The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing

References

• Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol [ Internet] 1994 [cited 2015 Oct 8]; 124:401-4. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2119916&tool=pmcentrez&rendertype=abstract; PMID:8106541; http://dx.doi.org/10.1083/jcb.124.4.401
   PubMed Web of Science ®Google Scholar
• Arwert EN, Hoste E, Watt FM. Epithelial stem cells, wound healing and cancer. Nat Rev Cancer [Internet] 2012 [cited 2015 Jul 29]; 12:170-80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22362215; PMID:22362215; http://dx.doi.org/10.1038/nrc3217
   PubMed Web of Science ®Google Scholar
• Schäfer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol [Internet] 2008 [cited 2015 Sep 15]; 9:628-38. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18628784; ; http://dx.doi.org/10.1038/nrm2455
   PubMed Web of Science ®Google Scholar
• Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci [Internet] 2009 [cited 2014 Nov 1]; 122:3209-13. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2736861&tool=pmcentrez&rendertype=abstract; PMID:19726630
   PubMed Web of Science ®Google Scholar
• Penn JW, Grobbelaar AO, Rolfe KJ. The role of the TGF-β family in wound healing, burns and scarring: a review. Int J Burns Trauma [Internet] 2012 [cited 2015 Oct 8]; 2:18-28. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3415964&tool=pmcentrez&rendertype=abstract; PMID:22928164
   PubMedGoogle Scholar
• Duperret EK, Dahal A, Ridky TW. Focal adhesion-independent integrin αv regulation of FAK and c-myc is necessary for 3D skin formation and tumor invasion. J Cell Sci [Internet] 2015 [cited 2015 Sep 14]; 128:3887-4013. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26359297; http://dx.doi.org/10.1242/jcs.175539
   Web of Science ®Google Scholar
• Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A. Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin. J Cell Sci [Internet] 2009 [cited 2013 Mar 12]; 122:278-88. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19118220; PMID:19118220
   PubMed Web of Science ®Google Scholar
• Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol [Internet] 2009 [cited 2013 Jan 14]; 129:217-28. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18633440; PMID:18633440; http://dx.doi.org/10.1038/jid.2008.201
   PubMed Web of Science ®Google Scholar
• Cavani A, Zambruno G, Marconi A, Manca V, Marchetti M, Giannetti A. Distinctive Integrin Expression in the Newly Forming Epidermis During Wound Healing in Humans. J Invest Dermatol [Internet] 1993 [cited 2014 Dec 12]; 101:600-4. Available from: http://dx.doi.org/10.1111/1523-1747.ep12366057; PMID:8409530
   PubMed Web of Science ®Google Scholar
• Clark RA, Ashcroft GS, Spencer MJ, Larjava H, Ferguson MW. Re-epithelialization of normal human excisional wounds is associated with a switch from α v β 5 to α v β 6 integrins. Br J Dermatol [Internet] 1996 [cited 2015 Jun 3]; 135:46-51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8776358; PMID:8776358; http://dx.doi.org/10.1111/j.1365-2133.1996.tb03606.x
   PubMed Web of Science ®Google Scholar
• Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, et al. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene [Internet] 2014 [cited 2014 Dec 12]; 34:516-24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24469034; PMID:24469034; http://dx.doi.org/10.1038/onc.2013.585
   PubMed Web of Science ®Google Scholar
• Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci [Internet] 2003 [cited 2015 Oct 8]; 116:217-24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12482908; PMID:12482908; http://dx.doi.org/10.1242/jcs.00229
   PubMed Web of Science ®Google Scholar
• Mamuya FA, Duncan MK. αV Integrins and TGF-β Induced EMT; a Circle of Regulation. J Cell Mol Med 2013; 16:445-55; http://dx.doi.org/10.1111/j.1582-4934.2011.01419.x
   Web of Science ®Google Scholar
• Massagué J. TGFbeta in Cancer. Cell [ Internet] 2008 [cited 2015 Feb 5]; 134:215-30. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3512574&tool=pmcentrez&rendertype=abstract; http://dx.doi.org/10.1016/j.cell.2008.07.001
   PubMed Web of Science ®Google Scholar
• Gordon KJ, Blobe GC. Role of transforming growth factor-β superfamily signaling pathways in human disease. Biochim Biophys Acta [Internet] 2008 [cited 2015 Jul 9]; 1782:197-228. Available from: http://www.sciencedirect.com/science/article/pii/S092544390800029X; PMID:18313409; http://dx.doi.org/10.1016/j.bbadis.2008.01.006
   PubMed Web of Science ®Google Scholar
• Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell [Internet] 2007 [cited 2013 Feb 16]; 12:313-27. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2424201&tool=pmcentrez&rendertype=abstract; PMID:17936557; http://dx.doi.org/10.1016/j.ccr.2007.08.020
   PubMed Web of Science ®Google Scholar
• Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, et al. Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK. Oncogene [Internet] 2006 [cited 2013 Mar 2]; 25:1081-9. Available from: www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2710133&tool=pmcentrez&rendertype=abstract; http://dx.doi.org/10.1038/sj.onc.1209130
   PubMed Web of Science ®Google Scholar
• Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol [Internet] 2005 [cited 2013 Feb 27]; 6:56-68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15688067; PMID:15688067; http://dx.doi.org/10.1038/nrm1549
   PubMed Web of Science ®Google Scholar
• Sulzmaier FJ, Jean C, Schlaepfer DD. FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer [Internet] 2014 [cited 2014 Aug 8]; 14:598-610. Available from: http://dx.doi.org/10.1038/nrc3792; PMID:25098269; http://dx.doi.org/10.1038/nrc3792
   PubMed Web of Science ®Google Scholar
• Chan T, Ghahary A, Demare J, Yang L, Iwashina T, Scott PG, Tredget EE. Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-beta1 transgenic mouse. Wound Repair Regen [Internet] 2002 [cited 2015 Oct 8]; 10:177-87. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12100379; PMID:12100379; http://dx.doi.org/10.1046/j.1524-475X.2002.11101.x
   PubMed Web of Science ®Google Scholar
• Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev [Internet] 2003 [cited 2015 Sep 14]; 83:835-70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12843410; PMID:12843410
   PubMed Web of Science ®Google Scholar
• Falanga V, Schrayer D, Cha J, Butmarc J, Carson P, Roberts AB, Kim SJ. Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice. Wound Repair Regen [Internet] 2004 [cited 2015 Oct 8]; 12:320-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15225210; PMID:15225210; http://dx.doi.org/10.1111/j.1067-1927.2004.012316.x
   PubMed Web of Science ®Google Scholar
• Amendt C, Mann A, Schirmacher P, Blessing M. Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. J Cell Sci [Internet] 2002 [cited 2015 Oct 8]; 115:2189-98. Available from: http://jcs.biologists.org/content/115/10/2189.abstract; PMID:11973359
   PubMed Web of Science ®Google Scholar
• Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol [ Internet] 1999 [cited 2015 Oct 8]; 1:260-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10559937; PMID:10559937; http://dx.doi.org/10.1038/12971
   PubMed Web of Science ®Google Scholar
• Escámez MJ, García M, Larcher F, Meana A, Muñoz E, Jorcano JL, Del Río M. An in vivo model of wound healing in genetically modified skin-humanized mice. J Invest Dermatol [Internet] 2004 [cited 2015 Oct 8]; 123:1182-91. Available from: http://dx.doi.org/10.1111/j.0022-202X.2004.23473.x; http://dx.doi.org/10.1111/j.0022-202X.2004.23473.x
   PubMed Web of Science ®Google Scholar
• Truong A-TN, Kowal-Vern A, Latenser BA, Wiley DE, Walter RJ. Comparison of dermal substitutes in wound healing utilizing a nude mouse model. J Burns Wounds [ Internet] 2005 [cited 2015 Sep 2]; 4:e4. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1501115&tool=pmcentrez&rendertype=abstract; PMID:16921409
   PubMedGoogle Scholar
• Wong VW, Sorkin M, Glotzbach JP, Longaker MT, Gurtner GC. Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol [Internet] 2011 [cited 2015 Oct 8]; 2011:1-8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2995912&tool=pmcentrez&rendertype=abstract
   Google Scholar
• Monteleon CL, McNeal A, Duperret EK, Oh SJ, Schapira E, Ridky TW. IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression. J Invest Dermatol [ Internet] 2015; 135(9):2258-65:[cited 2015 Jun 4]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25848980; PMID:25848980; http://dx.doi.org/10.1038/jid.2015.140
   PubMed Web of Science ®Google Scholar
• McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, et al. CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. Cancer Discov [Internet] 2015 [cited 2015 Oct 8]; 5:1072-85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26183406; PMID:26183406; http://dx.doi.org/10.1158/2159-8290.CD-15-0196
   PubMed Web of Science ®Google Scholar
• Ridky TW, Chow JM, Wong DJ, Khavari PA. Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. Nat Med [Internet] 2010 [cited 2012 Nov 15]; 16:1450-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21102459; http://dx.doi.org/10.1038/nm.2265
   PubMed Web of Science ®Google Scholar
• Goswami RK, Bajjuri KM, Forsyth JS, Das S, Hassenpflug W, Huang ZZ, Lerner RA, Felding-Habermann B, Sinha SC. Chemically Programmed Antibodies Targeting Multiple Alpha(v) Integrins and Their Effects on Tumor-Related Functions in Vitro. Bioconjug Chem [Internet] 2011 [cited 2015 Oct 19]; 22:1535-44. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3277862&tool=pmcentrez&rendertype=abstract; PMID:21774545; http://dx.doi.org/10.1021/bc2000879
   PubMed Web of Science ®Google Scholar
• Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. Role of the integrin α v β 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem [Internet] 1994 [cited 2015 Oct 20]; 269:6940-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8120056; PMID:8120056
   PubMed Web of Science ®Google Scholar
• Longmate WM, Dipersio CM. Integrin Regulation of Epidermal Functions in Wounds. Adv Wound Care [Internet] 2014 [cited 2015 Oct 18]; 3:229-46. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3955963&tool=pmcentrez&rendertype=abstract; http://dx.doi.org/10.1089/wound.2013.0516
   PubMedGoogle Scholar
• Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol [Internet] 2000 [cited 2013 Apr 21]; 20:755-9. Available from: http://mcb.asm.org/content/20/3/755.short; PMID:10629031; http://dx.doi.org/10.1128/MCB.20.3.755-759.2000
   PubMed Web of Science ®Google Scholar
• Huang X, Wu J, Cass D, Erle D. Inactivation of the integrin β 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol [Internet] 1996 [cited 2013 May 6]; 133:921-8. Available from: http://jcb.rupress.org/content/133/4/921.abstract; PMID:8666675; http://dx.doi.org/10.1083/jcb.133.4.921
   PubMed Web of Science ®Google Scholar
• AlDahlawi S, Eslami A, Häkkinen L, Larjava HS. The alphavbeta6 integrin plays a role in compromised epidermal wound healing. Wound Repair Regen [Internet] 2006 [cited 2015 Jun 1]; 14:289-97. Available from: http://proxy.library.upenn.edu:2077/doi/10.1111/j.1743-6109.2006.00123.x/full; PMID:16808807; http://dx.doi.org/10.1111/j.1743-6109.2006.00123.x
   PubMed Web of Science ®Google Scholar
• Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res [Internet] 2012 [cited 2015 Aug 10]; 49:35-43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22797712; PMID:22797712
   PubMed Web of Science ®Google Scholar
• Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, Gottrup F, Gurtner GC, Longaker MT. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen [Internet] 2009 [cited 2015 Feb 15]; 17:763-71. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2810192&tool=pmcentrez&rendertype=abstract; PMID:19903300; http://dx.doi.org/10.1111/j.1524-475X.2009.00543.x
   PubMed Web of Science ®Google Scholar
• Mustoe T. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg [Internet] 2004 [cited 2015 Jun 30]; 187:S65-70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15147994; http://dx.doi.org/10.1016/S0002-9610(03)00306-4
   PubMedGoogle Scholar
• Shen Y, Guo Y, Mikus P, Sulniute R, Wilczynska M, Ny T, Li J. Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood [Internet] 2012 [cited 2015 Oct 18]; 119:5879-87. Available from: http://www.bloodjournal.org/content/119/24/5879.abstract; PMID:22563086; http://dx.doi.org/10.1182/blood-2012-01-407825
   PubMed Web of Science ®Google Scholar
• Gooyit M, Peng Z, Wolter WR, Pi H, Ding D, Hesek D, Lee M, Boggess B, Champion MM, Suckow MA, et al. A Chemical Biological Strategy to Facilitate Diabetic Wound Healing. ACS Chem Biol [Internet] 2014 [cited 2015 Oct 18]; 9:105-10. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3947039&tool=pmcentrez&rendertype=abstract; PMID:24053680; http://dx.doi.org/10.1021/cb4005468
   PubMed Web of Science ®Google Scholar
• Koria P, Yagi H, Kitagawa Y, Megeed Z, Nahmias Y, Sheridan R, Yarmush ML. Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. Proc Natl Acad Sci U S A [Internet] 2011 [cited 2015 Oct 18]; 108:1034-9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3024670&tool=pmcentrez&rendertype=abstract; PMID:21193639; http://dx.doi.org/10.1073/pnas.1009881108
   PubMed Web of Science ®Google Scholar
• Marques da Costa R, Jesus FM, Aniceto C, Mendes M. Double-blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers. Am J Surg [Internet] 1997 [cited 2015 Oct 18]; 173:165-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9124619; PMID:9124619; http://dx.doi.org/10.1016/S0002-9610(97)89589-X
   PubMed Web of Science ®Google Scholar
• Pastar I, Stojadinovic O, Krzyzanowska A, Barrientos S, Stuelten C, Zimmerman K, Blumenberg M, Brem H, Tomic-Canic M. Attenuation of the transforming growth factor β-signaling pathway in chronic venous ulcers. Mol Med [Internet] 2010 [cited 2015 Nov 24]; 16:92-101. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2804290&tool=pmcentrez&rendertype=abstract; PMID:20069132; http://dx.doi.org/10.2119/molmed.2009.00149
   PubMed Web of Science ®Google Scholar
• Steed DL, Ricotta JJ, Prendergast JJ, Kaplan RJ, Webster MW, McGill JB, Schwartz SL. Promotion and Acceleration of Diabetic Ulcer Healing by Arginine-Glycine-Aspartic Acid (RGD) Peptide Matrix. Diabetes Care [Internet] 1995 [cited 2016 Jan 25]; 18:39-46. Available from: http://care.diabetesjournals.org/content/18/1/39.abstract; PMID:7698046; http://dx.doi.org/10.2337/diacare.18.1.39
   PubMed Web of Science ®Google Scholar
• Mertz PM, Davis SC, Franzen L, Uchima FD, Pickett MP, Pierschbacher MD, Polarek JW. Effects of an arginine-glycine-aspartic acid peptide-containing artificial matrix on epithelial migration in vitro and experimental second-degree burn wound healing in vivo. J Burn Care Rehabil [Internet] [cited 2016 Jan 25]; 17:199-206. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8736364; PMID:8736364; http://dx.doi.org/10.1097/00004630-199605000-00004
   PubMedGoogle Scholar
• Fong E, Tzlil S, Tirrell DA. Boundary crossing in epithelial wound healing. Proc Natl Acad Sci U S A [Internet] 2010 [cited 2016 Jan 25]; 107:19302-7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2984212&tool=pmcentrez&rendertype=abstract; PMID:20974917; http://dx.doi.org/10.1073/pnas.1008291107
   PubMed Web of Science ®Google Scholar
• Häkkinen L, Koivisto L, Gardner H, Saarialho-Kere U, Carroll JM, Lakso M, Rauvala H, Laato M, Heino J, Larjava H. Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol [Internet] 2004 [cited 2015 Jun 1]; 164:229-42. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1602209&tool=pmcentrez&rendertype=abstract; http://dx.doi.org/10.1016/S0002-9440(10)63113-6
   PubMed Web of Science ®Google Scholar
• Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest [Internet] 2010 [cited 2015 Oct 19]; 120:4445-52. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2993596&tool=pmcentrez&rendertype=abstract; PMID:21099114; http://dx.doi.org/10.1172/JCI43796
   PubMed Web of Science ®Google Scholar
• Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D, Bronson RT, Roes JT, Savill JS, Hynes RO. Ulcerative colitis and autoimmunity induced by loss of myeloid v integrins. Proc Natl Acad Sci [Internet] 2007 [cited 2015 Oct 19]; 104:15823-8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1994135&tool=pmcentrez&rendertype=abstract; PMID:17895374; http://dx.doi.org/10.1073/pnas.0707421104
   PubMed Web of Science ®Google Scholar
• Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med [Internet] 2013 [cited 2015 Jun 1]; 19:1617-24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3855865&tool=pmcentrez&rendertype=abstract; PMID:24216753; http://dx.doi.org/10.1038/nm.3282
   PubMed Web of Science ®Google Scholar
• McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, et al. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol [Internet] 2002 [cited 2015 Oct 19]; 22:7667-77. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=135679&tool=pmcentrez&rendertype=abstract; PMID:12370313; http://dx.doi.org/10.1128/MCB.22.21.7667-7677.2002
   PubMed Web of Science ®Google Scholar
• McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development [Internet] 2005 [cited 2015 Oct 19]; 132:165-76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15576410; PMID:15576410; http://dx.doi.org/10.1242/dev.01551
   PubMed Web of Science ®Google Scholar
• Neurath MF. New targets for mucosal healing and therapy in inflammatory bowel diseases. Mucosal Immunol [ Internet] 2014 [cited 2015 Oct 19]; 7:6-19. Available from: http://dx.doi.org/10.1038/mi.2013.73; PMID:24084775; http://dx.doi.org/10.1038/mi.2013.73
   PubMed Web of Science ®Google Scholar
• McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol [Internet] 2008 [cited 2014 Nov 26]; 172:1740-7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408432&tool=pmcentrez&rendertype=abstract; PMID:18467691; http://dx.doi.org/10.2353/ajpath.2008.070700
   PubMed Web of Science ®Google Scholar
• Xie Y, McElwee KJ, Owen GR, Häkkinen L, Larjava HS. Integrin β6-deficient mice show enhanced keratinocyte proliferation and retarded hair follicle regression after depilation. J Invest Dermatol [Internet] 2012 [cited 2012 Nov 13]; 132:547-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22113470; PMID:22113470; http://dx.doi.org/10.1038/jid.2011.381
   PubMed Web of Science ®Google Scholar
• Terai K, Call MK, Liu H, Saika S, Liu CY, Hayashi Y, Chikama T, Zhang J, Terai N, Kao CW-C, et al. Crosstalk between TGF-β and MAPK signaling during corneal wound healing. Invest Ophthalmol Vis Sci [Internet] 2011 [cited 2015 Oct 21]; 52:8208-15. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3208026&tool=pmcentrez&rendertype=abstract; PMID:21917935; http://dx.doi.org/10.1167/iovs.11-8017
   PubMed Web of Science ®Google Scholar
• Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan IR, Narayanan S, Erikci E, Li X, Blomqvist L, et al. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. J Clin Invest [Internet] 2015 [cited 2015 Oct 18]; 125:3008-26. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26121747; PMID:26121747; http://dx.doi.org/10.1172/JCI79052
   PubMed Web of Science ®Google Scholar
• Santoro MM, Gaudino G, Marchisio PC. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. Dev Cell [ Internet] 2003 [cited 2016 May 20]; 5:257-71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12919677; PMID:12919677; http://dx.doi.org/10.1016/S1534-5807(03)00201-6
   PubMed Web of Science ®Google Scholar
• Chernyavsky AI, Arredondo J, Karlsson E, Wessler I, Grando SA. The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem [Internet] 2005 [cited 2016 May 20]; 280:39220-8. Available from: http://www.jbc.org/content/280/47/39220.full; PMID:16150734; http://dx.doi.org/10.1074/jbc.M504407200
   PubMed Web of Science ®Google Scholar
• Su Y, Zheng L, Wang Q, Bao J, Cai Z, Liu A. The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells. BMC Cancer [Internet] 2010 [cited 2016 May 20]; 10:459. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2940800&tool=pmcentrez&rendertype=abstract; PMID:20796276; http://dx.doi.org/10.1186/1471-2407-10-459
   PubMed Web of Science ®Google Scholar