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Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure

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Pages 2323-2332 | Received 05 Mar 2015, Accepted 18 Apr 2015, Published online: 15 Jul 2015

References

  • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-7; PMID:9072974; http://dx.doi.org/10.1126/science.275.5308.1943.
  • Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 1997; 57:2124-9; PMID:9187108.
  • Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-62; PMID:9090379; http://dx.doi.org/10.1038/ng0497-356.
  • Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991; 254:274-7; PMID:1833819; http://dx.doi.org/10.1126/science.1833819.
  • Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 1997; 276:1848-50; PMID:9188528; http://dx.doi.org/10.1126/science.276.5320.1848.
  • Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 1987; 84:5034-7; PMID:3037531; http://dx.doi.org/10.1073/pnas.84.14.5034.
  • Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 2007; 128:129-39; PMID:17218260; http://dx.doi.org/10.1016/j.cell.2006.11.039.
  • Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128:157-70; PMID:17218262; http://dx.doi.org/10.1016/j.cell.2006.11.042.
  • Sun Z, Huang C, He J, Lamb KL, Kang X, Gu T, Shen WH, Yin Y. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep 2014; 6:844-54; PMID:24561254; http://dx.doi.org/10.1016/j.celrep.2014.01.030.
  • Amor DJ, Kalitsis P, Sumer H, Choo KH. Building the centromere: from foundation proteins to 3D organization. Trends Cell Biol 2004; 14:359-68; PMID:15246429; http://dx.doi.org/10.1016/j.tcb.2004.05.009.
  • Saunders WS, Chue C, Goebl M, Craig C, Clark RF, Powers JA, Eissenberg JC, Elgin SC, Rothfield NF, Earnshaw WC. Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J Cell Sci 1993; 104 (Pt 2):573-82; PMID:8505380.
  • Grewal SI, Elgin SC. Heterochromatin: new possibilities for the inheritance of structure. Curr Opin Genet Dev 2002; 12:178-87; PMID:11893491; http://dx.doi.org/10.1016/S0959-437X(02)00284-8.
  • Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 2001; 292:110-3; PMID:11283354; http://dx.doi.org/10.1126/science.1060118.
  • Guenatri M, Bailly D, Maison C, Almouzni G. Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol 2004; 166:493-505; PMID:15302854; http://dx.doi.org/10.1083/jcb.200403109.
  • Hall LE, Mitchell SE, O'Neill RJ. Pericentric and centromeric transcription: a perfect balance required. Chromosome Res 2012; 20:535-46; PMID:22760449; http://dx.doi.org/10.1007/s10577-012-9297-9.
  • Jurka J, Kapitonov VV, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J. Repbase Update, a database of eukaryotic repetitive elements. Cytogenet Genome Res 2005; 110:462-7; PMID:16093699; http://dx.doi.org/10.1159/000084979.
  • Bouzinba-Segard H, Guais A, Francastel C. Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function. Proc Natl Acad Sci U S A 2006; 103:8709-14; PMID:16731634; http://dx.doi.org/10.1073/pnas.0508006103.
  • Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C, Riva S, Biamonti G. Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res 2008; 36:423-34; PMID:18039709; http://dx.doi.org/10.1093/nar/gkm1056.
  • Schuster-Bockler B, Lehner B. Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature 2012; 488:504-7; PMID:22820252; http://dx.doi.org/10.1038/nature11273.
  • Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, et al. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 2011; 331:593-6; PMID:21233348; http://dx.doi.org/10.1126/science.1200801.
  • Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science 2003; 301:798-802; PMID:12907790; http://dx.doi.org/10.1126/science.1086887.
  • Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410:116-20; PMID:11242053; http://dx.doi.org/10.1038/35065132.
  • Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 2001; 410:120-4; PMID:11242054; http://dx.doi.org/10.1038/35065138.
  • Fischle W, Tseng BS, Dormann HL, Ueberheide BM, Garcia BA, Shabanowitz J, Hunt DF, Funabiki H, Allis CD. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 2005; 438:1116-22; PMID:16222246; http://dx.doi.org/10.1038/nature04219.
  • Bubien V, Bonnet F, Brouste V, Hoppe S, Barouk-Simonet E, David A, Edery P, Bottani A, Layet V, Caron O, et al. High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome. J Med Genet 2013; 50:255-63; PMID:23335809; http://dx.doi.org/10.1136/jmedgenet-2012-101339.
  • Bassi C, Ho J, Srikumar T, Dowling RJ, Gorrini C, Miller SJ, Mak TW, Neel BG, Raught B, Stambolic V. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 2013; 341:395-9; PMID:23888040; http://dx.doi.org/10.1126/science.1236188.
  • Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, Waldman T, Lord CJ, Ashworth A. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009; 1:315-22; PMID:20049735; http://dx.doi.org/10.1002/emmm.200900041.
  • Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proc Natl Acad Sci U S A 2013; 110:E89-98; PMID:23236145; http://dx.doi.org/10.1073/pnas.1216922110.
  • Chen ZH, Zhu M, Yang J, Liang H, He J, He S, Wang P, Kang X, McNutt MA, Yin Y, et al. PTEN interacts with histone H1 and controls chromatin condensation. Cell reports 2014; 8:2003-14; PMID:25199838; http://dx.doi.org/10.1016/j.celrep.2014.08.008.
  • Dialynas GK, Vitalini MW, Wallrath LL. Linking Heterochromatin Protein 1 (HP1) to cancer progression. Mutation Res 2008; 647:13-20; PMID:18926834; http://dx.doi.org/10.1016/j.mrfmmm.2008.09.007.
  • Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G. Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 2001; 276:38224-30; PMID:11454856.
  • Peng G, Yim EK, Dai H, Jackson AP, Burgt I, Pan MR, Hu R, Li K, Lin SY. BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 2009; 11:865-72; PMID:19525936; http://dx.doi.org/10.1038/ncb1895.
  • Carey M, Smale ST. Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions. CSH Protocols 2007; 2007:pdb prot4890.

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