Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

References

• Xie Z, Samuels BA, Tsai LH. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling–a hypothesis on neuronal migration. Cerebral cortex 2006; 16 Suppl 1:i64-8; PMID:16766709; http://dx.doi.org/10.1093/cercor/bhj170
   PubMedGoogle Scholar
• Contreras-Vallejos E, Utreras E, Gonzalez-Billault C. Going out of the brain: non-nervous system physiological and pathological functions of Cdk5. Cell Signal 2012; 24:44-52; PMID:21924349; http://dx.doi.org/10.1016/j.cellsig.2011.08.022
   PubMed Web of Science ®Google Scholar
• Huang E, Qu D, Zhang Y, Venderova K, Haque ME, Rousseaux MW, Slack RS, Woulfe JM, Park DS. The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nat Cell Biol 2010; 12:563-71; PMID:20473298; http://dx.doi.org/10.1038/ncb2058
   PubMed Web of Science ®Google Scholar
• Hsu F-N, Chen M-C, Lin K-C, Peng Y-T, Li P-C, Lin E, Chiang M-C, Hsieh J-T, Lin H. Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells. Am J Physiol Endocrinol Metabol 2013; 305:E975-E86; PMID:23941877; http://dx.doi.org/10.1152/ajpendo.00615.2012
   PubMed Web of Science ®Google Scholar
• Huang E, Qu D, Zhang Y, Venderova K, Haque ME, Rousseaux MWC, Slack RS, Woulfe JM, Park DS. The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nat Cell Biol 2010; 12:563-71; PMID:20473298; http://dx.doi.org/10.1038/ncb2058
   PubMed Web of Science ®Google Scholar
• Tian B, Yang Q, Mao Z. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol 2009; 11:211-8; PMID:19151707; http://dx.doi.org/10.1038/ncb1829
   PubMed Web of Science ®Google Scholar
• Turner NC, Lord CJ, Iorns E, Brough R, Swift S, Elliott R, Rayter S, Tutt AN, Ashworth A. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J 2008; 27:1368-77; PMID:18388863; http://dx.doi.org/10.1038/emboj.2008.61
   PubMed Web of Science ®Google Scholar
• Bolin C, Boudra MT, Fernet M, Vaslin L, Pennaneach V, Zaremba T, Biard D, Cordelieres FP, Favaudon V, Megnin-Chanet F, et al. The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. Cell Mol Life Sci 2012; 69:951-62; PMID:21922195; http://dx.doi.org/10.1007/s00018-011-0811-6
   PubMed Web of Science ®Google Scholar
• Eggers JP, Grandgenett PM, Collisson EC, Lewallen ME, Tremayne J, Singh PK, Swanson BJ, Andersen JM, Caffrey TC, High RR, et al. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clin Cancer Res 2011; 17:6140-50; PMID:21825040; http://dx.doi.org/10.1158/1078-0432.CCR-10-2288
   PubMed Web of Science ®Google Scholar
• Liang Q, Li L, Zhang J, Lei Y, Wang L, Liu DX, Feng J, Hou P, Yao R, Zhang Y, et al. CDK5 is essential for TGF-beta1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep 2013; 3:2932; PMID:24121667
   PubMed Web of Science ®Google Scholar
• Liu JL, Wang XY, Huang BX, Zhu F, Zhang RG, Wu G. Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis. Med Oncol 2011; 28:673-8; PMID:20354813; http://dx.doi.org/10.1007/s12032-010-9510-7
   PubMed Web of Science ®Google Scholar
• Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res 2006; 66:7509-15; PMID:16885348; http://dx.doi.org/10.1158/0008-5472.CAN-05-3048
   PubMed Web of Science ®Google Scholar
• Anantha RW, Vassin VM, Borowiec JA. Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair. J Biol Chem 2007; 282:35910-23; PMID:17928296; http://dx.doi.org/10.1074/jbc.M704645200
   PubMed Web of Science ®Google Scholar
• Shi W, Feng Z, Zhang J, Gonzalez-Suarez I, Vanderwaal RP, Wu X, Powell SN, Roti JLR, Gonzalo S, Zhang J. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis 2010; 31:994-1002; PMID:20130019; http://dx.doi.org/10.1093/carcin/bgq035
   PubMed Web of Science ®Google Scholar
• Sleeth KM, Sorensen CS, Issaeva N, Dziegielewski J, Bartek J, Helleday T. RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells. J Mol Biol 2007; 373:38-47; PMID:17765923; http://dx.doi.org/10.1016/j.jmb.2007.07.068
   PubMed Web of Science ®Google Scholar
• Wu X, Yang Z, Liu Y, Zou Y. Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. Biochem J 2005; 391:473-80; PMID:15929725; http://dx.doi.org/10.1042/BJ20051020
   PubMed Web of Science ®Google Scholar
• Alvino GM, Collingwood D, Murphy JM, Delrow J, Brewer BJ, Raghuraman MK. Replication in hydroxyurea: it's a matter of time. Mol Cell Biol 2007; 27:6396-406; PMID:17636020; http://dx.doi.org/10.1128/MCB.00719-07
   PubMed Web of Science ®Google Scholar
• Tourriere H, Pasero P. Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst) 2007; 6:900-13; PMID:17379579; http://dx.doi.org/10.1016/j.dnarep.2007.02.004
   PubMed Web of Science ®Google Scholar
• Hustedt N, Gasser SM, Shimada K. Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) 2013; 4:388-434; PMID:24705211; http://dx.doi.org/10.3390/genes4030388
   PubMed Web of Science ®Google Scholar
• Ge XQ, Blow JJ. Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol 2010; 191:1285-97; PMID:21173116; http://dx.doi.org/10.1083/jcb.201007074
   PubMed Web of Science ®Google Scholar
• Lambert S, Carr AM. Checkpoint responses to replication fork barriers. Biochimie 2005; 87:591-602; PMID:15989976; http://dx.doi.org/10.1016/j.biochi.2004.10.020
   PubMed Web of Science ®Google Scholar
• Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J 2007; 26:2719-31; PMID:17491592; http://dx.doi.org/10.1038/sj.emboj.7601714
   PubMed Web of Science ®Google Scholar
• Magdalou I, Lopez BS, Pasero P, Lambert SA. The causes of replication stress and their consequences on genome stability and cell fate. Semin Cell Dev Biol 2014; 30:154-64; PMID:24818779; http://dx.doi.org/10.1016/j.semcdb.2014.04.035
   PubMed Web of Science ®Google Scholar
• Paulsen RD, Cimprich KA. The ATR pathway: fine-tuning the fork. DNA Repair (Amst) 2007; 6:953-66; PMID:17531546; http://dx.doi.org/10.1016/j.dnarep.2007.02.015
   PubMed Web of Science ®Google Scholar
• Branzei D, Foiani M. The checkpoint response to replication stress. DNA Repair (Amst) 2009; 8:1038-46; PMID:19482564; http://dx.doi.org/10.1016/j.dnarep.2009.04.014
   PubMed Web of Science ®Google Scholar
• Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol 2008; 28:7345-53; PMID:18936170; http://dx.doi.org/10.1128/MCB.01079-08
   PubMed Web of Science ®Google Scholar
• Dutta A, Stillman B. cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J 1992; 11:2189-99; PMID:1318195
   PubMed Web of Science ®Google Scholar
• Fang F, Newport JW. Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle. J Cell Sci 1993; 106:983-94; PMID:8308077
   PubMed Web of Science ®Google Scholar
• Niu H, Erdjument-Bromage H, Pan ZQ, Lee SH, Tempst P, Hurwitz J. Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J Biol Chem 1997; 272:12634-41; PMID:9139719; http://dx.doi.org/10.1074/jbc.272.19.12634
   PubMed Web of Science ®Google Scholar
• Olson E, Nievera CJ, Klimovich V, Fanning E, Wu X. RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem 2006; 281:39517-33; PMID:17035231; http://dx.doi.org/10.1074/jbc.M605121200
   PubMed Web of Science ®Google Scholar
• Azqueta A, Collins AR. The essential comet assay: a comprehensive guide to measuring DNA damage and repair. Arch Toxicol 2013; 87:949-68; PMID:; http://dx.doi.org/10.1007/s00204-013-1070-0
   PubMed Web of Science ®Google Scholar
• Adams KE, Medhurst AL, Dart DA, Lakin ND. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 2006; 25:3894-904; PMID:16474843; http://dx.doi.org/10.1038/sj.onc.1209426
   PubMed Web of Science ®Google Scholar
• Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 2006; 281:9346-50; PMID:16431910; http://dx.doi.org/10.1074/jbc.M513265200
   PubMed Web of Science ®Google Scholar
• Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell 2009; 33:547-58; PMID:19285939; http://dx.doi.org/10.1016/j.molcel.2009.01.024
   PubMed Web of Science ®Google Scholar
• Illuzzi G, Fouquerel E, Ame JC, Noll A, Rehmet K, Nasheuer HP, Dantzer F, Schreiber V. PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress. Nucleic Acids Res 2014; 42:7776-92; PMID:24906880; http://dx.doi.org/10.1093/nar/gku505
   PubMed Web of Science ®Google Scholar
• Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair. Molecular Cell 2010; 37:492-502; PMID:20188668; http://dx.doi.org/10.1016/j.molcel.2010.01.021
   PubMed Web of Science ®Google Scholar
• Gelot C, Magdalou I, Lopez BS. Replication stress in Mammalian cells and its consequences for mitosis. Genes (Basel) 2015; 6:267-98; PMID:26010955
   PubMed Web of Science ®Google Scholar
• Lahkim Bennani-Belhaj K, Rouzeau S, Buhagiar-Labarchede G, Chabosseau P, Onclercq-Delic R, Bayart E, Cordelieres F, Couturier J, Amor-Gueret M. The Bloom syndrome protein limits the lethality associated with RAD51 deficiency. Mol Cancer Res 2010; 8:385-94; PMID:20215422; http://dx.doi.org/10.1158/1541-7786.MCR-09-0534
   PubMed Web of Science ®Google Scholar
• Arif A. Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5. Biochem Pharmacol 2012; 84:985-93; PMID:22795893; http://dx.doi.org/10.1016/j.bcp.2012.06.027
   PubMed Web of Science ®Google Scholar
• Liebl J, Furst R, Vollmar AM, Zahler S. Twice switched at birth: cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells. Cell Signal 2011; 23:1698-707; PMID:21741478; http://dx.doi.org/10.1016/j.cellsig.2011.06.020
   PubMed Web of Science ®Google Scholar
• Liebl J, Weitensteiner SB, Vereb G, Takacs L, Furst R, Vollmar AM, Zahler S. Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis. J Biol Chem 2010; 285:35932-43; PMID:20826806; http://dx.doi.org/10.1074/jbc.M110.126177
   PubMed Web of Science ®Google Scholar
• Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic Analysis of the Human CDK Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration. Mol Cell Proteomics 2014; PMID:25096995
   PubMed Web of Science ®Google Scholar
• Ajay AK, Upadhyay AK, Singh S, Vijayakumar MV, Kumari R, Pandey V, Boppana R, Bhat MK. Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Mol Cancer 2010; 9:204; PMID:20673369; http://dx.doi.org/10.1186/1476-4598-9-204
   PubMed Web of Science ®Google Scholar
• Upadhyay AK, Ajay AK, Singh S, Bhat MK. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Curr Cancer Drug Targets 2008; 8:741-52; PMID:19075597; http://dx.doi.org/10.2174/156800908786733405
   PubMed Web of Science ®Google Scholar
• Nagano T, Hashimoto T, Nakashima A, Hisanaga S, Kikkawa U, Kamada S. Cyclin I is involved in the regulation of cell cycle progression. Cell Cycle 2013; 12:2617-24; PMID:23907122; http://dx.doi.org/10.4161/cc.25623
   PubMed Web of Science ®Google Scholar
• Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY. Identification of DNA replication and cell cycle proteins that interact with PCNA. Nucleic Acids Res 1997; 25:5041-6; PMID:9396813; http://dx.doi.org/10.1093/nar/25.24.5041
   PubMed Web of Science ®Google Scholar
• Ame JC, Fouquerel E, Gauthier LR, Biard D, Boussin FD, Dantzer F, de Murcia G, Schreiber V. Radiation-induced mitotic catastrophe in PARG-deficient cells. J Cell Sci 2009; 122:1990-2002; PMID:19454480; http://dx.doi.org/10.1242/jcs.039115
   PubMed Web of Science ®Google Scholar
• Bolderson E, Petermann E, Croft L, Suraweera A, Pandita RK, Pandita TK, Helleday T, Khanna KK, Richard DJ. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Res 2014; 42:6326-36; PMID:24753408; http://dx.doi.org/10.1093/nar/gku276
   PubMed Web of Science ®Google Scholar
• Petermann E, Helleday T. Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol 2010; 11:683-7; PMID:20842177; http://dx.doi.org/10.1038/nrm2974
   PubMed Web of Science ®Google Scholar
• Carty MP, Zernik-Kobak M, McGrath S, Dixon K. UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J 1994; 13:2114-23; PMID:8187764
   PubMed Web of Science ®Google Scholar
• Oakley GG, Patrick SM. Replication protein A: directing traffic at the intersection of replication and repair. Front Biosci (Landmark Ed). 2010; 15:883-900; PMID:20515732; http://dx.doi.org/10.2741/3652
   PubMed Web of Science ®Google Scholar
• Patrick SM, Oakley GG, Dixon K, Turchi JJ. DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair. Biochemistry 2005; 44:8438-48; PMID:15938633; http://dx.doi.org/10.1021/bi048057b
   PubMed Web of Science ®Google Scholar
• Treuner K, Findeisen M, Strausfeld U, Knippers R. Phosphorylation of replication protein A middle subunit (RPA32) leads to a disassembly of the RPA heterotrimer. J Biol Chem 1999; 274:15556-61; PMID:10336450; http://dx.doi.org/10.1074/jbc.274.22.15556
   PubMed Web of Science ®Google Scholar
• Vassin VM, Anantha RW, Sokolova E, Kanner S, Borowiec JA. Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci 2009; 122:4070-80; PMID:19843584; http://dx.doi.org/10.1242/jcs.053702
   PubMed Web of Science ®Google Scholar
• Jones RM, Petermann E. Replication fork dynamics and the DNA damage response. Biochem J 2012; 443:13-26; PMID:22417748; http://dx.doi.org/10.1042/BJ20112100
   PubMed Web of Science ®Google Scholar
• Bryant HE, Petermann E, Schultz N, Jemth A-S, Loseva O, Issaeva N, Johansson F, Fernandez S, McGlynn P, Helleday T. PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J 2009; 28:2601-15; PMID:19629035; http://dx.doi.org/10.1038/emboj.2009.206
   PubMed Web of Science ®Google Scholar
• Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005; 19:1040-52; PMID:15833913; http://dx.doi.org/10.1101/gad.1301205
   PubMed Web of Science ®Google Scholar
• Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene 2004; 23:2658-63; PMID:14968113; http://dx.doi.org/10.1038/sj.onc.1207425
   PubMed Web of Science ®Google Scholar
• Ashworth A, Lord CJ, Reis-Filho JS. Genetic interactions in cancer progression and treatment. Cell 2011; 145:30-8; PMID:21458666; http://dx.doi.org/10.1016/j.cell.2011.03.020
   PubMed Web of Science ®Google Scholar
• Levacque Z, Rosales JL, Lee KY. Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients. Cell Cycle 2012; 11:4093-5; PMID:22987154; http://dx.doi.org/10.4161/cc.21886
   PubMed Web of Science ®Google Scholar
• Cuny GD. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Curr Pharm Design 2009; 15:3919-39; PMID:19751204; http://dx.doi.org/10.2174/138161209789649330
   PubMed Web of Science ®Google Scholar
• Godon C, Cordelieres FP, Biard D, Giocanti N, Megnin-Chanet F, Hall J, Favaudon V. PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility. Nucleic Acids Res 2008; 36:4454-64; PMID:18603595; http://dx.doi.org/10.1093/nar/gkn403
   PubMed Web of Science ®Google Scholar
• Biard DS. Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones. Nucleic Acids Res 2007; 35:3535-50; PMID:17483520; http://dx.doi.org/10.1093/nar/gkm195
   PubMed Web of Science ®Google Scholar
• Le Chalony C, Hoffschir F, Gauthier LR, Gross J, Biard DS, Boussin FD, Pennaneach V. Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells. Cell Mol Life Sci 2012; 69:2933-49; PMID:22460582; http://dx.doi.org/10.1007/s00018-012-0975-8
   PubMed Web of Science ®Google Scholar
• Biard DS, Despras E, Sarasin A, Angulo JF. Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing. Mol Cancer Res 2005; 3:519-29; PMID:16179499; http://dx.doi.org/10.1158/1541-7786.MCR-05-0044
   PubMed Web of Science ®Google Scholar
• Fernet M, Megnin-Chanet F, Hall J, Favaudon V. Control of the G2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radiosensitivity. DNA Repair (Amst) 2010; 9:48-57; PMID:19926348; http://dx.doi.org/10.1016/j.dnarep.2009.10.006
   PubMed Web of Science ®Google Scholar
• Michalet X, Ekong R, Fougerousse F, Rousseaux S, Schurra C, Hornigold N, van Slegtenhorst M, Wolfe J, Povey S, Beckmann JS, et al. Dynamic molecular combing: stretching the whole human genome for high-resolution studies. Science 1997; 277:1518-23; PMID:9278517; http://dx.doi.org/10.1126/science.277.5331.1518
   PubMed Web of Science ®Google Scholar
• Rimmele P, Komatsu J, Hupe P, Roulin C, Barillot E, Dutreix M, Conseiller E, Bensimon A, Moreau-Gachelin F, Guillouf C. Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage. Cancer Res 2010; 70:6757-66; PMID:20660370; http://dx.doi.org/10.1158/0008-5472.CAN-09-4691
   PubMed Web of Science ®Google Scholar
• Haddy N, Tartier L, Koscielny S, Adjadj E, Rubino C, Brugieres L, Pacquement H, Diallo I, de Vathaire F, Averbeck D, et al. Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors. Carcinogenesis 2014; 35:1745-9; PMID:24670918; http://dx.doi.org/10.1093/carcin/bgu077
   PubMed Web of Science ®Google Scholar
• Rouzeau S, Cordelieres FP, Buhagiar-Labarchede G, Hurbain I, Onclercq-Delic R, Gemble S, Magnaghi-Jaulin L, Jaulin C, Amor-Gueret M. Bloom's syndrome and PICH helicases cooperate with topoisomerase IIalpha in centromere disjunction before anaphase. PLoS One 2012; 7:e33905; PMID:22563370; http://dx.doi.org/10.1371/journal.pone.0033905
   PubMed Web of Science ®Google Scholar
• Savino TM, Gebrane-Younes J, De Mey J, Sibarita JB, Hernandez-Verdun D. Nucleolar assembly of the rRNA processing machinery in living cells. J Cell Biol 2001; 153:1097-110; PMID:11381093; http://dx.doi.org/10.1083/jcb.153.5.1097
   PubMed Web of Science ®Google Scholar
• Bieche I, Pennaneach V, Driouch K, Vacher S, Zaremba T, Susini A, Lidereau R, Hall J. Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome. Inter J Cancer Journal international du cancer 2013; 133:2791-800; PMID:23736962
   PubMed Web of Science ®Google Scholar
• Bieche I, Parfait B, Le Doussal V, Olivi M, Rio MC, Lidereau R, Vidaud M. Identification of CGA as a novel estrogen receptor-responsive gene in breast cancer: an outstanding candidate marker to predict the response to endocrine therapy. Cancer Res 2001; 61:1652-8; PMID:11245479
   PubMed Web of Science ®Google Scholar
• Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143:29-36; PMID:7063747; http://dx.doi.org/10.1148/radiology.143.1.7063747
   PubMed Web of Science ®Google Scholar
• Kaplan EL MP. Nonparametric estimation from incomplete observations. J Am Statist Association 1958; 53:457-81; http://dx.doi.org/10.1080/01621459.1958.10501452
   Web of Science ®Google Scholar
• Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer 1977; 35:1-39; PMID:831755; http://dx.doi.org/10.1038/bjc.1977.1
   PubMed Web of Science ®Google Scholar