The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2

References

• Papaioannou V, Silver LM. The T-box gene family. Bioessays 1998; 20(1):9-19; PMID:9504043; http://dx.doi.org/10.1002/(SICI)1521-1878(199801)20:1%3c9::AID-BIES4%3e3.0.CO;2-Q.
   PubMed Web of Science ®Google Scholar
• Smith J. T-box genes: What they do and how they do it. Trends Genet 1999; 15(4):154-8; PMID:10203826; http://dx.doi.org/10.1016/S0168-9525(99)01693-5
   PubMed Web of Science ®Google Scholar
• Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE. T-box genes in vertebrate development. Ann Rev Genet 2005; 39:219-39; PMID:16285859; http://dx.doi.org/10.1146/annurev.genet.39.073003.105925.
   PubMed Web of Science ®Google Scholar
• Packham EA, Brook JD. T-box genes in human disorders. Hum Mol Genet 2003; 12:R37-44; PMID:12668595; http://dx.doi.org/10.1093/hmg/ddg077.
   PubMed Web of Science ®Google Scholar
• Wansleben S, Peres J, Hare S, Goding CR, Prince S. T-box transcription factors in cancer biology. BBA–Rev on Cancer 2014; 1846(2):380-91.
   PubMed Web of Science ®Google Scholar
• Lingbeek ME, Jacobs JJL, van Lohuizen M. The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem 2002; 277:26120-7; PMID:12000749; http://dx.doi.org/10.1074/jbc.M200403200
   PubMed Web of Science ®Google Scholar
• Hoogaars WM, Barnett P, Rodriguez M, Clout DE, Moorman AF, Goding CR, Christoffels VM. TBX3 and its splice variant TBX3 + exon 2a are functionally similar. Pigment Cell Melanoma Res 2008; 21(3):379-87; PMID:18444963; http://dx.doi.org/10.1111/j.1755-148X.2008.00461.x
   PubMed Web of Science ®Google Scholar
• Burgucu D, Guney K, Sahinturk D, Ozbudak IH, Ozel D, Ozbilim G, Yavuzer U. Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. BMC Cancer 2012; 12:481; PMID:23082988; http://dx.doi.org/10.1186/1471-2407-12-481.
   PubMed Web of Science ®Google Scholar
• Dan J, Li M, Yang J, Li J, Okuka M, Ye X, Liua L. Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells. Sci Rep 2013; 3:3492; PMID:24336466.
   PubMed Web of Science ®Google Scholar
• Esmailpour T, Huang T. TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner. Stem Cells 2012; 30(10):2152-63; PMID:22865636; http://dx.doi.org/10.1002/stem.1187.
   PubMed Web of Science ®Google Scholar
• Morgan DO. Principles of CDK regulation. Nature 1995; 374:131-4; PMID:7877684; http://dx.doi.org/10.1038/374131a0.
   PubMed Web of Science ®Google Scholar
• Lim S, Kaldis P. Cdks, cyclins, and CKIs: roles beyond cell cycle regulation. Development 2013; 140:3079-93; PMID:23861057; http://dx.doi.org/10.1242/dev.091744.
   PubMed Web of Science ®Google Scholar
• Sherr CJ. The ins and outs of RB: coupling gene expression to the cell cycle clock. Trends Cell Biol 1994; 4(1):15-8; PMID:14731824; http://dx.doi.org/10.1016/0962-8924(94)90033-7.
   PubMedGoogle Scholar
• Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 1995; 15:2612-24; PMID:7739542.
   PubMed Web of Science ®Google Scholar
• Heichman KA, Roberts JM. Rules to replicate by. Cell 1994; 79:557-62; PMID:7954822; http://dx.doi.org/10.1016/0092-8674(94)90541-X.
   PubMed Web of Science ®Google Scholar
• King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell 1994; 79:563-71; PMID:7954823; http://dx.doi.org/10.1016/0092-8674(94)90542-8.
   PubMed Web of Science ®Google Scholar
• Arellano M, Moreno S. Regulation of CDK/cyclin complexes during the cell cycle. Int J Biochem Cell Biol 1997; 29:559-73; PMID:9363633; http://dx.doi.org/10.1016/S1357-2725(96)00178-1.
   PubMed Web of Science ®Google Scholar
• Wade M, Wahl GM. c-myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol 2006; 302:169-203; PMID:16620029.
   PubMed Web of Science ®Google Scholar
• Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 1997; 387:422-6; PMID:9163430; http://dx.doi.org/10.1038/387422a0.
   PubMed Web of Science ®Google Scholar
• Rudolph B, Saffrich R, Zwicker J, Henglein B, Muller R, Ansorge W, Eilers M. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. EMBO J 1996; 15:3065-76; PMID:8670807.
   PubMed Web of Science ®Google Scholar
• Evan G, Wyllie A, Gilbert C, Littlewood T, Land H, Brooks M, Waters C, Penn L, Hancock D. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 63:119-25; http://dx.doi.org/10.1016/0092-8674(92)90123-T.
   Web of Science ®Google Scholar
• Perez-Roger I, Solomon DLC, Sewing A, Land H. Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes. Oncogene 1997; 14:2373-81; PMID:9188852; http://dx.doi.org/10.1038/sj.onc.1201197.
   PubMed Web of Science ®Google Scholar
• Vlach J, Hennecke S, Alevizopoulos K, Conti D, Amati B. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J 1996; 15:6595-604; PMID:8978686.
   PubMed Web of Science ®Google Scholar
• Wu S, Cetinkaya C, Munoz-Alonso M.J, von der Lehr N, Bahram N, Beuger V, Eilers M, Leon J, Larsson L. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 2003; 22:351-60; PMID:12545156; http://dx.doi.org/10.1038/sj.onc.1206145.
   PubMed Web of Science ®Google Scholar
• Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, Tyner AL. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci USA 2001; 98(8):4510-5; PMID:11274368; http://dx.doi.org/10.1073/pnas.081074898.
   PubMed Web of Science ®Google Scholar
• Pusch O, Soucek T, Hengstschläger-Ottnad E, Bernaschek G, Hengstschläger M. Cellular targets for activation by c-Myc include the DNA metabolism enzyme thymidine kinase. DNA Cell Biol 1997; 16(6):737-47; PMID:9212167.
   PubMed Web of Science ®Google Scholar
• Hanson KD, Shichiri M, Follansbee MR, Sedivy JM. Effects of c-Myc expression on cell cycle progression. Mol Cell Biol 1994; 14(9):5748-55; PMID:8065309; http://dx.doi.org/10.1128/MCB.14.9.5748.
   PubMed Web of Science ®Google Scholar
• Suzuki A, Sekiya S, Büscher D, Izpisúa Belmonte JC, Taniguchi H. Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development 2008 May; 135(9):1589-95; http://dx.doi.org/10.1242/dev.016634.
   PubMed Web of Science ®Google Scholar
• Platonova N, Scotti M, Babich P, Bertoli G, Mento E, Meneghini V, Egeo A, Zucchi I, Merlo GR. TBX3, the gene mutated in ulnar-mammary syndrome, promotes growth of mammary epithelial cells via repression of p19ARF, independently of p53. Cell Tissue Res 2007; 328:301-16; PMID:17265068; http://dx.doi.org/10.1007/s00441-006-0364-4.
   PubMed Web of Science ®Google Scholar
• Govoni KE, Linares GR, Chen ST, Pourteymoor S, Mohan S. T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2. J Cell Biochem 2009 Feb 15; 106(3):482-90; http://dx.doi.org/10.1002/jcb.22035.
   PubMed Web of Science ®Google Scholar
• Bilican B, Goding CR. Cell cycle regulation of the T-box transcription factor tbx2. Exp Cell Res 2006; 312:2358-66; PMID:16730707; http://dx.doi.org/10.1016/j.yexcr.2006.03.033.
   PubMed Web of Science ®Google Scholar
• Wansleben S, Davis E, Peres J, Prince S. A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. Cell Death Dis 2013 Oct 10; 4:e846; http://dx.doi.org/10.1038/cddis.2013.365.
   PubMed Web of Science ®Google Scholar
• Selmi A, de Saint-Jean M, Jallas AC, Garin E, Hogarty MD, Bénard J, Puisieux A, Marabelle A, Valsesia-Wittmann S. TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma. Cancer Lett 2015 Feb 1; 357(1):412-8; http://dx.doi.org/10.1016/j.canlet.2014.11.056.
   PubMed Web of Science ®Google Scholar
• Guo J, Li T, Schipper J, Nilson KA, Fordjour FK, Cooper JJ, Gordân R, Price DH. Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol 2014; 15(10):482; PMID:25287278; http://dx.doi.org/10.1186/s13059-014-0482-3.
   PubMed Web of Science ®Google Scholar
• Sab∫ A, Amati B. Genome recognition by MYC. Cold Spring Harb Perspect Med 2014 Feb 1; 4(2): pii: a014191.
   Web of Science ®Google Scholar
• Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, et al. Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. Mol Cell 2015 May 7; 58(3):4 40-52.
   Web of Science ®Google Scholar
• Barton MC, Crowe AJ. Chromatin alteration, transcription and replication: What's the opening line to the story? Oncogene 2001 May 28; 20(24):3094-9; http://dx.doi.org/10.1038/sj.onc.1204334.
   PubMed Web of Science ®Google Scholar
• Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 1997; 387:422-6; PMID:9163430; http://dx.doi.org/10.1038/387422a0.
   PubMed Web of Science ®Google Scholar
• Pusch O, Soucek T, Hengstschläger-Ottnad E, Bernaschek G, Hengstschläger M. Cellular targets for activation by c-Myc include the DNA metabolism enzyme thymidine kinase. DNA Cell Biol 1997; 16(6):737-47; PMID:9212167.
   PubMed Web of Science ®Google Scholar
• Valovka T, Schönfeld M, Raffeiner P, Breuker K, Dunzendorfer-Matt T, Hartl M, Bister K. Transcriptional control of DNA replication licensing by Myc. Sci Rep 2013 Dec 6; 3:3444.
   PubMed Web of Science ®Google Scholar
• Alevizopoulos K, Vlach J, Hennecke S, Amati B. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J 1997 Sep 1; 16(17):5322-33; http://dx.doi.org/10.1093/emboj/16.17.5322.
   PubMed Web of Science ®Google Scholar
• Ogryzko VV, Wong P, Howard BH. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 1997 Aug; 17(8):4877-82.
   PubMed Web of Science ®Google Scholar
• Abrahams A, Mowla S, Parker MI, Goding CR, Prince S.UV-mediated regulation of the anti-senescence factor Tbx2. J Biol Chem 2008 Jan 25; 283(4):2223-30; http://dx.doi.org/10.1074/jbc.M705651200.
   PubMed Web of Science ®Google Scholar
• Oakes V, Wang W, Harrington B, Lee WJ, Beamish H, Chia KM, Pinder A, Goto H, Inagaki M, Pavey S, Gabrielli B. Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle. Cell Cycle 2014; 13(20):3302-11; PMID:25485510; http://dx.doi.org/10.4161/15384101.2014.949111.
   PubMed Web of Science ®Google Scholar
• Akiyama T, Ohuchi T, Sumida S, Matsumotot K, Toyoshima K. Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci USA 1992; 89:7900-4; PMID:1518810; http://dx.doi.org/10.1073/pnas.89.17.7900.
   PubMed Web of Science ®Google Scholar
• Jaumot M, Estañol JM, Casanovas O, Graña X, Agell N, Bachs O. The cell cycle inhibitor p21CIP is phosphorylated by cyclin A-CDK2 complexes. Biochem Biophys Res Commun 1997 Dec 18; 241(2):434-8; http://dx.doi.org/10.1006/bbrc.1997.7787.
   PubMed Web of Science ®Google Scholar
• Dai L, Liu Y, Liu J, Wen X, Xu Z, Wang Z, Sun H, Tang S, Maguire AR, Quan J, Zhang H, Ye T. A novel cyclinE/cyclinA-CDK inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: implications in cancer therapy. Cancer Lett 2013 Jun 1; 333(1):103-12; http://dx.doi.org/10.1016/j.canlet.2013.01.025.
   PubMed Web of Science ®Google Scholar
• Kumar PP, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM. Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife 2014 May 29; 3.
   PubMed Web of Science ®Google Scholar
• Mowla S, Pinnock R, Leaner VD, Goding CR, Prince S. PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration. Biochem J 2011 Jan 1; 433(1):145-53; http://dx.doi.org/10.1042/BJ20100886.
   PubMed Web of Science ®Google Scholar
• Peres J, Mowla S, Prince S. The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis. Oncotarget 2015 Jan 30; 6(3):1821-33.
   PubMed Web of Science ®Google Scholar
• Davis E, Teng H, Bilican B, Parker MI, Liu B, Carriera S, Goding CR, Prince S. Ectopic Tbx2 expression results in polyploidy and cisplatin resistance. Oncogene 2008 Feb 7; 27(7):976-84; http://dx.doi.org/10.1038/sj.onc.1210701.
   PubMed Web of Science ®Google Scholar
• Prince S, Carreira S, Vance KW, Abrahams A, Goding CR. Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor. Cancer Res 2004 Mar 1; 64(5):1669-74; http://dx.doi.org/10.1158/0008-5472.CAN-03-3286.
   PubMed Web of Science ®Google Scholar