Hmga1 deficiency: “SAC-King” the SAC genes to incite chromosomal instability

Lingling XianDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Karen A. ReddyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Biologic Chemistry, Center for Epigenics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Linda M. S. ResarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Oncology andInstitute for Cellular Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence[email protected]

References

Pierantoni GM, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Valente D, Izzo A, Fusco A. Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. Cell Cycle 2016; 15:812-8; PMID:26889953; http://dx.doi.org/10.1080/15384101.2016.1146835
PubMedGoogle Scholar
Resar LMS. The high mobility group A1 gene: transforming inflammatory signals into cancer? Cancer Res 2010; 70:436-439; PMID:20068164; http://dx.doi.org/10.1158/0008-5472.CAN-09-1212
PubMedGoogle Scholar
Shah SN, Cope L, Poh W, Belton A, Roy S, Talbot CC, Sukumar S, Huso DL, Resar LMS. HMGA1: A master regulator of tumor progression in triple-negative breast cancer cells. PLoS One 2013; 8:e63419; PMID:23658826; http://dx.doi.org/10.1371/journal.pone.0063419
PubMedGoogle Scholar
Schuldenfrei A, Belton A, Kowalski J, Talbot CC, Di Cello F, Poh W, Tsai H-L, Shah SN, Huso TH, et al. HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis. BMC Genomics 2011; 12:549; PMID:22053823; http://dx.doi.org/10.1186/1471-2164-12-549
PubMedGoogle Scholar
Shah SN, Kerr C, Cope L, Zambidis E, Liu C, Hillion J, Belton A, Huso DL, Resar LMS. HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. PLoS One 2012; 7:e48533; PMID:23166588; http://dx.doi.org/10.1371/journal.pone.0048533
PubMedGoogle Scholar
Pierantoni GM, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Federico A, Valente D, Medico E, Fusco A. Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget 2015; 6:17342-17353; PMID:26009897; http://dx.doi.org/10.18632/oncotarget.3944
PubMedGoogle Scholar
Kapanidou M, Lee S, Bolanos-Garcia VM. BubR1 kinase: protection against aneuploidy and premature aging. Trends Mol Med 2015; 21:364-372.; PMID:25964054; http://dx.doi.org/10.1016/j.molmed.2015.04.003
PubMedGoogle Scholar

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Hmga1 deficiency: “SAC-King” the SAC genes to incite chromosomal instability

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