759
Views
2
CrossRef citations to date
0
Altmetric
Research paper

DBDx-based drug combinations show highly potent therapeutic efficacy against human pancreatic cancer xenografts in athymic mice

, , , &
Pages 749-757 | Received 25 May 2019, Accepted 19 May 2020, Published online: 17 Jun 2020

References

  • Ilic M, Ilic I. 2016. Epidemiology of pancreatic cancer. World J Gastroenterol. 22:9694–9705. doi:10.3748/wjg.v22.i44.9694.
  • Mohammed A, Janakiram NB, Madka V, Li M, Asch AS, Rao CV. 2018. Current challenges and opportunities for chemoprevention of pancreatic cancer. Curr Med Chem. 25:2535–2544. doi:10.2174/0929867324666170209104453.
  • Tanase CP, Neagu AI, Necula LG, Mambet C, Enciu AM, Calenic B, Cruceru ML, Albulescu R. 2014. Cancer stem cells: involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics. World J Gastroenterol. 20:10790–10801. doi:10.3748/wjg.v20.i31.10790.
  • Teague A, Lim KH, Wang-Gillam A. 2015. Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies. Ther Adv Med Oncol. 7:68–84. doi:10.1177/1758834014564775.
  • Bittoni A, Andrikou K, Lanese A, Santoni M, Pellei C, Faloppi L, Del Prete M, Giampieri R, Cascinu S. 2015. Treatment of pancreatic cancer. Actuality and perspective. Recenti Prog Med. 106:208–216. doi:10.1701/1868.20404.
  • Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al. 2011. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. doi:10.1056/NEJMoa1011923.
  • Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al. 2013. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. doi:10.1056/NEJMoa1304369.
  • Liu XJ, Zheng YB, Li Y, Wu SY, Zhen YS. 2014. A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice. PLoS One. 9:e115790. doi:10.1371/journal.pone.0115790.
  • Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, et al. 1997. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 15:2403–2413. doi:10.1200/JCO.1997.15.6.2403.
  • Sidaway P. 2017. Pancreatic cancer: addition of capecitabine prolongs overall survival. Nat Rev Clin Oncol. 14:198. doi:10.1038/nrclinonc.2017.21.
  • Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, Harper PG, Dunn J, Tudur-Smith C, West J, et al. 2009. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol. 27:5513–5518. doi:10.1200/JCO.2009.24.2446.
  • Chung KH, Ryu JK, Son JH, Lee JW, Jang DK, Lee SH, Kim YT. 2017. Efficacy of capecitabine plus oxaliplatin combination chemotherapy for advanced pancreatic cancer after failure of first-Line gemcitabine-based therapy. Gut Liver. 11:298–305. doi:10.5009/gnl16307.
  • Cartwright TH, Cohn A, Varkey JA, Chen YM, Szatrowski TP, Cox JV, Schulz JJ. 2002. Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer. J Clin Oncol. 20:160–164. doi:10.1200/JCO.2002.20.1.160.
  • van den Borne P, Quax PH, Hoefer IE, Pasterkamp G. 2014. The multifaceted functions of CXCL10 in cardiovascular disease. Biomed Res Int. 2014:893106. doi:10.1155/2014/893106.
  • Lee EY, Lee ZH, Song YW. 2009. CXCL10 and autoimmune diseases. Autoimmun Rev. 8:379–383. doi:10.1016/j.autrev.2008.12.002.
  • Komai T, Okamura T, Yamamoto K, Fujio K. 2016. The effects of TGF-βs on immune responses. Nihon Rinsho Meneki Gakkai Kaishi. 39:51–58. doi:10.2177/jsci.39.51.
  • Hao S, Han X, Wang D, Yang Y, Li Q, Li X, Qiu CH. 2016. Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells. Immunology. 148:174–186. doi:10.1111/imm.12596.
  • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB 3rd. 2002. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern cooperative oncology group trial E2297. J Clin Oncol. 20:3270–3275. doi:10.1200/JCO.2002.11.149.
  • Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schönekäs H, Rost A, Neuhaus H, Haag C, Clemens M, Heinrich B, et al. 2006. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol. 24:3946–3952. doi:10.1200/JCO.2005.05.1490.
  • Zhang YD, Yang Q, Jiang ZM, Ma W, Zhou SW, Xie DR. Overall survival of patients with advanced pancreatic cancer improved with an increase in second-line chemotherapy after gemcitabine-based therapy. JOP. 2011;12:131–137.
  • Oberstein PE, Olive KP. 2013. Pancreatic cancer: why is it so hard to treat? Therap Adv Gastroenterol. 6:321–337. doi:10.1177/1756283X13478680.
  • Hoshi N, Kofunato Y, Yashima R, Shimura T, Takenoshita S. Treating side effects of FOLFIRINOX–A study of the effect of Hange-Shashin-To on preventing diarrhea. Gan To Kagaku Ryoho. 2015;42:2364–2366.
  • Kimbara S, Kondo S. 2016. Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma. World J Gastroenterol. 22:7440–7452. doi:10.3748/wjg.v22.i33.7440.
  • Yano A, Fujii Y, Iwai A, Kageyama Y, Kihara K. 2006. Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. Clin Cancer Res. 12:3003–3009. doi:10.1016/j.urolonc.2006.12.007.
  • Fan Z, Sehm T, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan NE. 2014. Dexamethasone alleviates tumor associated brain damage and angiogenesis. PLoS One. 9:e93264. doi:10.1371/journal.pone.0093264.
  • Aozuka Y, Koizumi K, Saitoh Y, Ueda Y, Sakurai H, Saiki I. 2004. Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16–BL6 melanoma cells orthotopically implanted into syngeneic mice. Cancer Lett. 216:35–42. doi:10.1016/j.canlet.2004.06.050.
  • Spano D, Marshall JC, Marino N, De Martino D, Romano A, Scoppettuolo MN, Bello AM, Di Dato V, Navas L, De Vita G, et al. 2013. Dipyridamole prevents triple-negative breast-cancer progression. Clin Exp Metastasis. 30:47–68. doi:10.1007/s10585-012-9506-0.
  • Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. 2016. Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. doi:10.3322/caac.21338.
  • Zheng YB, Gong JH, Liu XJ, Li Y, Zhen YS. 2017. A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis. Mol Carcinog. 56:1395–1404. doi:10.1002/mc.22600.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.