1,496
Views
2
CrossRef citations to date
0
Altmetric
Report

Phosphorylation and dephosphorylation regulate APC/CCdh1 substrate degradation

, &
Pages 3138-3145 | Received 01 Jun 2015, Accepted 27 Jul 2015, Published online: 23 Oct 2015

References

  • Irniger S, Piatti S, Michaelis C, Nasmyth K. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 1995; 81:269-78; PMID:7736579; http://dx.doi.org/10.1016/0092-8674(95)90337-2
  • King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 1995; 81:279-88; PMID:7736580; http://dx.doi.org/10.1016/0092-8674(95)90338-0
  • Lamb JR, Michaud WA, Sikorski RS, Hieter PA. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. Embo J 1994; 13:4321-8; PMID:7925276
  • Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 1996; 274:1201-4; PMID:8895471; http://dx.doi.org/10.1126/science.274.5290.1201
  • Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev 1996; 10:3081-93; PMID:8985178; http://dx.doi.org/10.1101/gad.10.24.3081
  • Cooper KF, Mallory MJ, Egeland DB, Jarnik M, Strich R. Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc Natl Acad Sci U S A 2000; 97:14548-53; PMID:11114178; http://dx.doi.org/10.1073/pnas.250351297
  • Huang JN, Park I, Ellingson E, Littlepage LE, Pellman D. Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p. J Cell Biol 2001; 154:85-94; PMID:11448992; http://dx.doi.org/10.1083/jcb.200102007
  • Irniger S, Nasmyth K. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. J Cell Sci 1997; 110(Pt 13):1523-31; PMID:9224769
  • Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 1999; 9:227-36; PMID:10074450; http://dx.doi.org/10.1016/S0960-9822(99)80111-0
  • Rudner AD, Murray AW. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J Cell Biol 2000; 149:1377-90; PMID:10871279; http://dx.doi.org/10.1083/jcb.149.7.1377
  • Shirayama M, Toth A, Galova M, Nasmyth K. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 1999; 402:203-7; PMID:10647015; http://dx.doi.org/10.1038/46080
  • Shirayama M, Zachariae W, Ciosk R, Nasmyth K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. Embo J 1998; 17:1336-49; PMID:9482731; http://dx.doi.org/10.1093/emboj/17.5.1336
  • Thornton BR, Toczyski DP. Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol 2003; 5:1090-4; PMID:14634663; http://dx.doi.org/10.1038/ncb1066
  • Tinker-Kulberg RL, Morgan DO. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev 1999; 13:1936-49; PMID:10444592; http://dx.doi.org/10.1101/gad.13.15.1936
  • Visintin R, Prinz S, Amon A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 1997; 278:460-3; PMID:9334304; http://dx.doi.org/10.1126/science.278.5337.460
  • Wasch R, Cross FR. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 2002; 418:556-62; PMID:12152084; http://dx.doi.org/10.1038/nature00856
  • Yeong FM, Lim HH, Wang Y, Surana U. Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase. Mol Cell Biol 2001; 21:5071-81; PMID:11438663; http://dx.doi.org/10.1128/MCB.21.15.5071-5081.2001
  • Zachariae W, Schwab M, Nasmyth K, Seufert W. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 1998; 282:1721-4; PMID:9831566; http://dx.doi.org/10.1126/science.282.5394.1721
  • Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 1998; 2:709-18; PMID:9885559; http://dx.doi.org/10.1016/S1097-2765(00)80286-5
  • Li M, Zhang P. The function of APC/CCdh1 in cell cycle and beyond. Cell Div 2009; 4:2; PMID:19152694; http://dx.doi.org/10.1186/1747-1028-4-2
  • Simpson-Lavy KJ, Oren YS, Feine O, Sajman J, Listovsky T, Brandeis M. Fifteen years of APC/cyclosome: a short and impressive biography. Biochem Soc Trans 2010; 38:78-82; PMID:20074039; http://dx.doi.org/10.1042/BST0380078
  • Dumitrescu TP, Saunders WS. The FEAR Before MEN: networks of mitotic exit. Cell Cycle 2002; 1:304-7; PMID:12461288; http://dx.doi.org/10.4161/cc.1.5.147
  • Jimenez J, Cid VJ, Cenamor R, Yuste M, Molero G, Nombela C, Sanchez M. Morphogenesis beyond cytokinetic arrest in Saccharomyces cerevisiae. J Cell Biol 1998; 143:1617-34; PMID:9852155; http://dx.doi.org/10.1083/jcb.143.6.1617
  • Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev 2008; 22:79-90; PMID:18172166; http://dx.doi.org/10.1101/gad.1601308
  • Toyn JH, Johnson AL, Donovan JD, Toone WM, Johnston LH. The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase. Genetics 1997; 145:85-96; PMID:9017392
  • Lopez-Aviles S, Kapuy O, Novak B, Uhlmann F. Irreversibility of mitotic exit is the consequence of systems-level feedback. Nature 2009; 459:592-5; PMID:19387440; http://dx.doi.org/10.1038/nature07984
  • Robbins JA, Cross FR. Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1. Mol Biol Cell 2010; 21(6):914-25; PMID:20089834
  • Schwab M, Lutum AS, Seufert W. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 1997; 90:683-93; PMID:9288748; http://dx.doi.org/10.1016/S0092-8674(00)80529-2
  • Simpson-Lavy KJ, Sajman J, Zenvirth D, Brandeis M. APC/CCdh1 specific degradation of Hsl1 and Clb2 is required for proper stress responses of S. cerevisiae. Cell Cycle 2009; 8:3003-9; PMID:19713762; http://dx.doi.org/10.4161/cc.8.18.9616
  • King L, Butler G. Ace2p, a regulator of CTS1 (chitinase) expression, affects pseudohyphal production in Saccharomyces cerevisiae. Curr Genet 1998; 34:183-91; PMID:9745020; http://dx.doi.org/10.1007/s002940050384
  • Ufano S, Pablo ME, Calzada A, del Rey F, Vazquez de Aldana CR. Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. J Cell Sci 2004; 117:545-57; PMID:14709718; http://dx.doi.org/10.1242/jcs.00880
  • Stegmeier F, Amon A. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet 2004; 38:203-32; PMID:15568976; http://dx.doi.org/10.1146/annurev.genet.38.072902.093051
  • Stegmeier F, Visintin R, Amon A. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 2002; 108:207-20; PMID:11832211; http://dx.doi.org/10.1016/S0092-8674(02)00618-9
  • Jackson AL, Pahl PM, Harrison K, Rosamond J, Sclafani RA. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 1993; 13:2899-908; PMID:8474449
  • Ogi H, Wang CZ, Nakai W, Kawasaki Y, Masumoto H. The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint. Gene 2008; 414:32-40; PMID:18372119; http://dx.doi.org/10.1016/j.gene.2008.02.010
  • Ferreira MF, Santocanale C, Drury LS, Diffley JF. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Mol Cell Biol 2000; 20:242-8; PMID:10594027; http://dx.doi.org/10.1128/MCB.20.1.242-248.2000
  • Viggiani CJ, Aparicio OM. New vectors for simplified construction of BrdU-Incorporating strains of Saccharomyces cerevisiae. Yeast 2006; 23:1045-51; PMID:17083135; http://dx.doi.org/10.1002/yea.1406
  • Kitada K, Johnson AL, Johnston LH, Sugino A. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol Cell Biol 1993; 13:4445-57; PMID:8321244
  • Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature 2008; 454:353-7; PMID:18552837; http://dx.doi.org/10.1038/nature07050
  • Mortensen EM, Haas W, Gygi M, Gygi SP, Kellogg DR. Cdc28-dependent regulation of the Cdc5/Polo kinase. Curr Biol 2005; 15:2033-7; PMID:16303563; http://dx.doi.org/10.1016/j.cub.2005.10.046
  • Biggs JR, Peterson LF, Zhang Y, Kraft AS, Zhang DE. AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol 2006; 26:7420-9; PMID:17015473; http://dx.doi.org/10.1128/MCB.00597-06
  • Harley ME, Allan LA, Sanderson HS, Clarke PR. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. Embo J 2010; 29(14):2407-20; PMID:20526282
  • Andrews PD, Stark MJ. Dynamic, Rho1p-dependent localization of Pkc1p to sites of polarized growth. J Cell Sci 2000; 113(Pt 15):2685-93; PMID:10893184
  • Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y, Pellman D. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 2006; 313:108-11; PMID:16763112; http://dx.doi.org/10.1126/science.1126747
  • Krause SA, Xu H, Gray JV. The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Eukaryot Cell 2008; 7:1880-7; PMID:18806213; http://dx.doi.org/10.1128/EC.00222-08
  • Yoshida S, Ikeda E, Uno I, Mitsuzawa H. Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1. Mol Gen Genet 1992; 231:337-44; PMID:1538690; http://dx.doi.org/10.1007/BF00292700
  • Simpson-Lavy KJ, Brandeis M. Phosphorylation of Cdc5 regulates its accumulation. Cell Div 2011; 6:23; PMID:22204387; http://dx.doi.org/10.1186/1747-1028-6-23
  • Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol 2014; 207(1):23-39; PMID:25287299
  • Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol 2014; 207:23-39; PMID:25287299; http://dx.doi.org/10.1083/jcb.201402041
  • Knop M, Siegers K, Pereira G, Zachariae W, Winsor B, Nasmyth K, Schiebel E. Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines. Yeast 1999; 15:963-72; PMID:10407276; http://dx.doi.org/10.1002/(SICI)1097-0061(199907)15:10B%3c963::AID-YEA399%3e3.0.CO;2-W
  • Raithatha SA, Stuart DT. Meiosis-specific regulation of the Saccharomyces cerevisiae S-phase cyclin CLB5 is dependent on MluI cell cycle box (MCB) elements in its promoter but is independent of MCB-binding factor activity. Genetics 2005; 169:1329-42; PMID:15654101; http://dx.doi.org/10.1534/genetics.104.036103
  • Sopko R, Huang D, Preston N, Chua G, Papp B, Kafadar K, Snyder M, Oliver SG, Cyert M, Hughes TR, et al. Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 2006; 21:319-30; PMID:16455487; http://dx.doi.org/10.1016/j.molcel.2005.12.011
  • Caviston JP, Longtine M, Pringle JR, Bi E. The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 2003; 14:4051-66; PMID:14517318; http://dx.doi.org/10.1091/mbc.E03-04-0247

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.