Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

References

• Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2:21-32; PMID:11413462; http://dx.doi.org/10.1038/35048096
   PubMed Web of Science ®Google Scholar
• Pines J. Four-dimensional control of the cell cycle. Nat Cell Biol 1999; 1:E73-9; PMID:10559915; http://dx.doi.org/10.1038/11041
   PubMed Web of Science ®Google Scholar
• Santamaria D, Barriere C, Cerqueira S, Hunt A, Tardy C, Newton K, Caceres JF, Dubus P, Malumbres M, Barbacid M. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007; 448:811-5; PMID:17700700; http://dx.doi.org/10.1038/nature06046
   PubMed Web of Science ®Google Scholar
• Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol 2008; 9:910-6; PMID:18813291; http://dx.doi.org/10.1038/nrm2510
   PubMed Web of Science ®Google Scholar
• Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H, Sicinski P. Cyclin E ablation in the mouse. Cell 2003; 114:431-43; PMID:12941272; http://dx.doi.org/10.1016/S0092-8674(03)00645-7
   PubMed Web of Science ®Google Scholar
• Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 2004; 118:477-91; PMID:15315760; http://dx.doi.org/10.1016/j.cell.2004.07.025
   PubMed Web of Science ®Google Scholar
• Mendez J. Cell proliferation without cyclin E-CDK2. Cell 2003; 114:398-9; PMID:12941268; http://dx.doi.org/10.1016/S0092-8674(03)00649-4
   PubMed Web of Science ®Google Scholar
• Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J 2003; 22:4794-803; PMID:12970191; http://dx.doi.org/10.1093/emboj/cdg482
   PubMed Web of Science ®Google Scholar
• Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 2009; 138:352-65; PMID:19592082; http://dx.doi.org/10.1016/j.cell.2009.04.062
   PubMed Web of Science ®Google Scholar
• Sicinska E, Aifantis I, Le L Cam, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 2003; 4:451-61; PMID:14706337; http://dx.doi.org/10.1016/S1535-6108(03)00301-5
   PubMed Web of Science ®Google Scholar
• Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, Cavadore JC, Doree M, Blanchard JM. Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 1994; 9:3127-38; PMID:7936635
   PubMed Web of Science ®Google Scholar
• Fesquet D, Labbe JC, Derancourt J, Capony JP, Galas S, Girard F, Lorca T, Shuttleworth J, Doree M, Cavadore JC. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J 1993; 12:3111-21; PMID:8344251
   PubMed Web of Science ®Google Scholar
• Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 1994; 78:713-24; PMID:8069918; http://dx.doi.org/10.1016/0092-8674(94)90535-5
   PubMed Web of Science ®Google Scholar
• Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J 1993; 12:3123-32; PMID:8393783
   PubMed Web of Science ®Google Scholar
• Solomon MJ, Harper JW, Shuttleworth J. 1993. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J. 12:3133-42; PMID:8344252
   PubMed Web of Science ®Google Scholar
• Ganuza M, Saiz-Ladera C, Canamero M, Gomez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaria D, Barbacid M. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 2012; 31:2498-510; PMID:22505032; http://dx.doi.org/10.1038/emboj.2012.94
   PubMed Web of Science ®Google Scholar
• Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 1995; 374:283-7; PMID:7533895; http://dx.doi.org/10.1038/374283a0
   PubMed Web of Science ®Google Scholar
• Larochelle S, Amat R, Glover-Cutter K, Sanso M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol 2012; 19:1108-15; PMID:23064645; http://dx.doi.org/10.1038/nsmb.2399
   PubMed Web of Science ®Google Scholar
• Egly JM, Coin F. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst) 2011; 10:714-21; PMID:21592869
   PubMed Web of Science ®Google Scholar
• Lolli G, Johnson LN. CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? Cell Cycle 2005; 4:572-7; PMID:15876871; http://dx.doi.org/10.4161/cc.4.4.1607
   PubMed Web of Science ®Google Scholar
• Bour G, Gaillard E, Bruck N, Lalevee S, Plassat JL, Busso D, Samama JP, Rochette-Egly C. Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7. Proc Natl Acad Sci U S A 2005; 102:16608-13; PMID:16275922; http://dx.doi.org/10.1073/pnas.0505556102
   PubMed Web of Science ®Google Scholar
• Lee DK, Duan HO, Chang C. From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J Biol Chem 2000; 275:9308-13; PMID:10734072; http://dx.doi.org/10.1074/jbc.275.13.9308
   PubMed Web of Science ®Google Scholar
• Rochette-Egly C, Adam S, Rossignol M, Egly JM, Chambon P. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 1997; 90:97-107; PMID:9230306; http://dx.doi.org/10.1016/S0092-8674(00)80317-7
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Bortner DM, Rosenberg MP. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol Cell Biol 1997; 17:453-9; PMID:8972226
   PubMed Web of Science ®Google Scholar
• Karsunky H, Geisen C, Schmidt T, Haas K, Zevnik B, Gau E, Moroy T. Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc. Oncogene 1999; 18:7816-24; PMID:10618723; http://dx.doi.org/10.1038/sj.onc.1203205
   PubMed Web of Science ®Google Scholar
• Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001; 411:1017-21; PMID:11429595; http://dx.doi.org/10.1038/35082500
   PubMed Web of Science ®Google Scholar
• Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc Natl Acad Sci U S A 1993; 90:11034-8; PMID:8248208; http://dx.doi.org/10.1073/pnas.90.23.11034
   PubMed Web of Science ®Google Scholar
• Lucibello FC, Sewing A, Brusselbach S, Burger C, Muller R. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J Cell Sci 1993; 105 (Pt 1):123-33; PMID:8360268
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion. Cell Cycle 2013; 12:3063-9; PMID:23974099; http://dx.doi.org/10.4161/cc.26130
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A 2012; 109:13314-8; PMID:22847439; http://dx.doi.org/10.1073/pnas.1205690109
   PubMed Web of Science ®Google Scholar
• Haas K, Johannes C, Geisen C, Schmidt T, Karsunky H, Blass-Kampmann S, Obe G, Moroy T. Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4. Oncogene 1997; 15:2615-23; PMID:9399649; http://dx.doi.org/10.1038/sj.onc.1201434
   PubMed Web of Science ®Google Scholar
• Geisen C, Moroy T. The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem 2002; 277:39909-18; PMID:12149264; http://dx.doi.org/10.1074/jbc.M205919200
   PubMed Web of Science ®Google Scholar
• Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P. Kinase-independent function of cyclin E. Mol Cell 2007; 25:127-39; PMID:17218276; http://dx.doi.org/10.1016/j.molcel.2006.11.029
   PubMed Web of Science ®Google Scholar
• Geng Y, Sicinski P. Differences in regulation and function of E-cyclins in human cancer cells. Cell Cycle 2013; 12:1165; PMID:23549169; http://dx.doi.org/10.4161/cc.24487
   PubMed Web of Science ®Google Scholar
• Coverley D, Laman H, Laskey RA. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 2002; 4:523-8; PMID:12080347; http://dx.doi.org/10.1038/ncb813
   PubMed Web of Science ®Google Scholar
• Ferguson RL, Maller JL. Centrosomal localization of cyclin E-Cdk2 is required for initiation of DNA synthesis. Curr Biol 2010; 20:856-60; PMID:20399658; http://dx.doi.org/10.1016/j.cub.2010.03.028
   PubMed Web of Science ®Google Scholar
• Ferguson RL, Pascreau G, Maller JL. The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. J Cell Sci 2010; 123:2743-9; PMID:20663915; http://dx.doi.org/10.1242/jcs.073098
   PubMed Web of Science ®Google Scholar
• Hemerly AS, Prasanth SG, Siddiqui K, Stillman B. Orc1 controls centriole and centrosome copy number in human cells. Science 2009; 323:789-93; PMID:19197067; http://dx.doi.org/10.1126/science.1166745
   PubMed Web of Science ®Google Scholar
• Berger C, Pallavi SK, Prasad M, Shashidhara LS, Technau GM. Cyclin E acts under the control of Hox-genes as a cell fate determinant in the developing central nervous system. Cell Cycle 2005; 4:422-5; PMID:15684605; http://dx.doi.org/10.4161/cc.4.3.1524
   PubMed Web of Science ®Google Scholar
• Berger C, Kannan R, Myneni S, Renner S, Shashidhara LS, Technau GM. Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev Biol 2010; 337:415-24; PMID:19914234; http://dx.doi.org/10.1016/j.ydbio.2009.11.012
   PubMed Web of Science ®Google Scholar
• Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, et al. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 2011; 21:655-68; PMID:21944720; http://dx.doi.org/10.1016/j.devcel.2011.08.009
   PubMed Web of Science ®Google Scholar
• Rogulja D, Young MW. Control of sleep by cyclin A and its regulator. Science 2012; 335:1617-21.
   PubMed Web of Science ®Google Scholar
• Coqueret O. Linking cyclins to transcriptional control. Gene 2002; 299:35-55; PMID:12459251; http://dx.doi.org/10.1016/S0378-1119(02)01055-7
   PubMed Web of Science ®Google Scholar
• Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 2004; 145:5439-47; PMID:15331580; http://dx.doi.org/10.1210/en.2004-0959
   PubMed Web of Science ®Google Scholar
• Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 1995; 9:2364-72; PMID:7557388; http://dx.doi.org/10.1101/gad.9.19.2364
   PubMed Web of Science ®Google Scholar
• Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 1999; 22:44-52; PMID:10319860; http://dx.doi.org/10.1038/8751
   PubMed Web of Science ®Google Scholar
• Knudsen KE, Diehl JA, Haiman CA, Knudsen ES. Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 2006; 25:1620-8; PMID:16550162; http://dx.doi.org/10.1038/sj.onc.1209371
   PubMed Web of Science ®Google Scholar
• Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD, Heighway J. Alternate splicing produces a novel cyclin D1 transcript. Oncogene 1995; 11:1005-11; PMID:7675441
   PubMed Web of Science ®Google Scholar
• Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006b; 26:4240-56; http://dx.doi.org/10.1128/MCB.02124-05
   PubMed Web of Science ®Google Scholar
• Zhong Z, Yeow WS, Zou C, Wassell R, Wang C, Pestell RG, Quong JN, Quong AA. Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res 70:2105-14; PMID:20179208; http://dx.doi.org/10.1158/0008-5472.CAN-08-1108
   PubMed Web of Science ®Google Scholar
• Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, et al. Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol 2006; 26:5449-69; PMID:16809779; http://dx.doi.org/10.1128/MCB.02074-05
   PubMed Web of Science ®Google Scholar
• Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, Pestell RG. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 2006; 103:11567-72; PMID:16864783; http://dx.doi.org/10.1073/pnas.0603363103
   PubMed Web of Science ®Google Scholar
• Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 2003; 114:323-34; PMID:12914697; http://dx.doi.org/10.1016/S0092-8674(03)00570-1
   PubMed Web of Science ®Google Scholar
• McMahon C, Suthiphongchai T, DiRenzo J, Ewen ME. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor. Proc Natl Acad Sci U S A 1999; 96:5382-7; PMID:10318892; http://dx.doi.org/10.1073/pnas.96.10.5382
   PubMed Web of Science ®Google Scholar
• Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides RJ. CDK-independent activation of estrogen receptor by cyclin D1. Cell 1997; 88:405-15; PMID:9039267; http://dx.doi.org/10.1016/S0092-8674(00)81879-6
   PubMed Web of Science ®Google Scholar
• Comstock CE, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A, Knudsen ES, Jessen WJ, Aronow BJ, Knudsen KE. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function. J Biol Chem 2011; 286:8117-27; PMID:21212260; http://dx.doi.org/10.1074/jbc.M110.170720
   PubMed Web of Science ®Google Scholar
• Knudsen KE, Cavenee WK, Arden KC. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res 1999; 59:2297-301; PMID:10344732
   PubMed Web of Science ®Google Scholar
• Ratineau C, Petry MW, Mutoh H, Leiter AB. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem 2002; 277:8847-53; PMID:11788592; http://dx.doi.org/10.1074/jbc.M110747200
   PubMed Web of Science ®Google Scholar
• Bienvenu F, Gascan H, Coqueret O. Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J Biol Chem 2001; 276:16840-7; PMID:11279133; http://dx.doi.org/10.1074/jbc.M100795200
   PubMed Web of Science ®Google Scholar
• Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, Neumeister P, et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 2003; 23:6159-73; PMID:12917338; http://dx.doi.org/10.1128/MCB.23.17.6159-6173.2003
   PubMed Web of Science ®Google Scholar
• Knudsen KE. Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis. Cell Cycle 2012; 11:3533-4; PMID:22951541; http://dx.doi.org/10.4161/cc.22039
   PubMed Web of Science ®Google Scholar
• Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 2012; 122:833-43; PMID:22307325; http://dx.doi.org/10.1172/JCI60256
   PubMed Web of Science ®Google Scholar
• Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature 2010; 463:374-8; PMID:20090754; http://dx.doi.org/10.1038/nature08684
   PubMed Web of Science ®Google Scholar
• Jin RJ, Lho Y, Wang Y, Ao M, Revelo MP, Hayward SW, Wills ML, Logan SK, Zhang P, Matusik RJ. Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res 2008; 68:3601-8; PMID:18483241; http://dx.doi.org/10.1158/0008-5472.CAN-08-0073
   PubMed Web of Science ®Google Scholar
• Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res 2010; 70:8802-11; PMID:20940395; http://dx.doi.org/10.1158/0008-5472.CAN-10-0312
   PubMed Web of Science ®Google Scholar
• Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR. Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol 2003; 161:817-26; PMID:12771130; http://dx.doi.org/10.1083/jcb.200212172
   PubMed Web of Science ®Google Scholar
• Song Y, Zhao C, Dong L, Fu M, Xue L, Huang Z, Tong T, Zhou Z, Chen A, Yang Z, Lu N, Zhan Q. Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis. Carcinogenesis 2008; 29:307-15; PMID:18048386; http://dx.doi.org/10.1093/carcin/bgm269
   PubMed Web of Science ®Google Scholar
• Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A 2008; 105:1442-7; PMID:18234856; http://dx.doi.org/10.1073/pnas.0708966105
   PubMed Web of Science ®Google Scholar
• Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE. Identification of CDK2 substrates in human cell lysates. Genome Biol 2008; 9:R149
   Web of Science ®Google Scholar
• Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol 2000; 149:1073-86; PMID:10831611; http://dx.doi.org/10.1083/jcb.149.5.1073
   PubMed Web of Science ®Google Scholar
• Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004; 116:167-79; PMID:14744429; http://dx.doi.org/10.1016/S0092-8674(04)00003-0
   PubMed Web of Science ®Google Scholar
• Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21:247-69; PMID:16212495; http://dx.doi.org/10.1146/annurev.cellbio.21.020604.150721
   PubMed Web of Science ®Google Scholar
• Hall A. Rho GTPases and the control of cell behaviour. Biochem Soc Trans 2005; 33:891-5; PMID:16246005; http://dx.doi.org/10.1042/BST20050891
   PubMed Web of Science ®Google Scholar
• Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008; 9:690-701; PMID:18719708; http://dx.doi.org/10.1038/nrm2476
   PubMed Web of Science ®Google Scholar
• Karlsson R, Pedersen ED, Wang Z, Brakebusch C. Rho GTPase function in tumorigenesis. Biochim Biophys Acta 2009; 1796:91-8; PMID:19327386
   PubMed Web of Science ®Google Scholar
• Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265:23-32; PMID:14697350; http://dx.doi.org/10.1016/j.ydbio.2003.06.003
   PubMed Web of Science ®Google Scholar
• Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, Giancotti FG. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 2001; 8:115-27; PMID:11511365; http://dx.doi.org/10.1016/S1097-2765(01)00285-4
   PubMed Web of Science ®Google Scholar
• Roovers K, Assoian RK. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol 2003; 23:4283-94; PMID:12773570; http://dx.doi.org/10.1128/MCB.23.12.4283-4294.2003
   PubMed Web of Science ®Google Scholar
• Roovers K, Klein EA, Castagnino P, Assoian RK. Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression. Dev Cell 2003; 5:273-84; PMID:12919678; http://dx.doi.org/10.1016/S1534-5807(03)00206-5
   PubMed Web of Science ®Google Scholar
• Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001; 3:950-7; PMID:11715015; http://dx.doi.org/10.1038/ncb1101-950
   PubMed Web of Science ®Google Scholar
• Philips A, Roux P, Coulon V, Bellanger JM, Vie A, Vignais ML, Blanchard JM. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts. J Biol Chem 2000; 275:5911-7; PMID:10681583; http://dx.doi.org/10.1074/jbc.275.8.5911
   PubMed Web of Science ®Google Scholar
• Besson A, Assoian RK, Roberts JM. Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors? Nat Rev Cancer 2004a; 4:948-55; http://dx.doi.org/10.1038/nrc1501
   PubMed Web of Science ®Google Scholar
• Shimada Y, Gulli MP, Peter M. Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. Nat Cell Biol 2000; 2:117-24; PMID:10655592; http://dx.doi.org/10.1038/35000073
   PubMed Web of Science ®Google Scholar
• Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, et al. p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J Biol Chem 2003; 278:52919-23; PMID:14530263; http://dx.doi.org/10.1074/jbc.M309334200
   PubMed Web of Science ®Google Scholar
• Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004b; 18:862-76; http://dx.doi.org/10.1101/gad.1185504
   PubMed Web of Science ®Google Scholar
• Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem 2004; 279:1885-91; PMID:14559914; http://dx.doi.org/10.1074/jbc.M306968200
   PubMed Web of Science ®Google Scholar
• Tanaka H, Yamashita T, Asada M, Mizutani S, Yoshikawa H, Tohyama M. Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol 2002; 158:321-9; PMID:12119358; http://dx.doi.org/10.1083/jcb.200202071
   PubMed Web of Science ®Google Scholar
• Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001; 3:245-52; PMID:11231573; http://dx.doi.org/10.1038/35060032
   PubMed Web of Science ®Google Scholar
• Tanaka H, Yamashita T, Yachi K, Fujiwara T, Yoshikawa H, Tohyama M. Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 2004; 127:155-64; PMID:15219678; http://dx.doi.org/10.1016/j.neuroscience.2004.05.010
   PubMed Web of Science ®Google Scholar
• Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008; 14:159-69; PMID:18267085; http://dx.doi.org/10.1016/j.devcel.2008.01.013
   PubMed Web of Science ®Google Scholar
• Guo H, Tian T, Nan K, Wang W. p57: A multifunctional protein in cancer (Review). Int J Oncol 2010; 36:1321-9; PMID:20428755; http://dx.doi.org/10.3892/ijo_00000536
   PubMed Web of Science ®Google Scholar
• Vlachos P, Joseph B. The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics. Oncogene 2009; 28:4175-88; PMID:19734939; http://dx.doi.org/10.1038/onc.2009.269
   PubMed Web of Science ®Google Scholar
• Guo H, Lv Y, Tian T, Hu TH, Wang WJ, Sui X, Jiang L, Ruan ZP, Nan KJ. Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma. Carcinogenesis 2011; 32:1897-904; PMID:22002319; http://dx.doi.org/10.1093/carcin/bgr220
   PubMed Web of Science ®Google Scholar
• Sakai K, Peraud A, Mainprize T, Nakayama J, Tsugu A, Hongo K, Kobayashi S, Rutka JT. Inducible expression of p57KIP2 inhibits glioma cell motility and invasion. J Neurooncol 2004; 68:217-23; PMID:15332324; http://dx.doi.org/10.1023/B:NEON.0000033380.08940.c8
   PubMed Web of Science ®Google Scholar
• Itoh Y, Masuyama N, Nakayama K, Nakayama KI, Gotoh Y. The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J Biol Chem 2007; 282:390-6; PMID:17092932; http://dx.doi.org/10.1074/jbc.M609944200
   PubMed Web of Science ®Google Scholar
• Assoian RK. Stopping and going with p27kip1. Dev Cell 2004; 6:458-9; PMID:15068785; http://dx.doi.org/10.1016/S1534-5807(04)00103-0
   PubMed Web of Science ®Google Scholar
• Larrea MD, Wander SA, Slingerland JM. p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 2009b; 8:3455-61; http://dx.doi.org/10.4161/cc.8.21.9789
   PubMed Web of Science ®Google Scholar
• Kawauchi T, Chihama K, Nabeshima Y, Hoshino M. Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol 2006; 8:17-26; PMID:16341208; http://dx.doi.org/10.1038/ncb1338
   PubMed Web of Science ®Google Scholar
• Larrea MD, Hong F, Wander SA, da Silva TG, Helfman D, Lannigan D, Smith JA, Slingerland JM. RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A 2009a; 106:9268-73; http://dx.doi.org/10.1073/pnas.0805057106
   PubMed Web of Science ®Google Scholar
• Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 2007; 67:9238-43; PMID:17909030; http://dx.doi.org/10.1158/0008-5472.CAN-07-1375
   PubMed Web of Science ®Google Scholar
• McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 2003; 23:216-28; PMID:12482975; http://dx.doi.org/10.1128/MCB.23.1.216-228.2003
   PubMed Web of Science ®Google Scholar
• Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 1998; 4:1449-52; PMID:9846587; http://dx.doi.org/10.1038/4042
   PubMed Web of Science ®Google Scholar
• Wu FY, Wang SE, Sanders ME, Shin I, Rojo F, Baselga J, Arteaga CL. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, tumorigenicity. Cancer Res 2006; 66:2162-72; PMID:16489017; http://dx.doi.org/10.1158/0008-5472.CAN-05-3304
   PubMed Web of Science ®Google Scholar
• Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 2005; 7:51-63; PMID:15652749; http://dx.doi.org/10.1016/j.ccr.2004.11.025
   PubMed Web of Science ®Google Scholar
• Diez-Juan A, Andres V. Coordinate control of proliferation and migration by the p27Kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts. Circ Res 2003; 92:402-10; PMID:12600894; http://dx.doi.org/10.1161/01.RES.0000059306.71961.ED
   PubMed Web of Science ®Google Scholar
• Goukassian D, Diez-Juan A, Asahara T, Schratzberger P, Silver M, Murayama T, Isner JM, Andres V. Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis. FASEB J 2001; 15:1877-85; PMID:11532967; http://dx.doi.org/10.1096/fj.01-0065com
   PubMed Web of Science ®Google Scholar
• Sun J, Marx SO, Chen HJ, Poon M, Marks AR, Rabbani LE. Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration. Circulation 2001; 103:2967-72; PMID:11413088; http://dx.doi.org/10.1161/01.CIR.103.24.2967
   PubMed Web of Science ®Google Scholar
• Neumeister P, Pixley FJ, Xiong Y, Xie H, Wu K, Ashton A, Cammer M, Chan A, Symons M, Stanley ER, et al. Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell 2003; 14:2005-15; PMID:12802071; http://dx.doi.org/10.1091/mbc.02-07-0102
   PubMed Web of Science ®Google Scholar
• Matsushime H. Macrophage cell cycle control by M-CSF/CSF-1. Rinsho Ketsueki 1995; 36:406-9; PMID:7783343
   PubMedGoogle Scholar
• Drobnjak M, Osman I, Scher HI, Fazzari M, Cordon-Cardo C. Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone. Clin Cancer Res 2000; 6:1891-5; PMID:10815912
   PubMed Web of Science ®Google Scholar
• Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 1993; 73:487-97; PMID:8343202; http://dx.doi.org/10.1016/0092-8674(93)90136-E
   PubMed Web of Science ®Google Scholar
• Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, Powell MJ, Pestell RG. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 2008; 283:7007-15; PMID:18180298; http://dx.doi.org/10.1074/jbc.M706992200
   PubMed Web of Science ®Google Scholar
• Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle 2006c; 5:2440-2; http://dx.doi.org/10.4161/cc.5.21.3428
   PubMed Web of Science ®Google Scholar
• Pestell RG. New roles of cyclin D1. Am J Pathol 2013; 183:3-9; PMID:23790801; http://dx.doi.org/10.1016/j.ajpath.2013.03.001
   PubMed Web of Science ®Google Scholar
• Li Z, Jiao X, Wang C, Ju X, Lu Y, Yuan L, Lisanti MP, Katiyar S, Pestell RG. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 2006a; 66:9986-94; http://dx.doi.org/10.1158/0008-5472.CAN-06-1596
   PubMed Web of Science ®Google Scholar
• Arsic N, Bendris N, Peter M, Begon-Pescia C, Rebouissou C, Gadea G, Bouquier N, Bibeau F, Lemmers B, Blanchard JM. A novel function for Cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol 2012; 196:147-62; PMID:22232705; http://dx.doi.org/10.1083/jcb.201102085
   PubMed Web of Science ®Google Scholar
• Bendris N, Arsic N, Lemmers B, Blanchard JM. Cyclin A2, Rho GTPases and EMT. Small GTPases 2012; 3:225-8; PMID:22735340; http://dx.doi.org/10.4161/sgtp.20791
   PubMedGoogle Scholar
• Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J. Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol Biol Cell 2002; 13:1030-45; PMID:11907280; http://dx.doi.org/10.1091/mbc.01-07-0361
   PubMed Web of Science ®Google Scholar
• Bendris N, Lemmers B, Blanchard JM, Arsic N. Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements. PLoS One 2011; 6:e22879
   Google Scholar
• Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, Garcia JF, Piris MA. Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells. Blood 1999; 94:765-72; PMID:10397744
   PubMed Web of Science ®Google Scholar
• Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 1999; 18:5321-33; PMID:10508165; http://dx.doi.org/10.1093/emboj/18.19.5321
   PubMed Web of Science ®Google Scholar
• Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H. Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J 1999; 18:5310-20; PMID:10508164; http://dx.doi.org/10.1093/emboj/18.19.5310
   PubMed Web of Science ®Google Scholar
• Wang YF, Chen JY, Chang SY, Chiu JH, Li WY, Chu PY, Tai SK, Wang LS. Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma. Int J Cancer 2008; 122:377-86; PMID:17918157
   PubMed Web of Science ®Google Scholar
• Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2:442-54; PMID:12189386; http://dx.doi.org/10.1038/nrc822
   PubMed Web of Science ®Google Scholar
• Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14:818-29; PMID:18539112; http://dx.doi.org/10.1016/j.devcel.2008.05.009
   PubMed Web of Science ®Google Scholar
• Thiery JP, Lim CT. Tumor dissemination: an EMT affair. Cancer Cell 2013; 23:272-3; PMID:23518345; http://dx.doi.org/10.1016/j.ccr.2013.03.004
   PubMed Web of Science ®Google Scholar
• Bendris N, Cheung CT, Leong HS, Lewis JD, Chambers AF, Blanchard JM, Lemmers B. Cyclin A2, a novel regulator of EMT. Cell Mol Life Sci; 2014; PMID:24879294
   PubMed Web of Science ®Google Scholar
• Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P, Mercurio AM. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 2006; 25:6959-67; PMID:16715134; http://dx.doi.org/10.1038/sj.onc.1209682
   PubMed Web of Science ®Google Scholar
• Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002; 2:133-42; PMID:12635176; http://dx.doi.org/10.1038/nrc725
   PubMed Web of Science ®Google Scholar
• Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005; 19:1974-9; PMID:16107613; http://dx.doi.org/10.1101/gad.1310805
   PubMed Web of Science ®Google Scholar
• Anastasiadis PZ, Moon SY, Thoreson MA, Mariner DJ, Crawford HC, Zheng Y, Reynolds AB. Inhibition of RhoA by p120 catenin. Nat Cell Biol 2000; 2:637-44; PMID:10980705; http://dx.doi.org/10.1038/35023588
   PubMed Web of Science ®Google Scholar
• Grosheva I, Shtutman M, Elbaum M, Bershadsky AD. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J Cell Sci 2001; 114:695-707; PMID:11171375
   PubMed Web of Science ®Google Scholar
• Loukil A, Zonca M, Rebouissou C, Baldin V, Coux O, Biard-Piechaczyk M, Blanchard JM, Peter M. High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy. J Cell Sci 2014; 127:2145-50; PMID:24634511; http://dx.doi.org/10.1242/jcs.139188
   PubMed Web of Science ®Google Scholar
• Barger JF, Plas DR. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis. Endocr Relat Cancer 2010; 17:R287-304; PMID:20699334; http://dx.doi.org/10.1677/ERC-10-0106
   PubMed Web of Science ®Google Scholar
• Dang CV. Links between metabolism and cancer. Genes Dev 2012; 26:877-90; PMID:22549953; http://dx.doi.org/10.1101/gad.189365.112
   PubMed Web of Science ®Google Scholar
• DeBerardinis RJ, Thompson CB. Cellular metabolism and disease: what do metabolic outliers teach us? Cell 2012; 148:1132-44; PMID:22424225; http://dx.doi.org/10.1016/j.cell.2012.02.032
   PubMed Web of Science ®Google Scholar
• Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21:297-308; PMID:22439925; http://dx.doi.org/10.1016/j.ccr.2012.02.014
   PubMed Web of Science ®Google Scholar
• Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer 2006; 6:449-58; PMID:16723991; http://dx.doi.org/10.1038/nrc1886
   PubMed Web of Science ®Google Scholar
• Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7:131-42; PMID:16493418; http://dx.doi.org/10.1038/nrm1835
   PubMed Web of Science ®Google Scholar