Neuronal cell cycle: the neuron itself and its circumstances

References

• Fisher RP. The CDK network: linking cycles of cell division and gene expression. Genes Cancer 2012; 3:731-8; PMID:23634260; http://dx.doi.org/10.1177/1947601912473308
   PubMedGoogle Scholar
• Williams GH, Stoeber K. The cell cycle and cancer. J Pathol 2012; 226:352-64; PMID:21990031; http://dx.doi.org/10.1002/path.3022
   PubMed Web of Science ®Google Scholar
• Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol 2008; 9:910-6; PMID:18813291; http://dx.doi.org/10.1038/nrm2510
   PubMed Web of Science ®Google Scholar
• Liu N, Lucibello FC, Engeland K, Müller R. A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F. Oncogene 1998; 16:2957-63; PMID:9662327
   PubMed Web of Science ®Google Scholar
• Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13:1501-12; PMID:10385618
   PubMed Web of Science ®Google Scholar
• Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J 1992; 11:961-71; PMID:1312467
   PubMed Web of Science ®Google Scholar
• Gong D, Ferrell JE Jr. The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell 2010; 21:3149-61; PMID:20660152; http://dx.doi.org/10.1091/mbc.E10-05-0393
   PubMed Web of Science ®Google Scholar
• Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc Natl Acad Sci USA 2009; 106:3184-9; PMID:19221029; http://dx.doi.org/10.1073/pnas.0809350106
   PubMed Web of Science ®Google Scholar
• Merrick KA, Fisher RP. Why minimal is not optimal: driving the mammalian cell cycle–and drug discovery–with a physiologic CDK control network. Cell Cycle 2012; 11:2600-5; PMID:22732498; http://dx.doi.org/10.4161/cc.20758
   PubMed Web of Science ®Google Scholar
• Gopinathan L, Ratnacaram CK, Kaldis P. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Results Probl Cell Differ 2011; 53:365-89. PMID:21630153; http://dx.doi.org/10.1007/978-3-642-19065-0_16
   PubMedGoogle Scholar
• Harashima H, Dissmeyer N, Schnittger A. Cell cycle control across the eukaryotic kingdom. Trends Cell Biol 2013; 23:345-56; PMID:23566594; http://dx.doi.org/10.1016/j.tcb.2013.03.002
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9:153-66; PMID:19238148; http://dx.doi.org/10.1038/nrc2602
   PubMed Web of Science ®Google Scholar
• Merrick KA, Fisher RP. Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycle. Cell Cycle 2010; 9:706-14; PMID:20139727
   PubMed Web of Science ®Google Scholar
• Santamaria D, Ortega S. Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 2006; 11:1164-88; PMID:16146805
   PubMed Web of Science ®Google Scholar
• Yasutis KM, Kozminski KG. Cell cycle checkpoint regulators reach a zillion. Cell Cycle 2013; 12:1501-9; PMID:23598718; http://dx.doi.org/10.4161/cc.24637
   PubMed Web of Science ®Google Scholar
• Cánepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life 2007; 59:419-26; PMID:17654117
   PubMed Web of Science ®Google Scholar
• Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008; 14:159-69; PMID:18267085; http://dx.doi.org/10.1016/j.devcel.2008.01.013
   PubMed Web of Science ®Google Scholar
• Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73:39-85; PMID:15189136
   PubMed Web of Science ®Google Scholar
• Rieder CL. Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints. Chromosome Res 2011; 19:291-306; PMID:21194009; http://dx.doi.org/10.1007/s10577-010-9178-z
   PubMed Web of Science ®Google Scholar
• Foster DA, Yellen P, Xu L, Saqcena M. Regulation of G1 cell cycle progression: distinguishing the restriction point from a nutrient-sensing cell growth checkpoint(s). Genes Cancer 2010; 1:1124-31; PMID:21779436; http://dx.doi.org/10.1177/1947601910392989
   PubMedGoogle Scholar
• Recolin B, van der Laan S, Tsanov N, Maiorano D. Molecular mechanisms of DNA replication checkpoint activation. Genes (Basel) 2014; 5:147-75; PMID:24705291; http://dx.doi.org/10.3390/genes5010147
   PubMed Web of Science ®Google Scholar
• Fesquet D, Labbé JC, Derancourt J, Capony JP, Galas S, Girard F, Lorca T, Shuttleworth J, Dorée M, Cavadore JC. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J. 1993; 12:3111-21; PMID:8344251
   PubMed Web of Science ®Google Scholar
• Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 1994; 78:713-24; PMID:8069918
   PubMed Web of Science ®Google Scholar
• Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J 1993; 12:3123-32; PMID:8393783
   PubMed Web of Science ®Google Scholar
• Solomon MJ, Lee T, Kirschner MW. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell 1992; 3:13-27; PMID:1532335
   PubMed Web of Science ®Google Scholar
• Labbé JC, Martinez AM, Fesquet D, Capony JP, Darbon JM, Derancourt J, Devault A, Morin N, Cavadore JC, Dorée M. p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes. EMBO J 1994; 13:5155-64; PMID:7957080
   PubMed Web of Science ®Google Scholar
• Gould KL, Nurse P. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 1989; 342:39-45; PMID:2682257
   PubMed Web of Science ®Google Scholar
• Meijer L, Azzi L, Wang JY. Cyclin B targets p34cdc2 for tyrosine phosphorylation. EMBO J 1991; 10:1545-54; PMID:1709096
   PubMed Web of Science ®Google Scholar
• Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25;257:1955-7; PMID:1384126
   PubMed Web of Science ®Google Scholar
• Parker LL, Atherton-Fessler S, Lee MS, Ogg S, Falk JL, Swenson KI, Piwnica-Worms H. Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J 1991; 10:1255-63; PMID:1850698
   PubMed Web of Science ®Google Scholar
• Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol 1997; 17:571-83; PMID:9001210
   PubMed Web of Science ®Google Scholar
• Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol 2006; 18:185-91; PMID:16488126
   PubMed Web of Science ®Google Scholar
• Draetta G, Eckstein J. Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta 1997; 1332:M53-63; PMID:9141461
   PubMed Web of Science ®Google Scholar
• Johnson ES, Kornbluth S. Phosphatases driving mitosis: pushing the gas and lifting the brakes. Prog Mol Biol Transl Sci 2012; 106:327-41; PMID:22340723; http://dx.doi.org/10.1016/B978-0-12-396456-4.00008-0
   PubMed Web of Science ®Google Scholar
• Koeller HB, Ross ME, Glickstein SB. Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. Neurobiol Dis 2008; 31:230-41; PMID:18585919; http://dx.doi.org/10.1016/j.nbd.2008.04.010
   PubMed Web of Science ®Google Scholar
• Müller M, Lutter D, Püschel AW. Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity. J Cell Sci 2010; 123:286-94; PMID:20026642; http://dx.doi.org/10.1242/jcs.058230
   PubMed Web of Science ®Google Scholar
• Okano HJ, Pfaff DW, Gibbs RB. RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. J Neurosci 1993; 13:2930-8; PMID:8331381
   PubMed Web of Science ®Google Scholar
• Schmetsdorf S, Gärtner U, Arendt T. Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons. Cereb Cortex 2007; 17:1821-9; PMID:17050646
   PubMed Web of Science ®Google Scholar
• Ting JH, Marks DR, Schleidt SS, Wu JN, Zyskind JW, Lindl KA, Blendy JA, Pierce RC, Jordan-Sciutto KL. Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits. J Neurochem 2014; 129:850-63; PMID:24460902; http://dx.doi.org/10.1111/jnc.12655
   PubMed Web of Science ®Google Scholar
• Cunningham JJ, Levine EM, Zindy F, Goloubeva O, Roussel MF, Smeyne RJ. The cyclin-dependent kinase inhibitors p19Ink4d and p27Kip1 are coexpressed in select retinal cells and act cooperatively to control cell cycle exit. Mol Cell Neurosci 2002; 19:359-74; PMID:11906209
   PubMed Web of Science ®Google Scholar
• Frank CL, Tsai LH. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron 2009; 62:312-26; PMID:19447088; http://dx.doi.org/10.1016/j.neuron.2009.03.029
   PubMed Web of Science ®Google Scholar
• Lim S, Kaldis P. Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development 2013; 140:3079-93; PMID:23861057; http://dx.doi.org/10.1242/dev.091744
   PubMed Web of Science ®Google Scholar
• Becker EB, Bonni A. Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol 2004; 72:1-25; PMID:15019174
   PubMed Web of Science ®Google Scholar
• Liu DX, Greene LA. Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res 2001; 305:217-28; PMID:11545259
   PubMed Web of Science ®Google Scholar
• Park DS, Morris EJ, Padmanabhan J, Shelanski ML, Geller HM, Greene LA. Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 1998; 143:457-67; PMID:9786955
   PubMed Web of Science ®Google Scholar
• Klein JA, Ackerman SL. Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 2003; 111:785-93; PMID:12639981
   PubMed Web of Science ®Google Scholar
• Kruman II. Why do neurons enter the cell cycle? Cell Cycle 2004; 3:769-73; PMID:15136759
   PubMed Web of Science ®Google Scholar
• Park DS, Levine B, Ferrari G, Greene LA. Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J Neurosci 1997; 17:8975-83; PMID:9364045
   PubMed Web of Science ®Google Scholar
• Park DS, Morris EJ, Bremner R, Keramaris E, Padmanabhan J, Rosenbaum M, Shelanski ML, Geller HM, Greene LA. Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage. J Neurosci 2000; 20:3104-14; PMID:10777774
   PubMed Web of Science ®Google Scholar
• Chen MJ, Ng JM, Peng ZF, Manikandan J, Yap YW, Llanos RM, Beart PM, Cheung NS. Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: evidence favouring cell cycle re-activation in concert with oxidative stress. Neurochem Int 2013; 62:719-30; PMID:23291249; http://dx.doi.org/10.1016/j.neuint.2012.12.015
   PubMed Web of Science ®Google Scholar
• Padmanabhan J, Park DS, Greene LA, Shelanski ML. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci 1999; 19:8747-56; PMID:10516294
   PubMed Web of Science ®Google Scholar
• Woods J, Snape M, Smith MA. The cell cycle hypothesis of Alzheimer disease: suggestions for drug development. Biochim Biophys Acta 2007; 1772:503-8; PMID:17223322
   PubMed Web of Science ®Google Scholar
• Verdaguer E, Susana Gde A, Clemens A, Pallàs M, Camins A. Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis. Biomed Pharmacother 2007; 61:390-9; PMID:17178208
   PubMed Web of Science ®Google Scholar
• Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem 2000; 275:11553-60; PMID:10766769
   PubMed Web of Science ®Google Scholar
• O'Hare MJ, Hou ST, Morris EJ, Cregan SP, Xu Q, Slack RS, Park DS. Induction and modulation of cerebellar granule neuron death by E2F-1. J Biol Chem 2000; 275:25358-64; PMID:10851232
   PubMed Web of Science ®Google Scholar
• Konishi Y, Bonni A. The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons. J Neurosci 2003; 23:1649-58; PMID:12629169
   PubMed Web of Science ®Google Scholar
• Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 2002; 9:1005-16; PMID:12049737
   PubMed Web of Science ®Google Scholar
• Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A. Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. Science 2008; 319:1665-8; PMID:18356527; http://dx.doi.org/10.1126/science.1152337
   PubMed Web of Science ®Google Scholar
• Iyirhiaro GO, Zhang Y, Estey C, O'Hare MJ, Safarpour F, Parsanejad M, Wang S, Abdel-Messih E, Callaghan SM, During MJ, et al. Regulation of ischemic neuronal death by E2F4-p130 protein complexes. J Biol Chem 2014; 289:18202-13; PMID:24828495 http://dx.doi.org/10.1074/jbc.M114.574145
   PubMed Web of Science ®Google Scholar
• Liu DX, Nath N, Chellappan SP, Greene LA. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev 2005; 19:719-32; PMID:15769944
   PubMed Web of Science ®Google Scholar
• Verdaguer E, García-Jordà E, Canudas AM, Domínguez E, Jiménez A, Pubill D, Escubedo E, Pallàs JC, Camins A. Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry. Neuroreport 2002; 13:413-6; PMID:11930151
   PubMed Web of Science ®Google Scholar
• Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, et al. Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci 2004; 24:10763-72; PMID:15564594
   PubMed Web of Science ®Google Scholar
• Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT. Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron 1992; 9:955-66; PMID:1419002
   PubMed Web of Science ®Google Scholar
• Park KH, Hallows JL, Chakrabarty P, Davies P, Vincent I. Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci 2007; 27:2969-78; PMID:17360920
   PubMed Web of Science ®Google Scholar
• Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M. Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci 2001; 24:25-31; PMID:11163884
   PubMed Web of Science ®Google Scholar
• Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ 2000;11:625-33; PMID:11149597
   PubMedGoogle Scholar
• Rohrer H, Thoenen H. Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation. J Neurosci 1987; 7:3739-48; PMID:3681410
   PubMed Web of Science ®Google Scholar
• Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J 2001; 20:3402-13; PMID:11432828
   PubMed Web of Science ®Google Scholar
• Morillo SM, Escoll P, de la Hera A, Frade JM. Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci USA 2010; 107:109-14; PMID:20018664 http://dx.doi.org/10.1073/pnas.0906121107
   PubMed Web of Science ®Google Scholar
• Shirazi Fard S, Jarrin M, Boije H, Fillon V, All-Eriksson C, Hallböök F. Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome. PLoS One 2013; 8:e59133; PMID:23527113 http://dx.doi.org/10.1371/journal.pone.0059133
   PubMedGoogle Scholar
• Donovan SL, Corbo JC. Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells. Mol Biol Cell 2012; 23:4362-72; PMID:23015754; http://dx.doi.org/10.1091/mbc.E12-04-0293
   PubMed Web of Science ®Google Scholar
• Pacal M, Bremner R. Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons. Dev Dyn 2012; 241:1525-44; PMID:22837015; http://dx.doi.org/10.1002/dvdy.23840
   PubMed Web of Science ®Google Scholar
• Morillo SM, Abanto EP, Román MJ, Frade JM. Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol Cell Biol 2012; 32:2722-37; PMID:22586272; http://dx.doi.org/10.1128/MCB.00239-12
   PubMed Web of Science ®Google Scholar
• Frade JM. Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. J Cell Sci 2000; 113:1139-48; PMID:10704365
   PubMed Web of Science ®Google Scholar
• Persengiev SP, Kondova II, Kilpatrick DL. E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. Mol Cell Biol. 1999; 19:6048-56; PMID:10454552
   PubMed Web of Science ®Google Scholar
• Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T. Aneuploidy and DNA replication in the normal human brain and Alzheimer disease. J Neurosci 2007; 27:6859-67; PMID:17596434
   PubMed Web of Science ®Google Scholar
• López-Sánchez N, Frade JM. Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. J Neurosci 2013; 33:7488-500; PMID:23616554; http://dx.doi.org/10.1523/JNEUROSCI.3849-12.2013
   PubMed Web of Science ®Google Scholar
• López-Sánchez N, Ovejero-Benito MC, Borreguero L, Frade JM. Control of neuronal ploidy during vertebrate development. Results Probl Cell Differ 2011; 53:547-63; PMID:21630159; http://dx.doi.org/10.1007/978-3-642-19065-0_22
   PubMedGoogle Scholar
• Wang W, Bu B, Xie M, Zhang M, Yu Z, Tao D. Neural cell cycle dysregulation and central nervous system diseases. Prog Neurobiol 2009;89:1-17; PMID:19619927; http://dx.doi.org/10.1016/j.pneurobio.2009.01.007
   PubMed Web of Science ®Google Scholar
• Byrnes KR, Faden AI. Role of cell cycle proteins in CNS injury. Neurochem Res 2007; 32:1799-807; PMID:17404835
   PubMed Web of Science ®Google Scholar
• Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci USA 2005; 102:8333-8; PMID:15923260
   PubMed Web of Science ®Google Scholar
• Osuga H, Osuga S, Wang F, Fetni R, Hogan MJ, Slack RS, Hakim AM, Ikeda JE, Park DS. Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci USA 2000; 97:10254-9; PMID:10944192
   PubMed Web of Science ®Google Scholar
• Arendt T, Brückner MK, Mosch B, Lösche A. Selective cell death of hyperploid neurons in Alzheimer disease. Am J Pathol 2010; 177:15-20; PMID:20472889; http://dx.doi.org/10.2353/ajpath.2010.090955
   PubMed Web of Science ®Google Scholar
• Frade JM, López-Sánchez N. A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75NTR. Cell Cycle 2010; 9:1934-41; PMID:20436277
   PubMed Web of Science ®Google Scholar
• Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, et al.; Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY) 2009; 1:382-8; PMID:19946466
   PubMedGoogle Scholar
• Yang Y, Geldmacher DS, Herrup K. DNA replication precedes neuronal cell death in Alzheimer disease. J Neurosci 2001; 21:2661-8; PMID:1306619
   PubMed Web of Science ®Google Scholar
• Arendt T. Cell cycle activation and aneuploid neurons in Alzheimer disease. Mol Neurobiol 2012; 46:125-35; PMID:22528601; http://dx.doi.org/10.1007/s12035-012-8262-0
   PubMed Web of Science ®Google Scholar
• Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer disease and amyloid precursor protein transgenic mouse models. J Neurosci 2006; 26:775-84; PMID:16421297
   PubMed Web of Science ®Google Scholar
• Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer disease brain. J Neurosci 1998; 18:2801-7; PMID:9525997
   PubMed Web of Science ®Google Scholar
• Smith TW, Lippa CF. Ki-67 immunoreactivity in Alzheimer disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 1995; 54:297-303; PMID:7745428
   PubMed Web of Science ®Google Scholar
• Nagy Z, Vatter-Bittner B, Braak H, Braak E, Yilmazer DM, Schultz C, Hanke J. Staging of Alzheimer-type pathology: an interrater-intrarater study. Dement Geriatr Cogn Disord 1997; 8:248-51; PMID:9213071
   PubMed Web of Science ®Google Scholar
• Yang Y, Mufson EJ, Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer disease. J Neurosci 2003; 23:2557-63; PMID:12684440
   PubMed Web of Science ®Google Scholar
• Hoozemans JJ, Brückner MK, Rozemuller AJ, Veerhuis R, Eikelenboom P, Arendt T. Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J Neuropathol Exp Neurol 2002; 61:678-88; PMID:12152783
   PubMed Web of Science ®Google Scholar
• McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochim Biophys Acta 2007; 1772:467-72; PMID:17095196
   PubMed Web of Science ®Google Scholar
• Absalon S, Kochanek DM, Raghavan V, Krichevsky AM. MiR-26b, upregulated in Alzheimer disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 2013; 33:14645-59; PMID:24027266; http://dx.doi.org/10.1523/JNEUROSCI.1327-13.2013
   PubMed Web of Science ®Google Scholar
• Hu XY, Zhang HY, Qin S, Xu H, Swaab DF, Zhou JN. Increased p75NTR expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients. Exp Neurol 2002; 178:104-11; PMID:12460612
   PubMed Web of Science ®Google Scholar
• Munoz L, Ammit AJ. Targeting p38 MAPK pathway for the treatment of Alzheimer disease. Neuropharmacology 2010; 58:561-8; PMID:19951717; http://dx.doi.org/10.1016/j.neuropharm.2009.11.010
   PubMed Web of Science ®Google Scholar
• Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer disease brains at different stages of neurofibrillary degeneration. J Alzheimers Dis 2001; 3:41-48; PMID:12214071
   PubMed Web of Science ®Google Scholar
• Sun A, Liu M, Nguyen XV, Bing G. P38 MAP kinase is activated at early stages in Alzheimer disease brain. Exp Neurol 2003; 183:394-405; PMID:14552880
   PubMed Web of Science ®Google Scholar
• Morgan KL, Chalovich EM, Strachan GD, Otis LL, Jordan-Sciutto KL. E2F4 expression patterns in SIV encephalitis. Neurosci Lett 2005; 382:259-64; PMID:15925101
   PubMed Web of Science ®Google Scholar
• Love S. Neuronal expression of cell cycle-related proteins after brain ischaemia in man. Neurosci Lett 2003; 353:29-32; PMID:14642430
   PubMed Web of Science ®Google Scholar
• Wen Y, Yang S, Liu R, Brun-Zinkernagel AM, Koulen P, Simpkins JW. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer disease-like tauopathy in female rats. J Biol Chem 2004; 279:22684-92; PMID:14982935
   PubMed Web of Science ®Google Scholar
• Rashidian J, Iyirhiaro G, Aleyasin H, Rios M, Vincent I, Callaghan S, Bland RJ, Slack RS, During MJ, Park DS. Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci USA 2005; 102:14080-5; PMID:16166266
   PubMed Web of Science ®Google Scholar
• Burns KA, Ayoub AE, Breunig JJ, Adhami F, Weng WL, Colbert MC, Rakic P, Kuan CY. Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex 2007; 17:2585-92; PMID:17259645
   PubMed Web of Science ®Google Scholar
• Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, et al.; The pRb/E2F cell-cycle pathway mediates cell death in Parkinson disease. Proc Natl Acad Sci USA 2007; 104:3585-90; PMID:17360686
   PubMed Web of Science ®Google Scholar
• Jordan-Sciutto KL, Dorsey R, Chalovich EM, Hammond RR, Achim CL. Expression patterns of retinoblastoma protein in Parkinson disease. J Neuropathol Exp Neurol 2003; 62:68-74; PMID:12528819
   PubMed Web of Science ®Google Scholar
• El-Khodor BF, Oo TF, Kholodilov N, Burke RE. Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta. Exp Neurol 2003; 179:17-27; PMID:12504864
   PubMed Web of Science ®Google Scholar
• Alvira D, Tajes M, Verdaguer E, de Arriba SG, Allgaier C, Matute C, Trullas R, Jiménez A, Pallàs M, Camins A. Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Neuroscience 2007; 146:350-65; PMID:17343987
   PubMed Web of Science ®Google Scholar
• Bowser R, Smith MA. Cell cycle proteins in Alzheimer disease: plenty of wheels but no cycle. J Alzheimers Dis 2002; 4:249-54; PMID:12226545
   PubMed Web of Science ®Google Scholar
• Ovejero-Benito MC, Frade JM. Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. PLoS One 2013; 8:e64890; PMID:23741412; http://dx.doi.org/10.1371/journal.pone.0064890
   PubMed Web of Science ®Google Scholar
• Shirazi Fard S, All-Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 2014; 13:408-17; PMID:24247150; http://dx.doi.org/10.4161/cc.27200
   PubMed Web of Science ®Google Scholar
• Frade JM, Bovolenta P, Martínez-Morales JR, Arribas A, Barbas JA, Rodríguez-Tébar A. Control of early cell death by BDNF in the chick retina. Development 1997; 124:3313-20; PMID:9310326
   PubMed Web of Science ®Google Scholar
• Frade JM, Barde YA. Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. Development 1999; 126:683-90; PMID:9895316
   PubMed Web of Science ®Google Scholar
• Nagy Z, Esiri MM, Cato AM, Smith AD. Cell cycle markers in the hippocampus in Alzheimer disease. Acta Neuropathol 1997; 94:6-15; PMID:9224524
   PubMed Web of Science ®Google Scholar
• Tsujioka Y, Takahashi M, Tsuboi Y, Yamamoto T, Yamada T. Localization and expression of cdc2 and cdk4 in Alzheimer brain tissue. Dement Geriatr Cogn Disord 1999; 10:192-8; PMID:10325446
   PubMed Web of Science ®Google Scholar
• Vincent I, Jicha G, Rosado M, Dickson DW. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer disease brain. J Neurosci 1997; 17:3588-98; PMID:9133382
   PubMed Web of Science ®Google Scholar
• Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer disease neurofibrillary degeneration. Acta Neuropathol 2002; 104:369-76; PMID:12200623
   PubMed Web of Science ®Google Scholar
• Dranovsky A, Vincent I, Gregori L, Schwarzman A, Colflesh D, Enghild J, Strittmatter W, Davies P, Goldgaber D. Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer disease pathology. Neurobiol Aging 2001; 22:517-28; PMID:11445251
   PubMed Web of Science ®Google Scholar
• Husseman JW, Nochlin D, Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol Aging 2000; 21:815-28; PMID:11124425
   PubMed Web of Science ®Google Scholar
• Vincent I, Bu B, Hudson K, Husseman J, Nochlin D, Jin L. Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer disease. Neuroscience 2001; 105:639-50; PMID:11516829
   PubMed Web of Science ®Google Scholar
• Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer disease. Am J Pathol 2000; 157:1983-90; PMID:11106571
   PubMed Web of Science ®Google Scholar
• Tomashevski A, Husseman J, Jin LW, Nochlin D, Vincent I. Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration. J Alzheimers Dis 2001; 3:195-207; PMID:12214061
   PubMed Web of Science ®Google Scholar
• Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA. Ectopic localization of phosphorylated histone H3 in Alzheimer disease: a mitotic catastrophe? Acta Neuropathol 2003; 105:524-8; PMID:12677454
   PubMed Web of Science ®Google Scholar
• Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK. GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 2013; 138:155-75; PMID:23348013; http://dx.doi.org/10.1016/j.pharmthera.2013.01.004
   PubMed Web of Science ®Google Scholar
• Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 2009; 5:311-22; PMID:19498435; http://dx.doi.org/10.1038/nrneurol.2009.54
   PubMed Web of Science ®Google Scholar
• Skaper SD. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol Disord Drug Targets 2008; 7:46-62; PMID:18289031
   PubMed Web of Science ®Google Scholar
• Ferrer I, Marín C, Rey MJ, Ribalta T, Goutan E, Blanco R, Tolosa E, Martí E. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J Neuropathol Exp Neurol 1999; 58:729-39; PMID:10411343
   PubMed Web of Science ®Google Scholar
• Kim AH, Bonni A. Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell Cycle 2008; 7:3819-22; PMID:19124971
   PubMed Web of Science ®Google Scholar
• Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 2013; 14:83-97; PMID:23325358 http://dx.doi.org/10.1038/nrm3507
   PubMed Web of Science ®Google Scholar
• Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 2007; 131:378-90; PMID:17956737
   PubMed Web of Science ®Google Scholar
• Wang F, Corbett D, Osuga H, Osuga S, Ikeda JE, Slack RS, Hogan MJ, Hakim AM, Park DS. Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. J Cereb Blood Flow Metab 2002; 22:171-82; PMID:11823715
   PubMed Web of Science ®Google Scholar
• Verdaguer E, Jiménez A, Canudas AM, Jordà EG, Sureda FX, Pallàs M, Camins A. Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment. J Pharmacol Exp Ther 2004; 308:609-16; PMID:14610234
   PubMed Web of Science ®Google Scholar