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CSN6 positively regulates c-Jun in a MEKK1-dependent manner

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Pages 3079-3087 | Received 11 Feb 2015, Accepted 26 Jul 2015, Published online: 01 Sep 2015

References

  • Wisdom R, Johnson RS, Moore C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J 1999; 18:188-97; PMID:9878062; http://dx.doi.org/10.1093/emboj/18.1.188
  • Bakiri L, Matsuo K, Wisniewska M, Wagner EF, Yaniv M. Promoter specificity and biological activity of tethered AP-1 dimers. Mol Cell Biol 2002; 22:4952-64; PMID:12052899; http://dx.doi.org/10.1128/MCB.22.13.4952-4964.2002
  • Smith LM, Wise SC, Hendricks DT, Sabichi AL, Bos T, Reddy P, Brown PH, Birrer MJ. cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotype. Oncogene 1999; 18:6063-70; PMID:10557095; http://dx.doi.org/10.1038/sj.onc.1202989
  • Blau L, Knirsh R, Ben-Dror I, Oren S, Kuphal S, Hau P, Proescholdt M, Bosserhoff AK, Vardimon L. Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation. Proc Natl Acad Sci U S A 2012; 109:E2875-84; PMID:23027969; http://dx.doi.org/10.1073/pnas.1203659109
  • Wang H, Birkenbach M, Hart J. Expression of Jun family members in human colorectal adenocarcinoma. Carcinogenesis 2000; 21:1313-7; PMID:10874008; http://dx.doi.org/10.1093/carcin/21.7.1313
  • Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 2007; 27:510-7; PMID:17101801; http://dx.doi.org/10.1128/MCB.01355-06
  • Zhao R, Yang HY, Shin J, Phan L, Fang L, Che TF, Su CH, Yeung SC, Lee MH. CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. Cell Cycle 2013; 12:935-43; PMID:23421998; http://dx.doi.org/10.4161/cc.23883
  • Nateri AS, Riera-Sans L, Da Costa C, Behrens A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004; 303:1374-8; PMID:14739463; http://dx.doi.org/10.1126/science.1092880
  • Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 1992; 70:777-89; PMID:1516134; http://dx.doi.org/10.1016/0092-8674(92)90311-Y
  • Luo Y, Yang C, Ye M, Jin C, Lee MH, Yeung SY, McKeehan WL. Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations. Cancer Metab 2013; 1(1):21; PMID:24279986
  • Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 2006; 23:899-911; PMID:16973441; http://dx.doi.org/10.1016/j.molcel.2006.07.028
  • Yujiri T, Sather S, Fanger GR, Johnson GL. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 1998; 282:1911-4; PMID:9836645; http://dx.doi.org/10.1126/science.282.5395.1911
  • Wei N, Deng XW. COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. Plant cell 1992; 4:1507-18; PMID:1467650; http://dx.doi.org/10.1105/tpc.4.12.1507
  • Gao S, Fang L, Qdaisat A, Yeung SC, Lee MH. COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer. Oncotarget 2015; in press
  • Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, et al. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 2011; 121:851-65; PMID:21317535; http://dx.doi.org/10.1172/JCI44111
  • Choi J, Guma S, Fang L, Phan F, Ivan C, Baggery K, Sood A, Lee MH. Regulating the ubiquitination of CDK inhibitor p27 Kip1 via CSN6-COP1 axis. Cell Cycle 2015; 14(14):2265-73; PMID:25945542; http://dx.doi.org/10.1080/15384101.2015 in press
  • Choi HH, Fang LK, Chen JS, Chou PC, Phan L, Su CH, Ivan C, Baggery K, Sood A, Yeung SC, et al. COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth. Oncotarget 2015; in press
  • Jeong WJ, Yoon J, Park JC, Lee SH, Lee SH, Kaduwal S, Kim H, Yoon JB, Choi KY. Ras stabilization through aberrant activation of Wnt/beta-catenin signaling promotes intestinal tumorigenesis. Science signal 2012; 5:ra30; PMID:22494971; http://dx.doi.org/10.1126/scisignal.2002242
  • Azzolin L, Zanconato F, Bresolin S, Forcato M, Basso G, Bicciato S, Cordenonsi M, Piccolo S. Role of TAZ as mediator of Wnt signaling. Cell 2012; 151:1443-56; PMID:23245942; http://dx.doi.org/10.1016/j.cell.2012.11.027
  • Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem 2008; 103:1219-30; PMID:17879958; http://dx.doi.org/10.1002/jcb.21504
  • Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, et al. CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6. Cell Cycle 2012; 11:4633-41; PMID:23187808; http://dx.doi.org/10.4161/cc.22887
  • Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, et al. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 2012; 11:4181-90; PMID:23095642; http://dx.doi.org/10.4161/cc.22413
  • Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, et al. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma. Oncogene 2011; 30:4791-801; PMID:21625211; http://dx.doi.org/10.1038/onc.2011.192
  • Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, et al. YAP/TAZ Incorporation in the beta-Catenin Destruction Complex Orchestrates the Wnt Response. Cell 2014; 158:157-70; PMID:24976009; http://dx.doi.org/10.1016/j.cell.2014.06.013
  • Zhao R, Phan L, Chen B, Yang HY, Chen J, Che TF, Qiao Y, Zhang J, Yeung SC, Lee MH. Ubiquitination-mediated p57Kip2 Degradation by CSN5 Confers Cancer Cell Proliferation. Cancer Hallmarks 2013; 1:133-44; http://dx.doi.org/10.1166/ch.2013.1013
  • Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 1999; 13:270-83; PMID:9990852; http://dx.doi.org/10.1101/gad.13.3.270
  • Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol 2003; 23:6790-7; PMID:12972599; http://dx.doi.org/10.1128/MCB.23.19.6790-6797.2003
  • Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR. COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol 2003; 23:6798-808; PMID:12972600; http://dx.doi.org/10.1128/MCB.23.19.6798-6808.2003
  • Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S, Kato JY. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem 2004; 279:43013-8; PMID:15299027; http://dx.doi.org/10.1074/jbc.M406559200
  • Menon S, Chi H, Zhang H, Deng XW, Flavell RA, Wei N. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nat Immunol 2007; 8:1236-45; PMID:17906629; http://dx.doi.org/10.1038/ni1514
  • Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun 2014; 5:5384; PMID:25395170; http://dx.doi.org/10.1038/ncomms6384
  • Choi HH, Su CH, Fang L, Zhang J, Yeung SC, Lee MH. CSN6 deregulation impairs genome integrity in a COP1-dependent pathway. Oncotarget 2015; 6:11779-93; PMID:25957415
  • Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell 2002; 9:945-56; PMID:12049732; http://dx.doi.org/10.1016/S1097-2765(02)00519-1
  • Lee MH, Zhao R, Phan L, Yeung SC. Roles of COP9 signalosome in cancer. Cell Cycle 2011; 10:3057-66; PMID:21876386; http://dx.doi.org/10.4161/cc.10.18.17320
  • Salmena L, Hakem R. From photomorphogenesis to cancer: a CSN journey. Cell Cycle 2013; 12:205-6; PMID:23287466; http://dx.doi.org/10.4161/cc.23422
  • Fang F, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Wang L, Chen C, et al. ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development Cancer Cell 2015; in press
  • Fang L, Yang Z, Zhou J, Tung JY, Hsiao CD, Wang L, Deng Y, Wang P, Wang J, Lee MH. Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer. Mol Cancer Ther 2015; 14:1476-87; PMID:25855785; http://dx.doi.org/10.1158/1535-7163.MCT-15-0030
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
  • Ho MY, Liang CM, Liang SM. MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis. Oncotarget 2015; 6:381-93; PMID:25575814
  • Wang Y, Zhou BP. Epithelial-Mesenchymal Transition—A Hallmark of Breast Cancer Metastasis. Cancer Hallmarks 2013; 1:38-49; PMID:24611128; http://dx.doi.org/10.1166/ch.2013.1004
  • Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012; 486:405-9; PMID:22722202; http://dx.doi.org/10.1038/nature11154
  • Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 2012; 486:353-60; PMID:22722193
  • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70; PMID:23000897; http://dx.doi.org/10.1038/nature11412
  • Pham TT, Angus SP, Johnson GL. MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. Genes Cancer 2013; 4:419-26; PMID:24386504; http://dx.doi.org/10.1177/1947601913513950
  • Rinaldi T, Bolotin-Fukuhara M, Frontali L. A Saccharomyces cerevisiae gene essential for viability has been conserved in evolution. Gene 1995; 160:135-6; PMID:7628709; http://dx.doi.org/10.1016/0378-1119(95)00212-O
  • Saha A, Deshaies RJ. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell 2008; 32:21-31; PMID:18851830; http://dx.doi.org/10.1016/j.molcel.2008.08.021
  • Maytal-Kivity V, Reis N, Hofmann K, Glickman MH. MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem 2002; 3:28; PMID:12370088; http://dx.doi.org/10.1186/1471-2091-3-28
  • Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Deshaies RJ. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 2001; 292:1382-5; PMID:11337588; http://dx.doi.org/10.1126/science.1059780
  • Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 1994; 372:798-800; PMID:7997270; http://dx.doi.org/10.1038/372798a0
  • Karandikar M, Xu S, Cobb MH. MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem 2000; 275:40120-7; PMID:10969079; http://dx.doi.org/10.1074/jbc.M005926200
  • Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A 1995; 92:6808-12; PMID:7624324; http://dx.doi.org/10.1073/pnas.92.15.6808
  • Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, et al. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst 2014; 106; PMID:24957076; http://dx.doi.org/10.1093/jnci/dju158
  • Phan L, Shin JH, Zhou Z, Gully C, Phan L, Velazquez-Torres T, Fuentes-Mattei E, Yeung G, Su CH, Wang H, et al. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming Nature Commun 2015; 6:7530; PMID:26179207; http://dx.doi.org/10.1038/ncomms8530 in press
  • Wen YY, Chou PC, Pham L, Su CH, Chen J, Hsieh YC, Xue Y-W, Qu C-J, Gully C, Parreno K, et al. DNA damage-mediated c-Myc degradation requires 14-3-3 sigma. Cancer Hallmarks 2013; 1:3-17; http://dx.doi.org/10.1166/ch.2013.1002
  • Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, et al. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 2012; 109:E1513-22; PMID:22611192; http://dx.doi.org/10.1073/pnas.1110287109

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