Target of rapamycin activation predicts lifespan in fruit flies

References

• Merker K, Stolzing A, Grune T. Proteolysis, caloric restriction and aging. Mech Ageing Dev 2001; 122:595-615; PMID:11322989; http://dx.doi.org/10.1016/S0047-6374(01)00219-6
   PubMed Web of Science ®Google Scholar
• Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972; 20:145-7; PMID:5016631; http://dx.doi.org/10.1111/j.1532-5415.1972.tb00787.x
   PubMed Web of Science ®Google Scholar
• Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal 2013; 19:1420-45; PMID:23642158; http://dx.doi.org/10.1089/ars.2012.5148
   PubMed Web of Science ®Google Scholar
• Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest 2013; 123:951-7; PMID:23454757; http://dx.doi.org/10.1172/JCI64125
   PubMed Web of Science ®Google Scholar
• Scialo F, Mallikarjun V, Stefanatos R, Sanz A. Regulation of lifespan by the mitochondrial electron transport chain: reactive oxygen species-dependent and reactive oxygen species-independent mechanisms. Antioxid Redox Signal 2013; 19:1953-69; PMID:22938137; http://dx.doi.org/10.1089/ars.2012.4900
   PubMed Web of Science ®Google Scholar
• Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA. Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev 2007; 87:1175-213; PMID:17928583; http://dx.doi.org/10.1152/physrev.00047.2006
   PubMed Web of Science ®Google Scholar
• Pamplona R. Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim Biophys Acta 2008; 1777:1249-62; PMID:18721793; http://dx.doi.org/10.1016/j.bbabio.2008.07.003
   PubMed Web of Science ®Google Scholar
• Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, et al. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY) 2011; 3:125-47; PMID:21386131
   PubMedGoogle Scholar
• Van Raamsdonk JM, Hekimi S. Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A 2012; 109:5785-90; PMID:22451939; http://dx.doi.org/10.1073/pnas.1116158109
   PubMed Web of Science ®Google Scholar
• Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003; 16:29-37; PMID:14679299; http://dx.doi.org/10.1152/physiolgenomics.00122.2003
   PubMed Web of Science ®Google Scholar
• Gems D, Partridge L. Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts. Annu Rev Physiol 2012; PMID:23190075
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102; PMID:17012837; http://dx.doi.org/10.4161/cc.5.18.3288
   PubMed Web of Science ®Google Scholar
• Gems D, de la Guardia Y. Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal 2013; 19:321-9; PMID:22870907; http://dx.doi.org/10.1089/ars.2012.4840
   PubMed Web of Science ®Google Scholar
• Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab 2011; 13:668-78; PMID:21641548; http://dx.doi.org/10.1016/j.cmet.2011.03.018
   PubMed Web of Science ®Google Scholar
• Spindler SR, Mote PL, Flegal JM. Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice. Age (Dordr) 2014; 36:9659; PMID:24816553; http://dx.doi.org/10.1007/s11357-014-9659-7
   PubMed Web of Science ®Google Scholar
• Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010; 11:35-46; PMID:20074526; http://dx.doi.org/10.1016/j.cmet.2009.11.010
   PubMed Web of Science ®Google Scholar
• Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221
   PubMed Web of Science ®Google Scholar
• Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID:19587680
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Paszkiewicz GM, Blagosklonny MV. Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet. Aging Cell 2014; 13:616-22; PMID:24655348; http://dx.doi.org/10.1111/acel.12211
   PubMed Web of Science ®Google Scholar
• Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007; 43:477-503; PMID:17640558; http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.034
   PubMed Web of Science ®Google Scholar
• Duttaroy A, Paul A, Kundu M, Belton A. A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics 2003; 165:2295-9; PMID:14704205
   PubMed Web of Science ®Google Scholar
• Curtis C, Landis GN, Folk D, Wehr NB, Hoe N, Waskar M, Abdueva D, Skvortsov D, Ford D, Luu A, et al. Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol 2007; 8:R262; PMID:18067683; http://dx.doi.org/10.1186/gb-2007-8-12-r262
   PubMed Web of Science ®Google Scholar
• Stefanatos R, Sriram A, Kiviranta E, Mohan A, Ayala V, Jacobs HT, Pamplona R, Sanz A. dj-1beta regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 2012; 11:3876-86; PMID:22983063; http://dx.doi.org/10.4161/cc.22073
   PubMed Web of Science ®Google Scholar
• Sanz A, Fernandez-Ayala DJ, Stefanatos RK, Jacobs HT. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY) 2010; 2:200-23; PMID:20453260
   PubMedGoogle Scholar
• Owusu-Ansah E, Song W, Perrimon N. Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell 2013; 155:699-712; PMID:24243023; http://dx.doi.org/10.1016/j.cell.2013.09.021
   PubMed Web of Science ®Google Scholar
• Sestini EA, Carlson JC, Allsopp R. The effects of ambient temperature on life span, lipid peroxidation, superoxide dismutase, and phospholipase A2 activity in Drosophila melanogaster. Exp Gerontol 1991; 26:385-95; PMID:1936197; http://dx.doi.org/10.1016/0531-5565(91)90050-V
   PubMed Web of Science ®Google Scholar
• Miquel J, Lundgren PR, Bensch KG, Atlan H. Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mech Ageing Dev 1976; 5:347-70; PMID:823384; http://dx.doi.org/10.1016/0047-6374(76)90034-8
   PubMed Web of Science ®Google Scholar
• Pearl R. The Rate of Living, Being an Account of Some Experimental Studies on the Biology of Life Duration. London: University of London Press, 1928.
   Google Scholar
• Buffenstein R. The naked mole-rat: a new long-living model for human aging research. J Gerontol A Biol Sci Med Sci 2005; 60:1369-77; PMID:16339321; http://dx.doi.org/10.1093/gerona/60.11.1369
   PubMed Web of Science ®Google Scholar
• de Magalhaes JP, Costa J, Church GM. An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J Gerontol A Biol Sci Med Sci 2007; 62:149-60; PMID:17339640; http://dx.doi.org/10.1093/gerona/62.2.149
   PubMed Web of Science ®Google Scholar
• Brys K, Vanfleteren JR, Braeckman BP. Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans. Exp Gerontol 2007; 42:845-51; PMID:17379464; http://dx.doi.org/10.1016/j.exger.2007.02.004
   PubMed Web of Science ®Google Scholar
• Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol 2004; 39:1137-43; PMID:15288688; http://dx.doi.org/10.1016/j.exger.2004.04.006
   PubMed Web of Science ®Google Scholar
• Speakman JR, Talbot DA, Selman C, Snart S, McLaren JS, Redman P, Krol E, Jackson DM, Johnson MS, Brand MD. Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 2004; 3:87-95; PMID:15153176; http://dx.doi.org/10.1111/j.1474-9728.2004.00097.x
   PubMed Web of Science ®Google Scholar
• Barja G. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies. Rejuvenation Res 2007; 10:215-24; PMID:17523876; http://dx.doi.org/10.1089/rej.2006.0516
   PubMed Web of Science ®Google Scholar
• Overgaard J, Sorensen JG, Petersen SO, Loeschcke V, Holmstrup M. Changes in membrane lipid composition following rapid cold hardening in Drosophila melanogaster. J Insect Physiol 2005; 51:1173-82; PMID:16112133; http://dx.doi.org/10.1016/j.jinsphys.2005.06.007
   PubMed Web of Science ®Google Scholar
• Pamplona R, Barja G, Portero-Otin M. Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann N Y Acad Sci 2002; 959:475-90; PMID:11976221; http://dx.doi.org/10.1111/j.1749-6632.2002.tb02118.x
   PubMed Web of Science ®Google Scholar
• Pamplona R, Barja G. An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms. Biogerontology 2011; 12:409-35; PMID:21755337; http://dx.doi.org/10.1007/s10522-011-9348-1
   PubMed Web of Science ®Google Scholar
• Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL. Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci U S A 2009; 106:9262-7; PMID:19470468; http://dx.doi.org/10.1073/pnas.0904115106
   PubMed Web of Science ®Google Scholar
• Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11:298-300; PMID:13332224; http://dx.doi.org/10.1093/geronj/11.3.298
   PubMedGoogle Scholar
• Vermeulen CJ, Bijlsma R. Changes in mortality patterns and temperature dependence of lifespan in Drosophila melanogaster caused by inbreeding. Heredity 2004; 92:275-81; PMID:14679396; http://dx.doi.org/10.1038/sj.hdy.6800412
   PubMed Web of Science ®Google Scholar
• Guderley H, St-Pierre J. Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change. J Exp Biol 2002; 205:2237-49; PMID:12110658
   PubMed Web of Science ®Google Scholar
• Geer BW, Perille TJ. Effects of dietary sucrose and environmental temperature on fatty acid synthesis in Drosophila melanogaster. Insect Biochemistry 1977; 7:371-9; http://dx.doi.org/10.1016/0020-1790(77)90040-3
   Google Scholar
• Gomez A, Sanchez-Roman I, Gomez J, Cruces J, Mate I, Lopez-Torres M, Naudi A, Portero-Otin M, Pamplona R, De la Fuente M, et al. Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity. Aging Cell 2014; 13:551-60; PMID:24612513; http://dx.doi.org/10.1111/acel.12205
   PubMed Web of Science ®Google Scholar
• Valencak TG, Ruf T. Feeding into old age: long-term effects of dietary fatty acid supplementation on tissue composition and life span in mice. J Comp Physiol B 2011; 181:289-98; PMID:20981551; http://dx.doi.org/10.1007/s00360-010-0520-8
   PubMed Web of Science ®Google Scholar
• Lopez-Dominguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, et al. The influence of dietary fat source on life Span in calorie restricted mice. J Gerontol A Biol Sci Med Sci 2014; http://dx.doi.org/10.1093/gerona/glu177
   Web of Science ®Google Scholar
• Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J 2006; 20:1064-73; PMID:16770005; http://dx.doi.org/10.1096/fj.05-5568com
   PubMed Web of Science ®Google Scholar
• Pamplona R, Portero-Otin M, Sanz A, Requena J, Barja G. Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain. Exp Gerontol 2004; 39:725-33; PMID:15130667; http://dx.doi.org/10.1016/j.exger.2004.01.006
   PubMed Web of Science ®Google Scholar
• Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007; 6:95-110; PMID:17266679; http://dx.doi.org/10.1111/j.1474-9726.2006.00267.x
   PubMed Web of Science ®Google Scholar
• Bjedov I, Partridge L. A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem Soc Trans 2011; 39:460-5; PMID:21428920; http://dx.doi.org/10.1042/BST0390460
   PubMed Web of Science ®Google Scholar
• Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, et al. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell reports 2013; 4:913-20; PMID:23994476; http://dx.doi.org/10.1016/j.celrep.2013.07.030
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Paszkiewicz GM, Blagosklonny MV. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) 2012; 4:899-916; PMID:23443503
   PubMedGoogle Scholar
• Yang W, Hekimi S. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol 2010; 8:e1000556; PMID:21151885; http://dx.doi.org/10.1371/journal.pbio.1000556
   PubMed Web of Science ®Google Scholar
• Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001; 292:104-6; PMID:11292874; http://dx.doi.org/10.1126/science.1057991
   PubMed Web of Science ®Google Scholar
• Hashizume O, Shimizu A, Yokota M, Sugiyama A, Nakada K, Miyoshi H, Itami M, Ohira M, Nagase H, Takenaga K, et al. Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development. Proc Natl Acad Sci U S A 2012; 109:10528-33; PMID:22689997; http://dx.doi.org/10.1073/pnas.1202367109
   PubMed Web of Science ®Google Scholar
• Sanz A, Soikkeli M, Portero-Otin M, Wilson A, Kemppainen E, McIlroy G, Ellila S, Kemppainen KK, Tuomela T, Lakanmaa M, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A 2010; 107:9105-10; PMID:20435911; http://dx.doi.org/10.1073/pnas.0911539107
   PubMed Web of Science ®Google Scholar