1,433
Views
14
CrossRef citations to date
0
Altmetric
Reports

Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells

, , , , &
Pages 2009-2018 | Received 08 Sep 2015, Accepted 17 May 2016, Published online: 23 Jun 2016

References

  • Bylund M, Andersson E, Novitch BG, Muhr J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 2003; 6:1162-8; PMID:14517545; http://dx.doi.org/10.1038/nn1131
  • Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007; 448:313-7; PMID:17554338; http://dx.doi.org/10.1038/nature05934
  • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72; PMID:18035408; http://dx.doi.org/10.1016/j.cell.2007.11.019
  • Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 2008; 26:903-11; PMID:18238855; http://dx.doi.org/10.1634/stemcells.2007-0951
  • Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 2005; 25:6031-46; PMID:15988017; http://dx.doi.org/10.1128/MCB.25.14.6031-6046.2005
  • Gao Z, Cox JL, Gilmore JM, Ormsbee BD, Mallanna SK, Washburn MP, Rizzino A. Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors. J Biol Chem 2012; 287:11384-97; PMID:22334693; http://dx.doi.org/10.1074/jbc.M111.320143
  • Mallanna SK, Ormsbee BD, Iacovino M, Gilmore JM, Cox JL, Kyba M, Washburn MP, Rizzino A. Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate. Stem Cells 2010; 28:1715-27; PMID:20687156; http://dx.doi.org/10.1002/stem.494
  • Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J. Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 2009; 5:214-26; PMID:19664995; http://dx.doi.org/10.1016/j.stem.2009.05.021
  • Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, Saitoh H, Yuasa Y, Niwa H, Kawasuji M, et al. Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun 2006; 351:920-6; PMID:17097055; http://dx.doi.org/10.1016/j.bbrc.2006.10.130
  • Wu Y, Guo Z, Wu H, Wang X, Yang L, Shi X, Du J, Tang B, Li W, Zhang Y. SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. PLoS One 2012; 7:e39606; PMID:22745796; http://dx.doi.org/10.1371/journal.pone.0039606
  • Zhao HY, Zhang YJ, Dai H, Zhang Y, Shen YF. CARM1 mediates modulation of Sox2. PLoS One 2011; 6:e27026; PMID:22046437; http://dx.doi.org/10.1371/journal.pone.0027026
  • Fang L, Zhang L, Wei W, Jin X, Wang P, Tong Y, Li J, Du JX, Wong J. A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation. Mol Cell 2014; 55:537-51; PMID:25042802; http://dx.doi.org/10.1016/j.molcel.2014.06.018
  • Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, Fields AP. The PRKCI and Sox2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer Cell 2014; 25:139-51; PMID:24525231; http://dx.doi.org/10.1016/j.ccr.2014.01.008
  • Ouyang J, Yu W, Liu J, Zhang N, Florens L, Chen J, Liu H, Washburn M, Pei D, Xie T. Cyclin-Dependent Kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent State. J Biol Chem 2015; 290:22782-94; PMID:26139602; http://dx.doi.org/10.1074/jbc.M115.658195
  • Fu J, Bian M, Jiang Q, Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 2007; 5:1-10; PMID:17259342; http://dx.doi.org/10.1158/1541-7786.MCR-06-0208
  • Fu J, Bian M, Liu J, Jiang Q, Zhang C. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A 2009; 106:6939-44; PMID:19357306; http://dx.doi.org/10.1073/pnas.0900833106
  • Harrington EA, Bebbington D, Moore J, Rasmussen RK, Ajose-Adeogun AO, Nakayama T, Graham JA, Demur C, Hercend T, Diu-Hercend A, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 2014; 10:262-7; http://dx.doi.org/10.1038/nm1003
  • Yin F, Lan R, Zhang X, Zhu L, Chen F, Xu Z, Liu Y, Ye T, Sun H, Lu F, et al. LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16. Mol Cell Biol 2014; 34:158-79; PMID:24190971; http://dx.doi.org/10.1128/MCB.00631-13
  • Du L, Yang Y, Xiao X, Wang C, Zhang X, Wang L, Li W, Zheng G, Wang S, Dong Z. Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma. Oral Oncol 2011; 47:709-13; PMID:21689966; http://dx.doi.org/10.1016/j.oraloncology.2011.05.017
  • Zhang X, Lu F, Wang J, Yin F, Xu Z, Qi D, Wu X, Cao Y, Liang W, Liu Y, et al. Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep 2014; 5:445-57; http://dx.doi.org/10.1016/j.celrep.2013.09.018
  • Wang J, Lu F, Ren Q, Sun H, Xu Z, Lan R, Liu Y, Ward D, Quan J, Ye T, et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res 2011; 71:7238-49; PMID:21975933; http://dx.doi.org/10.1158/0008-5472.CAN-11-0896
  • Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Invest 2012; 122:859-72; PMID:22307329; http://dx.doi.org/10.1172/JCI60818
  • Ding D, Xu H, Liang Q, Xu L, Zhao Y, Wang Y. Overexpression of Sox2 in C3H10T1/2 cells inhibits osteoblast differentiation through Wnt and MAPK signalling pathways. Int Orthop 2011; 36:1087-94; PMID:22012572; http://dx.doi.org/10.1007/s00264-011-1368-6
  • Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009; 5:491-503; PMID:19818703; http://dx.doi.org/10.1016/j.stem.2009.09.012
  • Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008; 3:568-74; PMID:18983970; http://dx.doi.org/10.1016/j.stem.2008.10.004
  • Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, et al. Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell 2015; 17:195-203; PMID:26253201; http://dx.doi.org/10.1016/j.stem.2015.06.003
  • Jeong CH, Cho YY, Kim MO, Kim SH, Cho EJ, Lee SY, Jeon YJ, Lee KY, Yao K, Keum YS, et al. Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells 2010; 28:2141-50; PMID:20945330; http://dx.doi.org/10.1002/stem.540
  • Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, et al. A class of 2, 4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem 2009; 52:3300-7; PMID:19402633; http://dx.doi.org/10.1021/jm9000314
  • Lan R, Lin G, Yin F, Xu J, Zhang X, Wang J, Wang Y, Gong J, Ding YH, Yang Z, et al. Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001. Lab Invest 2012; 92:1503-14; PMID:22890557; http://dx.doi.org/10.1038/labinvest.2012.114
  • Qi D, Wang Q, Li H, Zhang T, Lan R, Kwong D, Wong W, Wong K, Li S, Lu F. SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells. Mol Bio Syst 2015; 11:3059-67
  • Dephoure N, Gould KL, Gygi SP, Kellogg DR. Mapping and analysis of phosphorylation sites: a quick guide for cell biologists. Mol Biol Cell 2013; 24:535-42; PMID:23447708; http://dx.doi.org/10.1091/mbc.E12-09-0677
  • Savitski MM, Lemeer S, Boesche M, Lang M, Mathieson T, Bantscheff M. and Kuster B. Confident phosphorylation site localization using the Mascot Delta Score. Mol Cell Proteomics 2011; 10:M110.003830; PMID:21057138; http://dx.doi.org/10.1074/mcp.M110.003830

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.