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Cell Cycle Volume 16, 2017 - Issue 1
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Editorials: Cell Cycle Features

The unexpected role of mTORC1 in intestinal stem cells during calorie restriction

Masaki IgarashiDepartment of Biology, Glenn Labs for the Science of Aging, and Koch Institute, MIT, Cambridge,MA, USA
&
Leonard GuarenteDepartment of Biology, Glenn Labs for the Science of Aging, and Koch Institute, MIT, Cambridge,MA, USACorrespondence[email protected]
Pages 1-2 | Received 14 Jul 2016, Accepted 02 Aug 2016, Published online: 05 Sep 2016

References

  • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149:274-93; PMID:22500797; http://dx.doi.org/10.1016/j.cell.2012.03.017
  • Guarente L. Calorie restriction and sirtuins revisited. Genes Dev 2013; 27:2072-85; PMID:24115767; http://dx.doi.org/10.1101/gad.227439.113
  • Yilmatz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 2012; 486:490-5; PMID:22722868; http://dx.doi.org/10.1038/nature11163
  • Igarashi M, Guarente L. mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction. Cell 2016; 66:436-50. PMID:27345368; http://dx.doi.org/10.1016/j.cell.2016.05.044
  • Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol 2014;24:464-71. PMID:24786309; http://dx.doi.org/10.1016/j.tcb.2014.04.002

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