p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

References

• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10; PMID:11099028; http://dx.doi.org/10.1038/35042675
   PubMed Web of Science ®Google Scholar
• Beroud C, Soussi T. The UMD-p53 database: new mutations and analysis tools. Human mutation 2003; 21:176-81; PMID:12619103; http://dx.doi.org/10.1002/humu.10187
   PubMed Web of Science ®Google Scholar
• Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Jr., Butel JS, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356:215-21; PMID:1552940; http://dx.doi.org/10.1038/356215a0
   PubMed Web of Science ®Google Scholar
• Attardi LD. The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models. Mutat Res 2005; 569:145-57; PMID:15603759; http://dx.doi.org/10.1016/j.mrfmmm.2004.04.019
   PubMed Web of Science ®Google Scholar
• Bieging KT, Attardi LD. Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol 2012; 22:97-106; PMID:22154076; http://dx.doi.org/10.1016/j.tcb.2011.10.006
   PubMed Web of Science ®Google Scholar
• Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683-94; PMID:11463392; http://dx.doi.org/10.1016/S1097-2765(01)00214-3
   PubMed Web of Science ®Google Scholar
• Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7:673-82; PMID:11463391; http://dx.doi.org/10.1016/S1097-2765(01)00213-1
   PubMed Web of Science ®Google Scholar
• Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8; PMID:10807576; http://dx.doi.org/10.1126/science.288.5468.1053
   PubMed Web of Science ®Google Scholar
• Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deisseroth AB, Zhang WW, Kruzel E, et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 1995; 15:3032-40; PMID:7539102; http://dx.doi.org/10.1128/MCB.15.6.3032
   PubMed Web of Science ®Google Scholar
• Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303:1010-4; PMID:14963330; http://dx.doi.org/10.1126/science.1092734
   PubMed Web of Science ®Google Scholar
• Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 2004; 6:443-50; PMID:15077116; http://dx.doi.org/10.1038/ncb1123
   PubMed Web of Science ®Google Scholar
• Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003; 11:577-90; PMID:12667443; http://dx.doi.org/10.1016/S1097-2765(03)00050-9
   PubMed Web of Science ®Google Scholar
• Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74:957-67; PMID:8402885; http://dx.doi.org/10.1016/0092-8674(93)90719-7
   PubMed Web of Science ®Google Scholar
• Crighton D, Ryan KM. Splicing DNA-damage responses to tumour cell death. Biochim Biophys Acta 2004; 1705:3-15; PMID:15585169
   PubMed Web of Science ®Google Scholar
• Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387:299-303; PMID:9153396; http://dx.doi.org/10.1038/387299a0
   PubMed Web of Science ®Google Scholar
• Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387:296-9; PMID:9153395; http://dx.doi.org/10.1038/387296a0
   PubMed Web of Science ®Google Scholar
• Pinho SS, Reis CA. Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer 2015; 15:540-55; PMID:26289314; http://dx.doi.org/10.1038/nrc3982
   PubMed Web of Science ®Google Scholar
• Varki A, Kannagi R, Toole BP. Glycosylation Changes in Cancer. In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, eds. Essentials of Glycobiology. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. The Consortium of Glycobiology Editors, La Jolla, California, 2009.
   Google Scholar
• Ryan KM, O'Prey J, Vousden KH. Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53. Cancer Res 2004; 64:4415-8.
   PubMed Web of Science ®Google Scholar
• Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ, Lowe SW. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet 2005; 37:1289-95; PMID:16200064
   PubMed Web of Science ®Google Scholar
• Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM. Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Molecular Cell 2013; 50:394-406; PMID:23603120; http://dx.doi.org/10.1016/j.molcel.2013.03.016
   PubMed Web of Science ®Google Scholar
• Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 1993; 7:1111-25; PMID:8319904; http://dx.doi.org/10.1101/gad.7.7a.1111
   PubMed Web of Science ®Google Scholar
• Baudot AD, Haller M, Mrschtik M, Tait SW, Ryan KM. Using enhanced-mitophagy to measure autophagic flux. Methods 2015; 75:105-11; PMID:25498004; http://dx.doi.org/10.1016/j.ymeth.2014.11.014
   PubMed Web of Science ®Google Scholar
• Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-kappaB in p53-mediated programmed cell death. Nature 2000; 404:892-7; PMID:10786798; http://dx.doi.org/10.1038/35009130
   PubMed Web of Science ®Google Scholar
• Pellicciari C, Manfredi AA, Bottone MG, Schaack V, Barni S. A single-step staining procedure for the detection and sorting of unfixed apoptotic thymocytes. Eur J Histochem 1993; 37:381-90; PMID:7510545
   PubMed Web of Science ®Google Scholar
• Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H. p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 2003; 5:216-23; PMID:12598906; http://dx.doi.org/10.1038/ncb943
   PubMed Web of Science ®Google Scholar
• Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126:121-34; PMID:16839881; http://dx.doi.org/10.1016/j.cell.2006.05.034
   PubMed Web of Science ®Google Scholar
• el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75:817-25; PMID:8242752; http://dx.doi.org/10.1016/0092-8674(93)90500-P
   PubMed Web of Science ®Google Scholar
• Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J. The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci U S A 2002; 99:8467-72; PMID:12077306; http://dx.doi.org/10.1073/pnas.132268899
   PubMed Web of Science ®Google Scholar
• Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282:1497-501; PMID:9822382; http://dx.doi.org/10.1126/science.282.5393.1497
   PubMed Web of Science ®Google Scholar
• Johnson SW, Alhadeff JA. Mammalian alpha-L-fucosidases. Comp Biochem Physiol B 1991; 99:479-88; PMID:1769200; http://dx.doi.org/10.1016/0305-0491(91)90327-A
   PubMed Web of Science ®Google Scholar
• Tsay GC, Dawson G, Sung SS. Structure of the accumulating oligosaccharide in fucosidosis. J Biol Chem 1976; 251:5852-9; PMID:972144
   PubMed Web of Science ®Google Scholar
• Winchester B. Lysosomal metabolism of glycoproteins. Glycobiology 2005; 15:1r-15r; PMID:15647514; http://dx.doi.org/10.1093/glycob/cwi041
   PubMed Web of Science ®Google Scholar
• Yamashita K, Tachibana Y, Takada S, Matsuda I, Arashima S, Kobata A. Urinary glycopeptides of fucosidosis. J Biol Chem 1979; 254:4820-7; PMID:438217
   PubMed Web of Science ®Google Scholar
• Rapoport E, Pendu JL. Glycosylation alterations of cells in late phase apoptosis from colon carcinomas. Glycobiology 1999; 9:1337-45; PMID:10561459; http://dx.doi.org/10.1093/glycob/9.12.1337
   PubMed Web of Science ®Google Scholar
• Willems PJ, Gatti R, Darby JK, Romeo G, Durand P, Dumon JE, O'Brien JS. Fucosidosis revisited: a review of 77 patients. Am J Med Genet 1991; 38:111-31; PMID:2012122; http://dx.doi.org/10.1002/ajmg.1320380125
   PubMed Web of Science ®Google Scholar
• Willems PJ, Seo HC, Coucke P, Tonlorenzi R, O'Brien JS. Spectrum of mutations in fucosidosis. Eur J Hum Genet 1999; 7:60-7; PMID:10094192; http://dx.doi.org/10.1038/sj.ejhg.5200272
   PubMed Web of Science ®Google Scholar
• Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994; 371:346-7; PMID:8090205; http://dx.doi.org/10.1038/371346a0
   PubMed Web of Science ®Google Scholar
• Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 2004; 279:8076-83; PMID:14634023; http://dx.doi.org/10.1074/jbc.M307469200
   PubMed Web of Science ®Google Scholar
• Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90:809-19; PMID:9288759; http://dx.doi.org/10.1016/S0092-8674(00)80540-1
   PubMed Web of Science ®Google Scholar
• Jost CA, Marin MC, Kaelin WG, Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 1997; 389:191-4; PMID:9296498; http://dx.doi.org/10.1038/38298
   PubMed Web of Science ®Google Scholar
• Crighton D, O'Prey J, Bell HS, Ryan KM. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 2007; 14:1071-9; PMID:17304243; http://dx.doi.org/10.1038/sj.cdd.4402108
   PubMed Web of Science ®Google Scholar
• Long JS, Schoonen PM, Graczyk D, O'Prey J, Ryan KM. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene 2015; 34:5152-62; PMID:25659586; http://dx.doi.org/10.1038/onc.2014.436
   PubMed Web of Science ®Google Scholar
• Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-9; PMID:7834749; http://dx.doi.org/10.1016/0092-8674(95)90513-8
   PubMed Web of Science ®Google Scholar
• Mehta A, Block TM. Fucosylated glycoproteins as markers of liver disease. Dis Markers 2008; 25:259-65; PMID:19126969; http://dx.doi.org/10.1155/2008/264594
   PubMed Web of Science ®Google Scholar
• Warnes TW, Smith A. Tumour markers in diagnosis and management. Bailliere's Clin Gastroenterol 1987; 1:63-89; PMID:2437983
   PubMed Web of Science ®Google Scholar