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Cancer Biology & Therapy Volume 21, 2020 - Issue 11
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Research Paper

FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells

Hongzhao Lua School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, ChinaCorrespondence[email protected]
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Meichen Yina School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, ChinaView further author information
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Ling Wanga School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, ChinaView further author information
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Jia Chenga School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, ChinaView further author information
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Wei Chengb Department of Cell Biology and Genetics, School of Basic Medical Sciences, Jiaotong University Health Center, Xi’an, Shaanxi, ChinaView further author information
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Huanping Anc Department of Pharmacy and Medical Technology, Hanzhong Vocational and Technical College, Hanzhong, Shaanxi, ChinaView further author information
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Tao Zhanga School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, ChinaView further author information
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Pages 1014-1024 | Received 11 Oct 2019, Accepted 28 Aug 2020, Published online: 16 Oct 2020

  • Romaszko A, Świetlik E, Doboszyńska A, Szpruch P, Luks J. Lung cancer and multiple neoplasms: a retrospective analysis. In: Pokorski M, editor. Advances in respiratory cancerogenesis. Cham: Springer International Publishing Switzerland; 2016: 53–58.
  • Vinod SK, Sidhom MA, Gabriel GS, Lee MT, Delaney GP. Why do some lung cancer patients receive no anticancer treatment? J Thoracic Oncol. 2010;5(7):1025–1032. doi:10.1097/JTO.0b013e3181da85e4.
  • Latimer KM. Lung cancer: clinical presentation and diagnosis. FP Essent. 2018;130:23–26.
  • Yu L, Toriseva M, Tuomala M, Seikkula H, Elo T, Tuomela J, Kallajoki M, Mirtti T, Taimen P, Bostrom PJ, et al. Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy. Int J Cancer. 2016;139:140–152. doi:10.1002/ijc.30048.
  • Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996;93:9850–9857. doi:10.1073/pnas.93.18.9850.
  • Kettunen P, Furmanek T, Chaulagain R, Kvinnsland IH, Luukko K. Developmentally regulated expression of intracellular Fgf11-13, hormone-like Fgf15 and canonical Fgf16, −17 and −20 mRNAs in the developing mouse molar tooth. Acta Odontol Scand. 2011;69:360–366.
  • Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 2003;278:34226–34236. doi:10.1074/jbc.M303183200.
  • Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors are intracellular signaling proteins. Current Biol CB. 2001;11(10):793–797. doi:10.1016/S0960-9822(01)00232-9.
  • Gecz J, Baker E, Donnelly A, Ming JE, McDonald-McGinn DM, Spinner NB, Zackai EH, Sutherland GR, Mulley JC. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. Hum Genet. 1999;104:56–63. doi:10.1007/s004390050910.
  • Goldfarb M. Fibroblast growth factor homologous factors: evolution, structure, and function. Cytokine Growth Factor Rev. 2005;16(2):215–220. doi:10.1016/j.cytogfr.2005.02.002.
  • Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, Giza J, Tchetchik D, Kelley K, Vega A, et al. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 2007;55(3):449–463. doi:10.1016/j.neuron.2007.07.006.
  • Wang C, Hennessey JA, Kirkton RD, Wang C, Bryson V, Rosenberg PB, Bursac N, Pitt GS. FGF13 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Biophys J. 2011;100(3):420a–1a. doi:10.1016/j.bpj.2010.12.2490.
  • Li J, Wang Q, Wang H, Wu Y, Yin J, Chen J, Zheng Z, Jiang T, Xie L, Wu F, et al. Lentivirus mediating FGF13 enhances axon regeneration after spinal cord injury by stabilizing microtubule and improving mitochondrial function. J Neurotrauma. 2018;35(3):548–559. doi:10.1089/neu.2017.5205.
  • Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X. Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012;149(7):1549–1564. doi:10.1016/j.cell.2012.04.046.
  • Bublik DR, Bursac S, Sheffer M, Orsolic I, Shalit T, Tarcic O, Kotler E, Mouhadeb O, Hoffman Y, Fuchs G, et al. Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival. Proc Natl Acad Sci U S A. 2017;114(4):E496–e505. doi:10.1073/pnas.1614876114.
  • Manfredi JJ. Tumor suppression by p53 involves inhibiting an enabler, FGF13. Proc Natl Acad Sci U S A. 2017;114(4):632–633. doi:10.1073/pnas.1619815114.
  • Missiaglia E, Dalai I, Barbi S, Beghelli S, Falconi M, Della Peruta M, Piemonti L, Capurso G, Di Florio A, Delle Fave G, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(2):245–255. doi:10.1200/JCO.2008.21.5988.
  • Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015;4:215–266.
  • Qu WS, Tian DS, Guo ZB, Fang J, Zhang Q, Yu ZY, Xie MJ, Zhang HQ, Lu JG, Wang W. Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury. J Neuroinflammation. 2012;9(1):178. doi:10.1186/1742-2094-9-178.
  • Peng C, Zhao H, Song Y, Chen W, Wang X, Liu X, Zhang C, Zhao J, Li J, Cheng G, et al. SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-beta1/Smad signaling pathway and is associated with poor prognosis. J Exp Clin Cancer Res CR. 2017;36(1):141. doi:10.1186/s13046-017-0616-z.
  • Kupershmidt I, Su QJ, Grewal A, Sundaresh S, Halperin I, Flynn J, Shekar M, Wang H, Park J, Cui W, et al. Ontology-based meta-analysis of global collections of high-throughput public data. PloS One. 2010;5(9): e13066.
  • Tao HC, Wang HX, Dai M, Gu CY, Wang Q, Han ZG, Cai B. Targeting SHCBP1 inhibits cell proliferation in human hepatocellular carcinoma cells. As Pacific J Cancer Prev APJCP. 2013;14(10):5645–5650. doi:10.7314/APJCP.2013.14.10.5645.
  • Zhou Y, Tan Z, Chen K, Wu W, Zhu J, Wu G, Cao L, Zhang X, Zeng X, Li J, et al. Overexpression of SHCBP1 promotes migration and invasion in gliomas by activating the NF-kappaB signaling pathway. Molecular Carcinogenesis. 2018;57:1181–1190.
  • Feng W, Li HC, Xu K, Chen YF, Pan LY, Mei Y, Cai H, Jiang YM, Chen T, Feng DX. SHCBP1 is over-expressed in breast cancer and is important in the proliferation and apoptosis of the human malignant breast cancer cell line. Gene. 2016;587(1):91–97. doi:10.1016/j.gene.2016.04.046.
  • Asano E, Hasegawa H, Hyodo T, Ito S, Maeda M, Takahashi M, Hamaguchi M, Senga T. The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression. J Cell Sci. 2013;126(15):3263–3270. doi:10.1242/jcs.124875.
  • Piccaluga PP, Agostinelli C, Califano A, Rossi M, Basso K, Zupo S, Went P, Klein U, Zinzani PL, Baccarani M. Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. J Clin Invest. 2007;117(3):823. doi:10.1172/JCI26833.
  • Dilek C, Asmaa N, AlBandary A, Maimoona N, Hatim J, Abdelmoneim E, Taher A-T, Asma T, Dahish A, Al MO. Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. PloS One. 2013;8(5):e63204.
  • Dusetti NJ, Jiang YF, Vaccaro MI, Tomasini R, Samir AA, Calvo EL, Ropolo A, Fiedler F, Mallo GV, Dagorn JC. Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. Biochem Biophys Res Commun. 2002;290(2):641–649. doi:10.1006/bbrc.2001.6244.
  • Folkerts H, Wierenga AT, van den Heuvel FA, Woldhuis RR, Kluit DS, Jaques J, Schuringa JJ. Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis. Cell Death Dis 2019;10:421.
  • Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H, Minami M, Itoh Y, Tanaka S. A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Cancer Lett. 2009;275(1):27–34. doi:10.1016/j.canlet.2008.09.036.
  • Colak D, Nofal A, Albakheet A, Nirmal M, Jeprel H, Eldali A, Al-Tweigeri T, Tulbah A, Ajarim D, Malik OA, et al. Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. PloS One. 2013;8(5):e63204. doi:10.1371/journal.pone.0063204.
  • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol. 1998;18(2):753–761. doi:10.1128/MCB.18.2.753.
  • Meloche S, Pouyssegur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene. 2007;26:3227–3239.
  • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol. 2001;3(3):245. doi:10.1038/35060032.
  • Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, et al. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Mol Pharmacol. 2009;75(1):196–207. doi:10.1124/mol.108.049544.
  • Yuan H, Li ZM, Shao J, Ji WX, Xia W, Lu S. FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells. J Exp Clin Cancer Res CR. 2017;36(1):72. doi:10.1186/s13046-017-0534-0.
  • Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta ES, et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 2004;64(15):5270–5282. doi:10.1158/0008-5472.CAN-04-0731.
  • Krejci P, Mekikian PB, Wilcox WR. The fibroblast growth factors in multiple myeloma. Leukemia. 2006;20(6):1165–1168. doi:10.1038/sj.leu.2404202.
  • Munoz-Sanjuan I, Smallwood PM, Nathans J. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. J Biol Chem. 2000;275(4):2589–2597. doi:10.1074/jbc.275.4.2589.
  • Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J Biol Chem. 2002;277(51):49111–49119. doi:10.1074/jbc.M205520200.
  • Abbas S, Andrei O, Wei YZ, Bin Z, Modarressi MH, Billadeau DD, Masayoshi M, Yutaka T, Toshinari M. Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun. 2005;334:1365–1373. doi:10.1016/j.bbrc.2005.07.041.
  • Beurel E, Grieco SF, Jope RS. Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther. 2015;148:114–131. doi:10.1016/j.pharmthera.2014.11.016.
  • Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR. Functional Redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines. Dev Cell. 2007;12(6):957–971. doi:10.1016/j.devcel.2007.04.001.
  • Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Embo J. 1990;9(8):2431–2438. doi:10.1002/j.1460-2075.1990.tb07419.x.
  • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378(6559):785–789. doi:10.1038/378785a0.
  • Qingqing D, Xianghuo H, Weiya X, Jung-Mao H, Chun-Te C, Long-Yuan L, Dung-Fang L, Jer-Yen Y, Xiaoming X, Jaw-Ching L. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Res. 2007;67:4564. doi:10.1158/0008-5472.CAN-06-1788.
  • Schmandt R, Liu S, Mcglade C. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999;18(10):1867–1879. doi:10.1038/sj.onc.1202507.
  • Yong Z, Cunjie Z, Croucher DR, Soliman MA, Nicole SD, Adrian P, Lorne T, Tate SA, Rod W, Karen C. Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 2013;499:166. doi:10.1038/nature12308.

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