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Perspective

p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stress

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Pages 3373-3378 | Received 22 Jul 2015, Accepted 29 Aug 2015, Published online: 13 Nov 2015

References

  • Efeyan A, Serrano M. p53: guardian of the genome and policeman of the oncogenes. Cell Cycle 2007; 6:1006-10; PMID:17457049; http://dx.doi.org/10.4161/cc.6.9.4211
  • Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol 2007; 8:275-83; PMID:17380161; http://dx.doi.org/10.1038/nrm2147
  • El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al. WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis. Cancer Res 1994; 54:1169-74; PMID:8118801
  • Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ, Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992; 71:587-97; PMID:1423616; http://dx.doi.org/10.1016/0092-8674(92)90593-2
  • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-9; PMID:7834749; http://dx.doi.org/10.1016/0092-8674(95)90513-8
  • Lanigan F, Geraghty JG, Bracken AP. Transcriptional regulation of cellular senescence. Oncogene 2011; 30:2901-11; PMID:21383691; http://dx.doi.org/10.1038/onc.2011.34
  • Efeyan A, Collado M, Velasco-Miguel S, Serrano M. Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression. Oncogene 2007; 26:1645-9; PMID:16964282; http://dx.doi.org/10.1038/sj.onc.1209972
  • Adnane J, Jackson RJ, Nicosia SV, Cantor AB, Pledger WJ, Sebti SM. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene 2000; 19:5338-47; PMID:11103935; http://dx.doi.org/10.1038/sj.onc.1203956
  • Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J 1993; 12:461-8; PMID:8440237
  • Barak Y, Gottlieb E, Juven-Gershon T, Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Gen Dev 1994; 8:1739-49; PMID:7958853; http://dx.doi.org/10.1101/gad.8.15.1739
  • Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintas-Cardama A, Hamir AN, Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Gen Dev 2013; 27:1857-67; PMID:23973961; http://dx.doi.org/10.1101/gad.227249.113
  • Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N, Bourougaa K, Calvo F, Fahraeus R. P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol 2008; 10:1098-105; PMID:19160491; http://dx.doi.org/10.1038/ncb1770
  • Naski N, Gajjar M, Bourougaa K, Malbert-Colas L, Fahraeus R, Candeias MM. The p53 mRNA-Mdm2 interaction. Cell Cycle 2009; 8:31-4; PMID:19106616; http://dx.doi.org/10.4161/cc.8.1.7326
  • Malbert-Colas L, Ponnuswamy A, Olivares-Illana V, Tournillon AS, Naski N, Fahraeus R. HDMX folds the nascent p53 mRNA following activation by the ATM kinase. Mol Cell 2014; 54:500-11; PMID:24813712; http://dx.doi.org/10.1016/j.molcel.2014.02.035
  • Zhao L, Ackerman SL. Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol 2006; 18:444-52; PMID:16781856; http://dx.doi.org/10.1016/j.ceb.2006.06.005
  • Lisbona F, Hetz C. Turning off the unfolded protein response: an interplay between the apoptosis machinery and ER stress signaling. Cell Cycle 2009; 8:1643-4; PMID:19411860; http://dx.doi.org/10.4161/cc.8.11.8637
  • Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S, Fahraeus R. Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell 2010; 38:78-88; PMID:20385091; http://dx.doi.org/10.1016/j.molcel.2010.01.041
  • Pyronnet S, Dostie J, Sonenberg N. Suppression of cap-dependent translation in mitosis. Gen Dev 2001; 15:2083-93; PMID:11511540; http://dx.doi.org/10.1101/gad.889201
  • Mlynarczyk C, Fahraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A). Nat Commun 2014; 5:5067; PMID:25295585; http://dx.doi.org/10.1038/ncomms6067
  • Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K, Vojtesek B, Bruzzoni-Giovanelli H, Fahraeus R. Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene 2006; 25:6936-47; PMID:16983332; http://dx.doi.org/10.1038/sj.onc.1209996
  • Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. Modulation of mammalian life span by the short isoform of p53. Gen Dev 2004; 18:306-19; PMID:14871929; http://dx.doi.org/10.1101/gad.1162404
  • Ungewitter E, Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Gen Dev 2010; 24:2408-19; PMID:21041409; http://dx.doi.org/10.1101/gad.1987810
  • Takahashi R, Giannini C, Sarkaria JN, Schroeder M, Rogers J, Mastroeni D, Scrable H. p53 isoform profiling in glioblastoma and injured brain. Oncogene 2013; 32:3165-74; PMID:22824800; http://dx.doi.org/10.1038/onc.2012.322
  • Ho J, Benchimol S. Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 2003; 10:404-8; PMID:12719716; http://dx.doi.org/10.1038/sj.cdd.4401191
  • Riley KJ, Maher LJ, 3rd. p53 RNA interactions: new clues in an old mystery. RNA 2007; 13:1825-33; PMID:17804642; http://dx.doi.org/10.1261/rna.673407
  • Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn ER, Hill DL, Wang H, Zhang R. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 2007; 26:5029-37; PMID:17310983; http://dx.doi.org/10.1038/sj.onc.1210327
  • Horn HF, Vousden KH. Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene 2008; 27:5774-84; PMID:18560357; http://dx.doi.org/10.1038/onc.2008.189
  • Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell 2003; 12:1151-64; PMID:14636574; http://dx.doi.org/10.1016/S1097-2765(03)00431-3
  • Crighton D, Woiwode A, Zhang C, Mandavia N, Morton JP, Warnock LJ, Milner J, White RJ, Johnson DL. p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. The EMBO J 2003; 22:2810-20; PMID:12773395; http://dx.doi.org/10.1093/emboj/cdg265
  • Powell DJ, Hrstka R, Candeias M, Bourougaa K, Vojtesek B, Fahraeus R. Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47. Cell Cycle 2008; 7:950-9; PMID:18414054; http://dx.doi.org/10.4161/cc.7.7.5626