FANCD2 influences replication fork processes and genome stability in response to clustered DSBs

References

• Asaithamby A, Hu B, Chen DJ. Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Natl Acad Sci U S A 2011; 108:8293-8; PMID:21527720; http://dx.doi.org/10.1073/pnas.1016045108
   PubMed Web of Science ®Google Scholar
• Goodhead DT, Thacker J, Cox R. Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int J Radiat Biol 1993; 63:543-56; PMID:8099101; http://dx.doi.org/10.1080/09553009314450721
   PubMed Web of Science ®Google Scholar
• Sutherland BM, Bennett PV, Sidorkina O, Laval J. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc Natl Acad Sci U S A 2000; 97:103-8; PMID:10618378; http://dx.doi.org/10.1073/pnas.97.1.103
   PubMed Web of Science ®Google Scholar
• Brenner DJ, Ward JF. Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int J Radiat Biol 1992; 61:737-48; PMID:1351522; http://dx.doi.org/10.1080/09553009214551591
   PubMed Web of Science ®Google Scholar
• Blaisdell JO, Harrison L, Wallace SS. Base excision repair processing of radiation-induced clustered DNA lesions. Radiat Prot Dosimetry 2001; 97:25-31; PMID:11763354; http://dx.doi.org/10.1093/oxfordjournals.rpd.a006634
   PubMed Web of Science ®Google Scholar
• Harrison L, Hatahet Z, Purmal AA, Wallace SS. Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII. Nucleic Acids Res 1998; 26:932-41; PMID:9461450; http://dx.doi.org/10.1093/nar/26.4.932
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res 2001; 156:577-83; PMID:11604075; http://dx.doi.org/10.1667/0033-7587(2001)156%5b0577:CAFDTS%5d2.0.CO;2
   PubMed Web of Science ®Google Scholar
• Wang H, Wang X, Zhang P, Wang Y. The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation. DNA Repair (Amst) 2008; 7:725-33; PMID:18325854; http://dx.doi.org/10.1016/j.dnarep.2008.01.010
   PubMed Web of Science ®Google Scholar
• Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair 2005; 4:556-70; PMID:15811628; http://dx.doi.org/10.1016/j.dnarep.2005.02.001
   PubMed Web of Science ®Google Scholar
• Zafar F, Seidler SB, Kronenberg A, Schild D, Wiese C. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions. Radiat Res 2010; 173:27-39; PMID:20041757; http://dx.doi.org/10.1667/RR1910.1
   PubMed Web of Science ®Google Scholar
• Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. DNA Repair 2013; 12:936-46; PMID:24041488; http://dx.doi.org/10.1016/j.dnarep.2013.08.009
   PubMed Web of Science ®Google Scholar
• Fanconi G. Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.). I. Clinical aspects. Semin Hematol 1967; 4:233-40; PMID:6074578
   PubMedGoogle Scholar
• Kee Y, D'Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 2010; 24:1680-94; PMID:20713514; http://dx.doi.org/10.1101/gad.1955310
   PubMed Web of Science ®Google Scholar
• Moldovan GL, D'Andrea AD. How the fanconi anemia pathway guards the genome. Annu Rev Genet 2009; 43:223-49; PMID:19686080; http://dx.doi.org/10.1146/annurev-genet-102108-134222
   PubMed Web of Science ®Google Scholar
• Crossan GP, Patel KJ. The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. J Pathol 2012; 226:326-37; PMID:21956823; http://dx.doi.org/10.1002/path.3002
   PubMed Web of Science ®Google Scholar
• Kottemann MC, Smogorzewska A. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 2013; 493:356-63; PMID:23325218; http://dx.doi.org/10.1038/nature11863
   PubMed Web of Science ®Google Scholar
• Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001; 7:249-62; PMID:11239454; http://dx.doi.org/10.1016/S1097-2765(01)00173-3
   PubMed Web of Science ®Google Scholar
• Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, et al. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 2007; 129:289-301; PMID:17412408; http://dx.doi.org/10.1016/j.cell.2007.03.009
   PubMed Web of Science ®Google Scholar
• Bunting SF, Nussenzweig A. Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair. Mol Cell 2010; 39:164-6; PMID:20670885; http://dx.doi.org/10.1016/j.molcel.2010.07.016
   PubMed Web of Science ®Google Scholar
• Shen C, Houghton PJ. Targeting FANCD2 for therapy sensitization. Oncotarget 2014; 5:3426-7; PMID:24913333
   PubMed Web of Science ®Google Scholar
• Patil AA, Sayal P, Depondt ML, Beveridge RD, Roylance A, Kriplani DH, Myers KN, Cox A, Jellinek D, Fernando M, et al. FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents. Oncotarget 2014; 5:6414-24; PMID:25071006
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 2002; 100:2414-20; PMID:12239151; http://dx.doi.org/10.1182/blood-2002-01-0278
   PubMed Web of Science ®Google Scholar
• Panneerselvam J, Pickering A, Han B, Li L, Zheng J, Zhang J, Zhang Y, Fei P. Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate. Oncotarget 2014; 5:1326-37; PMID:24658369
   PubMed Web of Science ®Google Scholar
• Unno J, Itaya A, Taoka M, Sato K, Tomida J, Sakai W, Sugasawa K, Ishiai M, Ikura T, Isobe T, et al. FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair. Cell Rep 2014; 7:1039-47; PMID:24794430; http://dx.doi.org/10.1016/j.celrep.2014.04.005
   PubMed Web of Science ®Google Scholar
• Murina O, von Aesch C, Karakus U, Ferretti LP, Bolck HA, Hanggi K, Sartori AA. FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks. Cell Rep 2014; 7:1030-8; PMID:24794434; http://dx.doi.org/10.1016/j.celrep.2014.03.069
   PubMed Web of Science ®Google Scholar
• Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 2012; 22:106-16; PMID:22789542; http://dx.doi.org/10.1016/j.ccr.2012.05.015
   PubMed Web of Science ®Google Scholar
• Pichierri P, Rosselli F. The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J 2004; 23:1178-87; PMID:14988723; http://dx.doi.org/10.1038/sj.emboj.7600113
   PubMed Web of Science ®Google Scholar
• Mechali M, Lutzmann M. The cell cycle: now live and in color. Cell 2008; 132:341-3; PMID:18267067; http://dx.doi.org/10.1016/j.cell.2008.01.031
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 2002; 109:459-72; PMID:12086603; http://dx.doi.org/10.1016/S0092-8674(02)00747-X
   PubMed Web of Science ®Google Scholar
• Wang X, Andreassen PR, D'Andrea AD. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol 2004; 24:5850-62; PMID:15199141; http://dx.doi.org/10.1128/MCB.24.13.5850-5862.2004
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Hirano S, Ishiai M, Morishima K, Kitao H, Namikoshi K, Kimura M, Matsushita N, Arakawa H, Buerstedde JM, et al. Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol Cell Biol 2005; 25:34-43; PMID:15601828; http://dx.doi.org/10.1128/MCB.25.1.34-43.2005
   PubMed Web of Science ®Google Scholar
• Seki S, Ohzeki M, Uchida A, Hirano S, Matsushita N, Kitao H, Oda T, Yamashita T, Kashihara N, Tsubahara A, et al. A requirement of FancL and FancD2 monoubiquitination in DNA repair. GenesCells 2007; 12:299-310; http://dx.doi.org/10.1111/j.1365-2443.2007.01054.x
   Web of Science ®Google Scholar
• Lok BH, Powell SN. Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. Clin Cancer Res 2012; 18:6400-6; PMID:23071261; http://dx.doi.org/10.1158/1078-0432.CCR-11-3150
   PubMed Web of Science ®Google Scholar
• Plate I, Hallwyl SC, Shi I, Krejci L, Muller C, Albertsen L, Sung P, Mortensen UH. Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity. J Biol Chemis 2008; 283:29077-85; PMID:18703507; http://dx.doi.org/10.1074/jbc.M804881200
   PubMed Web of Science ®Google Scholar
• Chapman JR, Taylor MR, Boulton SJ. Playing the end game: DNA double-strand break repair pathway choice. Mol Cell 2012; 47:497-510; PMID:22920291; http://dx.doi.org/10.1016/j.molcel.2012.07.029
   PubMed Web of Science ®Google Scholar
• Averbeck NB, Ringel O, Herrlitz M, Jakob B, Durante M, Taucher-Scholz G. DNA end resection is needed for the repair of complex lesions in G1-phase human cells. Cell Cycle 2014; 13:2509-16; PMID:25486192; http://dx.doi.org/10.4161/15384101.2015.941743
   PubMed Web of Science ®Google Scholar
• Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Decaillet C, Gari K, Constantinou A. FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Mol Cell 2013; 51:678-90; PMID:23993743; http://dx.doi.org/10.1016/j.molcel.2013.07.023
   PubMed Web of Science ®Google Scholar
• Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A. Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. Cell Rep 2014; 9:1387-401; PMID:25456133; http://dx.doi.org/10.1016/j.celrep.2014.10.025
   PubMed Web of Science ®Google Scholar
• Montgomery E, Wilentz RE, Argani P, Fisher C, Hruban RH, Kern SE, Lengauer C. Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies. Cancer Biol Ther 2003; 2:248-52; PMID:12878857; http://dx.doi.org/10.4161/cbt.2.3.362
   PubMed Web of Science ®Google Scholar
• Hoffelder DR, Luo L, Burke NA, Watkins SC, Gollin SM, Saunders WS. Resolution of anaphase bridges in cancer cells. Chromosoma 2004; 112:389-97; PMID:15156327; http://dx.doi.org/10.1007/s00412-004-0284-6
   PubMed Web of Science ®Google Scholar
• Rosefort C, Fauth E, Zankl H. Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay. Mutagenesis 2004; 19:277-84; PMID:15215326; http://dx.doi.org/10.1093/mutage/geh028
   PubMed Web of Science ®Google Scholar
• Hu L, Filippakis H, Huang H, Yen TJ, Gjoerup OV. Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen. J Virol 2013; 87:13179-92; PMID:24067972; http://dx.doi.org/10.1128/JVI.02224-13
   PubMed Web of Science ®Google Scholar
• Piperno G, LeDizet M, Chang XJ. Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J Cell Biol 1987; 104:289-302; PMID:2879846; http://dx.doi.org/10.1083/jcb.104.2.289
   PubMed Web of Science ®Google Scholar
• Wang H, Zhang X, Wang P, Yu X, Essers J, Chen D, Kanaar R, Takeda S, Wang Y. Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res 2010; 38:3245-51; PMID:20150414; http://dx.doi.org/10.1093/nar/gkq069
   PubMed Web of Science ®Google Scholar
• Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD, Wang ZQ, Jasin M. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A 2005; 102:1110-5; PMID:15650050; http://dx.doi.org/10.1073/pnas.0407796102
   PubMed Web of Science ®Google Scholar
• Tarsounas M, Davies D, West SC. BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 2003; 22:1115-23; PMID:12606939; http://dx.doi.org/10.1038/sj.onc.1206263
   PubMed Web of Science ®Google Scholar
• Digweed M, Rothe S, Demuth I, Scholz R, Schindler D, Stumm M, Grompe M, Jordan A, Sperling K. Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis 2002; 23:1121-6; PMID:12117768; http://dx.doi.org/10.1093/carcin/23.7.1121
   PubMed Web of Science ®Google Scholar
• Asaithamby A, Chen DJ. Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat Res 2011; 711:87-99; PMID:21126526; http://dx.doi.org/10.1016/j.mrfmmm.2010.11.002
   PubMed Web of Science ®Google Scholar
• Kim H, D'Andrea AD. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012; 26:1393-408; PMID:22751496; http://dx.doi.org/10.1101/gad.195248.112
   PubMed Web of Science ®Google Scholar
• Yeo JE, Lee EH, Hendrickson EA, Sobeck A. CtIP mediates replication fork recovery in a FANCD2-regulated manner. Hum Mol Genet 2014; 23:3695-705; PMID:24556218; http://dx.doi.org/10.1093/hmg/ddu078
   PubMed Web of Science ®Google Scholar
• Parplys AC, Petermann E, Petersen C, Dikomey E, Borgmann K. DNA damage by X-rays and their impact on replication processes. Radiother Oncol 2012; 102:466-71; PMID:22326574; http://dx.doi.org/10.1016/j.radonc.2012.01.005
   PubMed Web of Science ®Google Scholar
• Laulier C, Cheng A, Stark JM. The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. Nucleic Acids Res 2011; 39:5935-44; PMID:21459848; http://dx.doi.org/10.1093/nar/gkr187
   PubMed Web of Science ®Google Scholar
• Huang Y, Hou H, Yi Q, Zhang Y, Chen D, Jiang E, Xia Y, Fenech M, Shi Q. The fate of micronucleated cells post X-irradiation detected by live cell imaging. DNA Repair 2011; 10:629-38; PMID:21543268; http://dx.doi.org/10.1016/j.dnarep.2011.04.010
   PubMed Web of Science ®Google Scholar
• Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD. Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest 2010; 120:3834-42; PMID:20921626; http://dx.doi.org/10.1172/JCI43391
   PubMed Web of Science ®Google Scholar
• Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ. Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Res 2011; 39:5474-88; PMID:21421565; http://dx.doi.org/10.1093/nar/gkr149
   PubMed Web of Science ®Google Scholar
• Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 2014; 157:565-79; PMID:24766806; http://dx.doi.org/10.1016/j.cell.2014.03.032
   PubMed Web of Science ®Google Scholar
• Asaithamby A, Chen DJ. Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res 2009; 37:3912-23; PMID:19401436; http://dx.doi.org/10.1093/nar/gkp237
   PubMed Web of Science ®Google Scholar
• Asaithamby A, Uematsu N, Chatterjee A, Story MD, Burma S, Chen DJ. Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res 2008; 169:437-46; PMID:18363429; http://dx.doi.org/10.1667/RR1165.1
   PubMed Web of Science ®Google Scholar
• Suzuki F, Suzuki K, Nikaido O. An improved soft agar method for determining neoplastic transformation in vitro. J Tissue Culture Methods 1983; 8:109-13; http://dx.doi.org/10.1007/BF01842703
   Google Scholar