A novel role for the deubiquitinase USP1 in the control of centrosome duplication

References

• Doxsey S, Zimmerman W, Mikule K. Centrosome control of the cell cycle. Trends Cell Biol 2005; 15:303-11; PMID:15953548; http://dx.doi.org/10.1016/j.tcb.2005.04.008
   PubMed Web of Science ®Google Scholar
• Doxsey S, McCollum D, Theurkauf W. Centrosomes in cellular regulation. Annu Rev Cell Dev Biol 2005; 21:411-34; PMID:16212501; http://dx.doi.org/10.1146/annurev.cellbio.21.122303.120418
   PubMed Web of Science ®Google Scholar
• Bornens M. Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol 2002; 14:25-34; PMID:11792541; http://dx.doi.org/10.1016/S0955-0674(01)00290-3
   PubMed Web of Science ®Google Scholar
• Vitre BD, Cleveland DW. Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol 2012; 24:809-15; PMID:23127609; http://dx.doi.org/10.1016/j.ceb.2012.10.006
   PubMed Web of Science ®Google Scholar
• Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009; 460:278-82; PMID:19506557; http://dx.doi.org/10.1038/nature08136
   PubMed Web of Science ®Google Scholar
• Nigg EA. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer 2002; 2:815-25; PMID:12415252; http://dx.doi.org/10.1038/nrc924
   PubMed Web of Science ®Google Scholar
• D'Assoro AB, Lingle WL, Salisbury JL. Centrosome amplification and the development of cancer. Oncogene 2002; 21:6146-53; PMID:12214243; http://dx.doi.org/10.1038/sj.onc.1205772
   PubMed Web of Science ®Google Scholar
• Chan JY. A clinical overview of centrosome amplification in human cancers. Int J Biol Sci 2011; 7:1122-44; PMID:22043171; http://dx.doi.org/10.7150/ijbs.7.1122
   PubMed Web of Science ®Google Scholar
• Nigg EA, Raff JW. Centrioles, centrosomes, and cilia in health and disease. Cell 2009; 139:663-78; PMID:19914163; http://dx.doi.org/10.1016/j.cell.2009.10.036
   PubMed Web of Science ®Google Scholar
• Korzeniewski N, Hohenfellner M, Duensing S. The centrosome as potential target for cancer therapy and prevention. Expert Opin Ther Targets 2013; 17:43-52; PMID:23062185; http://dx.doi.org/10.1517/14728222.2013.731396
   PubMed Web of Science ®Google Scholar
• Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell 2005; 17:331-9; PMID:15694335; http://dx.doi.org/10.1016/j.molcel.2005.01.008
   PubMed Web of Science ®Google Scholar
• Huang TT, D'Andrea AD. Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol 2006; 7:323-34; PMID:16633336; http://dx.doi.org/10.1038/nrm1908
   PubMed Web of Science ®Google Scholar
• Kim H, D'Andrea AD. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012; 26:1393-408; PMID:22751496; http://dx.doi.org/10.1101/gad.195248.112
   PubMed Web of Science ®Google Scholar
• Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol 2006; 8:339-47; PMID:16531995
   PubMed Web of Science ®Google Scholar
• Kee Y, D'Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 2010; 24:1680-94; PMID:20713514; http://dx.doi.org/10.1101/gad.1955310
   PubMed Web of Science ®Google Scholar
• D'Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 2003; 3:23-34; PMID:12509764; http://dx.doi.org/10.1038/nrc970
   PubMed Web of Science ®Google Scholar
• Oestergaard VH, Langevin F, Kuiken HJ, Pace P, Niedzwiedz W, Simpson LJ, Ohzeki M, Takata M, Sale JE, Patel KJ. Deubiquitination of FANCD2 is required for DNA crosslink repair. Mol Cell 2007; 28:798-809; PMID:18082605; http://dx.doi.org/10.1016/j.molcel.2007.09.020
   PubMed Web of Science ®Google Scholar
• Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL, D'Andrea AD. Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell 2009; 16:314-20; PMID:19217432; http://dx.doi.org/10.1016/j.devcel.2009.01.001
   PubMed Web of Science ®Google Scholar
• Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther 2013; 12:2651-62; PMID:24130053; http://dx.doi.org/10.1158/1535-7163.MCT-13-0103-T
   PubMed Web of Science ®Google Scholar
• Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol 2014; 10:298-304; PMID:24531842; http://dx.doi.org/10.1038/nchembio.1455
   PubMed Web of Science ®Google Scholar
• Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol 2011; 18:1390-400; PMID:22118673; http://dx.doi.org/10.1016/j.chembiol.2011.08.014
   PubMed Web of Science ®Google Scholar
• Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RA, Dixit VM. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell 2011; 146:918-30; PMID:21925315; http://dx.doi.org/10.1016/j.cell.2011.07.040
   PubMed Web of Science ®Google Scholar
• Ruzinova MB, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003; 13:410-8; PMID:12888293; http://dx.doi.org/10.1016/S0962-8924(03)00147-8
   PubMed Web of Science ®Google Scholar
• Sikder HA, Devlin MK, Dunlap S, Ryu B, Alani RM. Id proteins in cell growth and tumorigenesis. Cancer Cell 2003; 3:525-30; PMID:12842081; http://dx.doi.org/10.1016/S1535-6108(03)00141-7
   PubMed Web of Science ®Google Scholar
• Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000; 113 ( Pt 22):3897-905; PMID:11058077
   PubMed Web of Science ®Google Scholar
• Luise C, Capra M, Donzelli M, Mazzarol G, Jodice MG, Nuciforo P, Viale G, Di Fiore PP, Confalonieri S. An atlas of altered expression of deubiquitinating enzymes in human cancer. PloS One 2011; 6:e15891; PMID:21283576; http://dx.doi.org/10.1371/journal.pone.0015891
   PubMed Web of Science ®Google Scholar
• Garcia-Santisteban I, Peters GJ, Giovannetti E, Rodriguez JA. USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy. Mol Cancer 2013; 12:91; PMID:23937906; http://dx.doi.org/10.1186/1476-4598-12-91
   PubMed Web of Science ®Google Scholar
• Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature 2013; 495:255-9; PMID:23486064; http://dx.doi.org/10.1038/nature11941
   PubMed Web of Science ®Google Scholar
• Sato N, Mizumoto K, Nakamura M, Nakamura K, Kusumoto M, Niiyama H, Ogawa T, Tanaka M. Centrosome abnormalities in pancreatic ductal carcinoma. Clin Cancer Res 1999; 5:963-70; PMID:10353727
   PubMed Web of Science ®Google Scholar
• Zhang Y, Foreman O, Wigle DA, Kosari F, Vasmatzis G, Salisbury JL, van Deursen J, Galardy PJ. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest 2012; 122:4362-74; PMID:23187126; http://dx.doi.org/10.1172/JCI63084
   PubMed Web of Science ®Google Scholar
• Balczon R, Bao L, Zimmer WE, Brown K, Zinkowski RP, Brinkley BR. Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. J Cell Biol 1995; 130:105-15; PMID:7790366; http://dx.doi.org/10.1083/jcb.130.1.105
   PubMed Web of Science ®Google Scholar
• Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol 1999; 1:88-93; PMID:10559879; http://dx.doi.org/10.1038/10054
   PubMed Web of Science ®Google Scholar
• Cotto-Rios XM, Jones MJ, Huang TT. Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle 2011; 10:4009-16; PMID:22101265; http://dx.doi.org/10.4161/cc.10.23.18501
   PubMed Web of Science ®Google Scholar
• Cotto-Rios XM, Jones MJ, Busino L, Pagano M, Huang TT. APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. J Cell Biol 2011; 194:177-86; PMID:21768287; http://dx.doi.org/10.1083/jcb.201101062
   PubMed Web of Science ®Google Scholar
• Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev 2008; 22:2189-203; PMID:18662975; http://dx.doi.org/10.1101/gad.1700908
   PubMed Web of Science ®Google Scholar
• Dey P. Aneuploidy and malignancy: an unsolved equation. J Clin Pathol 2004; 57:1245-9; PMID:15563660; http://dx.doi.org/10.1136/jcp.2004.018952
   PubMed Web of Science ®Google Scholar
• Hasskarl J, Duensing S, Manuel E, Munger K. The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers. Oncogene 2004; 23:1930-8; PMID:14755252; http://dx.doi.org/10.1038/sj.onc.1207310
   PubMed Web of Science ®Google Scholar
• Man C, Rosa J, Yip YL, Cheung AL, Kwong YL, Doxsey SJ, Tsao SW. Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell 2008; 19:2389-401; PMID:18353975; http://dx.doi.org/10.1091/mbc.E07-09-0875
   PubMed Web of Science ®Google Scholar
• Wang X, Di K, Zhang X, Han HY, Wong YC, Leung SC, Ling MT. Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. Oncogene 2008; 27:4456-66; PMID:18372912; http://dx.doi.org/10.1038/onc.2008.87
   PubMed Web of Science ®Google Scholar
• Nalepa G, Enzor R, Sun Z, Marchal C, Park SJ, Yang Y, Tedeschi L, Kelich S, Hanenberg H, Clapp DW. Fanconi anemia signaling network regulates the spindle assembly checkpoint. J Clin Invest 2013; 123:3839-47; PMID:23934222; http://dx.doi.org/10.1172/JCI67364
   PubMed Web of Science ®Google Scholar
• Dodson H, Wheatley SP, Morrison CG. Involvement of centrosome amplification in radiation-induced mitotic catastrophe. Cell Cycle 2007; 6:364-70; PMID:17297293; http://dx.doi.org/10.4161/cc.6.3.3834
   PubMed Web of Science ®Google Scholar
• Hut HM, Lemstra W, Blaauw EH, Van Cappellen GW, Kampinga HH, Sibon OC. Centrosomes split in the presence of impaired DNA integrity during mitosis. Mol Biol Cell 2003; 14:1993-2004; PMID:12802070; http://dx.doi.org/10.1091/mbc.E02-08-0510
   PubMed Web of Science ®Google Scholar
• Inanc B, Morrison CG. Getting permission: how DNA damage causes centrosome amplification. Cell Cycle 2011; 10:1890-1; PMID:21673504; http://dx.doi.org/10.4161/cc.10.12.15648
   PubMed Web of Science ®Google Scholar
• Pihan GA. Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Front Oncol 2013; 3:277; PMID:24282781; http://dx.doi.org/10.3389/fonc.2013.00277
   PubMedGoogle Scholar
• Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011; 12:385-92; PMID:21527953; http://dx.doi.org/10.1038/nrm3115
   PubMed Web of Science ®Google Scholar