TEAD activity is restrained by MYC and stratifies human breast cancer subtypes

References

• Kress TR, Sab∫ A, Amati B. MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer 2015; 15:593-607; PMID:26383138; http://dx.doi.org/10.1038/nrc3984
   PubMed Web of Science ®Google Scholar
• McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 1998; 94:363-74; PMID:9708738; http://dx.doi.org/10.1016/S0092-8674(00)81479-8
   PubMed Web of Science ®Google Scholar
• Jaenicke LA, Eyss von B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N. Ubiquitin-Dependent turnover of MYC antagonizes MYC/PAF1C complex accumulation to drive transcriptional elongation. Mol Cell 2015; 61(1):54-67; PMID:26687678
   PubMed Web of Science ®Google Scholar
• Walz S, Lorenzin F, Morton J, Wiese KE, Eyss von B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature 2014; 511:483-7; PMID:25043018; http://dx.doi.org/10.1038/nature13473
   PubMed Web of Science ®Google Scholar
• Eyss von B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus L-A, Sauer M, Rosenwald A, Evan GI, et al. A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell 2015; 28:743-57; PMID:26678338; http://dx.doi.org/10.1016/j.ccell.2015.10.013
   PubMed Web of Science ®Google Scholar
• Yu F-X, Zhao B, Guan K-L. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell 2015; 163:811-28; PMID:26544935; http://dx.doi.org/10.1016/j.cell.2015.10.044
   PubMed Web of Science ®Google Scholar
• Ni L, Zheng Y, Hara M, Pan D, Luo X. Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Genes Dev 2015; 29:1416-31; PMID:26108669; http://dx.doi.org/10.1101/gad.264929.115
   PubMed Web of Science ®Google Scholar
• Zhao B, Li L, Tumaneng K, Wang C-Y, Guan K-L. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev 2010; 24:72-85; PMID:20048001; http://dx.doi.org/10.1101/gad.1843810
   PubMed Web of Science ®Google Scholar
• Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21:2747-61; PMID:17974916; http://dx.doi.org/10.1101/gad.1602907
   PubMed Web of Science ®Google Scholar
• Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, et al. Role of YAP/TAZ in mechanotransduction. Nature 2011; 474:179-83; PMID:21654799; http://dx.doi.org/10.1038/nature10137
   PubMed Web of Science ®Google Scholar
• Mo J-S, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim D-S, Guan K-L. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 2015; 17:500-10; PMID:25751140; http://dx.doi.org/10.1038/ncb3111
   PubMed Web of Science ®Google Scholar
• Choi S-Y, Huang P, Jenkins GM, Chan DC, Schiller J, Frohman MA. A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat Cell Biol 2006; 8:1255-62; PMID:17028579; http://dx.doi.org/10.1038/ncb1487
   PubMed Web of Science ®Google Scholar
• Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 2011; 147:759-72; PMID:22078877; http://dx.doi.org/10.1016/j.cell.2011.09.048
   PubMed Web of Science ®Google Scholar
• Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang C-Y, Chinnaiyan AM, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 2008; 22:1962-71; PMID:18579750; http://dx.doi.org/10.1101/gad.1664408
   PubMed Web of Science ®Google Scholar
• Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan K-L, Xu Y. Structural insights into the YAP and TEAD complex. Genes Dev 2010; 24:235-40; PMID:20123905; http://dx.doi.org/10.1101/gad.1865810
   PubMed Web of Science ®Google Scholar
• Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep 2014; 6:1059-72; PMID:24613358; http://dx.doi.org/10.1016/j.celrep.2014.02.038
   PubMed Web of Science ®Google Scholar
• Leung JY, Andrechek ER, Cardiff RD, Nevins JR. Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence. Oncogene 2012; 31:2545-54; PMID:21996730; http://dx.doi.org/10.1038/onc.2011.433
   PubMed Web of Science ®Google Scholar
• Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007; 130:1120-33; PMID:17889654; http://dx.doi.org/10.1016/j.cell.2007.07.019
   PubMed Web of Science ®Google Scholar
• Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan S-T, Luk JM, Wigler M, Hannon GJ, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006; 125:1253-67; PMID:16814713; http://dx.doi.org/10.1016/j.cell.2006.05.030
   PubMed Web of Science ®Google Scholar
• Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, et al. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 2011; 144:782-95; PMID:21376238; http://dx.doi.org/10.1016/j.cell.2011.02.031
   PubMed Web of Science ®Google Scholar
• Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D. A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev 2014; 28:432-7; PMID:24589775; http://dx.doi.org/10.1101/gad.233676.113
   PubMed Web of Science ®Google Scholar
• Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22:725-36; PMID:23201165; http://dx.doi.org/10.1016/j.ccr.2012.09.022
   PubMed Web of Science ®Google Scholar
• Eyss von B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, Tanh M-D, Otto A, Muegge K, Heinemann U, et al. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J 2012; 31:972-85; PMID:22157815; http://dx.doi.org/10.1038/emboj.2011.451
   PubMed Web of Science ®Google Scholar
• Mizuno H, Spike BT, Wahl GM, Levine AJ. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci USA 2010; 107:22745-50; PMID:21149740; http://dx.doi.org/10.1073/pnas.1017001108
   PubMed Web of Science ®Google Scholar