rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

References

• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi:10.3322/caac.21262. PMID:25651787.
   PubMed Web of Science ®Google Scholar
• Liu X, Jiang J, Yu C, Wang Y, Sun Y, Tang J, Chen T, Bi Y, Liu Y, Zhang ZJ. Secular trends in incidence and mortality of bladder cancer in China, 1990–2017: A joinpoint and age-period-cohort analysis. Cancer Epidemiol. 2019;61:95–103. doi:10.1016/j.canep.2019.05.011. PMID:31176961.
   PubMed Web of Science ®Google Scholar
• Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, et al. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell. 2017;171:540–56.e25. doi:10.1016/j.cell.2017.09.007. PMID:28988769.
   PubMed Web of Science ®Google Scholar
• Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur Urol. 2017;71:447–461. doi:10.1016/j.eururo.2016.05.041. PMID:27324428.
   PubMed Web of Science ®Google Scholar
• Chang SS, Bochner BH, Chou R, Dreicer R, Kamat AM, Lerner SP, Lotan Y, Meeks JJ, Michalski JM, Morgan TM, et al. Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline. J Urol. 2017;198:552–559. doi:10.1016/j.juro.2017.04.086. PMID:28456635.
   PubMed Web of Science ®Google Scholar
• Witjes JA, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, Ribal MJ, Van der Heijden AG, Sherif A. European Association of Urology. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol. 2014;65:778–792. doi:10.1016/j.eururo.2013.11.046. PMID:24373477.
   PubMed Web of Science ®Google Scholar
• Luqmani YA. Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract. 2005;14(Suppl 1):35–48. doi:10.1159/000086183. PMID:16103712.
   PubMed Web of Science ®Google Scholar
• Cross D, Burmester JK. Gene therapy for cancer treatment: past, present and future. Clin Med Res. 2006;4:218–227. doi:10.3121/cmr.4.3.218. PMID:16988102.
   PubMedGoogle Scholar
• He XD, Wang ZP, Wei HY, Zhou Q, Wang DG, Tian JQ, Fu SJ, Rodriguez R. Construction of urothelium-specific recombinant adenovirus and its inhibition in bladder cancer cell. Urol Int. 2009;82:209–213. doi:10.1159/000200802. PMID:19322012.
   PubMed Web of Science ®Google Scholar
• Wang D, Wang Z, Tian J, He X, Chowdhury WH, Zhang X, Li S, Rodriguez R. Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector. Urol Oncol. 2010;28:164–169. doi:10.1016/j.urolonc.2008.02.002. PMID:18440837.
   PubMed Web of Science ®Google Scholar
• Wang DG, Zhao MJ, Liu YQ, Liu XW, Niu HT, Song YF, Tian YX. Fiber-modified adenovirus-mediated suicide gene therapy can efficiently eliminate bladder cancer cells in vitro and in vivo. Oncotarget. 2016;7:71710–71717. doi:10.18632/oncotarget.12324. PMID:27687590.
   PubMedGoogle Scholar
• Ai J, Wang D, Wei Q, Li H, Gao G. Adeno-associated virus serotype vectors efficiently transduce normal prostate tissue and prostate cancer cells. Eur Urol. 2016;69:179–181. doi:10.1016/j.eururo.2015.10.019. PMID:26526960.
   PubMed Web of Science ®Google Scholar
• Cataldi MP, McCarty DM. Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes. J Virol. 2010;84:8673–8682. doi:10.1128/JVI.00641-10. PMID:20538857.
   PubMed Web of Science ®Google Scholar
• Wyndaele J, Riedl C, Taneja R, Lovász S, Ueda T, Cervigni M. GAG replenishment therapy for bladder pain syndrome/interstitial cystitis. Neurourol Urodyn. 2019;38:535–544. doi:10.1002/nau.23900. PMID:30592544.
   PubMed Web of Science ®Google Scholar
• Pan JG, Zhou X, Luo R, Han RF. The adeno-associated virus-mediated HSV-TK/GCV suicide system: a potential strategy for the treatment of bladder carcinoma. Med Oncol. 2012;29:1938–1947. doi:10.1007/s12032-011-0091-x. PMID:22011935.
   PubMed Web of Science ®Google Scholar
• Leten C, Trekker J, Struys T, Dresselaers T, Gijsbers R, Vande Velde G, Lambrichts I, Van Der Linden A, Verfaillie CM, Himmelreich U. Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach. Stem Cell Res Ther. 2015;6:163. doi:10.1186/s13287-015-0157-3. PMID:26345383.
   PubMed Web of Science ®Google Scholar
• Zychlinsky Scharff A, Albert ML, Ingersoll MA. Urinary tract infection in a small animal model: transurethral catheterization of male and female mice. J Vis Exp. 2017. doi:10.3791/54432. PMID:29286380.
   PubMed Web of Science ®Google Scholar
• Shen Y, Li Y, Ma X, Wan Q, Jiang Z, Liu Y, Zhang D, Liu X, Wu W. Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV. Int J Oncol. 2018;52:872–880. doi:10.3892/ijo.2018.4263. PMID:29393359.
   PubMed Web of Science ®Google Scholar
• Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, et al. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol. 2017;13:994–1001. doi:10.1038/nchembio.2442. PMID:28759015.
   PubMed Web of Science ®Google Scholar
• Tang M, Luo Z, Wu Y, Zhuang J, Li K, Hu D, Rong H, Xian B, Ge J. BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue. Stem Cell Res Ther. 2019;10:64. doi:10.1186/s13287-019-1151-y. PMID:30795805.
   PubMed Web of Science ®Google Scholar
• Zhao D, Zhang M, Yuan H, Meng C, Zhang B, Wu H. Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury in rats by downregulating the Bax/Bcl-2 ratio and caspase-3 and p-Ask-1 levels. Exp Mol Pathol. 2018;105:229–235. doi:10.1016/j.yexmp.2018.09.001. PMID:30184471.
   PubMed Web of Science ®Google Scholar
• Zhao MJ, Song YF, Niu HT, Tian YX, Yang XG, Xie K, Jing YH, Wang DG. Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. Oncotarget. 2016;7:8956–8967. doi:10.18632/oncotarget.6909. PMID:26788910.
   PubMedGoogle Scholar
• Chen Y, Huang H, Yao C, Su F, Guan W, Yan S, Ni Z. Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models. Cancer Med. 2016;5:2477–2486. doi:10.1002/cam4.798. PMID:27366865.
   PubMed Web of Science ®Google Scholar
• Choi SS, Chi BH, Chang IH, Kim KD, Lee SR, Kim SU, Lee HJ. Human neural stem cells overexpressing a carboxylesterase inhibit bladder tumor growth. Mol Cancer Ther. 2016;15:1201–1207. doi:10.1158/1535-7163.MCT-15-0636. PMID:27009215.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang J, Cheng H, Sun Y, Liu M, Wu Z, Pei R. Conditional control of suicide gene expression in tumor cells with theophylline-responsive ribozyme. Gene Ther. 2017;24:84–91. doi:10.1038/gt.2016.78. PMID:27874855.
   PubMed Web of Science ®Google Scholar
• Appaiahgari MB, Vrati S. Adenoviruses as gene/vaccine delivery vectors: promises and pitfalls. Expert Opin Biol Ther. 2015;15:337–351. doi:10.1517/14712598.2015.993374. PMID:25529044.
   PubMed Web of Science ®Google Scholar
• Irie A. Advances in gene therapy for bladder cancer. Curr Gene Ther. 2003;3:1–11. PMID:12553531.
   PubMedGoogle Scholar
• Baruteau J, Waddington SN, Alexander IE, Gissen P. Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects. J Inherit Metab Dis. 2017;40:497–517. doi:10.1007/s10545-017-0053-3. PMID:28567541.
   PubMed Web of Science ®Google Scholar
• Lin LF, Zhu G, Yoo JJ, Soker S, Sukhatme VP, Atala A. A system for the enhancement of adenovirus mediated gene transfer to uro-epithelium. J Urol. 2002;168:813–818. doi:10.1016/S0022-5347(05)64749-0. PMID:12131373.
   PubMed Web of Science ®Google Scholar
• Janssen D. ls clinical practice aligned with the latest scientific evidence on GAG therapy. Urologia. 2017;84:16–20. doi:10.5301/uj.5000259. PMID:28862729.
   PubMed Web of Science ®Google Scholar