PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte

References

• Holt JE, Tran SM, Stewart JL, Minahan K, Garcia-Higuera I, Moreno S, Jones KT. The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. Development 2011; 138:905-13; PMID:21270054; http://dx.doi.org/10.1242/dev.059022
   PubMed Web of Science ®Google Scholar
• Jessberger R. Age-related aneuploidy through cohesion exhaustion. EMBO Rep 2012; 13:539-46; PMID:22565322; http://dx.doi.org/10.1038/embor.2012.54
   PubMed Web of Science ®Google Scholar
• Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR, Adams DJ, Nasmyth K. Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev 2010; 24:2505-16; PMID:20971813; http://dx.doi.org/10.1101/gad.605910
   PubMed Web of Science ®Google Scholar
• Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, et al. Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2. Curr Biol 2010; 20:1511-21; PMID:20817533; http://dx.doi.org/10.1016/j.cub.2010.08.023
   PubMed Web of Science ®Google Scholar
• Kitajima TS, Ohsugi M, Ellenberg J. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell 2011; 146:568-81; PMID:21854982; http://dx.doi.org/10.1016/j.cell.2011.07.031
   PubMed Web of Science ®Google Scholar
• Zolnierowicz S. Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem Pharmacol 2000; 60:1225-35; PMID:11007961; http://dx.doi.org/10.1016/S0006-2952(00)00424-X
   PubMed Web of Science ®Google Scholar
• Khew-Goodall Y, Hemmings BA. Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A. FEBS Lett 1988; 238:265-8; PMID:2844601; http://dx.doi.org/10.1016/0014-5793(88)80493-9
   PubMed Web of Science ®Google Scholar
• Pan X, Chen X, Tong X, Tang C, Li J. Ppp2ca knockout in mice spermatogenesis. Reproduction 2015; PMID:25628439
   PubMed Web of Science ®Google Scholar
• Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, Song A, Jiang S, Lin Z, Guo S, et al. Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity. Aging (Albany NY) 2015; 7:223-32; PMID:25888638
   PubMedGoogle Scholar
• Gu P, Qi X, Zhou Y, Wang Y, Gao X. Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis 2012; 50:429-36; PMID:21998041; http://dx.doi.org/10.1002/dvg.20815
   PubMed Web of Science ®Google Scholar
• Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X. Protein phosphatase 2A catalytic subunit alpha (PP2Acalpha) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am J Pathol 2011; 178:2333-43; PMID:21514445; http://dx.doi.org/10.1016/j.ajpath.2011.01.041
   PubMed Web of Science ®Google Scholar
• Lu N, Liu Y, Tang A, Chen L, Miao D, Yuan X. Hepatocyte-specific ablation of PP2A catalytic subunit alpha attenuates liver fibrosis progression via TGF-beta1/Smad signaling. Biomed Res Int 2015; 2015:794862; PMID:25710025
   PubMedGoogle Scholar
• Schuh M, Ellenberg J. Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell 2007; 130:484-98; PMID:17693257; http://dx.doi.org/10.1016/j.cell.2007.06.025
   PubMed Web of Science ®Google Scholar
• Yoshida S, Kaido M, Kitajima TS. Inherent Instability of Correct Kinetochore-Microtubule Attachments during Meiosis I in Oocytes. Dev Cell 2015; 33:589-602; PMID:26028219; http://dx.doi.org/10.1016/j.devcel.2015.04.020
   PubMed Web of Science ®Google Scholar
• Hached K, Xie SZ, Buffin E, Cladiere D, Rachez C, Sacras M, Sorger PK, Wassmann K. Mps1 at kinetochores is essential for female mouse meiosis I. Development 2011; 138:2261-71; PMID:21558374; http://dx.doi.org/10.1242/dev.061317
   PubMed Web of Science ®Google Scholar
• Kitajima TS, Kawashima SA, Watanabe Y. The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 2004; 427:510-7; PMID:14730319; http://dx.doi.org/10.1038/nature02312
   PubMed Web of Science ®Google Scholar
• Winston NJ, Maro B. Changes in the activity of type 2A protein phosphatases during meiotic maturation and the first mitotic cell cycle in mouse oocytes. Biol Cell 1999; 91:175-83; PMID:10425704; http://dx.doi.org/10.1016/S0248-4900(99)80040-9
   PubMed Web of Science ®Google Scholar
• Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ. MARF1 regulates essential oogenic processes in mice. Science 2012; 335:1496-9; PMID:22442484; http://dx.doi.org/10.1126/science.1214680
   PubMed Web of Science ®Google Scholar
• Alexandre H, Van Cauwenberge A, Tsukitani Y, Mulnard J. Pleiotropic effect of okadaic acid on maturing mouse oocytes. Development 1991; 112:971-80; PMID:1718679
   PubMed Web of Science ®Google Scholar
• Lu Q, Dunn RL, Angeles R, Smith GD. Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis. Biol Reprod 2002; 66:29-37; PMID:11751260; http://dx.doi.org/10.1095/biolreprod66.1.29
   PubMed Web of Science ®Google Scholar
• Chang HY, Jennings PC, Stewart J, Verrills NM, Jones KT. Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720. J Biol Chem 2011; 286:14705-12; PMID:21383018; http://dx.doi.org/10.1074/jbc.M110.193227
   PubMed Web of Science ®Google Scholar
• Mailhes JB, Hilliard C, Fuseler JW, London SN. Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro. Chromosome Res 2003; 11:619-31; PMID:14516070; http://dx.doi.org/10.1023/A:1024909119593
   PubMed Web of Science ®Google Scholar
• Qi ST, Wang ZB, Ouyang YC, Zhang QH, Hu MW, Huang X, Ge Z, Guo L, Wang YP, Hou Y, et al. Overexpression of SETbeta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes. J Cell Sci 2013; 126:1595-603; PMID:23444375; http://dx.doi.org/10.1242/jcs.116541
   PubMed Web of Science ®Google Scholar
• Hu MW, Wang ZB, Jiang ZZ, Qi ST, Huang L, Liang QX, Schatten H, Sun QY. Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice. Biol Reprod 2014; 91:19; PMID:24899574; http://dx.doi.org/10.1095/biolreprod.114.120220
   PubMed Web of Science ®Google Scholar
• Morris JK, Mutton DE, Alberman E. Revised estimates of the maternal age specific live birth prevalence of Down's syndrome. J Med Screen 2002; 9:2-6; PMID:11943789; http://dx.doi.org/10.1136/jms.9.1.2
   PubMed Web of Science ®Google Scholar
• Foley EA, Maldonado M, Kapoor TM. Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nat Cell Biol 2011; 13:1265-71; PMID:21874008; http://dx.doi.org/10.1038/ncb2327
   PubMed Web of Science ®Google Scholar
• Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ. Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell 2012; 23:745-55; PMID:23079597; http://dx.doi.org/10.1016/j.devcel.2012.09.005
   PubMed Web of Science ®Google Scholar
• Touati SA, Buffin E, Cladiere D, Hached K, Rachez C, van Deursen JM, Wassmann K. Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nat Commun 2015; 6:6946; PMID:25897860; http://dx.doi.org/10.1038/ncomms7946
   PubMed Web of Science ®Google Scholar
• de Vries WN, Binns LT, Fancher KS, Dean J, Moore R, Kemler R, Knowles BB. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 2000; 26:110-2; PMID:10686600; http://dx.doi.org/10.1002/(SICI)1526-968X(200002)26:2%3c110::AID-GENE2%3e3.0.CO;2-8
   PubMed Web of Science ®Google Scholar
• Chambon JP, Touati SA, Berneau S, Cladiere D, Hebras C, Groeme R, McDougall A, Wassmann K. The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II. Curr Biol 2013; 23:485-90; PMID:23434280; http://dx.doi.org/10.1016/j.cub.2013.02.004
   PubMed Web of Science ®Google Scholar
• Dumont J, Desai A. Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis. Trends Cell Biol 2012; 22:241-9; PMID:22480579; http://dx.doi.org/10.1016/j.tcb.2012.02.007
   PubMed Web of Science ®Google Scholar
• Clift D, Schuh M. A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes. Nat Commun 2015; 6:7217; PMID:26147444; http://dx.doi.org/10.1038/ncomms8217
   PubMed Web of Science ®Google Scholar
• Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 2006; 127:983-97; PMID:17129783; http://dx.doi.org/10.1016/j.cell.2006.09.039
   PubMed Web of Science ®Google Scholar
• Welburn JP, Vleugel M, Liu D, Yates JR, 3rd, Lampson MA, Fukagawa T, Cheeseman IM. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell 2010; 38:383-92; PMID:20471944; http://dx.doi.org/10.1016/j.molcel.2010.02.034
   PubMed Web of Science ®Google Scholar
• Goto H, Yasui Y, Nigg EA, Inagaki M. Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells 2002; 7:11-7; PMID:NOT_FOUND; http://dx.doi.org/10.1046/j.1356-9597.2001.00498.x
   PubMed Web of Science ®Google Scholar
• Shuda K, Schindler K, Ma J, Schultz RM, Donovan PJ. Aurora kinase B modulates chromosome alignment in mouse oocytes. Mol Reprod Dev 2009; 76:1094-105; PMID:19565641; http://dx.doi.org/10.1002/mrd.21075
   PubMed Web of Science ®Google Scholar
• Smith GD, Sadhu A, Wolf DP. Transient exposure of rhesus macaque oocytes to calyculin-A and okadaic acid stimulates germinal vesicle breakdown permitting subsequent development and fertilization. Biol Reprod 1998; 58:880-6; PMID:9546716; http://dx.doi.org/10.1095/biolreprod58.4.880
   PubMed Web of Science ®Google Scholar
• Sun QY, Wu GM, Lai L, Bonk A, Cabot R, Park KW, Day BN, Prather RS, Schatten H. Regulation of mitogen-activated protein kinase phosphorylation, microtubule organization, chromatin behavior, and cell cycle progression by protein phosphatases during pig oocyte maturation and fertilization in vitro. Biol Reprod 2002; 66:580-8; PMID:11870061; http://dx.doi.org/10.1095/biolreprod66.3.580
   PubMed Web of Science ®Google Scholar
• Xu P, Virshup DM, Lee SH. B56-PP2A regulates motor dynamics for mitotic chromosome alignment. J Cell Sci 2014; 127:4567-73; PMID:25179604; http://dx.doi.org/10.1242/jcs.154609
   PubMed Web of Science ®Google Scholar
• Horn V, Thelu J, Garcia A, Albiges-Rizo C, Block MR, Viallet J. Functional interaction of Aurora-A and PP2A during mitosis. Mol Biol Cell 2007; 18:1233-41; PMID:17229885; http://dx.doi.org/10.1091/mbc.E06-12-1152
   PubMed Web of Science ®Google Scholar
• Saskova A, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J. Aurora kinase A controls meiosis I progression in mouse oocytes. Cell Cycle 2008; 7:2368-76; PMID:18677115; http://dx.doi.org/10.4161/cc.6361
   PubMed Web of Science ®Google Scholar
• Ding J, Swain JE, Smith GD. Aurora kinase-A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone-H3 phosphorylation in mouse oocytes. Mol Reprod Dev 2011; 78:80-90; PMID:21274965; http://dx.doi.org/10.1002/mrd.21272
   PubMed Web of Science ®Google Scholar
• Yao LJ, Zhong ZS, Zhang LS, Chen DY, Schatten H, Sun QY. Aurora-A is a critical regulator of microtubule assembly and nuclear activity in mouse oocytes, fertilized eggs, and early embryos. Biol Reprod 2004; 70:1392-9; PMID:14695913; http://dx.doi.org/10.1095/biolreprod.103.025155
   PubMed Web of Science ®Google Scholar
• Nikonova AS, Astsaturov I, Serebriiskii IG, Dunbrack RL, Jr., Golemis EA. Aurora A kinase (AURKA) in normal and pathological cell division. Cellular and molecular life sciences : CMLS 2013; 70:661-87; PMID:22864622; http://dx.doi.org/10.1007/s00018-012-1073-7
   PubMed Web of Science ®Google Scholar
• Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U. Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error. Mutat Res 2008; 651:14-29; PMID:18096427; http://dx.doi.org/10.1016/j.mrgentox.2007.10.015
   PubMed Web of Science ®Google Scholar
• Su YQ, Rubinstein S, Luria A, Lax Y, Breitbart H. Involvement of MEK-mitogen-activated protein kinase pathway in follicle-stimulating hormone-induced but not spontaneous meiotic resumption of mouse oocytes. Biol Reprod 2001; 65:358-65; PMID:11466201; http://dx.doi.org/10.1095/biolreprod65.2.358
   PubMed Web of Science ®Google Scholar
• Hoffman DB, Pearson CG, Yen TJ, Howell BJ, Salmon ED. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell 2001; 12:1995-2009; PMID:11451998; http://dx.doi.org/10.1091/mbc.12.7.1995
   PubMed Web of Science ®Google Scholar