar
• Park GB, Ko HS, Kim D. Sorafenib controls the epithelialmesenchymal transition of ovarian cancer cells via EGF and the CD44HA signaling pathway in a cell typedependent manner. Mol Med Rep. 2017;16:1826–1836. doi:10.3892/mmr.2017.6773.
   PubMed Web of Science ®Google Scholar
• Wu L, Wang X, Guo Y. Long non-coding RNA MALAT1 is upregulated and involved in cell proliferation, migration and apoptosis in ovarian cancer. Exp Ther Med. 2017;13:3055–3060. doi:10.3892/etm.2017.4304.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Cheng J, Wu Y, Qiu J, Sun Y, Tong X. LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer. Mol Med Rep. 2016;14:2465–2472. doi:10.3892/mmr.2016.5572.
   PubMed Web of Science ®Google Scholar