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Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors

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Pages 819-826 | Received 05 Oct 2015, Accepted 21 Jan 2016, Published online: 30 Mar 2016

References

  • Saklani A, Kutty SK. Plant-derived compounds in clinical trials. Drug Discov Today 2008; 13:161-71; PMID:18275914; http://dx.doi.org/10.1016/j.drudis.2007.10.010
  • Gao S, Hu M. Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem 2010; 10:550-67; PMID:20370701; http://dx.doi.org/10.2174/138955710791384081
  • Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H. Pharmacokinetic and oral bioavailability of andrographolide from andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine: International Journal of phytotherapy and phytopharmacology 2000; 7:351-64; PMID:11081986; http://dx.doi.org/10.1016/S0944-7113(00)80054-9
  • Chen HW, Huang CS, Li CC, Lin AH, Huang YJ, Wang TS, Yao HT, Lii CK. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharm 2014; 280:1-9; PMID:NOT_FOUND; http://dx.doi.org/10.1016/j.taap.2014.07.024
  • Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 2003; 3:147-58; PMID:14641821; http://dx.doi.org/10.1046/j.1359-4117.2003.01090.x
  • Hung SK, Hung LC, Kuo CD, Lee KY, Lee MS, Lin HY, Chen YJ, Fu SL. Andrographolide sensitizes ras-transformed cells to radiation in vitro and in vivo. Int J Radiat Oncol Biol Phys 2010; 77:1232-9; PMID:20610044; http://dx.doi.org/10.1016/j.ijrobp.2010.01.007
  • Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, Beider K, Avniel S, Kasem S, Galun E, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J: Off Pub FedAm Soc Exp Biol 2004; 18:1240-2; PMID:15180966
  • Spano JP, Andre F, Morat L, Sabatier L, Besse B, Combadiere C, Deterre P, Martin A, Azorin J, Valeyre D, et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol: Off JEur Soci Med Oncol / ESMO 2004; 15:613-7; PMID:NOT_FOUND; http://dx.doi.org/10.1093/annonc/mdh136
  • Wald O, Shapira OM, Izhar U. CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics 2013; 3:26-33; PMID:23382783; http://dx.doi.org/10.7150/thno.4922
  • Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle WE, Lillard JW, Jr. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer J Int du Cancer 2009; 125:2288-95; PMID:19610059; http://dx.doi.org/10.1002/ijc.24574
  • Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW, Jr. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res: Off J Am Assoc Cancer Res 2004; 10:8743-50; PMID:15623660; http://dx.doi.org/10.1158/1078-0432.CCR-04-0266
  • Shulby SA, Dolloff NG, Stearns ME, Meucci O, Fatatis A. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res 2004; 64:4693-8; PMID:15256432; http://dx.doi.org/10.1158/0008-5472.CAN-03-3437
  • Vindrieux D, Escobar P, Lazennec G. Emerging roles of chemokines in prostate cancer. Endocr-Relat Cancer 2009; 16:663-73; PMID:19556286; http://dx.doi.org/10.1677/ERC-09-0109
  • Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410:50-6; PMID:11242036; http://dx.doi.org/10.1038/35065016
  • Zhang Z, Ni C, Chen W, Wu P, Wang Z, Yin J, Huang J, Qiu F. Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis. BMC Cancer 2014; 14:49; PMID:24475985; http://dx.doi.org/10.1186/1471-2407-14-49
  • Kakinuma T, Hwang ST. Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 2006; 79:639-51; PMID:16478915; http://dx.doi.org/10.1189/jlb.1105633
  • Singh R, Stockard CR, Grizzle WE, Lillard JW, Jr., Singh S. Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer. Int J Oncol 2011; 39:373-81; PMID:21637913
  • Neogy S, Das S, Mahapatra SK, Mandal N, Roy S. Amelioratory effect of andrographis paniculata nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress. Environ Toxicol Pharmacol 2008; 25:321-8; PMID:21783869; http://dx.doi.org/10.1016/j.etap.2007.10.034
  • Singha PK, Roy S, Dey S. Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. J Ethnopharmacol 2007; 111:13–21.
  • Shi M-D, Lin H-H, Lee Y-C, Chao J-K, Lin R-A, Chen J-H. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chemico-Biological Interactions 2008; 174:201-10; PMID:18619950; http://dx.doi.org/10.1016/j.cbi.2008.06.006
  • Yan J, Chen Y, Fau - He C, He C Fau - Yang Z-Z, Yang ZZ Fau - Lu C, Lu C Fau - Chen X-S, Chen XS. Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
  • Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Mol Cell Biol 1999; 19:612-22; PMID:9858585; http://dx.doi.org/10.1128/MCB.19.1.612
  • Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM. Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas. Evidence-based Complementary and Alternative medicine : eCAM 2013; 2013:305898; PMID:23997793
  • Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. Andrographolide inhibits oral squamous cell carcinogenesis through NF-kappaB inactivation. J Dent Res 2011; 90:1246-52; PMID:21841043; http://dx.doi.org/10.1177/0022034511418341
  • Tapia-Rojas C, Schuller A, Lindsay CB, Ureta RC, Mejias-Reyes C, Hancke J, Melo F, Inestrosa NC. Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3beta: autoregulation of GSK-3beta in vivo. Biochem J 2015; 466:415-30; PMID:25423492; http://dx.doi.org/10.1042/BJ20140207
  • Woo RA, Poon RY. Cyclin-dependent kinases and S phase control in mammalian cells. Cell cycle (Georgetown, Tex) 2003; 2:316-24; PMID:12851482; http://dx.doi.org/10.4161/cc.2.4.468
  • Mashal RD, Lester S, Corless C, Richie JP, Chandra R, Propert KJ, Dutta A. Expression of cell cycle-regulated proteins in prostate cancer. Cancer Res 1996; 56:4159-63; PMID:8797586
  • Dutta A, Chandra R, Leiter LM, Lester S. Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer. Proc Nat Acad SciU S A 1995; 92:5386-90; PMID:7539916; http://dx.doi.org/10.1073/pnas.92.12.5386
  • Egloff AM, Weissfeld J, Land SR, Finn OJ. Evaluation of anticyclin B1 serum antibody as a diagnostic and prognostic biomarker for lung cancer. AnnNew York Acad Sci 2005; 1062:29-40; PMID:16461786; http://dx.doi.org/10.1196/annals.1358.005
  • Hagting A, Jackman M Fau - Simpson K, Simpson K Fau - Pines J, Pines J. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal.
  • Ornelas IM, Silva TM, Fragel-Madeira L, Ventura ALM. Inhibition of PI3K/Akt pathway impairs G2/M transition of cell cycle in late developing progenitors of the avian embryo retina. PloS one 2013; 8:e53517; PMID:23301080; http://dx.doi.org/10.1371/journal.pone.0053517
  • Li Y, Zhang P, Qiu F, Chen L, Miao C, Li J, Xiao W, Ma E. Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells. Life Sci 2012; 90:962-7; PMID:AMBIGUOUS; http://dx.doi.org/10.1016/j.lfs.2012.04.044
  • Gong D, Ferrell JE. The Roles of Cyclin A2, B1, and B2 in Early and Late Mitotic Events. Mol Biol Cell 2010; 21:3149-61; PMID:20660152; http://dx.doi.org/10.1091/mbc.E10-05-0393
  • Fung TK, Ma HT, Poon RY. Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor. Mol Biol Cell 2007; 18:1861-73; PMID:17344473; http://dx.doi.org/10.1091/mbc.E06-12-1092
  • Hsieh CY, Hsu MJ, Hsiao G, Wang YH, Huang CW, Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR. Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells. J Biol Chem 2011; 286:5942–55.
  • Donzelli M, Draetta GF. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO reports 2003; 4:671-7; PMID:12835754; http://dx.doi.org/10.1038/sj.embor.embor887
  • Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995; 80:225-36; PMID:7834742; http://dx.doi.org/10.1016/0092-8674(95)90405-0
  • Atherton-Fessler S, Liu F, Gabrielli B, Lee MS, Peng CY, Piwnica-Worms H. Cell cycle regulation of the p34cdc2 inhibitory kinases. Mol Biol Cell 1994; 5:989-1001; PMID:7841526; http://dx.doi.org/10.1091/mbc.5.9.989
  • Duronio RJ. Developing S-phase control. Genes Dev 2012; 26:746-50; PMID:22508722; http://dx.doi.org/10.1101/gad.191171.112
  • Liu G, Lozano G. p21 stability: linking chaperones to a cell cycle checkpoint. Cancer Cell 2005; 7:113–4.
  • Liu C, Nadiminty N, Tummala R, Chun JY, Lou W, Zhu Y, Sun M, Evans CP, Zhou Q, Gao AC. Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer 2011; 2:151–9.
  • Liu SH, Lin CH, Liang FP, Chen PF, Kuo CD, Alam MM, Maiti B, Hung SK, Chi CW, Sun CM, et al. Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy. Biochem Pharmacol 2014; 87:229–42.
  • Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D'Alessandro A, et al. Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle 2014; 13:2046–55.
  • Aksoy MO, Yang Y, Ji R, Reddy PJ, Shahabuddin S, Litvin J, Rogers TJ, Kelsen SG. CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol 2006; 290:L909-18; PMID:16339779; http://dx.doi.org/10.1152/ajplung.00430.2005
  • Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J Biol Chem 1996; 271:22878-84; PMID:8798467; http://dx.doi.org/10.1074/jbc.271.37.22878
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 1983; 65:55-63; PMID:6606682; http://dx.doi.org/10.1016/0022-1759(83)90303-4

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